Lucy Neave, Mari Thomas, Rens de Groot, Andrew J Doyle, Deepak Singh, George Adams, Anna L David, Katarzyna Maksym, Marie Scully
BACKGROUND: Preeclampsia is a gestational hypertensive disorder, characterised by maternal endothelial activation, and increased ratio of soluble fms-like tyrosine kinase inhibitor-1 (sFlt-1) to placental growth factor (PlGF). The von Willebrand Factor (VWF)/ADAMTS13 axis is of interest because of the underlying endothelial activation, and clinical overlap with pregnancy-associated thrombotic thrombocytopenic purpura. OBJECTIVES: To assess VWF, ADAMTS13, and VWF/ADAMTS13 ratio in preeclampsia, and look for associations with sFlt-1/PlGF ratio, and clinical features...
November 3, 2023: Journal of Thrombosis and Haemostasis: JTH