Sarah R Rivas, Mynor J Mendez Valdez, Jay S Chandar, Jelisah F Desgraves, Victor M Lu, Leo Ampie, Eric B Singh, Deepa Seetharam, Christian K Ramsoomair, Anna Hudson, Shreya M Ingle, Vaidya Govindarajan, Tara T Doucet-O'Hare, Catherine DeMarino, John D Heiss, Avindra Nath, Ashish H Shah
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches. Drug repositioning studies on antiretroviral therapy (ART) have shown promising potent antineoplastic effects in multiple cancers; however, its efficacy in GBM remains unclear. To better understand the pleiotropic anticancer effects of ART on GBM, we conducted a comprehensive drug repurposing analysis of ART in GBM to highlight its utility in translational neuro-oncology...
April 30, 2024: Cancers