Samieh Asadian, Hamed Mirzaei, Bagher Aziz Kalantari, Mohamad Reza Davarpanah, Morteza Mohamadi, Anastasia Shpichka, Leila Nasehi, Hamidreza Aboulkheyr Es, Peter Timashev, Mustapha Najimi, Nematollah Gheibi, Moustapha Hassan, Massoud Vosough
Targeted radionuclide therapy, known as molecular radiotherapy is a novel therapeutic module in cancer medicine. β-radiating radionuclides have definite impact on target cells via interference in cell cycle and particular signalings that can lead to tumor regression with minimal off-target effects on the surrounding tissues. Radionuclides play a remarkable role not only in apoptosis induction and cell cycle arrest, but also in the amelioration of other characteristics of cancer cells. Recently, application of novel β-radiating radionuclides in cancer therapy has been emerged as a promising therapeutic modality...
July 10, 2020: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
Yan Zhao, Ya-Ni Zhang, Kai-Ting Wang, Lei Chen
Lenvatinib, a multi-target tyrosine kinase inhibitor (TKI), is an emerging first-line therapy for hepatocellular carcinoma (HCC). Its application has changed the status of sorafenib as the only first-line TKI treatment for HCC for more than a decade. Evidence has shown that lenvatinib possesses antitumor proliferation and immunomodulatory activity in preclinical studies. In comparison, lenvatinib was non-inferior to sorafenib in overall survival (OS), and even shows superiority with regard to all the secondary efficacy endpoints...
July 10, 2020: Biochimica et Biophysica Acta. Reviews on Cancer
Chan-Ran Park, Jin-Seok Lee, Chang-Gue Son, Nam-Hun Lee
The tumor microenvironment (TME) is extremely complex, involving extensive interactions among stromal cells, immune cells, and signaling molecules. Therefore, an approach targeting the TME has emerged as a promising therapeutic strategy. Herbal medicines consist of multiple active compounds, which have multi-target effects. Therefore, they have been regarded as potential anticancer agents; multiple studies have explored their effects on the TME. In this review, we report the effects of 29 single herb medicines or herbal formulas on the TME, based on the findings of 64 published studies...
July 13, 2020: Phytotherapy Research: PTR
Amy Y Cheng, Harold K Simon, Judson Miller, Martha Wetzel, April Zmitrovich, Kiran B Hebbar
OBJECTIVES: High-flow nasal cannula (HFNC) is an oxygen delivery device that provides heated humidified air with higher flow rates. The purpose of this survey is to look at institutional practice patterns of HFNC initiation, weaning, and disposition for pediatric patients across the United States. METHODS: Survey was sent via electronic listservs to pediatric physicians in emergency medicine, hospital medicine, critical care, and urgent care. The questionnaire was divided into demographics and HFNC practices (initiation, management, and weaning)...
July 9, 2020: Pediatric Emergency Care
John A G Gibson, Thomas D Dobbs, Loukas Kouzaris, Arron Lacey, Simon Thompson, Ashley Akbari, Hayley A Hutchings, William C Lineaweaver, Ronan A Lyons, Iain S Whitaker
In medicine, "big data" refers to the interdisciplinary analysis of high-volume, diverse clinical and lifestyle information on large patient populations. Recent advancements in data storage and electronic record keeping have enabled the expansion of research in this field. In the United Kingdom, Big data has been highlighted as one of the government's "8 Great Technologies," and the Medical Research Council has invested more than £100 million since 2012 in developing the Health Data Research UK infrastructure...
July 9, 2020: Annals of Plastic Surgery
Mario Pagliaro, Yael Albo, Rosaria Ciriminna
Microencapsulated Ag nanoparticles, wee argument in this study, may shortly emerge as new generation antibacterials and antivirals of broad scope, low toxicity and affordable cost. The rediscovery of the medical uses of silver provides another noticeable example, this time at the interface of chemistry and medicine with implications concerning also COVID-19, of the real (and non-linear) progress of scientific research.
July 13, 2020: ChemMedChem
Haiyan Ren
There has been a large amount of interest in the development of genetically encoded cross-linkers that target functional groups naturally present in cells. Recently, a new class of unnatural amino acids that specifically react with target residues were developed and genetically incorporated. The selective reaction shows higher cross-linking efficiency, lower background and predictable cross-linking sites. It has been applied to enhance protein/peptide stability, pinpoint protein-protein interactions, stabilize protein complexes, engineer covalent protein inhibitors, identify phosphatases in living cells, etc...
July 13, 2020: Biochemical Society Transactions
Simon Craig, Mya Cubitt, Ashish Jaison, Steven Troupakis, Natalie Hood, Christina Fong, Adnan Bilgrami, Peter Leman, Juan Carlos Ascencio-Lane, Guruprasad Nagaraj, John Bonning, Gabriel Blecher, Rob Mitchell, Ellen Burkett, Sally M McCarthy, Amanda M Rojek, Kim Hansen, Helen Psihogios, Peter Allely, Simon Judkins, Lai Heng Foong, Stephen Bernard, Peter A Cameron
INTRODUCTION: The global pandemic of coronavirus disease 2019 (COVID-19) has caused significant worldwide disruption. Although Australia and New Zealand have not been affected as much as some other countries, resuscitation may still pose a risk to health care workers and necessitates a change to our traditional approach. This consensus statement for adult cardiac arrest in the setting of COVID-19 has been produced by the Australasian College for Emergency Medicine (ACEM) and aligns with national and international recommendations...
July 12, 2020: Medical Journal of Australia
Dayakar Alti, M Veeramohan Rao, D Narayana Rao, Radheshyam Maurya, Suresh K Kalangi
Resistance to antileishmanial drugs such as sodium stibogluconate (SSG), amphotericin B (Amp-B), and miltefosine is on the rise, and alternate strategies for effective treatment have gained importance in recent years. Although nanoparticle (NP)-based composite drugs that have emerged recently have been found to be effective, the associated toxicity limits their usage. Bimetallic NPs produced through reduction with medicinal plant extracts are proposed to overcome the toxicity of the NPs. In the present study, three types of gold-silver bimetallic nanoparticles (Au-Ag BNPs) were synthesized through a single-step reduction process using fenugreek, coriander, and soybean leaf extracts...
July 7, 2020: ACS Omega
Jonathon Deibel
Introduction: Epistaxis is a common presenting complaint in the emergency department. Proper technique to control the bleeding is essential. Active bleeding on an anticoagulant requires special consideration. Blood products and coagulopathy reversal are an important part of the resuscitation of an unstable bleeding patient on warfarin. Methods: This resource was created to simulate a high-acuity and moderate-frequency event seen in emergency departments and on hospital wards...
June 26, 2020: MedEdPORTAL Publications
Elizabeth Sanseau, Anita Thomas, Rosny Daniel, Julie Augenstein, Douglas Diekema
Introduction: Wilderness recreation is increasingly popular among people of all ages. Pediatric providers should have the skills to counsel on risk reduction and respond to medical emergencies in remote settings. However, few physicians receive training in wilderness medicine, and this simulation-based curriculum aims to address that gap. Methods: The scenario features an adolescent male in a remote setting with hypothermia, dehydration, and an ankle injury. The simulation is not resource intensive, utilizing a simulated patient actor and minimal equipment...
May 15, 2020: MedEdPORTAL Publications
Lindsey Jennings, Tessa Warner, Bastien Bacro-Duverger
Introduction: Opioid addiction and misuse constitute a public health crisis in the United States. Recent research supports buprenorphine induction in the emergency department (ED) setting for patients with opioid use disorder (OUD). However, education regarding buprenorphine induction for emergency medicine (EM) physicians, residents, and students is still limited. Methods: We created a 1-hour introductory workshop for the identification and treatment of opioid withdrawal and OUD in the ED for medical students going into EM and for EM interns...
May 15, 2020: MedEdPORTAL Publications
Antonio José Ruiz Moruno, Miguel Rodríguez Cola, Irena Jiménez Velasco, Rosa María Ruíz Delgado, Alicia González Rubio
OBJECTIVE: The effects of the Covid-19 health emergency have demonstrated the high vulnerability of people residing in medium and long-stay centers, with high mortality rates. Little data is available about contingency protocols to minimize the spread of the virus in these centers. The goal of this study was to describe the clinical and epidemiological features of patients affected by SARS-CoV-2 and the preventive and management measures adopted at the National Hospital for Paraplegics (Toledo, Castilla-La Mancha, Spain) to minimize the risk of transmission of Covid-19...
July 13, 2020: Revista Española de Salud Pública
Seshree Chetty, Dalene Venter, Aladdin Speelman
BACKGROUND: Emergency departments in South African public hospitals have a high patient load after hours, with inadequate numbers of health care professionals available to satisfy patient influx. In addition, there is often no provision of after-hours diagnostic reporting services in public hospitals, to an extent that the emergency physician is responsible for interpreting all radiographic images requested themseves. Emergency physicians, in this study, can be described as any medical doctor registered with the Health Professions Council of South Africa and working in the emergency department as a registrar or consultant physician because there were no physicians specialized in emergency medicine working at the hospitals selected for this study...
July 9, 2020: Journal of Medical Imaging and Radiation Sciences
James N MacLeod, Theodore S Kalbfleisch
The first equine reference genome was completed in 2007 and published in 2009. This major accomplishment has enabled equine science to advance in ways that broadly parallel the transformative impact that genomics has had on many animal species including humans. A conceptual overview of reference genomes, genome annotation, and the major implications for equine science is presented. The relationship between genomic sequencing and the accelerating application of precision P4 medicine is discussed in the context of human and equine patients...
August 2020: Veterinary Clinics of North America. Equine Practice
Alexander Zubov, Zamira Muruzheva, Maria Tikhomirova, Marina Karpenko
In the view of progressively aging human population and increased occurrence of dysmetabolic disorders, such as diabetes mellitus, cognitive impairment becomes a major threat to the national health. To date, the molecular mechanisms of cognitive dysfunction are partially described for diabetes and diseases of different nature, such as Alzheimer disease or Parkinson disease. The emergence of data pointing towards pleotropic effects of hypoglycaemic medicines indicates involvement of their targets in pathogenesis of cognitive impairment...
July 11, 2020: Archives of Physiology and Biochemistry
Kirsten Ostherr
The use of artificial intelligence in healthcare has led to debates about the role of human clinicians in the increasingly technological contexts of medicine. Some researchers have argued that AI will augment the capacities of physicians and increase their availability to provide empathy and other uniquely human forms of care to their patients. The human vulnerabilities experienced in the healthcare context raise the stakes of new technologies such as AI, and the human dimensions of AI in healthcare have particular significance for research in the humanities...
July 11, 2020: Journal of Medical Humanities
Shahd Horie, Bairbre McNicholas, Emanuele Rezoagli, Tài Pham, Ger Curley, Danny McAuley, Cecilia O'Kane, Alistair Nichol, Claudia Dos Santos, Patricia R M Rocco, Giacomo Bellani, John G Laffey
ARDS, first described in 1967, is the commonest form of acute severe hypoxemic respiratory failure. Despite considerable advances in our knowledge regarding the pathophysiology of ARDS, insights into the biologic mechanisms of lung injury and repair, and advances in supportive care, particularly ventilatory management, there remains no effective pharmacological therapy for this syndrome. Hospital mortality at 40% remains unacceptably high underlining the need to continue to develop and test therapies for this devastating clinical condition...
July 11, 2020: Intensive Care Medicine
Tibor Gyökeres, Eszter Schäfer, Attila Szepes, Zsuzsanna Vitális, Mária Papp, István Altorjay, László Czakó, Áron Vincze, Attila Bursics, Péter Kanizsai, Tamás Berényi
Gastrointestinal bleeding has a profound impact on public health due to its high prevalence and severity. With the elderly population taking more anticoagulants/antiaggregants/non-steroid anti-inflammatory drugs, the digestive bleeding will certainly raise more and more challenges in quantity as well as in severity for the public healthcare system. The emergency medicine specialists and gastroenterologists have a central role in the management of patients presenting with gastrointestinal bleeding. In certain cases, radiologists, invasive radiologists, intensive care specialists and surgeons should also be involved in the decision making process and management of patients...
July 2020: Orvosi Hetilap
Madeline Abrams, Noah Reichman, Deepak Khatri, Nitesh V Patel, Randy S D'Amico, Tamika Wong, Sherese Fralin, Mona Li, Marc Symons, David Langer, Christopher G Filippi, John A Boockvar
Neuro-oncological research is at the forefront of the rising cancer therapy market, as evidenced by its growing revenue and the multitude of clinical trials investigating innovative treatment approaches. The Feinstein Institute for Medical Research, in conjunction with the Department of Neurosurgery at Lenox Hill Hospital and the Zucker School of Medicine at Hofstra / Northwell, sponsored The Brain Tumor Biotech Summit in New York City in June 2019. The aim of the Summit was to provide a forum that encourages collaboration between cancer specialists, biotechnology and pharmaceutical industry leaders, and the investment community in order to promote innovation and advance emerging therapies for brain tumors...
July 7, 2020: Clinical Neurology and Neurosurgery
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