Fakhar H Waqas, Mahmoud Shehata, Walid A M Elgaher, Antoine Lacour, Naziia Kurmasheva, Fabio Begnini, Anders E Kiib, Julia Dahlmann, Chutao Chen, Andreas Pavlou, Thomas B Poulsen, Sylvia Merkert, Ulrich Martin, Ruth Olmer, David Olagnier, Anna K H Hirsch, Stephan Pleschka, Frank Pessler
In addition to antioxidative and anti-inflammatory properties, activators of the cytoprotective nuclear factor erythroid-2-like-2 (NRF2) signaling pathway have antiviral effects, but the underlying antiviral mechanisms are incompletely understood. We evaluated the ability of the NRF2 activators 4-octyl itaconate (4OI), bardoxolone methyl (BARD), sulforaphane (SFN), and the inhibitor of exportin-1 (XPO1)-mediated nuclear export selinexor (SEL) to interfere with influenza virus A/Puerto Rico/8/1934 (H1N1) infection of human cells...
July 2023: PLoS Pathogens