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JOURNAL ARTICLE
Michelle M Kameda-Smith, Katherine Green, Dana L Hutton, Noor Ul Owase Jeelani, Dominic N P Thompson, Darren Hargrave, Kristian Aquilina
OBJECTIVE: Cerebellar pilocytic astrocytomas (cPAs) in childhood have long been recognized to have a good prognosis after total resection, but the outcome after incomplete resective surgery remains largely unpredictable, with the incidence of radiological progressive disease ranging from 18% to 100%. It has been traditionally thought that gross-total resection was required for long-term survival, and small residuals were classically resected in a subsequent operation. METHODS: The authors analyzed their pediatric low-grade glioma (PLGG) database for cases treated between 1985 and 2020 and filtered for intracranial PAs, to determine what clinical or radiological factors precipitated revisional resective surgery in their single quaternary care center cohort...
May 17, 2024: Journal of Neurosurgery. Pediatrics
#2
JOURNAL ARTICLE
Kivanc Atesok, Daniel J Scott, Shepard Hurwitz, Christopher E Gross
Periprosthetic joint infection (PJI) after total ankle arthroplasty (TAA) is a dreaded complication that may lead to catastrophic outcomes. Risk factors include a history of surgery on the operated ankle, low preoperative function scores, diabetes, extended surgical time, and postoperative wound-healing problems. Clinical presentation varies and may include increasing ankle pain and swelling, high temperature, local erythema, wound drainage, and dehiscence. The initial diagnostic evaluation should include plain radiographs, erythrocyte sedimentation rate, C-reactive protein levels, and leukocyte count...
May 16, 2024: Journal of the American Academy of Orthopaedic Surgeons
#3
JOURNAL ARTICLE
Raul E Ruiz-Lozano, Eugenia M Ramos-Dávila, Maria F Colorado-Zavala, Manuel E Quiroga-Garza, Nadim S Azar, Hazem M Mousa, Victor L Perez, Maite Sainz-de-la-Maza, C Stephen Foster, Alejandro Rodriguez-Garcia
BACKGROUND: To analyze the clinical course and outcomes of autoimmune vs. non-autoimmune surgically induced scleral necrosis (SISN). METHODS: Multicentric, retrospective, comparative cohort study. Eighty-two eyes of 70 patients with SISN were classified according to pathogenic mechanism into autoimmune vs. non-autoimmune. Main outcome measures included necrosis onset, type of surgery, associated systemic disease, visual acuity, and treatment were analysed in patients followed for ≥ 6 months...
May 17, 2024: Ocular Immunology and Inflammation
#4
JOURNAL ARTICLE
Mitesh Karn, Basant Kumar Mahato, Liladhar Ojha, Yeshika Thapa, Suman Bhatta, Sushil Sharma, Sachita Chapagain, Sunita Ranabhat, Bhoj Raj Neupane, Deependra Man Shrestha
Retroperitoneal spindle cell neoplasms are diagnostically challenging. Malignant peripheral nerve sheath tumours (MPNSTs) can sometimes present as sporadic primary retroperitoneal tumours. MPNSTs are usually high-grade and highly aggressive tumours and are associated with a poor prognosis. Low-grade MPNSTs are very rarely described. This current case report describes a case of sporadic primary low-grade MPNST presenting as retroperitoneal spindle cell neoplasm. The diagnosis, imaging and immunohistopathological findings, as well as its successful surgical management, are presented...
May 2024: Journal of International Medical Research
#5
JOURNAL ARTICLE
Jurgen Sota, Silvana Guerriero, Giuseppe Lopalco, Abdurrahman Tufan, Gaafar Ragab, Ibrahim AlMaglouth, Marcello Govoni, Petros P Sfikakis, Micol Frassi, Antonio Vitale, Riza Can Kardas, Paola Triaggianese, Maria Sole Chimenti, Aos A Aboabat, Matteo Piga, Sara Monti, Gian Domenico Sebastiani, Derya Yildirim, Alessandro Conforti, Stefano Gentileschi, Rosanna Dammacco, Andrea Hinojosa-Azaola, Perla Ayumi Kawakami-Campos, Francesca Ruffilli, Jiram Torres-Ruiz, Maissa Thabet, Amira Atig, Piero Ruscitti, Giulia Cataldi, Ombretta Viapiana, Gülen Hatemi, Alican Karakoç, Stefania Costi, Annamaria Iagnocco, Francesca Crisafulli, George Fragoulis, Emanuela Del Giudice, Mohamed Tharwat Hegazy, Maria Pia Paroli, Ali Şahin, Maria Morrone, Florenzo Iannone, Daniela Opris-Belinski, Kazi Nur Asfina, Patrizia Barone, Carla Gaggiano, Hamit Kucuk, Maria Francesca Gicchino, Francesco Carubbi, Valeria Caggiano, Katerina Laskari, Samar Tharwat, Haner Direskeneli, Fatma Alibaz-Oner, Gizem Sevik, Armin Maier, Ahmed Hatem Laymouna, Giacomo Emmi, Nurullah Akkoç, Maria Tarsia, Jessica Sbalchiero, Giovanni Conti, Rosaria Spinella, Francesco La Torre, Enrico Tombetti, Rana Hussein Amin, Angela Mauro, Anastasios Karamanakos, Ester Carreño, Alex Fonollosa, Marco Cattalini, Luciana Breda, Alejandra de-la-Torre, Ewa Wiesik-Szewczyk, Carlos Cifuentes-González, Seza Ozen, Maria Antonietta Mazzei, Gian Marco Tosi, Bruno Frediani, Alberto Balistreri, Ezgi Deniz Batu, Vishali Gupta, Luca Cantarini, Claudia Fabiani
PURPOSE: The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet's disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown. METHODS: Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time...
May 17, 2024: Ocular Immunology and Inflammation
#6
JOURNAL ARTICLE
Elisa Fernández-Fernández, Emma Brugarolas, Irene Monjo-Henry, Marta Novella-Navarro, Alejandro Balsa, Eugenio De Miguel
OBJECTIVES: To investigate whether hypoechoic wall thickness is influenced by the systole or diastole moment in the cardiac cycle and if this can influence ultrasound (US) assessments of giant cell arteritis (GCA). METHODS: US videos of 100 consecutive patients (50 with GCA, 50 without) performed between January 2021 and June 2023 were reviewed. Intima-media thickness (IMT) of temporal (including common trunk, frontal and parietal branches), axillary and subclavian arteries were measured at two different time points, at systolic peak (SP) and at the end-diastole (ED)...
May 17, 2024: Rheumatology
#7
JOURNAL ARTICLE
Jaroslaw Dulski, Peizhou Jiang, Wen-Lang Lin, Dennis W Dickson, Zbigniew K Wszolek
OBJECTIVES: To validate a recently published study in which skin biopsy was reported as a valuable alternative to brain biopsy in diagnosing CSF1R -related disorder ( CSF1R -RD). METHODS: Blinded evaluation of skin samples was performed by independent reviewers using light and electron microscopy collected from a group of CSF1R variant carriers (n = 10) with various genotypes (mono and biallelic), different stages of the disease (asymptomatic and symptomatic), and exposed to different therapies (glucocorticoids, hematopoietic stem cell transplantation, and TREM2 agonist), and from a group of healthy controls (n = 5)...
June 11, 2024: Neurology
#8
JOURNAL ARTICLE
Hadassa Kwetsie, Malu van Schaijk, Sven Van Der Lee, Dederieke Maes-Festen, Leontine W Ten Hoopen, Mieke M van Haelst, Michael Coesmans, Esther Van Den Berg, Marie Claire Y De Wit, Yolande Pijnenburg, Eleonora Aronica, Erik Boot, Agnies M Van Eeghen
BACKGROUND AND OBJECTIVES: Knowledge of young-onset Alzheimer disease in adults with Down syndrome has greatly improved clinical care. However, little is known about dementia in rare genetic neurodevelopmental disorders (RGNDs). In this review, a comprehensive overview is provided of reports on dementia and cognitive/adaptive trajectories in adults with RGNDs. METHODS: A systematic literature review was conducted in Embase, Medline ALL, and PsycINFO on December 6, 2022...
June 11, 2024: Neurology
#9
JOURNAL ARTICLE
Adam de Havenon, Iyanuoluwa Ayodele, Brooke Alhanti, Brian Mac Grory, Ying Xian, Gregg Fonarow, Eric E Smith, Bradford B Worrall
OBJECTIVES: A reliable method of predicting large vessel occlusion (LVO) stroke in data sets without neuroimaging could be retrospectively applied to expand research efforts. METHODS: We conducted a retrospective, cross-sectional cohort analysis of the Get With The Guidelines (GWTG)-Stroke registry. We included adult patients with a final diagnosis of ischemic stroke from 2016 to 2021 who had brain and vascular imaging and excluded those with missing data or posterior circulation stroke...
June 11, 2024: Neurology
#10
JOURNAL ARTICLE
Alexandra Hastings, Patrick Cullinane, Sarah Wrigley, Tamas Revesz, Huw R Morris, John C Dickson, Zane Jaunmuktane, Thomas T Warner, Eduardo De Pablo-Fernández
BACKGROUND AND OBJECTIVES: Degeneration of the presynaptic nigrostriatal dopaminergic system is one of the main biological features of Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which can be measured using single-photon emission CT imaging for diagnostic purposes. Despite its widespread use in clinical practice and research, the diagnostic properties of presynaptic nigrostriatal dopaminergic (DAT) imaging in parkinsonism have never been evaluated against the diagnostic gold standard of neuropathology...
June 11, 2024: Neurology
#11
REVIEW
Richard N Rees, Alastair J Noyce, Anette E Schrag
Parkinson disease (PD) remains a progressive and incurable disease. Research over the past decade provides strong evidence of a detectible phase before the clinical diagnosis, known as the prodromal phase of PD (pPD). In this article, we review the debate about disclosure of risk of progression to PD and related disorders to individuals through the perspectives of the pillars of medical ethics: beneficence, nonmaleficence, autonomy, and justice. There is evidence that lifestyle modification may have positive effects on onset and progression of PD, providing justification of potential benefit...
June 11, 2024: Neurology
#12
JOURNAL ARTICLE
Isabel Vidal, Ana Patrícia Antunes, Carlos Morgado, Nuno Simas, Rafael Roque, Luísa Albuquerque
Optic neuropathies include a wide range of disorders from ischemic, toxic, demyelinating, or inflammatory processes with acute/subacute onset to more gradual compressive or genetic etiologies. Accurate clinical history and multimodality optic nerve imaging including MRI and optical coherence tomography have greatly improved the diagnosis of patients with optic neuropathies. We report a case of a woman with severe monocular visual acuity deficit. Optic nerve sheath enhancement seen on MRI led to a broad differential diagnosis including demyelinating causes, optic nerve sheath meningioma (ONSM), tuberculosis, and sarcoid optic neuropathy...
June 11, 2024: Neurology
#13
REVIEW
Tomotaka Tanaka, Masafumi Ihara, Kazuki Fukuma, Nishant K Mishra, Matthias J Koepp, Alla Guekht, Akio Ikeda
Poststroke epilepsy (PSE) is associated with higher mortality and poor functional and cognitive outcomes in patients with stroke. With the remarkable development of acute stroke treatment, there is a growing number of survivors with PSE. Although approximately 10% of patients with stroke develop PSE, given the significant burden of stroke worldwide, PSE is a significant problem in stroke survivors. Therefore, the attention of health policymakers and significant funding are required to promote PSE prevention research...
June 11, 2024: Neurology
#14
JOURNAL ARTICLE
Simon M Petzinna, Lara C Burg, Claus-Juergen Bauer, Pantelis Karakostas, Jan H Terheyden, Charlotte Behning, Frank G Holz, Peter Brossart, Robert P Finger, Valentin S Schäfer
OBJECTIVES: The objective of this study was to prospectively evaluate the diagnostic efficacy of transorbital ultrasound (TOS) in patients newly diagnosed with giant cell arteritis (GCA), presenting with visual symptoms. METHODS: Patients with newly diagnosed, untreated GCA were examined using TOS, assessing central retinal artery flow velocity [peak systolic velocity (PSV), end-diastolic velocity (EDV), resistance index (RI)], and optic nerve diameter (OND). Vascular ultrasound was conducted to evaluate the superficial temporal arteries, their branches, facial, axillary, carotid, and vertebral arteries...
May 17, 2024: Rheumatology
#15
JOURNAL ARTICLE
Eduardo Martín-Nares, Griselda Romero-Sánchez, Edwin Ulises Cortez-Domínguez, Lilian Guadalupe Cano-Cruz, Andrea Hinojosa-Azaola
OBJECTIVES: We aimed to characterize the clinical and radiological features, and outcomes, of a large cohort of hypertrophic pachymeningitis (HP) patients from a single center. METHODS: We conducted a retrospective study at a tertiary referral center, encompassing patients diagnosed with HP between 2003 and 2022. The diagnosis of HP relied on the identification of thickening of the dura mater via magnetic resonance imaging (MRI) of the brain or spine. RESULTS: We included 74 patients with a mean age of 43...
May 17, 2024: Rheumatology
#16
JOURNAL ARTICLE
Lien Moreel, Albrecht Betrains, Ellen De Langhe, Steven Vanderschueren, Daniel Blockmans
No abstract text is available yet for this article.
May 17, 2024: Rheumatology
#17
JOURNAL ARTICLE
S Vishnu Priyan, R Vinod Kumar, C Moorthy, V S Nishok
Retinal disorders pose a serious threat to world healthcare because they frequently result in visual loss or impairment. For retinal disorders to be diagnosed precisely, treated individually, and detected early, deep learning is a necessary subset of artificial intelligence. This paper provides a complete approach to improve the accuracy and reliability of retinal disease identification using images from OCT (Retinal Optical Coherence Tomography). The Hybrid Model GIGT, which combines Generative Adversarial Networks (GANs), Inception, and Game Theory, is a novel method for diagnosing retinal diseases using OCT pictures...
May 14, 2024: Journal of X-ray Science and Technology
#18
JOURNAL ARTICLE
Renzo Bianchi, Gail Swingler, Irvin Sam Schonfeld
For decades, the Maslach Burnout Inventory (MBI) has been regarded as the "gold standard" for the assessment of burnout. The present paper demonstrates that the MBI fails to measure the construct it is purported to measure. On a deeper level, the problems affecting the MBI question the very idea of burnout. These problems may be unsurprising in light of the genesis of the burnout construct. Burnout emerged in the mid-1970s as a largely predefined entity. Burnout's definition was not predicated on robust empirical investigations or sound theorizing, nor was it anchored in a systematic review of the literature on stress and health...
May 13, 2024: Work: a Journal of Prevention, Assessment, and Rehabilitation
#19
JOURNAL ARTICLE
Rachel D Wellons, Sydney E Duhe, Sara G MacDowell, Sara Oxborough, K C Madhav
BACKGROUND: Health disparities (HD) impact care delivery and health outcomes in individuals with vestibular disorders (IVD). OBJECTIVE: The purpose of this study is to identify whether health disparities (HD) exist in Vestibular Rehabilitation (VR) between individuals identifying as Caucasians or racial or ethnic minorities (REM). METHODS: This study was a retrospective chart review of IVD who attended outpatient VR between 1/2014 and 9/2020...
May 11, 2024: Journal of Vestibular Research: Equilibrium & Orientation
#20
JOURNAL ARTICLE
Xia Yu, Liyong Ma, Hongjie Wang, Yong Zhang, Hai Du, Kaiyuan Xu, Lianfang Wang
BACKGROUND: Congenital heart disease (CHD) seriously affects children's health and quality of life, and early detection of CHD can reduce its impact on children's health. Tetralogy of Fallot (TOF) and ventricular septal defect (VSD) are two types of CHD that have similarities in echocardiography. However, TOF has worse diagnosis and higher morality than VSD. Accurate differentiation between VSD and TOF is highly important for administrative property treatment and improving affected factors' diagnoses...
April 18, 2024: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
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