Gino Giannaccini, Laura Betti, Andrea Pirone, Lionella Palego, Ortenzio Fabiani, Laura Fabbrini, Giovanni Mascia, Laura Giusti, Marco Macchia, Mario Giusiani, Claudia Martini, Antonio Lucacchini
The first effects of 3,4-methylen-dioxy-metamphetamine (MDMA, "ecstasy"), on serotonin 1A (5-HT(1A)) receptors in rat hippocampus were determined by means of [(3)H]-8-hydroxy-dipropylamino-tetralin ([(3)H]-8-OH-DPAT) and 5'guanosine-(gamma-[(35)S]-thio)triphosphate ([(35)S]-GTPgammaS) binding as well as inhibition of forskolin (FK)-stimulated adenylyl cyclase (AC) activity. The study was completed by [(35)S]-GTPgammaS functional autoradiography experiments carried out in frontal sections of rat brain, including the hippocampal region...
December 2007: Neurochemistry International