Ying Li, Runmin Li, Xianhuang Li, Liping Liu, Jianting Zhu, Dongying Li
BACKGROUND: Type 2 diabetes is an emergent worldwide health crisis, and rates are growing globally. Aerobic exercise is an essential measure for patients with diabetes, which has the advantages of flexible time and low cost. Aerobic exercise is a popular method to reduce blood glucose. Due to the lack of randomized trials to compare the effects of various aerobic exercises, it is difficult to judge the relative efficacy. Therefore, we intend to conduct a network meta-analysis to evaluate these aerobic exercises...
May 7, 2021: Medicine (Baltimore)
Miaomiao Zhao, Xiya Gui, Qiuling Wu, Linghui Xia, Yadan Wang
RATIONALE: Until recently, the survival rate in patients with Philadelphia-positive acute lymphoblastic leukemia (Ph+ ALL) was approximately 30%. Tyrosine kinase inhibitors (TKIs), which are a new class of drugs that target BCR-ABL fusion protein, have shown to be effective in treating Ph+ ALL in adults. However, the resistance mechanisms that promote the disease recurrence have altered the initial success of these revolutionary agents. PATIENT CONCERNS: A 71-year-old Chinese female patient who suffered from severe shoulder and back pain for 1 week...
May 7, 2021: Medicine (Baltimore)
Khalid Al Saleh, Rakan M AlQahtani
Acute physiology and chronic health evaluation II (APACHE-II) scoring system is used to classify disease severity of patients in the intensive care unit. However, several limitations render the scoring system inadequate in identifying risk factors associated with outcomes. Little is known about the association of platelet count patterns, and the timing of platelet count and other hematologic parameters in predicting mortality in patients with sepsis.This retrospective observational study included 205 septic shock patients, with an overall mortality of 47...
May 7, 2021: Medicine (Baltimore)
Valerie Tarsia
This group of paintings portrays the beauty and strength of frontline clinicians in a hectic emergency room during the COVID-19 pandemic. Head-to-toe personal protective equipment covers their fear. Vibrant colors and strange perspectives help question the reality through which they and their patients lived.
April 1, 2021: AMA Journal of Ethics
Christopher G AhnAllen
Trainees are expected to encounter clinical training environments and situations that utilize methods of force as a component of clinical care. These include emergency care, critical care, and psychiatry. Several educational recommendations are offered in this paper related to these situations-including de-escalation training and crisis management skills, trauma-informed care, person-centered care approaches, and compassionate care approaches-to support trainee development across clinical care settings. Trainees require supervisors' focused attention to consider and implement force when caring for a diverse range of patients and retraumatization risk...
April 1, 2021: AMA Journal of Ethics
Jenny Victoria Tran, Mette Brekke, Odd Martin Vallersnes
BACKGROUND: Poisonings by substances of abuse are potentially dangerous and indicate risky substance use behaviour. To be prepared to handle patients with poisonings by substances of abuse, we need updated knowledge about the kinds of substances we can be expected to encounter. Most substance use-related poisonings in Oslo are treated at the OAEOC, and we describe the poisonings observed there in the period 2014-2018. MATERIAL AND METHOD: We included all patients treated for poisoning by substances of abuse at the OAEOC in the years 2014-18, with the exception of lone ethanol poisonings...
April 29, 2021: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Rasmus Dehli Thorkildsen, Frode Thu, Lars-Eldar Myrseth, Magne Røkkum
BACKGROUND: Subcutaneous contraceptive implants are recommended to be placed in the medial upper arm. Here, the implant lies close to important neurovascular structures. CASE PRESENTATION: We have treated two women with ulnar nerve injuries after removal of such implants. Patient 1 sustained a near complete nerve injury. Despite nerve grafting and a distal nerve transfer, she had a poor outcome. Patient 2 had a partial injury and has made a reasonable recovery after neurolysis of the ulnar nerve that was entrapped in scar tissue...
April 15, 2021: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Ann-Elin Meling Stokland, Ida Kloster, Bjørn Egil Vikse, Arne Skjold, Renate Vik, Bjørn Gunnar Nedrebø
BACKGROUND: Pheochromocytoma is referred to as 'the great mimic' with a broad spectrum of presenting symptoms. In the following case, the diagnosis had an unusual presentation as a medical emergency - pheochromocytoma crisis. CASE PRESENTATION: A previously healthy woman in her fifties was admitted due to abdominal pain and dyspnoea. At admission she was haemodynamically stable, with stable respiration, but arterial blood gas showed serious lactic acidosis with pH 6...
April 27, 2021: Tidsskrift for Den Norske Lægeforening: Tidsskrift for Praktisk Medicin, Ny Række
Bruna Maria de Sá Pereira, Rafaela Montalvão de Azevedo, João Victor da Silva Guerra, Paulo A Faria, Sheila Coelho Soares-Lima, Beatriz De Camargo, Mariana Maschietto
Non-coding RNAs are involved with maintenance and regulation of physiological mechanisms and are involved in pathological processes, such as cancer. Among the small ncRNAs, miRNAs are the most explored in tumorigenesis, metastasis development, and resistance to chemotherapy. These small molecules of ~ 22 nucleotides are modulated during early renal development, involved in the regulation of gene expression and Wilms' tumor progression. Wilms' tumors are embryonic tumors with few mutations and complex epigenetic dysregulation...
May 5, 2021: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
Katherine A Black, Lijun Duan, Lungelo Mandyoli, Bruna P Selbach, Weizhen Xu, Sabine Ehrt, James C Sacchettini, Kyu Y Rhee
Comparative sequence analysis has enabled the annotation of millions of genes from organisms across the evolutionary tree. However, this approach has inherently biased the annotation of phylogenetically ubiquitous, rather than species-specific, functions. The ecologically unusual pathogen Mycobacterium tuberculosis (Mtb) has evolved in humans as its sole reservoir and emerged as the leading bacterial cause of death worldwide. However, the physiological factors that define Mtb's pathogenicity are poorly understood...
July 5, 2021: Journal of Experimental Medicine
Cassandra B Klune, Benita Jin, Laura A DeNardo
The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions play key roles in memory, cognition, decision making, social behaviors, and mood. Dysfunction in mPFC is implicated in psychiatric disorders in which these behaviors go awry. The prolonged maturation of mPFC likely enables complex behaviors to emerge, but also increases their vulnerability to disruption. Many foundational studies have characterized either mPFC synaptic or behavioral development without establishing connections between them...
May 5, 2021: ELife
Phillip Huyett, Neil Bhattacharyya
STUDY OBJECTIVES: To determine the incremental increases in healthcare utilization and expenditures associated with sleep disorders. METHODS: Adults with a diagnosis of a sleep disorder (ICD-10 code G47.x) within the medical conditions file of the 2018 Medical Expenditure Panel Survey medical conditions file were identified. This dataset was then linked to the consolidated expenditures file and comparisons in healthcare utilization and expenditures were made between those with and without sleep disorders...
May 4, 2021: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
Olga Tarasova, Vladimir Poroikov
Nowadays, computational approaches play an important role in the design of new drug-like compounds and optimization of pharmacotherapeutic treatment of diseases. The emerging growth of viral infections, including those caused by the Human Immunodeficiency Virus (HIV), Ebola virus, recently detected coronavirus, and some others, leads to many newly infected people with a high risk of death or severe complications. A huge amount of chemical, biological, clinical data is at the disposal of the researchers. Therefore, there are many opportunities to find the relationships between the particular features of chemical data and the antiviral activity of biologically active compounds based on machine learning approaches...
May 3, 2021: Current Medicinal Chemistry
Carla Petrella, Maria Grazia Di Certo, Francesca Gabanella, Christian Barbato, Flavio Maria Ceci, Antonio Greco, Massimo Ralli, Antonella Polimeni, Antonio Angeloni, Cinzia Severini, Mario Vitali, Giampiero Ferraguti, Mauro Ceccanti, Marco Lucarelli, Carola Severi, Marco Fiore
The Mediterranean diet is worldwide recognized as a good prototype of nutrition due to the conspicuous intake of olive oil, nuts, red wine, legumes, fruit, and vegetables, all fundamental elements rich in antioxidant substances and polyphenols. Polyphenols are a wide range of phytochemicals and/or synthetic chemical compounds with proven beneficial properties for human health. In the present review, we critically summarize the well-characterized antioxidant and anti-inflammatory properties of polyphenols contained in the olives and extra virgin olive oil and of resveratrol, a non-flavonoid phenolic compound...
May 3, 2021: Current Medicinal Chemistry
Mudasir Nabi Peerzada, Aysha Gaur, Amir Azam
Human African and American trypanosomiasis are the vector-borne parasitic diseases that have killed millions of people early, and many people are still suffering from these neglected diseases. The causative agents of these infections are parasitic protozoans of the genus Trypanosoma. Current treatment regimens against these endemic diseases have several limitations in terms of safety, efficacy, route of administration, and some of them have lost efficacy due to the emergence of resistance in their respective parasites...
May 3, 2021: Current Medicinal Chemistry
Rahul Sharma, Dharmendra Khokhar, Bhanushree Gupta, Purnendu Saxena, Kallol Kumar Ghosh, Arvind Kumar Geda, Kamil Kuca
There is a new public health crisis threatening the world with the emergence and spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease was later named as a novel Coronavirus disease or COVID-19. It was then declared a pandemic by the World Health Organization on March 11, 2020. The virus originated in bats and was transmitted to humans through yet unknown intermediary animals in Wuhan, Hubei province, China, in December 2019. As of February 5, 2021, 103 million laboratory-confirmed cases and nearly 2...
May 3, 2021: Current Medicinal Chemistry
Mitsuru Toda, Karlyn D Beer, Kathryn M Kuivila, Tom M Chiller, Brendan R Jackson
BACKGROUND: The fungus Aspergillus fumigatus ( A. fumigatus ) is the leading cause of invasive mold infections, which cause severe disease and death in immunocompromised people. Use of triazole antifungal medications in recent decades has improved patient survival; however, triazole-resistant infections have become common in parts of Europe and are emerging in the United States. Triazoles are also a class of fungicides used in plant agriculture, and certain triazole-resistant A. fumigatus strains found causing disease in humans have been linked to environmental fungicide use...
May 2021: Environmental Health Perspectives
Sabrina Aït Amiri, Cyrille Deboux, Feryel Soualmia, Nancy Chaaya, Maxime Louet, Eric Duplus, Sandrine Betuing, Brahim Nait Oumesmar, Nicolas Masurier, Chahrazade El Amri
Multiple sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS) that causes severe motor, sensory, and cognitive impairments. Kallikrein-related peptidase (KLK)6 is the most abundant serine protease secreted in the CNS, mainly by oligodendrocytes, the myelin-producing cells of the CNS, and KLK6 is assumed to be a robust biomarker of MS, since it is highly increased in the cerebrospinal fluid (CSF) of MS patients. Here, we report the design and biological evaluation of KLK6's low-molecular-weight inhibitors, para -aminobenzyl derivatives...
May 5, 2021: Journal of Medicinal Chemistry
Ignacio Sainz
The third phase of the Cardiac Rehabilitation Program (CRP) is a lifelong, maintenance phase beginning 3 to 6 months after the cardiac event. Individualized surveillance and monitoring schedules are established. The exercise prescription guidelines are practically identical to those of the other phases of the CRP with personalized monitoring. Currently, with the emergence of the COVID-19 pandemic, telerehabilitation and telemonitoring are of great value in this phase. The benefits of phase 3 have been demonstrated with prolonged survival by 1...
May 5, 2021: Panminerva Medica
Stephanie Best, Helen Brown, Zornitza Stark, Janet C Long, Larissa Ng, Jeffrey Braithwaite, Natalie Taylor
RATIONALE, AIMS AND OBJECTIVES: Teamworking across sociotechnical boundaries in healthcare is growing as technological advances in medicine abound. With this progress, teams need to find new ways of working together in non-traditional settings. The novel field of clinical genomics provides the opportunity to rethink the existing approach to teamworking and how it needs to evolve. Our aim was to identify the key factors influencing teamworking in the emerging field of clinical genomics and how can they be applied in practice...
May 5, 2021: Journal of Evaluation in Clinical Practice
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