Hongdi Ma, Taidou Hu, Wanyin Tao, Jiyu Tong, Zili Han, Dietmar Herndler-Brandstetter, Zheng Wei, Ruize Liu, Tingyue Zhou, Qiuyuan Liu, Xuemei Xu, Kaiguang Zhang, Rongbin Zhou, Judy H Cho, Hua-Bing Li, Hailiang Huang, Richard A Flavell, Shu Zhu
Inflammatory bowel diseases (IBD) are known to have complex, genetically influenced etiologies, involving dysfunctional interactions between the intestinal immune system and the microbiome. Here, we characterized how the RNA transcript from an IBD-associated long non-coding RNA locus ("CARINH-Colitis Associated IRF1 antisense Regulator of Intestinal Homeostasis") protects against IBD. We show that CARINH and its neighboring gene coding for the transcription factor IRF1 together form a feedforward loop in host myeloid cells...
April 13, 2023: Cell Research