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MULTICENTER STUDY
Elisabetta Moscarella, Attilio Varricchio, Eugenio Stabile, Anna Franzone, Francesco Granata, Antonio Rapacciuolo, Gennaro Galasso, Claudia Capozzolo, Plinio Cirillo, Vittorio Monda, Ida Monterforte, Francesco Borgia, Orlando Piro, Giulio Bonzani, Bruno Trimarco, Giovanni Esposito
BACKGROUND/PURPOSE: Coronary in-stent restenosis (ISR) is a clinical problem for which a satisfactory solution has not been found yet. Bioabsorbable drug eluting vascular scaffolds (BVSs) provide transient vessel scaffolding combined with prolonged drug delivery capability. The aim of this study was to investigate the safety of BVS for the treatment of coronary ISR. METHODS/MATERIALS: Between January 2013 and June 2013, 27 patients (31 lesions), presenting with either stable or unstable angina due to coronary ISR, were enrolled in a single arm, prospective, open label registry...
October 2015: Cardiovascular Revascularization Medicine: Including Molecular Interventions
#42
MULTICENTER STUDY
Elodie Odore, François Lokiec, Esteban Cvitkovic, Mohamed Bekradda, Patrice Herait, Fabrice Bourdel, Carmen Kahatt, Emmanuel Raffoux, Anastasios Stathis, Catherine Thieblemont, Bruno Quesnel, David Cunningham, Maria E Riveiro, Keyvan Rezaï
BACKGROUND AND OBJECTIVES: OTX015 (MK-8628) is a novel inhibitor of the bromodomain and extraterminal (BET)-bromodomain (BRD) protein family, binding specifically to bromodomains BRD2/3/4 and impacting the epigenetic regulation of several oncogenes. We characterized the pharmacokinetics of this first-in-class BET-BRD inhibitor administered as a single agent, including population pharmacokinetic modelling. METHODS: A dose-escalation, phase Ib study was performed with oral OTX015 in patients with haematologic malignancies, at doses starting from 10 mg once daily (QD) with continuous or discontinuous schedules...
March 2016: Clinical Pharmacokinetics
#43
RANDOMIZED CONTROLLED TRIAL
Ramon Orriols, Rosana Hernando, Adelaida Ferrer, Sonia Terradas, Bruno Montoro
BACKGROUND: No prospective study has assessed eradication treatment of early Pseudomonas aeruginosa colonisation in bronchiectasis not due to cystic fibrosis (CF). OBJECTIVES: To evaluate the efficacy of 3 months of nebulised tobramycin after a short course of intravenous antibiotics in the eradication of P. aeruginosa and its clinical consequences in non- CF bronchiectasis following initial P. aeruginosa infection. METHODS: A 15-month, single-masked, randomised study including 35 patients was conducted in a tertiary university hospital...
2015: Respiration; International Review of Thoracic Diseases
#44
RANDOMIZED CONTROLLED TRIAL
Lesley De Pietri, Marcello Bianchini, Roberto Montalti, Nicola De Maria, Tommaso Di Maira, Bruno Begliomini, Giorgio Enrico Gerunda, Fabrizio di Benedetto, Guadalupe Garcia-Tsao, Erica Villa
UNLABELLED: Bleeding is a feared complication of invasive procedures in patients with cirrhosis and significant coagulopathy (as defined by routine coagulation tests) and is used to justify preprocedure use of fresh frozen plasma (FFP) and/or platelets (PLT). Thromboelastography (TEG) provides a more comprehensive global coagulation assessment than routine tests (international normalized ratio [INR] and platelet count), and its use may avoid unnecessary blood product transfusion in patients with cirrhosis and significant coagulopathy (defined in this study as INR >1...
February 2016: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#45
RANDOMIZED CONTROLLED TRIAL
Rafael Simó, Bruno Guerci, Guntram Schernthaner, Baptist Gallwitz, Juan Rosas-Guzmàn, Francesco Dotta, Andreas Festa, Ming Zhou, Jacek Kiljański
OBJECTIVE: The risk of cardiovascular morbidity and mortality is significantly increased in patients with diabetes; thus, it is important to determine whether glucose-lowering therapy affects this risk over time. Changes in cardiovascular risk markers were examined in patients with type 2 diabetes treated with exenatide twice daily (a glucagon-like peptide-1 receptor agonist) or glimepiride (a sulfonylurea) added to metformin in the EURopean EXenAtide (EUREXA) study. RESEARCH DESIGN AND METHODS: Patients with type 2 diabetes failing metformin were randomized to add-on exenatide twice daily (n = 515) or glimepiride (n = 514) until treatment failure defined by hemoglobin A1C...
September 4, 2015: Cardiovascular Diabetology
#46
JOURNAL ARTICLE
Esma Saâda-Bouzid, Fanny Burel-Vandenbos, Dominique Ranchère-Vince, Isabelle Birtwisle-Peyrottes, Bruno Chetaille, Corinne Bouvier, Marie-Christine Château, Michel Peoc'h, Maxime Battistella, Audrey Bazin, Jocelyn Gal, Jean-François Michiels, Jean-Michel Coindre, Florence Pedeutour, Laurence Bianchini
HMGA2, CDK4, and JUN genes have been described as frequently coamplified with MDM2 in atypical lipomatous tumor, well-differentiated liposarcoma, and dedifferentiated liposarcoma. We studied the frequency of amplification of these genes in a series of 48 dedifferentiated liposarcomas and 68 atypical lipomatous tumors/well-differentiated liposarcomas. We correlated their amplification status with clinicopathological features and outcomes. Histologically, both CDK4 (P=0.007) and JUN (P=0.005) amplifications were associated with dedifferentiated liposarcoma, whereas amplification of the proximal parts of HMGA2 (5'-untranslated region (UTR) and exons 1-3) was associated with atypical lipomatous tumor/well-differentiated liposarcoma (P=0...
November 2015: Modern Pathology
#47
JOURNAL ARTICLE
Anouck Schneider, Jacques Puechberty, Bee Ling Ng, Christine Coubes, Vincent Gatinois, Magali Tournaire, Manon Girard, Bruno Dumont, Pauline Bouret, Julia Magnetto, Amaria Baghdadli, Franck Pellestor, David Geneviève
Intellectual disability (ID) is a frequent feature but is highly clinically and genetically heterogeneous. The establishment of the precise diagnosis in patients with ID is challenging due to this heterogeneity but crucial for genetic counseling and appropriate care for the patients. Among the etiologies of patients with ID, apparently balanced de novo rearrangements represent 0.6%. Several mechanisms explain the ID in patients with apparently balanced de novo rearrangement. Among them, disruption of a disease gene at the breakpoint, is frequently evoked...
December 2015: American Journal of Medical Genetics. Part A
#48
JOURNAL ARTICLE
Cristina Quintavalle, Chiara Viviani Anselmi, Francesca De Micco, Giuseppina Roscigno, Gabriella Visconti, Bruno Golia, Amelia Focaccio, Bruno Ricciardelli, Enzo Perna, Laura Papa, Elvira Donnarumma, Gerolama Condorelli, Carlo Briguori
BACKGROUND: Neutrophil gelatinase-associated lipocalin (NGAL) is an early marker of acute kidney injury (AKI). METHODS AND RESULTS: Urine NGAL and serum NGAL (sNGAL) were assessed at 2, 6, 24, and 48 hours after contrast media (CM) exposure in 458 high-risk patients (development set). Optimal thresholds in predicting contrast-induced AKI (serum creatinine [sCr] increase ≥0.3 mg/dL at 48 hours after CM administration) were identified. Major adverse events (MAE; death, dialysis, nonfatal myocardial infarction, sustained kidney injury, and myocardial revascularization) at 1 year were assessed...
September 2015: Circulation. Cardiovascular Interventions
#49
MULTICENTER STUDY
Katherine N Bachmann, Alexander G Bruno, Miriam A Bredella, Melanie Schorr, Elizabeth A Lawson, Corey M Gill, Vibha Singhal, Erinne Meenaghan, Anu V Gerweck, Kamryn T Eddy, Seda Ebrahimi, Stuart L Koman, James M Greenblatt, Robert J Keane, Thomas Weigel, Esther Dechant, Madhusmita Misra, Anne Klibanski, Mary L Bouxsein, Karen K Miller
Somewhat paradoxically, fracture risk, which depends on applied loads and bone strength, is elevated in both anorexia nervosa and obesity at certain skeletal sites. Factor-of-risk (Φ), the ratio of applied load to bone strength, is a biomechanically based method to estimate fracture risk; theoretically, higher Φ reflects increased fracture risk. We estimated vertebral strength (linear combination of integral volumetric bone mineral density [Int.vBMD] and cross-sectional area from quantitative computed tomography [QCT]), vertebral compressive loads, and Φ at L4 in 176 women (65 anorexia nervosa, 45 lean controls, and 66 obese)...
February 2016: Journal of Bone and Mineral Research
#50
JOURNAL ARTICLE
Gustavo Davi Rabelo, Bruno Augusto Nassif Travençolo, Marcio Augusto Oliveira, Marcelo Emílio Beletti, Marina Gallottini, Fernando Ricardo Xavier da Silveira
OBJECTIVE: The aim of this study was to evaluate the effects of zoledronic acid (ZA) on the cortical bone channels network (CBCN) and osteocyte organization in relation to the bone channels. MATERIALS AND METHODS: Eighteen male Wistar rats were divided into control (CG) and test groups (TG). Twelve animals from TG received 3 ZA doses (7.5 µg/kg), and 6 animals from CG did not receive any medication. TG animals were euthanized at 14 (n = 6) and 75 (n = 6) dadys after drug injection...
December 2015: Archives of Endocrinology and Metabolism
#51
JOURNAL ARTICLE
Sylvain Grangeon, Alejandro Fernandez-Martinez, Fabienne Warmont, Alexandre Gloter, Nicolas Marty, Agnieszka Poulain, Bruno Lanson
BACKGROUND: Vernadite is a nanocrystalline and turbostratic phyllomanganate which is ubiquitous in the environment. Its layers are built of (MnO6)(8-) octahedra connected through their edges and frequently contain vacancies and (or) isomorphic substitutions. Both create a layer charge deficit that can exceed 1 valence unit per layer octahedron and thus induces a strong chemical reactivity. In addition, vernadite has a high affinity for many trace elements (e.g., Co, Ni, and Zn) and possesses a redox potential that allows for the oxidation of redox-sensitive elements (e...
2015: Geochemical Transactions
#52
JOURNAL ARTICLE
Michele Visentin, Bruno Stieger, Michael Merz, Gerd A Kullak-Ublick
The somatostatin analog octreotide can lead to hyperbilirubinemia without evidence of liver injury. Here we investigate whether octreotide inhibits the main sinusoidal/canalicular bilirubin carriers and whether it is a transport substrate. Octreotide showed the most potent inhibitory effect toward OATP1B1-mediated transport and weaker inhibition for OATP1B3- and MRP2-mediated transport. Octreotide had no effect on OATP2B1-mediated transport. Octreotide inhibited [(3)H]estradiol-17-β-glucuronide (E17βG) influx mediated by OATP1B1, 1B3, and multidrug resistance-associated protein 2 (MRP2) in a concentration-dependent manner, and the IC50 values were computed to be 23 μM (95% confidence interval [CI] 18-29), 68 μM (95% CI 50-91), and 116...
November 2015: Journal of Pharmacology and Experimental Therapeutics
#53
REVIEW
Dorcas E Beaton, Sarah Dyer, Annelies Boonen, Suzanne M M Verstappen, Reuben Escorpizo, Diane V Lacaille, Ailsa Bosworth, Monique A M Gignac, Amye Leong, Oana Purcaru, Sarah Leggett, Cathy Hofstetter, Ingemar F Peterson, Kenneth Tang, Bruno Fautrel, Claire Bombardier, Peter S Tugwell
OBJECTIVE: Indicators of work role functioning (being at work, and being productive while at work) are important outcomes for persons with arthritis. As the worker productivity working group at OMERACT (Outcome Measures in Rheumatology), we sought to provide an evidence base for consensus on standardized instruments to measure worker productivity [both absenteeism and at-work productivity (presenteeism) as well as critical contextual factors]. METHODS: Literature reviews and primary studies were done and reported to the OMERACT 12 (2014) meeting to build the OMERACT Filter 2...
January 2016: Journal of Rheumatology
#54
JOURNAL ARTICLE
Bruno Cimatti, Edgard Eduard Engel, Marcello Henrique Nogueira-Barbosa, Paulo Donato Frighetto, José Batista Volpon
OBJECTIVE: Macroporous cement with mechanical properties similar to cancellous bone may improve the treatment of large bone defects in relation to solid acrylic cement. The aim of this study was to compare physical and mechanical characteristics of a polymethyl methacrylate (PMMA) based porous cement with cancellous bone. METHODS: Compressive strength and pore size, interconnectivity, and distribution of cylindrical porous PMMA cement samples containing 10% (G1), 20% (G2) or 30% (G3) effervescent components were analyzed...
July 2015: Acta Ortopedica Brasileira
#55
JOURNAL ARTICLE
Marcelo C Pasquini, Mei-Jie Zhang, Bruno C Medeiros, Philippe Armand, Zhen-Huan Hu, Taiga Nishihori, Mahmoud D Aljurf, Görgün Akpek, Jean-Yves Cahn, Mitchell S Cairo, Jan Cerny, Edward A Copelan, Abhinav Deol, César O Freytes, Robert Peter Gale, Siddhartha Ganguly, Biju George, Vikas Gupta, Gregory A Hale, Rammurti T Kamble, Thomas R Klumpp, Hillard M Lazarus, Selina M Luger, Jane L Liesveld, Mark R Litzow, David I Marks, Rodrigo Martino, Maxim Norkin, Richard F Olsson, Betul Oran, Attaphol Pawarode, Michael A Pulsipher, Muthalagu Ramanathan, Ran Reshef, Ayman A Saad, Wael Saber, Bipin N Savani, Harry C Schouten, Olle Ringdén, Martin S Tallman, Geoffrey L Uy, William A Wood, Baldeep Wirk, Waleska S Pérez, Minoo Batiwalla, Daniel J Weisdorf
The presence of monosomal karyotype (MK+) in acute myeloid leukemia (AML) is associated with dismal outcomes. We evaluated the impact of MK+ in AML (MK+AML, n = 240) and in myelodysplastic syndrome (MDS) (MK+MDS, n = 221) on hematopoietic cell transplantation outcomes compared with other cytogenetically defined groups (AML, n = 3360; MDS, n = 1373) as reported to the Center for International Blood and Marrow Transplant Research from 1998 to 2011. MK+ AML was associated with higher disease relapse (hazard ratio, 1...
February 2016: Biology of Blood and Marrow Transplantation
#56
JOURNAL ARTICLE
Goetz Bosse, Wiltrud Abels, Ferdinand Mtatifikolo, Baltazar Ngoli, Bruno Neuner, Klaus-Dieter Wernecke, Claudia Spies
INTRODUCTION: Surgical services are increasingly seen to reduce death and disability in Sub-Saharan Africa, where hospital-based mortality remains alarmingly high. This study explores two implementation approaches to improve the quality of perioperative care in a Tanzanian hospital. Effects were compared to a control group of two other hospitals in the region without intervention. METHODS: All hospitals conducted quality assessments with a Hospital Performance Assessment Tool...
2015: PloS One
#57
JOURNAL ARTICLE
Alessandro Venditti, Laura Guarcini, Armandodoriano Bianco, Sergio Rosselli, Maurizio Bruno, Felice Senatore
A complete chemical investigation of Achillea ligustica All. growing at Lipari (Aeolian Island, Sicily) has been carried out. Seventeen metabolites have been isolated and characterised from dichloromethane and methanol extracts of flowers and aerial parts, and GC/MS analyses of petroleum ether extracts was carried out, revealing a composition in sesquiterpenoids similar to those reported for populations from Greece, Sicily and Algeria, showing the presence of (3RS,6RS)-2,6-dimethyl-1,7-octadiene-3,6-diol (1), 2,6-dimethyl-octa-3(E),7-diene-2,6-diol (2), iso-seco-tanapartholide (3) from DCM fraction...
2016: Natural Product Research
#58
JOURNAL ARTICLE
Talia Retter, Bruno Rossion
The human brain is remarkably adept at extracting identity information from faces, although understanding this process remains a challenge. Here, a novel neural measure of objective discrimination between two individual face identities at the system level of organization is presented. This measure utilizes fast periodic visual stimulation (FPVS) in electroencephalography (EEG) combined with an adaptation paradigm (as in Ales & Norcia, 2009). Adaptation to a facial identity is induced through repetition of one identity displayed over a 10-second baseline, flickering at a base rate of 6 images per second (6 Hz)...
2015: Journal of Vision
#59
JOURNAL ARTICLE
Soki Nakamura, Ikuya Murakami
After adaptation to a rapidly moving grating, a drifting grating placed at the adapted region appears to last shorter than its actual duration ("adaptation-based time compression", Johnston et al 2006). This effect occurs retinotopically (Bruno et al 2010), though there might be some spatiotopic component as well (Burr et al 2007). The spatial tuning of this effect has been reported to have a narrow spatial window (Ayhan et al 2009), such that the effect of adaptation never transfers to unadapted locations in its vicinity...
2015: Journal of Vision
#60
JOURNAL ARTICLE
Bruno Richard, Rebecca Birkett, Bruce Hansen, Aaron Johnson
When asked to determine perceived contrast in natural scenes, humans rely more heavily on a subset of spatial frequency bands around the peak of the CSF (Haun & Peli, 2013). Interestingly, the bands used by observers shift as a function of the global amplitude spectra of natural images: observers use lower spatial frequencies for natural images with steeper slopes (α>1), and higher spatial frequencies for natural images with shallower slopes (α< 1). We aimed to explore this effect further by directly manipulating slope discrimination thresholds to both steep and shallow slopes with trans-cranial Direct Current Stimulation (tDCS)...
2015: Journal of Vision
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