Shuangtao Li, Yongchang He, Dharshaun Turner, Naili Wei, Luyao Ma, Devin H Taylor, Danielle T Taylor, Xiaoyu Ji, Jie Wu
Background: The cannabinoid receptor 2 (CB2R), a cannabinoid receptor primarily expressed in immune cells, has been found in the brain, particularly in the hippocampus, where it plays crucial roles in modulating various neural functions, including synaptic plasticity, neuroprotection, neurogenesis, anxiety and stress responses, and neuroinflammation. Despite this growing understanding, the intricate electrophysiological characteristics of hippocampal neurons in CB2R knockout (CB2R KO) mice remain elusive. Aim and Methods: This study aimed to comprehensively assess the electrophysiological traits of hippocampal synaptic and network functions in CB2R KO mice...
January 22, 2024: Cannabis and Cannabinoid Research