Rubeena Maqbool, Mudasir Maqbool, Mehrukh Zehravi, Irfat Ara
Menstrual-related issues have significant public-health ramifications. Women who are having menstruation troubles should get their mental health checked by healthcare specialists. In young women, a menstrual-related condition has serious health implications. Young females who have menstrual issues miss job and school, and their behavioural and mental development suffers as a result. Depression and anxiety have an impact on women's menstrual periods in adults. Symptoms like as cramps, tiredness, backache, swelling abdomen, and painful breasts have also been described in women with menstrual misery...
July 22, 2021: International Journal of Adolescent Medicine and Health
L E Rondeau, G De Palma, A Caminero
It is estimated that one-fifth of the general population experiences adverse reactions to food.1 There is evidence of an increase in the prevalence of well-defined food sensitivities such as celiac disease, food allergy, and food intolerance, suggesting a critical role of yet unknown environmental factors as modifiers of disease expression.1 The role of microorganisms in inciting sensitivity to foods has garnered significant attention. Notably, microbes have the capacity to promote sensitivity to foods by modulating mucosal barrier integrity, inducing aberrant immune responses, or by modifying food antigen immunogenicity...
July 22, 2021: Allergy
Assia Hamdi, Aymen Halouani, Ines Aouf, Johan Viaene, Belsem Marzouk, Jamil Kraiem, Hela Jaïdane, Yvan Vander Heyden
Haplophyllum tuberculatum is a plant commonly used in folk medicine to treat several diseases including vomiting, nausea, infections, rheumatism, and gastric pains. In the current study, H. tuberculatum essential oils, hydrosols, the pure compounds R -(+)-limonene, S -(-)-limonene, and 1-octanol, as well as their combinations R -(+)-limonene/1-octanol and S -(-)-limonene/1-octanol, were screened for their cytotoxicity on HEp-2 cells after 24, 48, and 72 h, and then tested for their activity against Coxsackievirus B3 and B4 (CV-B3 and CV-B4) at 3 different moments: addition of the plant compounds before, after, or together with virus inoculation...
July 22, 2021: Planta Medica
Nima Mehran, Varun Singla, Kelechi R Okoroha, Justin J Mitchell
Articular cartilage injuries of the knee are being observed with increasing frequency in athletes and have proven to be difficult to treat given the limited regenerative ability of cartilage and the potential for progressive joint degeneration. A wide range of surgical treatments such as microfracture, autologous chondrocyte implantation, and osteochondral autograft and allograft have demonstrated promising results in these high-demand individuals. These procedures permit healing of cartilage defects while decreasing pain and restoring function with patient-reported outcomes demonstrating significant improvement at short-, mid-, and long-term follow-up...
July 22, 2021: Journal of the American Academy of Orthopaedic Surgeons
Takaaki Murata, Hidemitsu Ogino, Naoko Isogai, Hiroyuki Kashiwagi, Rai Shimoyama, Jun Kawachi
INTRODUCTION AND IMPORTANCE: Blunt abdominal aortic injury (BAAI) resulting from blunt abdominal trauma is rare; therefore, there are no standard guidelines for its treatment. Herein, we report the successful treatment of BAAI via endovascular aortic repair (EVAR) performed immediately after emergency laparotomy to repair a bowel injury. CASE PRESENTATION: A 78-year-old man was injured after being caught between a shovel car and the bumper of his own car for approximately 15 s...
July 18, 2021: International Journal of Surgery Case Reports
Muhammad Wahyudi, Ziad Alaztha
INTRODUCTION: Fibrous dysplasia is tumor like lesions of bone which develop as substitution of bone by an expansion of fibrous connective tissue mixed with hard trabeculae. Chondrosarcomas is one of common malignant primary bone tumor derived from heterogenous group of neoplasm producing chondroid matrix. Chondrosarcoma arising in fibrous dysplasia, especially in monostotic fibrous dysplasia is a very rare case. CASE REPORT: A 54-year-old male presented with chief complaint of pain on left thigh...
July 9, 2021: International Journal of Surgery Case Reports
Maja Goršič, Yu Song, Boyi Dai, Domen Novak
Trunk exoskeletons are wearable devices that support humans during physically demanding tasks by reducing biomechanical loads on the back. While most trunk exoskeletons are rigid devices, more lightweight soft exoskeletons (exosuits) have recently been developed. One such exosuit is the HeroWear Apex, which achieved promising results in the developers' own work but has not been independently evaluated. This paper thus presents an evaluation of the Apex with 20 adult participants during multiple brief tasks: standing up from a stool with a symmetric or asymmetric load, lifting a unilateral or bilateral load from the floor to waist level, lifting the same bilateral load with a 90-degree turn to the right, lowering a bilateral load from waist level to floor, and walking while carrying a bilateral load...
July 9, 2021: Journal of Biomechanics
Margherita Fabbri, Clémence Leung, Guillaume Baille, Matthieu Béreau, Christine Brefel Courbon, Giovanni Castelnovo, Nicolas Carriere, Philippe Damier, Luc Defebvre, Anne Doe de Maindreville, Frederique Fluchere, Marie Fuzzatti, David Grabli, David Maltete, Vanessa Rousseau, Agnès Sommet A, Claire Thalamas, Claire Thiriez, Olivier Rascol, Fabienne Ory-Magne
BACKGROUND: In 2020 the coronavirus disease 19 (COVID-19) pandemic imposed a total and sudden lockdown. We aimed to investigate the consequences of the first COVID-19 lockdown (mid-March - mid-April 2020) on motor and non-motor symptoms (NMS) in a cohort of French people with Parkinson's disease (PwP). METHODS: PwP were enrolled either by an on-line survey sent from the national France Parkinson association (FP) to reach the French community of PwP or as part of outpatients' telemedicine visits followed by an hospital-based Parkinson Expert Center (PEC)...
July 13, 2021: Parkinsonism & related Disorders
Fadi Al Saiegh, Lucas Philipp, Liam P Hughes, Thiago Scharth Montenegro, Kevin Hines, Glenn A Gonzalez, Aria Mahtabfar, Carrie Andrews, Kavantissa Keppetipola, Daniel Franco, Karim Hafazalla, Omaditya Khanna, Nikolaos Mouchtouris, Dwight Mitchell Self, Joshua Heller, Srinivas Prasad, Jack Jallo, Ashwini D Sharan, James S Harrop
BACKGROUND: Instrumented fusion procedures are essential in the treatment of degenerative lumbar spine disease to alleviate pain and improve neurologic function, but are being performed with increasing incidence and variability. OBJECTIVE: We implemented a training module for neurosurgery residents that is based on evidence-based criteria for lumbar fusion surgery and measured its effectiveness in the residents' decision making regarding whether patients should or should not undergo instrumented fusion...
July 19, 2021: World Neurosurgery
Greg J Marchand, Kelly Ware, Ahmed Taher Masoud, Alexa King, Stacy Ruther, Giovanna Brazil, Kaitlynne Cieminski, Nicolas Calteux, Catherine Coriell, Hollie Ulibarri, Julia Parise, Amanda Arroyo, Diana Chen, Maria Pierson, Rasa Rafie, Katelyn Sainz
OBJECTIVE: To review all high quality available evidence regarding the effect of intraoperative bupivacaine 24 hours (or 8.9 half-lives) after intraoperative administration at time of gynaecologic surgery and to ascertain whether a second mechanism of action, beyond the initial prevention of sodium channel depolarization and blockade of nerve impulses, may be occurring. DATA SOURCES: We searched all major databases with an algorithm designed to include all randomized trials that used any form of local bupivacaine, regardless of dose or route of administration, at the time of any gynaecologic surgery and compared its use with saline placebo...
July 19, 2021: Journal of Obstetrics and Gynaecology Canada: JOGC
Mason Nistel, Nathalie Nguyen, Dan Atkins, Heather Miyazawa, Cassandra Burger, Glenn T Furuta, Calies Menard-Katcher
BACKGROUND: - Eosinophilic Esophagitis (EoE) is a chronic allergen-mediated disease of the esophagus. Pharmacologic treatment has largely relied on repurposing corticosteroids. Ciclesonide (CIC) is a corticosteroid for the treatment of asthma with biochemical properties that improve topical potency. OBJECTIVE: This study aimed to determine if CIC decreased clinicopathological features of EoE. METHODS: - We performed a retrospective cohort study of EoE patients treated with CIC at a pediatric hospital from 2010-2019...
July 19, 2021: Journal of Allergy and Clinical Immunology in Practice
Chao Zeng, Nancy E Lane, Xiaoxiao Li, Jie Wei, Houchen Lyu, Mingjie Shao, Guanghua Lei, Yuqing Zhang
OBJECTIVES: There is still a large unmet need for novel osteoarthritis (OA) treatments that could provide clinically important effects on long-term pain relief (≥12 months). We examined the relation of bariatric surgery along with weight loss to analgesic prescription and all-cause mortality among individuals with OA. METHODS: We conducted a cohort study among individuals with OA using The Health Improvement Network. We compared the rate of no analgesic prescription ≥12 consecutive months and the risk of all-cause mortality using inverse probability weighting Cox-proportional hazard models and the difference in number of analgesic prescriptions (non-steroidal anti-inflammatory drugs, opioids, and paracetamol) in the 50th , 75th and 90th percentiles using quantile regression model between bariatric and non-bariatric cohorts...
July 19, 2021: Osteoarthritis and Cartilage
Nolan B Condron, Benjamin S Kester, John M Tokish, Matthias A Zumstein, Reuben Gobezie, Markus Scheibel, Brian J Cole
Orthoregeneration is defined as a solution for orthopaedic conditions that harnesses the benefits of biology to improve healing, reduce pain, improve function, and optimally, provide an environment for tissue regeneration. Options include drugs, surgical intervention, scaffolds, biologics as a product of cells, and physical and electro-magnetic stimuli. The goal of regenerative medicine is to enhance the healing of tissue after musculoskeletal injuries as both isolated treatment and adjunct to surgical management, using novel therapies to improve recovery and outcomes...
July 19, 2021: Arthroscopy
Masayuki Oshima, Kazuyoshi Aoyama
BACKGROUND: The study purpose was to determine the safety and efficacy of different doses of epidural fentanyl plus local anesthetics on ambulation for patients who had elective cesarean delivery. METHODS: A prospective study at a single community hospital used posturography to compute Sway area for assessment of standing stability [ISRCTN14517337]. Continuous epidural infusion of 0.2% ropivacaine containing either 2.5 mcg.mL-1 (Group 1, n = 8) or 5 mcg...
July 19, 2021: Brazilian Journal of Anesthesiology
Mona Aslani, Seyed Shahabeddin Mortazavi-Jahromi, Abbas Mirshafiey
Known as one of the most sophisticated systems of the human body, the nervous system consists of neural cells and controls all parts of the body. It is closely related to the immune system. The effects of inflammation and immune reactions have been observed in the pathogenesis of some neurological disorders. Defined as the gene expression regulators, miRNAs participate in cellular processes. miR-146a is a mediator in the neuroimmune system, leaving substantial effects on the homeostasis of immune and brain cells, neuronal identities acquisition, and immune responses regulation in the nervous system...
July 19, 2021: Immunology Letters
Aditya Joshi, Jacob E Tallman, Joshua K Calvert, Taylor Brewer, Nicole L Miller, Lee Yang, John R Asplin, Ryan S Hsi
OBJECTIVE: To describe the patterns of complementary and alternative medicine (CAM) among patients with kidney stones and analyze the alkali content of commonly used CAM therapies. METHODS: We prospectively conducted structured interviews with patients who presented to a specialty stone clinic for the management of kidney stones. Open-ended questions were used to elicit information regarding CAM knowledge, formulation/dosing, and patterns of use. Several common CAM therapies were then analyzed for their alkali, organic anion, and sugar content...
July 19, 2021: Urology
Myron Yaster, Sean H Flack, Lynn D Martin, Philip G Morgan
Dr. Anne Marie Lynn (1949 -present), Professor Emeritus of Anesthesiology, Pain Medicine, and Pediatrics at the University of Washington, Seattle was one of the most influential women in pediatric anesthesiology of her generation. Dr. Lynn embodies the spirit of discovery and advancement that have created the practice of pediatric anesthesiology as we know it today. A pioneer in pain medicine pharmacology, particularly morphine and ketorolac, her research transformed pediatric anesthesia, pediatric pain medicine, and pediatric intensive care medicine...
July 22, 2021: Paediatric Anaesthesia
Krishnan Chakravarthy, James FitzGerald, Andrew Will, Karen Trutnau, Robert Corey, David Dinsmoor, Leonid Litvak
OBJECTIVES: Spinal cord stimulation (SCS) is a treatment for chronic neuropathic pain. Recently, SCS has been enhanced further with evoked compound action potential (ECAP) sensing. Characteristics of the ECAP, if appropriately isolated from concurrent stimulation artifact (SA), may be used to control, and aid in the programming of, SCS systems. Here, we characterize the sensitivity of the ECAP growth curve slope (S) to both neural response (|Sresp |) and SA contamination (|Sart |) for four spinal ECAP estimation methods with a novel performance measure (|Sresp /Sart |)...
July 22, 2021: Neuromodulation: Journal of the International Neuromodulation Society
Mayank Jayaram, Chang Wang, Lu Wang, Kevin C Chung
INTRODUCTION: The Michigan Hand Outcomes Questionnaire (MHQ) is a patient-reported outcome measure previously validated in patients with rheumatoid arthritis (RA) using classical test theory. Rasch analysis is a more rigorous method of questionnaire validation that has not been used to test the psychometric properties of the MHQ in patients with RA. The objective of this study is to evaluate the validity and reliability of the MHQ for measuring outcomes in patients with RA with metacarpophalangeal joint deformities...
2021: PloS One
Katrin Hillmer, Judith Kappesser, Christiane Hermann
BACKGROUND: Social context such as the relationship between a person experiencing pain and a caregiver has been shown to affect the experience of pain, yet, results are not consistent. Possibly, differential effects of interpersonal relationships are modulated by affective states expressed by social partners. Viewing partner pictures in experimental designs is not only associated with lowered perceived pain intensity, but also affects neural responses. However, the role of affective modulation is not clear...
2021: PloS One
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