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JOURNAL ARTICLE
Joanna M Wardlaw, Hugues Chabriat, Frank-Erik de Leeuw, Stéphanie Debette, Martin Dichgans, Fergus Doubal, Hanna Jokinen, Aristeidis H Katsanos, Raffaele Ornello, Leonardo Pantoni, Marco Pasi, Aleksandra M Pavlovic, Salvatore Rudilosso, Reinhold Schmidt, Julie Staals, Martin Taylor-Rowan, Salman Hussain, Arne G Lindgren
A quarter of ischaemic strokes are lacunar subtype, typically neurologically mild, usually resulting from intrinsic cerebral small vessel pathology, with risk factor profiles and outcome rates differing from other stroke subtypes. This European Stroke Organisation (ESO) guideline provides evidence-based recommendations to assist with clinical decisions about management of lacunar ischaemic stroke to prevent adverse clinical outcomes. The guideline was developed according to ESO standard operating procedures and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) methodology...
March 2024: European Stroke Journal
#2
JOURNAL ARTICLE
Loris Riccardo Lopetuso, Sara Deleu, Lihi Godny, Valentina Petito, Pierluigi Puca, Federica Facciotti, Harry Sokol, Gianluca Ianiro, Luca Masucci, Maria Abreu, Iris Dotan, Samuel Paul Costello, Ailsa Hart, Tariq H Iqbal, Sudarshan Paramsothy, Maurizio Sanguinetti, Silvio Danese, Herbert Tilg, Fabio Cominelli, Theresa T Pizarro, Alessandro Armuzzi, Giovanni Cammarota, Antonio Gasbarrini, Séverine Vermeire, Franco Scaldaferri
BACKGROUND: Several randomised clinical trials (RCTs) performing faecal microbiota transplantation (FMT) for the management of inflammatory bowel disease (IBD), particularly for ulcerative colitis, have recently been published, but with major variations in study design. These include differences in administered dose, route and frequency of delivery, type of placebo and evaluated endpoints. Although the overall outcomes appear to be promising, they are highly dependent on both donor and recipient factors...
September 2023: Gut
#3
JOURNAL ARTICLE
Anna V Ivanina Foureau, Wei Sha, David M Foureau, James T Symanowski, Carol J Farhangfar, Kathryn F Mileham
BACKGROUND: Metabolomics studies to date have described widespread metabolic reprogramming events during the development of non-squamous non-small cell lung cancer (NSCLC). Extending far beyond the Warburg effect, not only is carbohydrate metabolism affected, but also metabolism of amino acids, cofactors, lipids, and nucleotides. METHODS: We evaluated the clinical impact of metabolic reprogramming. We performed comparative analysis of publicly available data on non-squamous NSCLC, to identify concensus altered metabolic pathways...
December 2022: Translational Lung Cancer Research
#4
JOURNAL ARTICLE
Harikrishnan Rajendran, Amir Haluts, Nir S Gov, Ofer Feinerman
Social groups often need to overcome differences in individual interests and knowledge to reach consensus decisions. Here, we combine experiments and modeling to study conflict resolution in emigrating ant colonies during binary nest selection. We find that cohesive emigration, without fragmentation, is achieved only by intermediate-sized colonies. We then impose a conflict regarding the desired emigration target between colony subgroups. This is achieved using an automated selective gate system that manipulates the information accessible to each ant...
December 28, 2021: Current Biology: CB
#5
JOURNAL ARTICLE
Kamil İnci, Nazlıhan Boyacı, İskender Kara, Gül Gürsel
While plateau airway pressure alone is an unreliable estimate of lung overdistension inspiratory transpulmonary pressure (PL) is an important parameter to reflect it in patients with ARDS and there is no concensus about which computation method should be used to calculate it. Recent studies suggest that different formulas may lead to different tidal volume and PEEP settings. The aim of this study is to compare 3 different inspiratory PL measurement method; direct measurement (PLD ), elastance derived (PLE ) and release derived (PLR ) methods in patients with multiple mechanical abnormalities...
September 3, 2021: Journal of Clinical Monitoring and Computing
#6
JOURNAL ARTICLE
A Belhassen, S Toujani, A El Ouni, Z Meddeb, C Abdelkefi, T Larbi, S Hamzaoui, K Bouslama
AIM OF THE STUDY: Our study aimed to identify the characteristics of cardiac involvement in eosinophilic granulomatosis with polyangiitis (EGPA). METHODS: We conducted a retrospective analytic study including EGPA cases diagnosed between 2000 and 2019 in an internal medicine department. Diagnosis was made according to the 1990 American College of Rheumatology criteria and the 2012 Chapel Hill Concensus. RESULTS: Eleven EGPA cases were included, 64% of patients were female...
February 23, 2021: Annales de Cardiologie et D'angéiologie
#7
JOURNAL ARTICLE
Valentina Laurita Longo, Emmanuel Nene Odjidja, Thierry Kamba Beia, Manuela Neri, Karina Kielmann, Irene Gittardi, Amanda Isabella Di Rosa, Michela Boldrini, Gian Benedetto Melis, Giovanni Scambia, Antonio Lanzone
BACKGROUND: Improvements in medical technologies have seen over-medicalization of childbirth. Caesarean section (CS) is a lifesaving procedure proven effective in reducing maternal and perinatal mortality across the globe. However, as with any medical procedure, the CS intrinsically carries some risk to its beneficiaries. In recent years, CS rates have risen alarmingly in high-income countries. Many exceeding the World Health Organisation (WHO) recommendation of a 10 to 15% annual CS rate...
December 10, 2020: BMC Pregnancy and Childbirth
#8
JOURNAL ARTICLE
José A de la Peña-Celaya, Jocelyn Aguilar-Luevano, Luisa Ma Alcivar-Cedeño, José L Álvarez-Vera, Irene Anaya-Cuellar, Erika Añorve-Hernández, Luara L Arana-Luna, Luis Arteaga-Ortíz, Pamela E Báez-Islas, Luisa I Banda-García, Ramón A Bates-Martín, Dafne Itzel Campa-Monroy, Mariela Cardiel-Silva, Ángel de Jesús Castillo-Salas, Xóchitl Cota-Rangel, Guillermo Díaz-Vargas, M Eugenia Espitia-Ríos, Patricia Estrada-Domínguez, Denisse Fermín-Caminero, Alinka García-Camacho, Carolina García-Castillo, Katheryn B Garzón-Velásquez, Carlos Gil-Rondero, Lidia V Guerra-Alarcón, Ana K Hernández-Colín, Eleazar Hernández-Ruiz, Areli E Hernández-Alcántara, Silvia A Hernández-Cervantes, Wilfrido Herrera-Olivares, Gregorio Ignacio-Ibarra, Sergio I Inclán-Alarcón, Faustino Leyto-Cruz, Juan P Macías-Flores, Andrea Martínez-de la Vega, Mario Alberto Martínez-Ramírez, Jorge Martínez-Coronel, Jesús Emanuel Medina-Coral, Lizeth Meza-Dávalos, Leire Montoya-Jiménez, Alba Morales-Hernández, Elizabeth Morales-López, Javier de Jesús Morales-Adrián, Maricruz Morales-de Azcué, Aldo Mújica-Martínez, Juan L Murillo-Cruz, Jéssica Nájera-Martínez, Iris Mabel Narváez-Sarmiento, Lorena Nava-Villegas, Marco A Nava-Alpide, Juan J Orellana Garibay, Ma Teresa Palafox-Zaldívar, Orlando G Palma-Moreno, Eugenia P Paredes-Lozano, Ma Luisa Pedraza-Colín, Juan M Pérez-Zúñiga, Alejandra B Pérez-Lizardi, Flavio Rojas-Castillejos, Eduardo Romero-Martínez, Hilda Romero-Rodelo, Josué Ruiz-Contreras, Azucena Saavedra-González, Erick Saucedo-Montes, Luis G Silva-Michel, Karina Silva-Vera, Óscar Teomitzi-Sánchez, Fredy Tepepa-Flores, Yanet Ventura-Enríquez, Atenas Villela-Peña, Shendel P Vilchis-González, Nidia Zapata-Canto, Pedro A Zárate-Rodríguez, Martha Alvarado-Ibarra
To identify this increasingly common pathology, known as multiple myeloma (MM), it is necessary to refer to the specific factors that characterize it; to this end, the classic criteria known as CRAB (hyperkalemia, renal failure, anemia, and lytic lesions) are available, in which renal failure is one of the most frequent complications. Recently, three indisputable biomarkers have been described for the diagnostic support for MM, which are: more than 10% of clonal plasma cells in bone marrow or, a biopsy that corroborates the presence of a plasmacytoma, light chain ratio ≥ 100 mg/dL and more than one focal lesion on magnetic resonance imaging...
2020: Gaceta Médica de México
#9
REVIEW
Julio A Ramirez, Daniel M Musher, Scott E Evans, Charles Dela Cruz, Kristina A Crothers, Chadi A Hage, Stefano Aliberti, Antonio Anzueto, Francisco Arancibia, Forest Arnold, Elie Azoulay, Francesco Blasi, Jose Bordon, Steven Burdette, Bin Cao, Rodrigo Cavallazzi, James Chalmers, Patrick Charles, Jean Chastre, Yann-Erick Claessens, Nathan Dean, Xavier Duval, Muriel Fartoukh, Charles Feldman, Thomas File, Filipe Froes, Stephen Furmanek, Martin Gnoni, Gustavo Lopardo, Carlos Luna, Takaya Maruyama, Rosario Menendez, Mark Metersky, Donna Mildvan, Eric Mortensen, Michael S Niederman, Mathias Pletz, Jordi Rello, Marcos I Restrepo, Yuichiro Shindo, Antoni Torres, Grant Waterer, Brandon Webb, Tobias Welte, Martin Witzenrath, Richard Wunderink
BACKGROUND: Community-acquired pneumonia (CAP) guidelines have improved the management and outcomes of patients with CAP, primarily by standardization of initial empiric therapy. But current society-published guidelines exclude immunocompromised patients. RESEARCH QUESTION: There is no concensus regarding the initial management of immunocompromised patients with suspected CAP. STUDY DESIGN AND METHODS: This consensus document was created by a multidisciplinary panel of 45 physicians with experience in the management of CAP in immunocompromised patients...
June 16, 2020: Chest
#10
M P Mathey, J Bouquet de Jolinière, A Major, B Conrad, F Khomsi, D Betticher, M Devouassoux, A Feki
INTRODUCTION: Small cell carcinoma of the ovary (SCC) is a very rare (less than 1 % of ovarien neoplasia), highly undifferentiated, aggressive malignancy affecting young women and linked to a poor prognosis. Overall survive rate is very low (about 16 %). SCCOHT has recently been shown to be associated with SMARCA4 gene mutations and shows some genetic similarities to malignant rhabdoid tumors (MRT). PRESENTATION OF CASE: After a reminder of the clinical, histological description of the SCCOHT and concensus about the medical management, we describe the rare case of a 22 years old patient with complete remission after diagnosis of un undifferentiated SCCOHT stage IV treated by conservative surgery and high-doses chemotherapy, 30 months after diagnosis...
November 30, 2019: International Journal of Surgery Case Reports
#11
JOURNAL ARTICLE
Herman P Kaldeway, Evert-Jan Ter Borg, Ewoudt M W van de Garde, Jan B A Habraken, Monique M C van Buul
PURPOSE: The aim of this retrospective study was to evaluate the diagnostic value of semiquantitative parameters in salivary gland scintigraphy (SGS) in the diagnostic work-up of primary Sjögren's Syndrome (SS) using the American-European consensus criteria (AECC) as the gold standard. PATIENTS AND METHODS: 99mTc-pertechnetate-SGS was performed in 110 patients with suspected primary SS. Uptake ratios (URs) and excretion fractions (EFs) for all parotid and submandibular salivary glands were calculated...
February 21, 2019: Nuclear Medicine Communications
#12
JOURNAL ARTICLE
Corinna Lang-Schwarz, Balint Melcher, Franziska Haumaier, Klaus Lang-Schwarz, Thomas Rupprecht, Michael Vieth, William Sterlacci
Tumor budding is an independent prognostic factor in colorectal cancer (CRC) and has recently been well defined by the International Concensus Conference on Tumor Budding (ITBCC). Tumor-infiltrating lymphocytes (TILs) are also an issue in different human cancers and correlate with prognosis in CRC. Here we evaluate the combination of budding and TILs in CRC with regard to prognosis. Hematoxylin and eosin (H&E)-stained slides of 501 CRC patients, diagnosed between 2005 and 2010, were reevaluated for tumor budding according to the ITBCC criteria...
September 2018: Human Pathology
#13
JOURNAL ARTICLE
Eva Karamitopoulou, Martin Wartenberg, Inti Zlobec, Silvia Cibin, Mathias Worni, Beat Gloor, Alessandro Lugli
AIMS: Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy with rising incidence. Biomarkers that would help the prognostic stratification of patients are needed urgently. Although tumour budding (BD) is a strong and independent prognostic factor in PDAC it is not included in histopathology reports, due partly to the lack of a standardised scoring system. The aim of the present work is to assess the reliability and reproducibility of the BD scoring system proposed recently by the International Tumour Budding Consensus Conference (ITBCC) 2016 in a well-characterised PDAC cohort (n = 120) with complete clinicopathological and follow-up information...
July 2018: Histopathology
#14
JOURNAL ARTICLE
Wojciech Marlicz, Karolina Skonieczna-Zydecka, Igor Łoniewski
No abstract text is available yet for this article.
January 2018: American Journal of Gastroenterology
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
#16
JOURNAL ARTICLE
Jesper Holst Pedersen, Jens Benn Sørensen, Zaigham Saghir, Øystein Fløtten, Odd Terje Brustugun, Haseem Ashraf, Trond-Eirik Strand, Signe Friesland, Hirsh Koyi, Lars Ek, Sven Nyrén, Per Bergman, Antti Jekunen, Eeva-Maija Nieminen, Tomas Gudbjartsson
INTRODUCTION: We review the current knowledge of CT screening for lung cancer and present an expert-based, joint protocol for the proper implementation of screening in the Nordic countries. MATERIALS AND METHODS: Experts representing all the Nordic countries performed literature review and concensus for a joint protocol for lung cancer screening. RESULTS AND DISCUSSION: Areas of concern and caution are presented and discussed. We suggest to perform CT screening pilot studies in the Nordic countries in order to gain experience and develop specific and safe protocols for the implementation of such a program...
October 2017: Acta Oncologica
#17
REVIEW
Gabriel Samasca, Aaron Lerner, Anamaria Girbovan, Genel Sur, Iulia Lupan, Peter Makovicky, Torsten Matthias, Hugh J Freeman
BACKGROUND: New treatments in coeliac disease are being vigorously pursued to either replace or facilitate the difficult-tofollow gluten-free diet. DESIGN: The present review intends to summarise the challenges in gluten-free diet adherence during the transitional period, as reflected in the last Prague consensus, published in 2016. RESULTS: The honourable panel members recommended that dietary adherence and the consequences of nonadherence represent key components for discussion in the transitional period setting...
May 2017: European Journal of Clinical Investigation
#18
JOURNAL ARTICLE
Gul Kanyilmaz, Meryem Aktan, Mehmet Koc, Hikmettin Demir, Lütfi Saltuk Demir
AIMS: To evaluate the incidental dose to the internal mammary chain (IMC) in patients treated with three-dimensional conformal radiotherapy, to estimate the predictors affecting the magnitude of IMC receiving dose and to determine the predictive role of clinical parameters on survival. MATERIALS AND METHODS: Between 2009 and 2015, 348 patients undergoing RT for breast cancer were retrospectively analyzed. All patients underwent our department's routine procedure for breast cancer...
June 2017: La Radiologia Medica
#19
EDITORIAL
Rhian E Davies, Ian C Gilchrist
Patients with atrial fibrillation (AF) when stented with thin-strut colbalt chrome stents may have a similar outcome to patients without AF. Management of patients with AF potentially place patients at enhanced bleeding risk with triple antithrombotic therapy, or potential thrombotic risk if either oral anticoagulation is held or anti-platelet therapy is truncated. Guideline-based oral anticoagulation for AF is expanding this patient group presenting to the cardiac catheterization laboratory, yet management decisions are still based on limited studies and rely on expert concensus...
September 2016: Catheterization and Cardiovascular Interventions
#20
JOURNAL ARTICLE
Tamar Rubin, Jacqueline Clayton, Denise Adams, Rabin Persad, Sunita Vohra
BACKGROUND: Heterogeneity has been noted in the selection and reporting of disease-specific, pediatric outcomes in randomized controlled trials (RCTs). The consequence is invalid results or difficulty comparing results across trials. The primary objective of this systematic review was to assess primary outcome and outcome measure selection and reporting, in pediatric eosinophilic esophagitis (EoE) treatment trials. As secondary objectives, we compared trial disease definition to established concensus guidelines, and the efficacy of current EoE treatments...
2016: Allergy, Asthma, and Clinical Immunology
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