Shang-Wen Lin, Yan-Jye Shyong, Ping-Chung Kuo, Jui-Chen Tsai
Sebacoyl dinalbuphine ester (SDE) is a nalbuphine (NA) prodrug capable of biotransformation in vivo and prolong the duration of NA, maximize its effect in pain and pruritus management. However, the large molecular weight, low skin penetration, and stability concerns of SDE make it difficult to be used in local skin delivery. Nanostructured lipid carrier (NLC) is a lipid-based nanoparticulate system that has the potential for formulating SDE in order to promote drug delivery through the skin. The aim of this study was to develop SDE-loaded NLC formulations (SDE-NLC) with good stability, sustained release characteristics, and sufficient antipruritic effect...
February 23, 2021: International Journal of Pharmaceutics
Wen-Wu Li, Yang Yang, Tian-Zhi Guo, Peyman Sahbaie, Xiao-You Shi, Qin Guang, Wade S Kingery, Leonore A Herzenberg, J David Clark
BACKGROUND: Up-regulated interleukin 6 (IL-6) signaling, immune system activation, and pronociceptive autoantibodies are characteristic of complex regional pain syndrome (CRPS). IL-6 is known to promote B cell differentiation, thus we hypothesized that IL-6 signaling plays a crucial role in the development of adaptive immune responses and nociceptive sensitization in a murine tibia fracture model of CRPS. METHODS: Mice deficient in IL-6 expression (IL-6-/- ) or B cell deficient (muMT) underwent tibia fracture and 3 weeks of cast immobilization or sham injury...
February 23, 2021: Brain, Behavior, and Immunity
Eduardo A Lacayo, Sara Velayati, Ahmed Elsakka, Lynn Brody, Joseph P Erinjeri, Etay Ziv, Franz E Boas, Constantinos T Sofocleous, Mikhail Silk, Vicky Makker, William P Tew, Hooman Yarmohammadi
PURPOSE: To evaluate the safety and efficacy of two locoregional therapies (LRT) including hepatic artery embolization (HAE) and transarterial radioembolization (TARE) in treating patients with metastatic ovarian cancer to the liver. METHODS: From October 2010 to May 2019, the data of 15 consecutive patients (median age, 54 ± 9.8; range, 35-78) with hepatic metastatic ovarian cancer that were treated with either HAE (n = 6, 40%) or TARE (n = 9, 60%) were reviewed...
February 23, 2021: Journal of Vascular and Interventional Radiology: JVIR
Alejandra Chávez-Riveros, Eduardo Hernández-Vázquez, Ángel Ramírez-Trinidad, Antonio Nieto-Camacho, Luis D Miranda
Non-Steroidal Anti-inflammatory Drugs (NSAIDs) are some of the most prescribed medications for pain but the incidence of adverse effects -especially during chronic treatment- points out the requirement of new analgesics. In this study, we showed an efficient two-steps synthesis of diphenylamine-containing dipeptides consisting of a multicomponent process followed by a Buchwald-Hartwig cross-coupling reaction. We prepared 16 diphenylamine derivatives and evaluated their in vivo anti-inflammatory activity through an ear edema model using 12-O-tetradecanoylpholbol-13-acetate...
February 23, 2021: Bioorganic & Medicinal Chemistry Letters
Ezgi Yasar, Erdogan Kavlak, Serkan Turkucar, Deniz Bayraktar, Ceyhun Acari, Erbil Unsal
PURPOSE: The aim was to compare the effects of yoga and home exercise program on lower extremity functional status, pain, and quality of life in children with enthesitis related arthritis (ERA). METHODS: Twenty-one children with ERA were divided into two groups as yoga (n = 11) and home exercise (n = 10). Yoga group performed supervised yoga exercises twice a week for eight weeks. Home exercise group performed video-based exercises for the same period. Pain in rest and activity, lower extremity functional status, and quality of life were evaluated at baseline and following eight weeks...
February 23, 2021: Complementary Therapies in Medicine
Takashi Hozumi, Setsu Sawai, Tatsuya Jitsuishi, Keiko Kitajo, Kazuhide Inage, Yawara Eguchi, Yasuhiro Shiga, Miyako Narita, Sumihisa Orita, Seiji Ohtori, Atsushi Yamaguchi
BACKGROUND: Chronic pain is a highly refractory and complicated condition that persists even without nociception. Several genome-wide gene expression analyses have shown that the immune response and inflammatory cytokines affect chronic pain establishment in the acute pain phase. However, compared with the acute phase, the chronic phase has a poorly elucidated gene expression profile. This study aimed to determine the gene expression profile in the spinal cord of a neuropathic pain mouse model in the chronic phase to elucidate the chronic pain characteristics...
February 23, 2021: Neuroscience Letters
Joanna Sharpless, Bethany-Rose Daubman, David Ryley, Sarah Byrne-Martelli
No abstract text is available yet for this article.
February 23, 2021: Journal of Pain and Symptom Management
Sinead Daly, Nicholas C A Claydon, Robert G Newcombe, Joon Seong, Martin Addy, Nicola X West
OBJECTIVES: To determine whether a microneedle patch combined with 5% topical lidocaine reduces dental injection pain more than a patch without microneedles combined with 5% topical lidocaine. METHODS: This proof of principle randomised, two-treatment, double-blind, crossover split-unit design study in 16 healthy participants investigated levels of perceived pain from 3 increasing pain provoking challenges, when topical 5% lidocaine dental gel was applied to the oral mucosa with a microneedle patch and a patch with no microneedles, prior to infiltration with local anaesthesia on 2 visits...
February 23, 2021: Journal of Dentistry
Liting Sun, Ruilong Xia, Jinwen Jiang, Ting Wen, Zhuoya Huang, Ran Qian, Ming-Dong Zhang, Mingcheng Zhou, Changgeng Peng
Voltage-gated sodium channels (Nav s) 1.7, 1.8, and 1.9 are predominately expressed in peripheral sensory neurons and are critical for action potential propagation in nociceptors. Unexpectedly, we found that expression of SCN9A, SCN10A, SCN11A, and SCN2A, the alpha subunit of Nav 1.7, Nav 1.8, Nav 1.9 and Nav 1.2, respectively, are up-regulated in spinal dorsal horn (SDH) neurons of miR-96 knockout mice. These mice also have de-repression of CACNA2D1/2 in DRG and display heat and mechanical allodynia that could be attenuated by intrathecal or intraperitoneal injection of Nav 1...
February 23, 2021: Progress in Neurobiology
Jane Tucker, Joanne Salas, Zidong Zhang, Richard Grucza, Jeffrey F Scherrer
The CDC Guideline for Prescribing Opioids for Chronic Pain cautioned against high dose prescribing but did not provide guidance on type of opioid for new pain episodes. We determined if new prescriptions for Schedule II opioids vs. tramadol decreased in the 18 months after vs. before the CDC guideline and if this decrease was associated with physician specialty. New opioid prescriptions, provider type and covariates were measured using a nationally distributed, Optum® de-identified Electronic Health Record (EHR) data base...
February 23, 2021: Preventive Medicine
Danielle Pillet-Shore
What happens when a friend starts talking about her own substance use and misuse? This article provides the first investigation of how substance use is spontaneously topicalized in naturally occurring conversation. It presents a detailed analysis of a rare video-recorded interaction showing American English-speaking university students talking about their own substance (mis)use in a residential setting. During this conversation, several substance (mis)use informings are disclosed about one participant, and this study elucidates what occasions each disclosure, and how participants respond to each disclosure...
February 26, 2021: Sociology of Health & Illness
Megan Franzetti, Emily Dries, Brady Stevens, Lisa Berkowitz, Sheldon C Yao
Context: Osteopathic manipulative treatment (OMT) is used to treat chronic pain conditions. However, few guidelines focusing on chronic pain management include recommendations for OMT. Objectives: To evaluate previous literature on the use of OMT for improving chronic pain. Methods: A literature search was conducted on MEDLINE/PubMed and ScienceDirect on August 26-27, 2019, using the terms "osteopathic," "chronic," and "pain," yielding a total of 312 MEDLINE/PubMed articles and 515 ScienceDirect articles...
March 1, 2021: Journal of the American Osteopathic Association
Tamer M Khalaf, Mohamed Z Ramadan, Adham E Ragab, Mohammed H Alhaag, Khalil A AlSharabi
BACKGROUND: The handling of unknown weights, which is common in daily routines either at work or during leisure time, is suspected to be highly associated with the incidence of low back pain (LBP). OBJECTIVES: To investigate the effects of knowledge and magnitude of a load (to be lifted) on brain responses, autonomic nervous activity, and trapezius and erector spinae muscle activity. METHODS: A randomized, within-subjects experiment involving manual lifting was conducted, wherein 10 participants lifted three different weights (1...
2021: PloS One
Janusiya Anajan Muthulingam, Søren Schou Olesen, Tine Maria Hansen, Christina Brock, Asbjørn Mohr Drewes, Jens Brøndum Frøkjær
BACKGROUND & AIMS: Chronic abdominal pain is the primary symptom of chronic pancreatitis, but unfortunately it is difficult to treat. Vagal nerve stimulation studies have provided evidence of anti-nociceptive effect in several chronic pain conditions. We investigated the pain-relieving effects of transcutaneous vagal nerve stimulation in comparison to sham treatment in chronic pancreatitis patients. METHODS: We conducted a randomised double-blinded, sham-controlled, crossover trial in patients with chronic pancreatitis...
2021: PloS One
Kug Jin Jeon, Chena Lee, Yoon Joo Choi, Sang-Sun Han
The prevalence of temporomandibular joint disorder (TMD) is gradually increasing, and magnetic resonance imaging (MRI) is becoming increasingly common as a modality used to diagnose TMD. Edema and osteonecrosis in the bone marrow of the mandibular condyle have been considered to be precursors of osteoarthritis, but these changes are not evaluated accurately and quantitatively on routine MRI. The iterative decomposition of water and fat with echo asymmetry and least-squares estimation (IDEAL-IQ) method, as a cutting-edge MRI technique, can separate fat and water using three asymmetric echo times and the three-point Dixon method...
2021: PloS One
Osama Mosalem, Fawzi Abu Rous, Abdullah Al-Abcha, Shouq Kherallah, Jacob Burch
INTRODUCTION: Pyomyositis has been described in association with hematological malignancies. It is rarely associated with solid cancers, particularly colorectal carcinoma. Colorectal carcinoma can present with local or systemic abscesses by causing perforation of the colonic mucosa, followed by local or hematogenous spread of infection. CASE PRESENTATION: A 68-year-old male with a history of hypertension and type II diabetes mellitus presented to the emergency department with a 3-day history of left thigh pain...
December 2020: Permanente Journal
Faith Brown, Maggie Guinta, Jenna Swindler, Denise Allison, Craig Selander, Brenda Raynor
BACKGROUND: Perioperative pain management guidelines recommend using multimodal analgesia to improve pain control while reducing opioids administered. The primary objective of this study was to assess whether implementing multimodal analgesia on general surgery postoperative pain management order sets would reduce opioid quantities postoperatively. METHODS: Opioid-naive patients undergoing nonemergent general surgery procedures were evaluated before and after order set revision...
December 2020: Permanente Journal
Sameer Nazeeruddin, Fabio Butti, Gilles Herren
The rate of emergency operations for incarcerated and strangulated ventral hernias is about 10-15% with worse outcomes than elective surgery. A recent laparoscopic technique called Enhanced view totally extra peritoneal approach (eTEP) was shown to be indicated in elective repair of ventral and incisional hernias and it has been shown to have lower rate of postoperative morbidity compared to the Rives-Stoppa technique, while having the same indications. However the eTEP laparoscopic technique has not been yet reported in emergency ventral hernia repair...
February 15, 2021: Swiss Medical Weekly
Angela Sandri, Maria Paola Cecchini, Marianna Riello, Alice Zanini, Riccardo Nocini, Mirta Fiorio, Michele Tinazzi
Every day our sensory systems perceive and integrate a variety of stimuli containing information vital for our survival. Pain acts as a protective warning system, eliciting a response to remove harmful stimuli; it may also be a symptom of an illness or present as a disease itself. There is a growing need for additional pain-relieving therapies involving the multisensory integration of smell and taste in pain modulation, an approach that may provide new strategies for the treatment and management of pain. While pain, smell, and taste share common features and are strongly linked to emotion and cognition, their interaction has been poorly explored...
February 26, 2021: Pain and Therapy
Ana Fernández-Montes, Guillermo de Velasco, Santiago Aguín, Cristina Farriols, María Guirado-Risueño, Vanessa G Jerviz-Guía, María Victoria Baeza-Nadal, Rodolfo Chicas-Sett, José Luis Fírvida, Francisco García-Navalón, Patricia Martín, Carmen Perezagua-Marín, Dulce Rodríguez, Joan Santamaría, Tamara Saurí, Manuel Cobo
Management of chronic pain is crucial to improve the quality of life of cancer and palliative care patients. Opioid-based treatments used to control pain can be prolonged over time. Unfortunately, constipation is one of the most disturbing adverse effects of long-term use of opioids. Opioid-induced constipation (OIC) occurs when opioids bind to the specific receptors present in the gastrointestinal (GI) tract, and can affect any patients receiving chronic opioid therapy, including cancer patients. The limited efficacy of laxatives to treat OIC symptoms prompted the search for new therapeutic strategies...
February 26, 2021: Current Treatment Options in Oncology
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