Xiangqin Kuang, Zhuojun Zhang, Difeng Li, Wenhao Bao, Jinyuan Pan, Ping Zhou, Han Chen, Zhiqing Gao, Xiaoyi Xie, Chunxiao Yang, Ge Zhu, Zhongqiu Zhou, Ruiming Tang, Zhengfu Feng, Lihuan Zhou, Xiaoli Feng, Lan Wang, Jianan Yang, Lili Jiang
BACKGROUND: Bladder cancer (BLCA) is a malignancy that frequently metastasizes and leads to poor patient prognosis. It is essential to understand the molecular mechanisms underlying the progression and metastasis of BLCA and identify potential biomarkers. METHODS: The expression of peptidase inhibitor 16 (PI16) was analysed using quantitative PCR, immunoblotting and immunohistochemistry assays. The functional roles of PI16 were evaluated using wound healing, transwell, and human umbilical vein endothelial cell tube formation assays, as well as in vivo tumour models...
July 31, 2023: Cellular & Molecular Biology Letters