Jay L P Fieldhouse, Dirk N van Paassen, Marie-Paule E van Engelen, Sterre C M De Boer, Willem L Hartog, Simon Braak, Linda J Schoonmade, Sigfried N T M Schouws, Welmoed A Krudop, Mardien L Oudega, Henk J M M Mutsaerts, Charlotte E Teunissen, Everard G B Vijverberg, Yolande A L Pijnenburg
Behavioral variant frontotemporal dementia (bvFTD) is a neurodegenerative disorder characterized by diverse and prominent changes in behavior and personality. One of the greatest challenges in bvFTD is to capture, measure and predict its disease progression, due to clinical, pathological and genetic heterogeneity. Availability of reliable outcome measures is pivotal for future clinical trials and disease monitoring. Detection of change should be objective, clinically meaningful and easily assessed, preferably associated with a biological process...
2024: Frontiers in Aging Neuroscience