Margherita Zen, Marta Loredo Martinez, Francesco Benvenuti, Mariele Gatto, Francesca Saccon, Maddalena Larosa, Luca Iaccarino, Andrea Doria
OBJECTIVE: The withdrawal of oral anticoagulation (OAC) in patients with SLE and secondary aPL syndrome (SAPS) who become seronegative has not been clearly investigated to date. Our aim was to evaluate the prevalence of aPL seroconversion and the prognosis of SLE patients with SAPS who withdrew OAC after aPL negativization. METHODS: We retrospectively analysed data of all SLE patients (ACR criteria) with SAPS (Sydney criteria) prospectively followed-up in our clinic...
September 17, 2020: Rheumatology
Tomoyuki Mizuno, Brooks T McPhail, Suyog Kamatkar, Scott Wexelblatt, Laura Ward, Uwe Christians, Henry T Akinbi, Alexander A Vinks
BACKGROUND AND OBJECTIVE: Buprenorphine has been shown to be effective in treating infants with neonatal opioid withdrawal syndrome. However, an evidence-based buprenorphine dosing strategy has not been established in the treatment of neonatal opioid withdrawal syndrome because of a lack of exposure-response data. The aim of this study was to develop an integrated pharmacokinetic and pharmacodynamic model to predict buprenorphine treatment outcomes in newborns with neonatal opioid withdrawal syndrome...
September 17, 2020: Clinical Pharmacokinetics
Jordana B Cohen, Thomas C Hanff, Vicente Corrales-Medina, Preethi William, Nicolas Renna, Nelson R Rosado-Santander, Juan E Rodriguez-Mori, Jonas Spaak, Jaime Andrade-Villanueva, Tara I Chang, Alejandro Barbagelata, Carlos E Alfonso, Eduardo Bernales-Salas, Johanna Coacalla, Carlos Augusto Castro-Callirgos, Karen E Tupayachi-Venero, Carola Medina, Renzo Valdivia, Mirko Villavicencio, Charles R Vasquez, Michael O Harhay, Jesse Chittams, Tiffany Sharkoski, James Brian Byrd, Daniel L Edmonston, Nancy Sweitzer, Julio A Chirinos
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), is associated with high incidence of multiorgan dysfunction and death. Angiotensin-converting enzyme 2 (ACE2), which facilitates SARS-CoV-2 host cell entry, may be impacted by angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), two commonly used antihypertensive classes. In a multicenter, international randomized controlled trial that began enrollment on March 31, 2020, participants are randomized to continuation vs withdrawal of their long-term outpatient ACEI or ARB upon hospitalization with COVID-19...
September 16, 2020: Journal of Clinical Hypertension
Juhani Kalsi, Markku Tervo, Timo Tervo
Objective: The aim of the present study was twofold. The first aim was to explore how frequently physicians evaluate driving fitness when a patient has a serious alcohol problem, which is accomplished by examining differences in physicians' compliance with their intervention/notification obligation among different alcohol-related ICD-10 diagnoses. The second aim was to explore how many heavy alcohol users have a valid driving license. Methods: Data from all patients with an alcohol-related ICD-10 diagnosis code as a cause of a hospital visit were collected during a three-month period from Kuopio University Hospital and North Karelia Central Hospital...
October 2019: Nordisk Alkohol- & Narkotikatidskrift: NAT
Masaki Shiota, Asako Machidori, Tatsuro Abe, Keisuke Monji, Eiji Kashiwagi, Ario Takeuchi, Ryosuke Takahashi, Junichi Inokuchi, Akira Yokomizo, Seiji Naito, Masatoshi Eto
OBJECTIVES: To assess the impact of antiandrogen withdrawal syndrome after bicalutamide withdrawal in castration-resistant prostate cancer patients treated with androgen receptor-axis targeted agents. METHODS: The study cohort comprised 94 patients treated with abiraterone (n = 34) or enzalutamide (n = 60) as a first-line androgen receptor-axis targeted agent for castration-resistant prostate cancer despite combined androgen blockade by castration with bicalutamide as the first-line therapy...
September 15, 2020: International Journal of Urology: Official Journal of the Japanese Urological Association
Changrong Zhang, Yongquan Huang, Peiwu Li, Xinlin Chen, Fengbin Liu, Qiuke Hou
BACKGROUND: Ginger or ginger extracts have been used in traditional medicine relieve pain caused by diarrhea predominant irritable bowel syndrome (IBS-D), but few data exists about its effectiveness. This present study was to validate the effect of ginger on visceral pain, and to further explore the possible underlying mechanism by which ginger is used to relieve IBS-D intestinal hypersensitivity. METHODS: First, the IBS-D rat model was established by chemical stimulation and acute and chronic pressure stimulation...
September 14, 2020: BMC complementary medicine and therapies
Zin Thawdar Oo, Htoo Kyaw
Cocaine has been used increasingly nowadays because of its abundant availability and recreational effects. Along with that, we have been experiencing many cases presenting with cocaine intoxication and withdrawal effects, including hypertension and chest pain syndrome. In the modern era, many medical advances related to myocardial infarction treatment have been made, including not only medical therapy but also urgent or emergent reperfusion, and revascularization therapies. In percutaneous coronary revascularization therapy, a second-generation drug-eluting stent (DES) with dual antiplatelet therapy is the first-line treatment compared to bare-metal stent (BMS) with significant reduced risk of stent thrombosis and restenosis...
August 11, 2020: Curēus
Walid M Maalouli, Brian S Hilliard
The use of venlafaxine, a selective serotonin and norepinephrine reuptake inhibitor, for the management of depression in women of childbearing age has been on the rise, and there have been multiple case reports in the literature tying venlafaxine in-utero exposure to a form of neonatal encephalopathy presenting as neonatal abstinence syndrome. We present the case of a 5-day-old term infant whose mother was on venlafaxine throughout her pregnancy and presented with hypothermia, poor feeding, and decreased activity level...
2020: SAGE Open Medical Case Reports
Hongmei Ding, Cuiqin Shi, Xianghuai Xu, Li Yu
Chronic cough is defined as a cough lasting for ≥8 weeks with a normal chest radiograph. The common causes of chronic cough are cough variant asthma (CVA), upper airway cough syndrome/postnasal drip syndrome (UACS/PNDs), eosinophilic bronchitis (EB), gastroesophageal reflux-related chronic cough (GERC) and atopic cough (AC). Drug-induced chronic cough, a rare cause of chronic cough, refers to a chronic cough caused by certain drugs. In addition to angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), there are cases reporting that some drugs such as omeprazole and leflumide that can cause cough...
September 2, 2020: Annals of Palliative Medicine
Eliza Buyers, Amy E Sass, Cameron D Severn, Laura Pyle, Melanie Cree-Green
STUDY OBJECTIVE: Describe why adolescents with Polycystic Ovary Syndrome (PCOS) chose the etonogestrel (ENG) contraceptive implant, determine the 12-month continuation rate and characterize factors related to discontinuation. DESIGN: Setting, and Participants: Retrospective chart review of adolescents seen at a tertiary care children's hospital between July 1, 2008 and August 30, 2019 with PCOS diagnosis confirmed per NIH criteria and ≥ 12-month ENG follow-up...
September 9, 2020: Journal of Pediatric and Adolescent Gynecology
Rachel M Smith, Brian Benzio, Andrew L Hendrickson, Evan D Telford, Andrew J Franck
No abstract text is available yet for this article.
August 19, 2020: Joint Commission Journal on Quality and Patient Safety
Markus Stuppe, Jochen Facklam, Detlef Schumacher
Surgical treatment of patients with alcohol use disorder can lead to disturbances (withdrawal syndrome, delirium) which require intensive care treatment. In a surgical ward, the diagnosis of an alcohol related disorder is not always simple. Oftentimes patients conceal or trivialize the issue and as a result are admitted to the hospital in a non-abstinent or unstable state. It is risky to assume that patients with alcohol use disorder will successfully be supplied with alcohol in general hospitals. The risk can be reduced through presurgical identification and alcohol withdrawal of such patients...
September 2020: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
Sangmin Park, Jung Geol Lim, Hee Jin Chang, Eungseok Oh
Orthostatic tremor (OT) is not an uncommon symptom in various neurodegenerative diseases. However, the nature and pathophysiology of OT involve a complex network of tremors and dopaminergic pathways. We assessed patients who complained of prominent leg tremors described as "shaky leg." We analyzed their characteristics and evaluated them with neuroimaging and electrophysiological tools. A total of 23 patients who experienced an uncomfortable symptom of leg tremor were retrospectively enrolled from April 2014 to October 2019...
September 10, 2020: Neuro-degenerative Diseases
Dawn L Lindsay, Kenneth Freedman, Margaret Jarvis, Piper Lincoln, Jessica Williams, Lewis S Nelson, Taleen Safarian
: The American Society of Addiction Medicine (ASAM) Clinical Practice Guideline on Alcohol Withdrawal Management provides guidance on the identification and management of alcohol withdrawal in adults with varying degrees of syndrome severity. The guideline addresses both ambulatory and inpatient care and considers special patient populations. The Guideline was primarily developed following the RAND/UCLA Appropriateness Method (RAM), a process to determine the appropriateness of a set of clinical procedures...
August 31, 2020: Journal of Addiction Medicine
Tanya Calvey, Florian Scheibein, Noha Ahmed Saad, Tomohiro Shirasaka, Lisa Dannatt, M J Stowe, Bigya Shah, Venkata Lakshmi Narasimha, Angelo Bruschi, Eric Peyron, Joy Louise Gumikiriza-Onoria, Abhishek Ghosh, Sagun Ballav Pant, Anne Yee, Woraphat Ratta-Apha, Ramyadarshni Vadivel, Kristiana Siste, Tanay Maiti, Saïd Boujraf, Paolo Grandinetti, Nirvana Morgan, Sidharth Arya
: Alcohol use is a major risk factor for infectious disease and reduction of harms associated with alcohol consumption are essential during times of humanitarian crises, such as the COVID-19 pandemic. As a network of early career professionals working in the area of addiction medicine, we provide our views with regards to national actions related to reducing alcohol-related harm and providing care for people with alcohol use disorder during COVID-19. We believe that COVID-19 related measures have affected alcohol consumption in the majority of countries represented in this commentary...
September 8, 2020: Journal of Addiction Medicine
Raul F Palma-Alvarez, Juan Duque-Yemail, Elena Ros-Cucurull, María Robles-Martínez, Marta Perea-Ortueta, Lara Grau-López, Josep A Ramos-Quiroga
Quinolones are an antibiotic group widely used due to their antimicrobial action and security profile, however, it has been described neuropsychiatric adverse effects, being induced-psychotic episodes one of the most clinically relevant. Nevertheless, this secondary effect has been scarcely studied. A literature search using PRISMA guidelines was performed between 01/01/1962 and 01/31/2019 on PubMed and ScienceDirect, including manuscripts which described substance-induced psychotic disorder according to DSM-5 and in which the symptomatology was not attributable to an acute confusional state (delirium) or to other induced psychiatric disorders...
May 2020: Actas Españolas de Psiquiatría
Harpreet K Rai, Pranavkumar Patel, Kalpana Reddy
Metformin is the first-line therapy for patients with type 2 diabetes, and its most common adverse effects are gastrointestinal. Lactic acidosis associated with metformin use is rare. Here, we report the case of a 77-year-old man with a medical history of diabetes (treated with metformin), hypertension, chronic alcohol abuse, and prostate and bladder cancer, who presented with abdominal pain, nausea, vomiting, and diarrhea for five days. He was admitted with severe metabolic acidosis due to metformin toxicity (metformin-associated lactic acidosis) with metformin level 23 mcg/mL (therapeutic range approximately 1-2 mcg/mL) in the setting of acute kidney failure due to acute pancreatitis and sepsis secondary to aspiration pneumonia...
August 3, 2020: Curēus
Gian Pietro Sechi, M Margherita Sechi
No abstract text is available yet for this article.
September 8, 2020: JAMA Internal Medicine
Thomas D Brothers, Paxton Bach
No abstract text is available yet for this article.
September 8, 2020: JAMA Internal Medicine
Jane Fornoff, Theresa Sandidge
BACKGROUND: Opioid use has reached historically high levels across the United States and infants exposed during pregnancy are at risk of developing a drug withdrawal syndrome called neonatal abstinence syndrome (NAS). The prevalence of birth defects among Illinois infants exhibiting NAS has not been estimated. METHODS: We linked birth certificate data for Illinois-resident infants born in Illinois in 2015 or 2016 to previously collected NAS and Adverse Pregnancy Outcome Reporting System birth defect data...
September 8, 2020: Birth Defects Research
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