Jun Wang, Jing Liang, Mingxin He, Qi Xie, Qingming Wu, Guanxin Shen, Baoli Zhu, Jun Yu, Li Yu, Xiaohua Tan, Lanlan Wei, Jun Ren, Youyong Lv, Lijuan Deng, Qian Yin, Hao Zhou, Wei Wu, Min Zhang, Wenyan Yang, Mingqiang Qiao, Rong Shu, Zhongjun Xia, Zhiming Li, Ziming Huang, Weiguo Hu, Liang Wang, Zhi Liu, Guoliang Pi, Hua Ren, Yong Ji, Zhe Liu, Xiaofei Qi, Peng Chen, Liang Shao, Feng Chen, Xiaojun Xu, Weiqing Chen, Qiang Wang, Zhi Guo
The human gut microbiota represents a complex ecosystem that is composed of bacteria, fungi, viruses, and archaea. It affects many physiological functions including metabolism, inflammation, and the immune response. The gut microbiota also plays a role in preventing infection. Chemotherapy disrupts an organism's microbiome, increasing the risk of microbial invasive infection; therefore, restoring the gut microbiota composition is one potential strategy to reduce this risk. The gut microbiome can develop colonization resistance, in which pathogenic bacteria and other competing microorganisms are destroyed through attacks on bacterial cell walls by bacteriocins, antimicrobial peptides, and other proteins produced by symbiotic bacteria...
December 2022: Journal of Cancer Research and Therapeutics