Jia Wang, Guanya Li, Gang Ji, Yang Hu, Wenchao Zhang, Weibin Ji, Juan Yu, Yu Han, Guangbin Cui, Huaning Wang, Peter Manza, Nora D Volkow, Gene-Jack Wang, Yi Zhang
BACKGROUND: Neuroimaging studies have revealed alterations in habenular (Hb) structure and functional connectivity (FC) in psychiatric conditions. Particularly, the Hb plays a critical role in regulating negative emotions, which trigger excessive food-intake and obesity. However, obesity and weight-loss intervention (i.e., laparoscopic sleeve gastrectomy-LSG) associated changes in Hb structure and FC have not been studied. METHODS: We used voxel-based morphometry analysis to measure changes in gray-matter volume (GMV) in Hb in 56 patients with obesity at pre-LSG (PreLSG) and 12-month post-LSG (PostLSG12 ), and in 78 normal-weight (NW) controls...
July 20, 2023: Biological Psychiatry