Eduardo Frias-Anaya, Helios Gallego-Gutierrez, Brendan Gongol, Shantel Weinsheimer, Catherine Chinhchu Lai, Marco Orecchioni, Aditya Sriram, Cassandra M Bui, Bliss Nelsen, Preston Hale, Angela Pham, Robert Shenkar, Dorothy DeBiasse, Rhonda Lightle, Romuald Girard, Ying Li, Abhinav Srinath, Richard Daneman, Eric Nudleman, Hao Sun, Monica Guma, Alexandre Dubrac, Omar Mesarwi, Klaus Ley, Helen Kim, Issam A Awad, Mark H Ginsberg, Miguel Alejandro Lopez-Ramirez
BACKGROUND: Heterogeneity in the severity of cerebral cavernous malformations (CCMs) disease, including brain bleedings and thrombosis that cause neurological disabilities in patients, suggests that environmental, genetic, or biological factors act as disease modifiers. Still, the underlying mechanisms are not entirely understood. Here, we report that mild hypoxia accelerates CCM disease by promoting angiogenesis, neuroinflammation, and vascular thrombosis in the brains of CCM mouse models...
April 25, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology