Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Alexandra Hastings, Patrick Cullinane, Sarah Wrigley, Tamas Revesz, Huw R Morris, John C Dickson, Zane Jaunmuktane, Thomas T Warner, Eduardo De Pablo-Fernández
BACKGROUND AND OBJECTIVES: Degeneration of the presynaptic nigrostriatal dopaminergic system is one of the main biological features of Parkinson disease (PD), multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), which can be measured using single-photon emission CT imaging for diagnostic purposes. Despite its widespread use in clinical practice and research, the diagnostic properties of presynaptic nigrostriatal dopaminergic (DAT) imaging in parkinsonism have never been evaluated against the diagnostic gold standard of neuropathology...
June 11, 2024: Neurology
#2
JOURNAL ARTICLE
Yoya Ono, Koh Tadokoro, Taijun Yunoki, Toru Yamashita, Daisuke Sato, Hiroyasu Sato, Shintaro Akamatsu, Heisuke Mizukami, Yasuyuki Ohta, Yoshihisa Yamano, Akio Kimura, Shimohata Takayoshi
INTRODUCTION: Anti-immunoglobulin-like cell adhesion molecule 5 (IgLON5) disease is a rare autoimmune encephalitis that can mimic progressive supranuclear palsy or corticobasal syndrome. Moreover, anti-IgLON5 disease can present with symptoms characteristic of multiple system atrophy (MSA), such as cerebellar ataxia and autonomic dysfunction. However, the clinical features of anti-IgLON5 disease resembling MSA have not been well established. METHODS: We enrolled 35 patients with suspected MSA for whom anti-IgLON5 antibody tests were requested...
April 30, 2024: Parkinsonism & related Disorders
#3
JOURNAL ARTICLE
Negin Holland, George Savulich, P Simon Jones, David J Whiteside, Duncan Street, Peter Swann, Michelle Naessens, Maura Malpetti, Young T Hong, Tim D Fryer, Timothy Rittman, Eoin Mulroy, Franklin I Aigbirhio, Kailash P Bhatia, John T O'Brien, James B Rowe
BACKGROUND/OBJECTIVE: The corticobasal syndrome (CBS) is a complex asymmetric movement disorder, with cognitive impairment. Although commonly associated with the primary 4-repeat-tauopathy of corticobasal degeneration, clinicopathological correlation is poor, and a significant proportion is due to Alzheimer's disease (AD). Synaptic loss is a pathological feature of many clinical and preclinical tauopathies. We therefore measured the degree of synaptic loss in patients with CBS and tested whether synaptic loss differed according to β-amyloid status...
April 26, 2024: Movement Disorders: Official Journal of the Movement Disorder Society
#4
JOURNAL ARTICLE
Diane M A Swallow, Carl E Counsell
BACKGROUND: We conducted a systematic review to identify existing ICD-10 coding validation studies in progressive supranuclear palsy and corticobasal syndrome [PSP/CBS]) and, in a new study, evaluated the accuracy of ICD-10 diagnostic codes for PSP/CBS in Scottish hospital inpatient and death certificate data. METHODS: Original studies that assessed the accuracy of specific ICD-10 diagnostic codes in PSP/CBS were sought. Separately, we estimated the positive predictive value (PPV) of specific codes for PSP/CBS in inpatient hospital data (SMR01, SMR04) compared to clinical diagnosis in four regions...
April 12, 2024: Journal of Neurology
#5
JOURNAL ARTICLE
Gregory Mathoux, Cecilia Boccalini, Aurelien Lathuliere, Max Scheffler, Giovanni B Frisoni, Valentina Garibotto
BACKGROUND: This case report presents a patient with progressive memory loss and choreiform movements. CASE PRESENTATION: Neuropsychological tests indicated multi-domain amnestic mild cognitive impairment (aMCI), and neurological examination revealed asymmetrical involuntary hyperkinetic movements. Imaging studies showed severe left-sided atrophy and hypometabolism in the left frontal and temporoparietal cortex. [18 F]Flortaucipir PET exhibited moderately increased tracer uptake in hypometabolic areas...
April 4, 2024: EJNMMI Research
#6
JOURNAL ARTICLE
Dario Saracino
Cortico-basal degeneration is a relatively uncommon cause of degenerative parkinsonism in the elderly. From a clinical point of view, it manifests as a cortico-basal syndrome (CBS), featuring a highly asymmetrical akinetic-rigid syndrome, dystonia, myoclonus and cognitive-behavioral impairment with predominant apraxia. Other clinical phenotypes are possible, including variants with mainly language or behavioral impairment, or with axial, symmetrical parkinsonism resembling progressive supranuclear palsy (PSP)...
March 1, 2024: Gériatrie et Psychologie Neuropsychiatrie du Vieillissement
#7
JOURNAL ARTICLE
Jeffrey S Phillips, Nagesh Adluru, Moo K Chung, Hamsanandini Radhakrishnan, Christopher A Olm, Philip A Cook, James C Gee, Katheryn A Q Cousins, Sanaz Arezoumandan, David A Wolk, Corey T McMillan, Murray Grossman, David J Irwin
INTRODUCTION: Multimodal evidence indicates Alzheimer's disease (AD) is characterized by early white matter (WM) changes that precede overt cognitive impairment. WM changes have overwhelmingly been investigated in typical, amnestic mild cognitive impairment and AD; fewer studies have addressed WM change in atypical, non-amnestic syndromes. We hypothesized each non-amnestic AD syndrome would exhibit WM differences from amnestic and other non-amnestic syndromes. MATERIALS AND METHODS: Participants included 45 cognitively normal (CN) individuals; 41 amnestic AD patients; and 67 patients with non-amnestic AD syndromes including logopenic-variant primary progressive aphasia (lvPPA, n = 32), posterior cortical atrophy (PCA, n = 17), behavioral variant AD (bvAD, n = 10), and corticobasal syndrome (CBS, n = 8)...
2024: Frontiers in Neuroscience
#8
REVIEW
Priyadarshi Prajjwal, Nikhil Deep Kolanu, Yeruva Bheemeswara Reddy, Aneeqa Ahmed, Mohammed Dheyaa Marsool Marsool, Krupanagram Santoshi, Himani Harshad Pattani, Jobby John, Kiran Kishor Chandrasekar, Omniat Amir Hussin
BACKGROUND: Parkinson's disease (PD) is a condition that affects movement and is usually seen in those over the age of 50. It is caused by the death of dopaminergic neurons, particularly in the substantia nigra. PD has shifted from being perceived as an uncommon condition to a significant neurological illness, mostly due to the increasing number of elderly individuals and the impact of environmental factors. Parkinson's plus syndromes, such as progressive supranuclear palsy (PSP), multiple system atrophy (MSA), corticobasal degeneration (CBD), and vascular Parkinsonism (VaP), provide difficulties in distinguishing them clinically from PD since they have similar characteristics...
April 2024: Health Science Reports
#9
JOURNAL ARTICLE
Yuki Momota, Shogyoku Bun, Jinichi Hirano, Kei Kamiya, Ryo Ueda, Yu Iwabuchi, Keisuke Takahata, Yasuharu Yamamoto, Toshiki Tezuka, Masahito Kubota, Morinobu Seki, Ryo Shikimoto, Yu Mimura, Taishiro Kishimoto, Hajime Tabuchi, Masahiro Jinzaki, Daisuke Ito, Masaru Mimura
Previous studies have developed and explored magnetic resonance imaging (MRI)-based machine learning models for predicting Alzheimer's disease (AD). However, limited research has focused on models incorporating diverse patient populations. This study aimed to build a clinically useful prediction model for amyloid-beta (Aβ) deposition using source-based morphometry, using a data-driven algorithm based on independent component analyses. Additionally, we assessed how the predictive accuracies varied with the feature combinations...
April 1, 2024: Scientific Reports
#10
JOURNAL ARTICLE
Dror Shir, Nick Corriveau-Lecavalier, Camilo Bermudez Noguera, Leland Barnard, Nha Trang Thu Pham, Hugo Botha, Joseph R Duffy, Heather M Clark, Rene L Utianski, David S Knopman, Ronald C Petersen, Bradley F Boeve, Melissa E Murray, Aivi T Nguyen, R Ross Reichard, Dennis W Dickson, Gregory S Day, Walter K Kremers, Neill R Graff-Radford, David T Jones, Mary M Machulda, Julie A Fields, Jennifer L Whitwell, Keith A Josephs, Jonathan Graff-Radford
BACKGROUND: Primary progressive aphasia (PPA) defines a group of neurodegenerative disorders characterised by language decline. Three PPA variants correlate with distinct underlying pathologies: semantic variant PPA (svPPA) with transactive response DNA-binding protein of 43 kD (TDP-43) proteinopathy, agrammatic variant PPA (agPPA) with tau deposition and logopenic variant PPA (lvPPA) with Alzheimer's disease (AD). Our objectives were to differentiate PPA variants using clinical and neuroimaging features, assess progression and evaluate structural MRI and a novel 18-F fluorodeoxyglucose positron emission tomography (FDG-PET) image decomposition machine learning algorithm for neuropathology prediction...
March 21, 2024: Journal of Neurology, Neurosurgery, and Psychiatry
#11
REVIEW
Andrew Kertesz, Elizabeth Finger, David G Munoz
We present a review of the definition, classification, and epidemiology of primary progressive aphasia (PPA); an update of the taxonomy of the clinical syndrome of PPA; and recent advances in the neuroanatomy, pathology, and genetics of PPA, as well as the search for biomarkers and treatment. PPA studies that have contributed to concepts of language organization and disease propagation in neurodegeneration are also reviewed. In addition, the issues of heterogeneity versus the relationships of the clinical phenotypes and their relationship to biological, pathological, and genetic advances are discussed, as is PPA's relationship to other conditions such as frontotemporal dementia, corticobasal degeneration, progressive supranuclear palsy, Pick disease, and amyotrophic lateral sclerosis...
March 1, 2024: Cognitive and Behavioral Neurology: Official Journal of the Society for Behavioral and Cognitive Neurology
#12
JOURNAL ARTICLE
Tomoya Kawazoe, Keizo Sugaya, Yasuhiro Nakata, Masato Okitsu, Kazushi Takahashi
INTRODUCTION: The present study characterized the degeneration of nigrostriatal dopaminergic neurons in the early stages of parkinsonian disorders using integrative neuroimaging analysis with neuromelanin-sensitive MRI and 123 I-FP-CIT dopamine transporter (DAT) SPECT. METHODS: Thirty-one, 30, and 29 patients with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS) with abnormal specific binding ratio (SBR) in either hemisphere (mean ± 2SD), and parkinsonism-predominant multiple system atrophy (MSA-P), respectively, were enrolled...
2024: Clinical parkinsonism & related disorders
#13
JOURNAL ARTICLE
Diane M A Swallow, Peter Murchie, Carl E Counsell
BACKGROUND: Early diagnosis in progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) is important for clinical care and key to developing successful disease-modifying agents. The patient-dependent phases of decision-making made before contact with a healthcare professional have been inadequately studied. OBJECTIVES: To evaluate the patient-dependent phases of decision-making from symptom onset, comparing this to clinician and/or health system delays within the overall diagnostic pathway...
February 18, 2024: Movement Disorders Clinical Practice
#14
COMMENT
(no author information available yet)
[This corrects the article DOI: 10.1093/braincomms/fcad296.].
2024: Brain communications
#15
JOURNAL ARTICLE
Daniele Urso, Salvatore Nigro, Benedetta Tafuri, Roberto De Blasi, Joana B Pereira, Giancarlo Logroscino
BACKGROUND: Cognitive changes are common in corticobasal syndrome (CBS) and significantly impact quality of life and caregiver burden. However, there is a scarcity of studies investigating the neural substrates of cognitive changes in CBS, and currently, reliable predictors of cognitive impairment are lacking. The nucleus basalis of Meynert (NbM), which serves as the primary source of cortical cholinergic innervation, has been functionally associated with cognition. This study aimed to explore whether patients with CBS exhibit reduced NbM volumes compared to healthy controls and whether NbM degeneration can serve as a predictor of cognitive impairment in CBS patients...
February 1, 2024: Biological Psychiatry
#16
JOURNAL ARTICLE
Timothy P Siejka, Kelly L Bertram, Huiliang M Tang, Dominic Thyagarajan, Terence J O'Brien, Helmut Butzkueven, Lucy Vivash, Ian H Harding
INTRODUCTION: Atypical parkinsonian syndromes (APS) are rare neurodegenerative syndromes for which parkinsonism is one significant feature. APS includes progressive supranuclear palsy (PSP), multiple system atrophy (MSA) and corticobasal syndrome (CBS). The diagnosis of APS remains reliant on clinical features with no available diagnostic or prognostic biomarker. Clinical scales remain the gold standard assessment measures in clinical trials and research. The lack of standardised approach for research cohorts has contributed to shortcomings in disease understanding and limits collaboration between researchers...
2024: BMJ neurology open
#17
REVIEW
Kurt A Jellinger
Depression is one of the most frequent neuropsychiatric symptoms in corticobasal degeneration (CBD), a rare, sporadic, and late-onset progressive neurodegenerative disorder of unknown etiology. It is clinically characterized by a levodopa-poorly responsible akinetic-rigid syndrome, apraxia, limb dystonia, cognitive, mood, behavioral, and language disorders. This 4-repeat (4R) tauopathy is morphologically featured by asymmetric frontoparietal atrophy, neuronal loss, and gliosis in cortex and subcortex including substantia nigra, ballooned/achromatic neurons with filamentous 4R tau aggregates in cortex and striatum, widespread thread-like structures, pathognomonic "astroglial plaques", "tufted astrocytes", and numerous "coiled bodies" (in astrocytes and oligodendroglia) in cerebral white matter...
March 2024: Journal of Neural Transmission
#18
JOURNAL ARTICLE
Jacy Bezerra Parmera, Camila de Godoi Carneiro, Isabel Junqueira de Almeida, Marcos Castello Barbosa de Oliveira, Pedro Melo Barbosa, Adalberto Studart-Neto, Carla Rachel Ono, Ricardo Nitrini, Carlos Alberto Buchpiguel, Egberto Reis Barbosa, Sonia Maria Dozzi Brucki, Artur Martins Coutinho
BACKGROUND: Corticobasal syndrome (CBS) is associated with diverse underlying pathologies, including the four-repeat (4R)-tauopathies. The Movement Disorders Society (MDS) criteria for progressive supranuclear palsy (PSP) proposed the novel category "probable 4R-tauopathy" to address the phenotypic overlap between PSP and corticobasal degeneration (CBD). OBJECTIVES: To investigate the clinical ability of the MDS-PSP criteria for probable 4R-tauopathy in predicting a negative amyloid-PET in CBS...
December 18, 2023: Movement Disorders Clinical Practice
#19
JOURNAL ARTICLE
Ikuko Aiba, Yuichi Hayashi, Takayoshi Shimohata, Mari Yoshida, Yuko Saito, Koichi Wakabayashi, Takashi Komori, Masato Hasegawa, Takeshi Ikeuchi, Aya M Tokumaru, Keita Sakurai, Shigeo Murayama, Kazuko Hasegawa, Toshiki Uchihara, Yasuko Toyoshima, Yufuko Saito, Ichiro Yabe, Satoshi Tanikawa, Keizo Sugaya, Kentaro Hayashi, Terunori Sano, Masaki Takao, Motoko Sakai, Harutoshi Fujimura, Hiroshi Takigawa, Tadashi Adachi, Ritsuko Hanajima, Osamu Yokota, Tomoko Miki, Yasushi Iwasaki, Michio Kobayashi, Nobutaka Arai, Takuya Ohkubo, Takanori Yokota, Keiko Mori, Masumi Ito, Chiho Ishida, Masaharu Tanaka, Jiro Idezuka, Masato Kanazawa, Kenju Aoki, Masashi Aoki, Takafumi Hasegawa, Hirohisa Watanabe, Atsushi Hashizume, Hisayoshi Niwa, Keizo Yasui, Keita Ito, Yukihiko Washimi, Eiichiro Mukai, Akatsuki Kubota, Tatsushi Toda, Kenji Nakashima
The clinical presentation of corticobasal degeneration is diverse, while the background pathology of corticobasal syndrome is also heterogeneous. Therefore, predicting the pathological background of corticobasal syndrome is extremely difficult. Herein, we investigated the clinical findings and course in patients with pathologically, genetically and biochemically verified corticobasal degeneration and corticobasal syndrome with background pathology to determine findings suggestive of background disorder. Thirty-two patients were identified as having corticobasal degeneration...
2023: Brain communications
#20
JOURNAL ARTICLE
Robert I McGeachan, Declan King
This scientific commentary relates to 'Clinical course of pathologically confirmed corticobasal degeneration and corticobasal syndrome', by Aiba et al . (https://doi.org/10.1093/braincomms/fcad296).
2023: Brain communications
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
