Şule Haskoloğlu, Gökcan Öztürk, Nazlı Deveci Demirbaş, Can Akal, Candan İslamoğlu, Kübra Baskın, Aylin Heper, Ömer Erdeve, Serdar Ceylaner, Figen Doğu, Aydan İkincioğulları
Junctional epidermolysis bullosa (JEB) is a rare, incurable, devastating, and mostly fatal congenital genetic disorder characterized by painful blistering of the skin and mucous membranes in response to minor trauma or pressure. JEB is classified roughly into 2 subtypes: JEB-Herlitz is caused by mutations on genes encoding laminin-332. The authors present a patient consulted with a suspicion of primary immunodeficiency due to skin sores that started at the age of 1 month and a history of 3 siblings who died with similar sores, who was diagnosed with JEB-Herlitz after detecting a homozygous LAMC2 gene mutation in WES analysis...
April 23, 2024: American Journal of Dermatopathology
Juan Liu, Guiqi Zhang, Qiuyan Zhao, Juan Wang, Jing Zhang, Chuanyi Bai
This study aims to investigate the impact of specialized nursing care at fracture sites coordinated with disease progression monitoring in thoracolumbar spine fractures. Patients diagnosed with definitive thoracolumbar spine fractures and underwent surgical treatment at our hospital between February 2022 and August 2023 were selected. Patients were divided into a treatment group (specialized nursing care at fracture sites coordinated with disease progression monitoring)and a control group (conventional care) based on different nursing methods...
April 22, 2024: International Journal of Neuroscience
Maria Marcelly Lúcio Mota, Igor Hudson Albuquerque E Aguiar, Anderson Silva de Lima, Olavo Barbosa de Oliveira Neto, Pâmela Lopes Pedro da Silva, Eduarda Correia Moretti, George Azevedo Lemos
PURPOSE OF REVIEW: Laser acupuncture (LA) demonstrates promising results in the treatment of musculoskeletal disorders. However, its effects on temporomandibular disorder (TMD) are not yet fully understood. Thus, the aim of this systematic review and network meta-analysis was to assess the effectiveness of LA on pain intensity and maximum mouth opening range (MMO) related to TMD. A search was carried out in 11 electronic databases and references of included studies to locate randomized clinical trials (RCTs) that evaluated LA as a primary treatment for TMD...
April 22, 2024: Current Pain and Headache Reports
Ahmad Parvinian, Scott M Thompson, John J Schmitz, Brian T Welch, Rebecca Hibbert, Daniel A Adamo, A Nicholas Kurup
PURPOSE OF REVIEW: To provide an update on the current state of percutaneous thermal ablation in the treatment of sarcoma. RECENT FINDINGS: Data continue to accrue in support of ablation for local control and palliation of specific sarcoma subtypes such as extra-abdominal desmoid fibromatosis and for broader indications such as the treatment of oligometastatic disease. The synergistic possibilities of various combination therapies such as cryoablation and immunotherapy represent intriguing areas of active investigation...
April 22, 2024: Current Oncology Reports
Alexander Egeberg, Jason E Hawkes, Najwa Somani, Russel Burge, Kyoungah See, Gaia Gallo, Missy McKean-Matthews, Melinda Gooderham, George Han, April Armstrong
INTRODUCTION: Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin-17A, is approved for the treatment of moderate-to-severe plaque psoriasis. Since scalp psoriasis can be burdensome and challenging to treat with non-systemic therapies, this post hoc analysis focused on scalp psoriasis in patients with moderate-to-severe plaque psoriasis and baseline scalp involvement. The analysis considered a holistic concept of clearance through 5 years of ixekizumab treatment...
April 22, 2024: Dermatology and Therapy
Karen Dennehy, Amy Lynch, Catriona Reddin, Bart Daly, Tim Dukelow, Michelle Canavan, Maria Costello, Robert Murphy
PURPOSE: Comprehensive geriatric assessment (CGA) is the cornerstone of high-quality care for older adults. There is no current gold standard to guide what should be included as the baseline measure for CGAs. We examined what metrics are being captured in CGA baseline assessments completed by community based integrated care teams in Ireland. METHODS: CGA's care pathways in Ireland are usually initiated with a written document that establish patients baseline in various assessment areas...
April 22, 2024: European Geriatric Medicine
Srinivasan Periasamy, Yun-Ju Chen, Dur-Zong Hsu, Dar-Jen Hsieh
Osteoarthritis (OA) of the knee is a common degenerative articular disorder and is one of the main causes of pain and functional disability. Cartilage damage is frequently linked to elevated osteoarthritis incidence. Supercritical carbon dioxide (scCO2 ) decellularized cartilage graft produced from the porcine cartilage is an ideal candidate for cartilage tissue engineering. In the present study, we derived collagen type II (Col II) solution from the scCO2 decellularized porcine cartilage graft (dPCG) and compared its efficacy with hyaluronic acid (HA) in the surgical medial meniscectomy (MNX) induced post-traumatic osteoarthritis (PTOA) model...
February 3, 2024: Bioresources and Bioprocessing
Jaideep Dutta
Haemorrhoidal disease is identified by declension of the inflamed and bleeding of vascular tissues of the anal canal. Traditionally, haemorrhoids are associated with chronic constipation and the most common symptoms are irritation in anus region, pain and discomfort, swelling around anus, tender lumps around the anus and rectal bleeding (depending upon the grade of haemorrhoid). Among the several conventional treatment procedures (commonly mentioned as, rubber band litigation, sclerotherapy and electrotherapy), laser haemorrhoidoplasty is an out-patient and less-invasive laparoscopic procedure...
April 22, 2024: Lasers in Medical Science
Yahong Xue, Huifen Zhou, Yusha Zeng, Chen Wang, Yun Yang, Xiaopeng Wang, Zongqi He, Yibo Yao, Xiaofeng Wang, Zhimin Fan
BACKGROUND: Some Chinese scholars have initially explored the efficacy of electroacupuncture at Baliao acupoint in patients with functional anorectal pain (FAP). However, their studies are performed in a single center, or the sample size is small. Therefore, we aim to further explore the efficacy of electroacupuncture at Baliao acupoint on the treatment of FAP. METHODS: In this multicenter randomized controlled trial, 136 eligible FAP patients will be randomly allocated into an electroacupuncture group or sham electroacupuncture group at a 1:1 ratio...
April 22, 2024: International Journal of Colorectal Disease
F G A M van Haren, M A H Steegers, K C P Vissers, S A S van den Heuvel
PURPOSE: In treating cancer, different chemotherapy regimens cause chemotherapy-induced peripheral neuropathy (CIPN). Despite recent international guidelines, a gold standard for diagnosis, treatment, and care is lacking. To identify the current clinical practice and the physicians' point of view and ideas for improvement, we evaluated CIPN care by interviewing different specialists involved. METHODS: We performed semi-structured, audio-recorded, transcribed, and coded interviews with a purposive sample of oncologists, pain specialists, and neurologists involved in CIPN patients' care...
April 22, 2024: Supportive Care in Cancer
Palak Nandolia, Khanak Nandolia, Ravi Hari Phulware, Sonal Saran
No abstract text is available yet for this article.
April 22, 2024: Skeletal Radiology
Kei Sakamoto, Osamu Miyazaki, Ayako Imai, Reiko Okamoto, Yoshiyuki Tsutsumi, Mikiko Miyasaka, Atsuhito Seki, Takako Yoshioka, Shunsuke Nosaka
Osteoid osteoma (OO) is a common, benign bone tumor. However, there are no case reports of OO associated with osteogenesis imperfecta (OI), or pathological fractures in OO. A 3-year-old girl with OI sustained a complete right tibial diaphyseal fracture. Bony fusion was completed after 4 months of conservative therapy; nevertheless, 18 months later spontaneous pain appeared at the fracture site, without any cause. Plain radiographs showed a newly apparent, rounded area of translucency 1 cm in diameter, just overlapping the previous fracture...
April 22, 2024: Skeletal Radiology
Jian Tang, Qi Chen, Li Xiang, Ting Tu, Ying Zhang, Cehua Ou
This study explores the molecular underpinnings of neuropathic pain (NPP) and neuroinflammation, focusing on the role of TRIM28 in the regulation of autophagy and microglia ferroptosis. Leveraging transcriptomic data associated with NPP, we identified TRIM28 as a critical regulator of ferroptosis. Through comprehensive analysis, including Gene Ontology enrichment and protein-protein interaction network assessments, we unveiled GSK3B as a downstream target of TRIM28. Experimental validation confirmed the capacity of TRIM28 to suppress GSK3B expression and attenuate autophagic processes in microglia...
April 22, 2024: Molecular Neurobiology
Fengzhao Zhu, Dongqing Jia, Yaqing Zhang, Chencheng Feng, Yan Peng, Ya Ning, Xue Leng, Jianmin Li, Yue Zhou, Changqing Li, Bo Huang
OBJECTIVE: Tubular microdiskectomy (tMD) is one of the most commonly used for treating lumbar disk herniation. However, there still patients still complain of persistent postoperative residual low back pain (rLBP) postoperatively. This study attempts to develop a nomogram to predict the risk of rLBP after tMD. METHODS: The patients were divided into non-rLBP (LBP VAS score < 2) and rLBP (LBP VAS score ≥ 2) group...
April 22, 2024: European Spine Journal
Jun-Peng Liu, Xing-Chen Yao, Yue Wu, Zi-Yu Xu, Meng Li, Ming Shi, Jie Ren, Xin-Ru Du
PURPOSE: To investigate the effectiveness and safety of separation surgery for Epidural Spinal Cord Compression (ESCC) graded ≥ 2 in patients with Multiple Myeloma (MM), analyze factors influencing surgical outcomes, and develop a preliminary treatment decision framework for these patients. METHODS: A retrospective analysis was conducted on clinical data from 35 MM patients who underwent separation surgery for ESCC graded ≥ 2 between 2013 and 2018...
April 22, 2024: European Spine Journal
Erin Y Harmon, Li Shen Chong, Morgan D Marruso
PURPOSE: Effective pain management is vital for hip fracture recovery, yet the factors influencing pain reporting and pain medication use during inpatient rehabilitation for hip fractures are not well understood. This observational study aimed to (a) determine how cognitive abilities, expressive and receptive language abilities, and age are related to average daily pain intensity and analgesic use and (b) how average daily pain intensity and analgesic use are related to length of stay and functional outcomes in rehabilitation...
April 22, 2024: Rehabilitation Psychology
Vivien Hui In Cheung, Lauren J Christie, Terri Maister, Devlin Higgins, David Williams, Nikki Woods, Melissa Armstrong, Susan Hart
OBJECTIVE: To identify patients presenting to an acute medical hospital with common signs and symptoms that occur in people with eating disorders (EDs), and determine by retrospective file audit if these are diagnosed cases of an ED. METHOD: The investigators screened electronic medical records of people 16 years and older for common signs and symptoms of an ED such as hypokalemia, in patients presenting to an acute hospital in Sydney, Australia from 2018 to 2020...
April 22, 2024: International Journal of Eating Disorders
Jingen Hu, Caibao Hu
Endoscopic carpal tunnel release (ECTR) techniques have been established as a successful treatment for carpal tunnel syndrome and have proven equally effective as traditional open carpal tunnel release (OCTR) techniques in relieving pain and numbness. However, patients who undergo OCTR are more likely to experience scar tenderness and pillar pain and take longer to return to work. We present here a method of metacarpal small incision for carpal tunnel release (MSICTR) as a safe, reliable, cost-effective alternative surgical decompression of the median nerve of the wrist...
April 5, 2024: Journal of Visualized Experiments: JoVE
Ying-Chen Kuo, Lin-Fen Hsieh, Ya-Fang Liu, Chia-Sung Chang
INTRODUCTION: Corticosteroid injection effectively treats de Quervain disease, and due to the high prevalence of the intracompartmental septum in the first extensor compartment, ultrasound guidance improves injection accuracy. OBJECTIVE: To compare the effectiveness, adverse events, and the recurrence rate between ultrasound-guided and palpation-guided injection in patients with de Quervain disease. DESIGN: Prospective, single-blind, randomized controlled trial...
April 22, 2024: PM & R: the Journal of Injury, Function, and Rehabilitation
Qingbao Li, Hanxiao Nie, Zifan Wang, Shihong Li, Yibin Wang, Naiqi Chen, Wei Wang, Fei Xu, Deli Zhang
OBJECTIVES: A single nerve block provides excellent analgesia in a short time, but rebound pain after the nerve block disappears has attracted researchers' attention. The aim of this study is to evaluate the effect of perineural dexamethasone on rebound pain after sciatic nerve block and femoral nerve block in patients undergoing unicompartmental knee arthroplasty (UKA). METHODS: In a double-blinded fashion, We recruited 72 patients undergoing UKA, each of whom received sciatic and femoral nerve block...
April 22, 2024: Clinical Journal of Pain
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