Abderaouf Hamza, Julien Masliah-Planchon, Cindy Neuzillet, Jérémie H Lefèvre, Magali Svrcek, Sophie Vacher, Christine Bourneix, Matthieu Delaye, Diane Goéré, Peggy Dartigues, Emmanuelle Samalin, Marc Hilmi, Julien Lazartigues, Elodie Girard, Jean-François Emile, Eugénie Rigault, Virginie Dangles-Marie, Nathalie Rioux-Leclercq, Christelle de la Fouchardière, David Tougeron, Andrea Casadei-Gardini, Pascale Mariani, Frédérique Peschaud, Wulfran Cacheux, Astrid Lièvre, Ivan Bièche
The management of anal squamous cell carcinoma (ASCC) has yet to experience the transformative impact of precision medicine. Conducting genomic analyses may uncover novel prognostic biomarkers and offer potential directions for the development of targeted therapies. To that end, we assessed the prognostic and theragnostic implications of pathogenic variants identified in 571 cancer-related genes from surgical samples collected from a homogeneous, multicentric French cohort of 158 ASCC patients who underwent abdominoperineal resection treatment...
October 31, 2023: International Journal of Cancer. Journal International du Cancer