Victoria Bitsadze, Jamilya Khizroeva, Ismail Elalamy, Makatsariya Alexander
Objectives Assess all risk factors of venous thromboembolism (VTE) in pregnancy and puerperium. Methods Different guidelines for VTE prevention have been analyzed. Results Various recommendations have appeared for practitioners during the last 10-15 years on the basis of the risk factors analysis in order to prevent VTE in pregnant women more effectively. Nevertheless, none of these recommendations can yet take into account all risk factors, although convenient scoring systems have emerged for risk assessment and clear recommendations on anti-thrombotic prophylaxis regimens in risk groups in recent years...
October 26, 2020: Journal of Perinatal Medicine
Clifford L Freeman, Candace D McNaughton, Tyler W Barrett
No abstract text is available yet for this article.
November 2020: Annals of Emergency Medicine
Jordan R Pollock, Tanner R Bollig, Jack M Haglin, Benjamin J Sandefur, Douglas E Rappaport, Rachel A Lindor
STUDY OBJECTIVE: The change in reimbursement rates for emergency physician services has yet to be quantified. We attempted to fill this knowledge gap by evaluating the monetary trends in Medicare reimbursement rates over the last 20 years for the most common emergency medicine services. METHODS: We obtained commonly used Current Procedural Terminology (CPT) codes in emergency medicine from the American College of Emergency Physicians website. We queried the Physician Fee Schedule Look-Up Tool from the Centers for Medicare & Medicaid Services for each of the included CPT codes, and we extracted reimbursement data...
November 2020: Annals of Emergency Medicine
Tomislav Jednačak, Ivana Mikulandra, Predrag Novak
Macrolide antibiotics are macrocyclic compounds that are clinically used and prescribed for the treatment of upper and lower respiratory tract infections. They inhibit the synthesis of bacterial proteins by reversible binding to the 23S rRNA at or near the peptidyl transferase center. However, their excellent antibacterial profile was largely compromised by the emergence of bacterial resistance. Today, fighting resistance to antibiotics is one of the greatest challenges in medicinal chemistry. Considering various physicochemical properties of macrolides, understanding their structure and interactions with macromolecular targets is crucial for the design of new antibiotics efficient against resistant pathogens...
October 21, 2020: International Journal of Molecular Sciences
Karolina A Zielińska, Vladimir L Katanaev
The CXCL12/CXCR4 signaling pathway has emerged in the recent years as a key player in breast cancer tumorigenesis. This pathway controls many aspects of breast cancer development including cancer cell proliferation, motility and metastasis to all target organs. Moreover, the CXCL12/CXCR4 cascade affects both immune and stromal cells, creating tumor-supporting microenvironment. In this review, we examine state-of-the-art knowledge about detrimental roles of the CXCL12/CXCR4 signaling, discuss its therapeutic potential and suggest further research directions beneficial both for basic research and personalized medicine in breast cancer...
October 21, 2020: Cancers
Peter Everts, Kentaro Onishi, Prathap Jayaram, José Fábio Lana, Kenneth Mautner
Emerging autologous cellular therapies that utilize platelet-rich plasma (PRP) applications have the potential to play adjunctive roles in a variety of regenerative medicine treatment plans. There is a global unmet need for tissue repair strategies to treat musculoskeletal (MSK) and spinal disorders, osteoarthritis (OA), and patients with chronic complex and recalcitrant wounds. PRP therapy is based on the fact that platelet growth factors (PGFs) support the three phases of wound healing and repair cascade (inflammation, proliferation, remodeling)...
October 21, 2020: International Journal of Molecular Sciences
Nidhi Singh, SachchidaNand Rai, Veer Singh, Mohan P Singh
COVID-19 has forsaken the world because of extremely high infection rates and high mortality rates. At present we have neither medicine nor vaccine to prevent this pandemic. Lockdowns, curfews, isolations, quarantines, and social distancing are the only ways to mitigate their infection. This is badly affecting the mental health of people. Hence, there is an urgent need to address this issue. Coronavirus disease 2019 (COVID-19) is caused by a novel Betacorona virus named SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) which has emerged in the city of Wuhan in China and declared a pandemic by WHO since it affected almost all the countries the world, infected 24,182,030 people and caused 825,798 death as per data are compiled from John Hopkins University (JHU)...
October 19, 2020: Journal of Chemical Neuroanatomy
Sarah J MacEachern, Nils Daniel Forkert
Precision medicine is an emerging approach to clinical research and patient care that focuses on understanding and treating disease by integrating multimodal or 'multi-omics' data from an individual to make patient-tailored decisions. With the large and complex datasets generated using precision medicine diagnostic approaches, novel techniques to process and understand these complex data were needed. At the same time, computer science has progressed rapidly to develop techniques that enable the storage, processing, and analysis of these complex datasets, a feat that traditional statistics and early computing technologies could not accomplish...
October 22, 2020: Genome Génome / Conseil National de Recherches Canada
Karin J Baatjes, Alex V Keiller, Alwyn J Louw, Marietjie Van Rooyen
BACKGROUND: Varied and limited opportunities to assist during operations, hamper surgical procedural training. Furthermore, the trainee's view of the procedure differs from that of the operating surgeon. New solutions could emerge when instruction under direct supervision can be combined with technological advances in surgical practice. This study assesses the feasibility of using the GoPro HERO™ to record operations for educational purposes, from the perspective of the surgical and technical team...
October 9, 2020: Clinical Teacher
Cristina Sorlini, Marco Femia, Giovanni Nattino, Pietro Bellone, Elisa Gesu, Paolo Francione, Michele Paternò, Pasquale Grillo, Aurora Ruffino, Guido Bertolini, Maurizio Cariati, Francesca Cortellaro
The diffusion of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) worldwide prompted the World Health Organization to declare the status of pandemic. The molecular diagnosis of SARS-CoV-2 infection is based on the detection of viral RNA on different biological specimens. Unfortunately, the test may require several hours to be performed. In the present study, we evaluated the diagnostic accuracy of lung point-of-care ultrasound (POCUS) for SARS-CoV-2 pneumonia in a cohort of symptomatic patients admitted to one emergency department (ED) in a high-prevalence setting...
October 22, 2020: Internal and Emergency Medicine
Mariamena Arbitrio, Francesca Scionti, Maria Teresa Di Martino, Daniele Caracciolo, Licia Pensabene, Pierfrancesco Tassone, Pierosandro Tagliaferri
Interindividual variability in drug efficacy and toxicity is a major challenge in clinical practice. Variations in drug pharmacokinetics (PKs) and pharmacodynamics (PDs) can be, in part, explained by polymorphic variants in genes encoding drug metabolizing enzymes and transporters (absorption, distribution, metabolism, and excretion) or in genes encoding drug receptors. Pharmacogenomics (PGx) has allowed the identification of predictive biomarkers of drug PKs and PDs and the current knowledge of genome-disease and genome-drug interactions offers the opportunity to optimize tailored drug therapy...
October 22, 2020: Clinical and Translational Science
Nathan A Jacobson, Darshan Nagaraju, Jennifer M Miller, Matthew E Bernard
The COVID-19 pandemic has presented new challenges in how Primary Care clinicians care for community patients. Our organization quickly allocated 1 of our community clinic sites into a dedicated COVID Clinic caring for the COVID positive or any patient with COVID like symptoms to minimize contact with the well patients. A prerequisite for all patients to be seen in the COVID Care Clinic was a virtual visit staffed with Advanced Practice Providers that would further determine if the patient needed to seek emergency medical care or be seen in the COVID Clinic...
January 2020: Journal of Primary Care & Community Health
Samuel Wilson, Andrew Rixon, Stephanie Hartanto, Peter White, Simon Judkins
Emergency medicine (EM) is a discipline with complex leadership demands. However, studies of EM physician leadership and ED leadership are in their infancy. As such, there is a lack of clarity about the forms, antecedents, enablers, barriers and consequences of EM physician leadership. A systematic review of the scientific literature was conducted to reveal the different conceptualisations of EM physician leadership, the activities involved in the practice of leadership, and the knowledge and skills of effective ED leaders...
October 21, 2020: Emergency Medicine Australasia: EMA
Monalisa Mohanty, Samita Mohanty, Sanat Kumar Bhuyan, Ruchi Bhuyan
The present era accentuate the use of alternative medicines as drugs extracted from several plant parts. These herbal medicines otherwise called ethnomedicines are now the source of many imperative drugs in this contemporary world. Furthermore with ever rising oral problems by luxurious lifestyle in this modern society, there is a soaring need for use of potent medicinal plants like horse radish (Moringa oleifera Lam.) against various oral ailments. Therefore, use of herbal medicines in reducing the adverse effects of various conventional allopathic medicines and harmful side effects of conventional antibiotics has emerged as an evolved technique in pharmaceutical science...
October 22, 2020: Phytotherapy Research: PTR
Erin Newcomer, Guang Yang, Bei Sun, Hongbo Luo, Duanwen Shen, Samuel Achilefu, Valerie Ratts, Joan Riley, John Yeh, Quing Zhu
Objectives: To investigate the laser safety of photoacoustic imaging. In photoacoustic imaging, a pulsed laser of several nanoseconds is used to illuminate biological tissue, and photoacoustic waves generated by optical absorption are used to form images of the tissue. Photoacoustic imaging is emerging in clinical applications; however, its potential use in reproductive medicine has yet to be reported. Design: Assessment of photoacoustic laser safety before its adoption by clinical reproductive medicine...
August 2020: F&S science
Lily Van, Tracy Heung, Sarah L Malecki, Christian Fenn, Andrea Tyrer, Marcos Sanches, Eva W C Chow, Erik Boot, Maria Corral, Satya Dash, Susan R George, Anne S Bassett
Background: The 22q11.2 microdeletion is the pathogenic copy number variation (CNV) associated with 22q11.2 deletion syndrome (22q11.2DS, formerly known as DiGeorge syndrome). Familiar endocrinological manifestations include hypoparathyroidism and hypothyroidism, with recent elucidation of elevated risk for obesity in adults. In this study, we aimed to determine whether adults with 22q11.2DS have an increased risk of developing type 2 diabetes (T2D). Methods: We studied the effect of the 22q11...
September 2020: EClinicalMedicine
Yi Cao, Guozhong Xing, Huai Lin, Nan Zhang, Houzhi Zheng, Kaiyou Wang
Science, engineering, and medicine ultimately demand fast information processing with ultra-low power consumption. The recently developed spin-orbit torque (SOT)-induced magnetization switching paradigm has been fueling opportunities for spin-orbitronic devices, i.e., enabling SOT memory and logic devices at sub-nano second and sub-picojoule regimes. Importantly, spin-orbitronic devices are intrinsic of nonvolatility, anti-radiation, unlimited endurance, excellent stability, and CMOS compatibility, toward emerging applications, e...
October 23, 2020: IScience
İlker Yağcı, Selda Sarıkaya, F Figen Ayhan, Ayse Bahsi, Başak Bilir Kaya, Belgin Erhan, Emine Dündar Ahi, Sevil Okan, Yasemin Özkan, Merve Damla Korkmaz, Elif Yakşi, Derya Demirbağ Kabayel, Hande Özdemir, Gülseren Kayalar, Canan Çelik, Fatma Nur Kesiktaş, Hanife Çağlar Yagcı, Lale Altan
Objectives: The outbreak of novel coronavirus-2019 (COVID-19) has affected Turkey very seriously, as well as all around the world. Many urgent and radical measures were taken due to the high contagious risk and mortality rate of the outbreak. It is noteworthy that isolation recommendations and the provision of health services for pandemic have a negative impact on Physical Medicine and Rehabilitation (PMR) services. In this study, we aimed to evaluate the effects of COVID-19 on the PMR services and physiatrists immediately after the first month of pandemic in Turkey...
September 2020: Turkish journal of physical medicine and rehabilitation
Peter Timashev, Vladimir Mironov
Bioprinting is a rapidly emerging biomedical research field. Three-dimensional bioprinting is defined as a robotic additive, layer-by-layer biofabrication of functional tissues and organs from living cells, and biomaterials according to a digital model. Bioprinting can revolutionize medicine by automated robotic production of human tissues and organs suitable for transplantation. Bioprinting is based on sophisticated high technology, and it is obvious that only technologically advanced countries can make a real contribution to this rapidly evolving multidisciplinary field...
2020: International journal of bioprinting
Ying Wu, Guoqiang Dong, Chunquan Sheng
Necroptosis, a genetically programmed form of necrotic cell death, serves as an important pathway in human diseases. As a critical cell-killing mechanism, necroptosis is associated with cancer progression, metastasis, and immunosurveillance. Targeting necroptosis pathway by small molecule modulators is emerging as an effective approach in cancer therapy, which has the advantage to bypass the apoptosis-resistance and maintain antitumor immunity. Therefore, a better understanding of the mechanism of necroptosis and necroptosis modulators is necessary to develop novel strategies for cancer therapy...
September 2020: Acta Pharmaceutica Sinica. B
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