Zhe Ma, Bin Jing, Yuxia Li, Huagang Yan, Zhaoxia Li, Xiangyu Ma, Zhizheng Zhuo, Lijiang Wei, Haiyun Li
Mild cognitive impairment (MCI) exhibits a high risk of progression to Alzheimer's disease (AD), and it is commonly deemed as the precursor of AD. It is important to find effective and robust ways for the early diagnosis of MCI. In this paper, a random forest-based method combining multiple morphological metrics was proposed to identify MCI from normal controls (NC). Voxel-based morphometry, deformation-based morphometry, and surface-based morphometry were utilized to extract morphological metrics such as gray matter volume, Jacobian determinant value, cortical thickness, gyrification index, sulcus depth, and fractal dimension...
December 23, 2019: Journal of Alzheimer's Disease: JAD