Ohana Leticia Tavares da Silva, Maria Karolaynne da Silva, Joao Firmino Rodrigues-Neto, Joao Paulo Matos Santos Lima, Vinicius Manzoni, Shopnil Akash, Umberto Laino Fulco, Mohammed Bourhia, Turki M Dawoud, Hiba-Allah Nafidi, Baye Sitotaw, Shahina Akter, Jonas Ivan Nobre Oliveira
Yellow fever outbreaks are prevalent, particularly in endemic regions. Given the lack of an established treatment for this disease, significant attention has been directed toward managing this arbovirus. In response, we developed a multiepitope vaccine designed to elicit an immune response, utilizing advanced immunoinformatic and molecular modeling techniques. To achieve this, we predicted B- and T-cell epitopes using the sequences from all structural (E, prM, and C) and nonstructural proteins of 196 YFV strains...
May 12, 2024: Scientific Reports