keyword

Hippocampal neurogenesis

keyword
https://read.qxmd.com/read/32219328/trim32-deficiency-impairs-synaptic-plasticity-by-excitatory-inhibitory-imbalance-via-notch-pathway
#1
Michael Ntim, Qi-Fa Li, Yue Zhang, Xiao-Da Liu, Na Li, Hai-Lun Sun, Xuan Zhang, Bakhtawar Khan, Bin Wang, Qiong Wu, Xue-Fei Wu, Williams Walana, Khizar Khan, Quan-Hong Ma, Jie Zhao, Shao Li
Synaptic plasticity is the neural basis of physiological processes involved in learning and memory. Tripartite motif-containing 32 (TRIM32) has been found to play many important roles in the brain such as neural stem cell proliferation, neurogenesis, inhibition of nerve proliferation, and apoptosis. TRIM32 has been linked to several nervous system diseases including autism spectrum disorder, depression, anxiety, and Alzheimer's disease. However, the role of TRIM32 in regulating the mechanism of synaptic plasticity is still unknown...
March 26, 2020: Cerebral Cortex
https://read.qxmd.com/read/32214165/hippocampal-mitochondrial-dysfunction-and-psychiatric-relevant-behavioral-deficits-in-spinocerebellar-ataxia-1-mouse-model
#2
Filip Tichanek, Martina Salomova, Jan Jedlicka, Jitka Kuncova, Pavel Pitule, Tereza Macanova, Zuzana Petrankova, Zdenek Tuma, Jan Cendelin
Spinocerebellar ataxia 1 (SCA1) is a devastating neurodegenerative disease associated with cerebellar degeneration and motor deficits. However, many patients also exhibit neuropsychiatric impairments such as depression and apathy; nevertheless, the existence of a causal link between the psychiatric symptoms and SCA1 neuropathology remains controversial. This study aimed to explore behavioral deficits in a knock-in mouse SCA1 (SCA1154Q/2Q ) model and to identify the underlying neuropathology. We found that the SCA1 mice exhibit previously undescribed behavioral impairments such as increased anxiety- and depressive-like behavior and reduced prepulse inhibition and cognitive flexibility...
March 25, 2020: Scientific Reports
https://read.qxmd.com/read/32211762/epigenetic-modifications-of-gabaergic-interneurons-contributes-to-the-deficits-in-adult-hippocampus-neurogenesis-and-depression-like-behavior-in-prenatally-stressed-mice
#3
Haiquan Zhong, Jing Rong, Chunting Zhu, Min Liang, Yingchun Li, Rong Zhou
BACKGROUND: Prenatal stress (PRS) is considered a risk factor for depressive disorder. Adult hippocampal neurogenesis is believed to play a role in the regulation of affective behaviours. GABAergic interneuron is a key modulator in adult hippocampal neurogenesis. Growing evidence indicates that PRS has adverse effects on adult hippocampal neurogenesis and DNA epigenetic modifications of GABAergic system. The aim of this study is to investigate whether epigenetic GABAergic dysfunction participates in the negative impact of PRS on adult hippocampal neurogenesis and -related emotional behaviors...
March 25, 2020: International Journal of Neuropsychopharmacology
https://read.qxmd.com/read/32210026/ginsenoside-compound-k-induces-adult-hippocampal-proliferation-and-survival-of-newly-generated-cells-in-young-and-elderly-mice
#4
Jung-Mi Oh, Jae Hoon Jeong, Sun Young Park, Sungkun Chun
Cognitive impairment can be associated with reduced adult hippocampal neurogenesis, and it may contribute to age-associated neurodegenerative diseases such as Alzheimer's (AD). Compound K (CK) is produced from the protopanaxadiol (PPD)-type ginsenosides Rb1, Rb2, and Rc by intestinal microbial conversion. Although CK has been reported as an inducing effector for neuroprotection and improved cognition in hippocampus, its effect on adult neurogenesis has not been explored yet. Here, we investigated the effect of CK on hippocampal neurogenesis in both young (2 months) and elderly (24 months) mice...
March 23, 2020: Biomolecules
https://read.qxmd.com/read/32209056/effects-of-hypericum-scabrum-extract-on-dentate-gyrus-synaptic-plasticity-in-high-fat-diet-fed-rats
#5
Ghazaleh Omidi, Arezoo Rezvani-Kamran, Ahmad Ganji, Somayeh Komaki, Farshid Etaee, Masoumeh Asadbegi, Alireza Komaki
High-fat diet (HFD) can induce deficits in neural function, oxidative stress, and decrease hippocampal neurogenesis. Hypericum (H.) scabrum extract (Ext) contains compounds that could treat neurological disorders. This study aimed to examine the neuroprotective impacts of the H. scabrum Ext on hippocampal synaptic plasticity in rats that were fed HFD. Fifty-four male Wistar rats (220 ± 10 g) were randomly arranged in six groups: (1) HFD group; (2) HFD + Ext300 group; (3) HFD + Ext100 group; (4) Control group; (5) Ext 300 mg/kg group; (6) Ext 100 mg/kg group...
March 24, 2020: Journal of Physiological Sciences: JPS
https://read.qxmd.com/read/32205527/sex-differences-in-the-development-of-anxiodepressive-like-behavior-of-mice-subjected-to-sciatic-nerve-cuffing
#6
Andrea Cardenas, John Caniglia, Denis Keljalic, Eugene Dimitrov
We investigated the contribution of nucleus locus ceruleus (LC) to the development of pain-associated affective behavior. Mice of both sexes were subjected to sciatic nerve cuffing, a model of peripheral nerve injury, and monitored for 45 days. While the thermal and mechanical thresholds were equally decreased in both males and females, only the male mice developed anxiodepressive-like behavior, which was complemented by suppressed hippocampal neurogenesis. Furthermore, the LC activity was lower in males when compared to females subjected to sciatic cuffing...
March 20, 2020: Pain
https://read.qxmd.com/read/32201282/a-selective-d2-dopamine-receptor-agonist-alleviates-depression-through-up-regulation-of-tyrosine-hydroxylase-and-increased-neurogenesis-in-hippocampus-of-the-prenatally-stressed-rats
#7
Mahino Fatima, Mir Hilal Ahmad, Saurabh Srivastav, Moshahid Alam Rizvi, Amal Chandra Mondal
Prenatal stress (PNS) has its negative impact on both the infant hippocampal neurogenesis and pregnancy outcomes in the neonates that serve as a risk factor for postnatal depression in adult offsprings. Therefore, main objectives of the present study were to evaluate the effect of maternal chronic unpredictable mild stress (CUMS) on behavioural changes, levels of oxidative stress, changes in selective developmental signaling genes and neurogenesis in the adult brain of Wistar rats and its reversal through a selective non-ergoline D2 type dopamine receptor (D2R) agonist Ropinirole (ROPI)...
March 19, 2020: Neurochemistry International
https://read.qxmd.com/read/32194381/dbcamp-rescues-the-neurons-from-degeneration-in-kainic-acid-injured-hippocampus-enhances-neurogenesis-learning-and-memory
#8
Muddanna Sakkattu Rao, Ebtesam M Abd-El-Basset
Dibutyryl cyclic adenosine monophosphate (dBcAMP) is a cell-permeable synthetic analog of cyclic adenosine monophosphate (cAMP). Although the elevation of cAMP levels was reported to promote the functional recovery in spinal cord injury, its role in neurogenesis or functional recovery after hippocampal injury is unknown. The objective of the study was to investigate the effects of dBcAMP on learning, memory, and hippocampal neurogenesis in the excitotoxically lesioned hippocampus. An excitotoxic lesion was induced in the hippocampi of 4-month-old male BALB/c mice by injecting 0...
2020: Frontiers in Behavioral Neuroscience
https://read.qxmd.com/read/32194226/cxcr5-knockdown-attenuates-hippocampal-neurogenesis-deficits-and-cognitive-impairment-in-a-mouse-model-of-sepsis-associated-encephalopathy
#9
Yanan Shen, Ling Jing, Yuan Zhang, Hongguang Bao, Akbar Vohra, Yanna Si, Cailong Pan, Yan Xing
In this study, we investigated the potential role of C-X-C chemokine receptor type (CXCR) 5 in neurocognitive function in a mouse model of sepsis-associated encephalopathy (SAE). Adult male C57BL/6J mice received intracereboroventricular injections of small interfering RNAs (siRNAs) against CXCR5 or scrambled control siRNA. After 3 days, SAE was induced by cecal ligation and puncture (CLP, n=16 per group). Memory and learning ability were tested using the Morris water maze (MWM) on days 5-9 after CLP. Hippocampal expression of CXCR5, interleukin (IL)-1β and IL-6 were measured by western blot...
March 16, 2020: Neuroscience
https://read.qxmd.com/read/32184163/roles-of-fatty-acid-binding-protein-7-in-ischemic-neuronal-injury-and-ischemia-induced-neurogenesis-after-transient-forebrain-ischemia
#10
Tatsuya Kato, Hideyuki Yoshioka, Yuji Owada, Hiroyuki Kinouchi
Fatty acid binding protein 7 (FABP7) has a protective role in the central nervous system injury and regulates neurogenesis during brain development; however, its roles in neuronal injury and neurogenesis after cerebral ischemia have not been elucidated. In this study, the expression of FABP7 after ischemia was studied and the effects of genetic FABP7 inhibition on neuronal injury and neurogenesis after ischemia were investigated. Male FABP7 knockout (KO) mice on a C57BL/6J background and their wild-type (WT) littermates were subjected to transient forebrain ischemia for 20 minutes...
March 14, 2020: Brain Research
https://read.qxmd.com/read/32179291/seizure-induced-neuroinflammation-contributes-to-ectopic-neurogenesis-and-aggressive-behavior-in-pilocarpine-induced-status-epilepticus-mice
#11
Xinjian Zhu, Yuanyuan Yao, Jiurong Yang, Qiyue Ge, Diejing Niu, Xiufang Liu, Chenchen Zhang, Guangming Gan, Aifeng Zhang, Honghong Yao
Epilepsy is a chronic neurological disorder often associated with recurrent seizures. A growing body of evidence suggests that seizures cause structural and functional alterations of the brain. It is reported that behavioral abnormalities frequently occur in patients with epilepsy and experimental epilepsy models. However, the precise pathological mechanisms associated with these epilepsy comorbidities remain largely unknown. Neurogenesis persists throughout life in the hippocampal dentate gyrus (DG) to maintain proper brain function...
March 7, 2020: Neuropharmacology
https://read.qxmd.com/read/32174782/tooth-loss-early-in-life-induces-hippocampal-morphology-remodeling-in-senescence-accelerated-mouse-prone-8-samp8-mice
#12
Masahisa Katano, Kyoko Kajimoto, Mitsuo Iinuma, Kagaku Azuma, Kin-Ya Kubo
Long-term tooth loss is associated with the suppression of hippocampal neurogenesis and impairment of hippocampus-dependent cognition with aging. The morphologic basis of the hippocampal alterations, however, remains unclear. In the present study, we investigated whether tooth loss early in life affects the hippocampal ultrastructure in senescence-accelerated mouse prone 8 (SAMP8) mice, using transmission electron microscopy. Male SAMP8 mice were randomized into control or tooth-loss groups. All maxillary molar teeth were removed at 1 month of age...
2020: International Journal of Medical Sciences
https://read.qxmd.com/read/32169583/oxytocin-has-sex-specific-effects-on-social-behaviour-and-hypothalamic-oxytocin-immunoreactive-cells-but-not-hippocampal-neurogenesis-in-adult-rats
#13
Paula Duarte-Guterman, Stephanie E Lieblich, Wansu Qiu, Jared E J Splinter, Kimberly A Go, Laura Casanueva-Reimon, Liisa A M Galea
Oxytocin regulates social behaviours, pair bonding and hippocampal neurogenesis but most studies have used adult males. Our study investigated the effects of oxytocin on social investigation and adult hippocampal neurogenesis in male and female rats. Oxytocin has poor penetration of the blood-brain barrier, therefore we tested a nanoparticle drug, TRIOZAN™ (Ovensa Inc.), which permits greater blood-brain-barrier penetration. Adult male and female rats were injected daily (i.p.) for 10 days with either: oxytocin in PBS (0...
March 10, 2020: Hormones and Behavior
https://read.qxmd.com/read/32168100/endurance-exercise-induced-expression-of-autophagy-related-protein-coincides-with-anabolic-expression-and-neurogenesis-in-the-hippocampus-of-the-mouse-brain
#14
Yongchul Jang
Autophagy and neurogenesis play a pivotal role in maintaining cellular homeostasis of neurons in the brain. Endurance exercise (EXE) serves as a potent regulator of both autophagy and neurogenesis in the hippocampus of the brain; however, the underlying molecular mechanisms of the dual expression remains unclear. Thus, we examined the signaling pathways of EXE-induced autophagy and neurogenesis-associated protein expression in the hippocampus. C57BL/6 male mice (10 weeks old) were randomly divided into two groups: control group (n = 10) and EXE group (EXE, n = 10)...
March 12, 2020: Neuroreport
https://read.qxmd.com/read/32152318/functional-hypoxia-drives-neuroplasticity-and-neurogenesis-via-brain-erythropoietin
#15
Debia Wakhloo, Franziska Scharkowski, Yasmina Curto, Umer Javed Butt, Vikas Bansal, Agnes A Steixner-Kumar, Liane Wüstefeld, Ashish Rajput, Sahab Arinrad, Matthias R Zillmann, Anna Seelbach, Imam Hassouna, Katharina Schneider, Abdul Qadir Ibrahim, Hauke B Werner, Henrik Martens, Kamilla Miskowiak, Sonja M Wojcik, Stefan Bonn, Juan Nacher, Klaus-Armin Nave, Hannelore Ehrenreich
Erythropoietin (EPO), named after its role in hematopoiesis, is also expressed in mammalian brain. In clinical settings, recombinant EPO treatment has revealed a remarkable improvement of cognition, but underlying mechanisms have remained obscure. Here, we show with a novel line of reporter mice that cognitive challenge induces local/endogenous hypoxia in hippocampal pyramidal neurons, hence enhancing expression of EPO and EPO receptor (EPOR). High-dose EPO administration, amplifying auto/paracrine EPO/EPOR signaling, prompts the emergence of new CA1 neurons and enhanced dendritic spine densities...
March 9, 2020: Nature Communications
https://read.qxmd.com/read/32151947/notch-pathway-up-regulation-via-curcumin-mitigates-bisphenol-a-bpa-induced-alterations-in-hippocampal-oligodendrogenesis
#16
Ankit Tandon, Sangh Jyoti Singh, Manjeet Gupta, Nivedita Singh, Jai Shankar, Nidhi Arjaria, Shweta Goyal, Rajnish Kumar Chaturvedi
CNS myelination process involves proliferation and differentiation of oligodendrocyte progenitor cells (OPCs). Defective myelination causes onset of neurological disorders. Bisphenol-A (BPA), a component of plastic items, exerts adverse effects on human health. Our previous studies indicated that BPA impairs neurogenesis and myelination process stimulating cognitive dysfunctions. But, the underlying mechanism(s) of BPA induced de-myelination and probable neuroprotection by curcumin remains elusive. We found that curcumin protected BPA mediated adverse effects on oligosphere growth kinetics...
January 8, 2020: Journal of Hazardous Materials
https://read.qxmd.com/read/32143275/neuroprotective-role-of-dietary-supplementation-with-omega-3-fatty-acids-in-the-presence-of-basal-forebrain-cholinergic-neurons-degeneration-in-aged-mice
#17
Debora Cutuli, Eugenia Landolfo, Davide Decandia, Annalisa Nobili, Maria Teresa Viscomi, Livia La Barbera, Stefano Sacchetti, Paola De Bartolo, Annacarmen Curci, Marcello D'Amelio, Stefano Farioli-Vecchioli, Laura Petrosini
As major components of neuronal membranes, omega-3 polyunsaturated fatty acids (n-3 PUFA) exhibit a wide range of regulatory functions. Recent human and animal studies indicate that n-3 PUFA may exert beneficial effects on aging processes. Here we analyzed the neuroprotective influence of n-3 PUFA supplementation on behavioral deficits, hippocampal neurogenesis, volume loss, and astrogliosis in aged mice that underwent a selective depletion of basal forebrain cholinergic neurons. Such a lesion represents a valid model to mimic a key component of the cognitive deficits associated with dementia...
March 4, 2020: International Journal of Molecular Sciences
https://read.qxmd.com/read/32142666/interneuron-accumulation-of-phosphorylated-tau-impairs-adult-hippocampal-neurogenesis-by-suppressing-gabaergic-transmission
#18
Jie Zheng, Hong-Lian Li, Na Tian, Fei Liu, Lu Wang, Yaling Yin, Lupeng Yue, Longyu Ma, You Wan, Jian-Zhi Wang
No abstract text is available yet for this article.
March 5, 2020: Cell Stem Cell
https://read.qxmd.com/read/32142656/too-much-tau-in-interneurons-impairs-adult-hippocampal-neurogenesis-in-alzheimer-s-disease
#19
Ramsey Najm, Antara Rao, Yadong Huang
Understanding why adult hippocampal neurogenesis (AHN) is impaired in Alzheimer's disease (AD) is essential for unravelling its role in pathogenesis. In this issue of Cell Stem Cell, Zheng et al. (2020) report that human tau accumulation in dentate gyrus GABAergic interneurons disrupts AHN and strengthening GABAergic signaling restores AHN and improves cognition in an AD mouse model.
March 5, 2020: Cell Stem Cell
https://read.qxmd.com/read/32138257/gabaergic-input-affects-intracellular-calcium-levels-in-developing-granule-cells-of-adult-rat-hippocampus
#20
Davide Lattanzi, Michael Di Palma, Riccardo Cuppini, Patrizia Ambrogini
In the dentate gyrus (DG) of the mammalian hippocampus, granule neurons are generated from neural stem cells (NSCs) throughout the life span and are integrated into the hippocampal network. Adult DG neurogenesis is regulated by multiple intrinsic and extrinsic factors that control NSC proliferation, maintenance, and differentiation into mature neurons. γ-Aminobutyric acid (GABA), released by local interneurons, regulates the development of neurons born in adulthood by activating extrasynaptic and synaptic GABAA receptors...
March 3, 2020: International Journal of Molecular Sciences
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