Michela Perrone, Martina Pagano, Carmela Belardo, Flavia Ricciardi, Federica Ricciardi, Antimo Fusco, Maria Consiglia Trotta, Rosmara Infantino, Francesca Gargano, Andrea Parente, Rosa Giacca, Gorizio Pieretti, Livio Luongo, Sabatino Maione, Serena Boccella, Francesca Guida
Following insults or injury, microglia cells are activated contributing to the cytotoxic response or by promoting an immune-mediated damage resolution. Microglia cells express HCA2R, a hydroxy carboxylic acid (HCA) receptor, which has been shown to mediate neuroprotective and anti-inflammatory effects. In this study we found that HCAR2 expression levels were increased in cultured rat microglia cells after Lipopolysaccharide (LPS) exposure. In a similar fashion, the treatment with MK 1903, a potent full agonist of HCAR2, increased the receptor protein levels...
February 14, 2023: Neuropharmacology