Annika van Oosbree, Lindsay Leigh, Michael Burt, Ryan Garry
Colorectal cancer (CRC) is the third most common cancer to cause death in the world. Despite the recent change in age from 50 to 45 in some societies' recommendations for CRC screening, its incidence is increasing in patients under 50 years. We present a case of a 35-year-old female with no family history of CRC who presented to the emergency department with abdominal pain, vomiting, and obstipation and was found to have sporadic obstructing transverse colon adenocarcinoma.
August 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Miguel Hueso, Rafael Álvarez, David Marí, Vicent Ribas-Ripoll, Karim Lekadir, Alfredo Vellido
Artificial intelligence (AI) generative models driven by the integration of AI and natural language processing technologies, such as OpenAI's chatbot generative pre-trained transformer large language model (LLM), are receiving much public attention and have the potential to transform personalized medicine. Dialysis patients are highly dependent on technology and their treatment generates a challenging large volume of data that has to be analyzed for knowledge extraction. We argue that, by integrating the data acquired from hemodialysis treatments with the powerful conversational capabilities of LLMs, nephrologists could personalize treatments adapted to patients' lifestyles and preferences...
September 21, 2023: Revista de Investigación Clínica; Organo del Hospital de Enfermedades de la Nutrición
Mymuna Ashna, Neeharika Senthilkumar, Pallab Sanpui
Regenerative medicine (RM) is a multidisciplinary field that utilizes the inherent regenerative potential of human cells to generate functionally and physiologically acceptable human cells, tissues, and organs in vivo or ex vivo . An appropriate biomaterial scaffold with desired physicochemical properties constitutes an important component of a successful RM approach. Among various forms of biomaterials explored until the present day, hydrogels have emerged as a versatile candidate for tissue engineering and regenerative medicine (TERM) applications such as scaffolds for spatial patterning and delivering therapeutic agents, or substrates to enhance cell growth, differentiation, and migration...
September 21, 2023: ACS Biomaterials Science & Engineering
Eduard Valdes, Taolin Fang, Michael Boffa, Jennifer A Frontera
OBJECTIVES: Critically ill patients eliminate levetiracetam (LEV) more rapidly than healthy controls, yet low doses are commonly used for seizure prophylaxis in the ICU setting. We compared the rates of achievement of target serum levels and new onset seizure (clinical and/or electrographic) among patients who received low (500 mg bid) versus high (750-1,000 ;mg bid) dose LEV. DESIGN: Prospective, observational study. SETTING: Tertiary care, academic center...
September 20, 2023: Critical Care Medicine
Recai Ergün, Dilek Ergün, Esin Özkan, Özlem Kar Kurt, Merve Bacanlı, Muslu Kazım Körez
OBJECTIVE: We aimed to evaluate the enzyme activity of chitotriosidase as a biomarker in early diagnosis silicosis, and to investigate immune system response and oxidative stress caused by silica exposure. MATERIALS AND METHODS: Silicosis patients (n = 116), exposed to silica without disease (n = 76), and healthy individuals(n = 55) were included. Serum levels of chitotriosidase, proinflammatory cytokines, oxidant-antioxidant and immune parameters were measured...
September 19, 2023: Journal of Occupational and Environmental Medicine
Ugur Kucuk, Melissa Pham, Mohummad Hassan Raza Raja, Muhammad Hamza Saad Shaukat, Richard Clark
INTRODUCTION: Increasing and easy availability of so-called natural/herbal supplements pose the unique challenge of identifying associated side effects, including arrhythmias in otherwise-healthy individuals. CASE PRESENTATION: A 25-year-old female patient presented to the emergency department with fatigue and lightheadedness. The electrocardiogram showed complete AV block with a junctional escape rhythm at 55 beats per minute with QT prolongation (542ms). One week ago, she started to use a herbal medication (Muscle Eze Advanced) for muscle cramps after workouts...
July 2023: South Dakota Medicine: the Journal of the South Dakota State Medical Association
Jozef Klembara, Marcello Ruta, Jason Anderson, Taran Mayer, Miroslav Hain, Daniel Valaška
We redescribe the holotype and only known specimen of the early eureptile Coelostegus prothales from the Upper Carboniferous of the Czech Republic using photogrammetric scanning and a virtual 3D rendition of its skull. New information is available on several skull and lower jaw bones, including the postorbital, supratemporal, tabular, postparietal, angular, and prearticular. The new data also permit the correct identification of previously undetected or mis-identified elements (e.g., supratemporal; quadratojugal; angular)...
2023: PloS One
Kamila Romanowski, Mohammad Ehsanul Karim, Mark Gilbert, Victoria J Cook, James C Johnston
BACKGROUND: Recent data have demonstrated that healthcare use after treatment for respiratory tuberculosis (TB) remains elevated in the years following treatment completion. However, it remains unclear which TB survivors are high healthcare users and whether any variation exists within this population. Thus, the primary objective of this study was to identify distinct profiles of high healthcare-use TB survivors to help inform post-treatment support and care. METHODS: Using linked health administrative data from British Columbia, Canada, we identified foreign-born individuals who completed treatment for incident respiratory TB between 1990 and 2019...
2023: PloS One
Kandaswamy Paramasivan, Ashwin Prakash, Sarthak Gupta, Bhairav Phukan, Pavithra M R, Balaji Venugopal
COVID-19 has impacted the healthcare system across the globe. The study will span three pandemic waves in 2020, 2021, and 2022. The goal is to learn how the pandemic affects antenatal care (ANC) and emergency delivery care for pregnant women in Tamil Nadu, India, and how medical services respond. The study employs counterfactual analysis to evaluate the causal impact of the pandemic. A feedforward in combination with a simple auto-regressive neural network (AR-Net) is used to predict the daily number of calls for ambulance services (CAS)...
2023: PloS One
Tian Tian, Yichen Liang, Zhipeng Peng, Yanqiu Cheng, Kuanmin Chen
The assessment of the resilience of Urban Rail Transit Networks (URTNs) and the analysis of their evolutionary characteristics during network growth can help in the design of efficient, safe, and sustainable networks. However, there have been few studies regarding the change of resilience in long-term network development. As for the existing resilience studies, they rarely consider the entire cycle of accident occurrence and repair; furthermore, they ignore the changes in network transportation performance during emergencies...
2023: PloS One
Kai Chen, Yiqun Ma, Michelle L Bell, Wan Yang
No abstract text is available yet for this article.
September 21, 2023: JAMA
Adam Lound, Jane Bruton, Kathryn Jones, Nira Shah, Barry Williams, Jamie Gross, Benjamin Post, Sophie Day, Stephen J Brett, Helen Ward
INTRODUCTION: People living with frailty risk adverse outcomes following even minor illnesses. Admission to hospital or the intensive care unit is associated with potentially burdensome interventions and poor outcomes. Decision-making during an emergency is fraught with complexity and potential for conflict between patients, carers and clinicians. Advance care planning is a process of shared decision-making which aims to ensure patients are treated in line with their wishes. However, planning for future care is challenging and those living with frailty are rarely given the opportunity to discuss their preferences...
2023: PloS One
Daniel T L Shek, Tingyin Wong, Xiang Li, Lu Yu
The use of online teaching mode has grown rapidly in recent years, particularly under the COVID-19 pandemic. To promote the learning motivation of students and teaching effectiveness, development of attractive online teaching material such as videos is important. In the present study, we developed 15 theory-related videos and 9 case-based videos in the context of a leadership course focusing on psychological well-being and psychosocial competence. Using a qualitative research methodology via focus groups (N = 48 students) to evaluate these videos, six themes emerged from the data, including video arrangement, design of videos, content of videos, benefits to students' pre-lesson self-learning, benefits to students' learning of course content, and contribution to students' class participation...
2023: PloS One
Dominic Byron-Chance, Lucía Gomez, Ashton Jade Hollwarth, Thomas Anthony George Dutton
Air sac cannulation is used both as an emergency procedure in avian patients with severe upper respiratory compromise, as well as a means of routine ventilation for surgery of the head and neck. The objective of this retrospective study was to describe and quantify the complications associated with air sac cannulation in birds. Medical records were retrieved for all patients that underwent caudal thoracic or abdominal air sac cannulation at a single center between August 2004 and October 2020. Patient signalment, indication for air sac cannulation, location of air sac cannula (ASC) placement, occurrence and category of complications encountered, and survival data were recorded...
September 2023: Journal of Avian Medicine and Surgery
Annie Carrier, François Bolduc, Nathalie Delli-Colli, Finn Makela, Anne Hudon, Marie-Eve Caty, Arnaud Duhoux, Michaël Beaudoin
BACKGROUND:  Since they are key witnesses to the systemic difficulties and social inequities experienced by vulnerable patients, health and social service (HSS) professionals and clinical managers must act as change agents. Using their expertise to achieve greater social justice, change agents employ a wide range of actions that span a continuum from the clinical (microsystem) to the societal (macrosystem) sphere and involve actors inside and outside the HSS system. Typically, however, clinical professionals and managers act in a circumscribed manner, that is, within the clinical sphere and with patients and colleagues...
September 21, 2023: JMIR Research Protocols
Elle Lett, Nguyen Khai Tran, Nkemjika Nweke, Mytien Nguyen, Jung G Kim, Eric Holmboe, William McDade, Dowin Boatright
IMPORTANCE: Previous studies have demonstrated sex-specific disparities in performance assessments among emergency medicine (EM) residents. However, less work has focused on intersectional disparities by ethnoracial identity and sex in resident performance assessments. OBJECTIVE: To estimate intersectional sex-specific ethnoracial disparities in standardized EM resident assessments. DESIGN, SETTING, AND PARTICIPANTS: This retrospective cohort study used data from the Association of American Medical Colleges and the Accreditation Council for Graduate Medical Education Milestones (Milestones) assessments to evaluate ratings for EM residents at 128 EM training programs in the US...
September 5, 2023: JAMA Network Open
Arthur L Kellermann, Russ S Kotwal, Todd E Rasmussen
IMPORTANCE: Military medicine in the US was established to treat wounded and ill service members and to protect the health and well-being of our military forces at home and abroad. To accomplish these tasks, it has developed the capacity to rapidly adapt to the changing nature of war and emerging health threats; throughout our nation's history, innovations developed by military health professionals have been quickly adopted by civilian medicine and public health for the benefit of patients in the US and around the world...
September 5, 2023: JAMA Network Open
David R Boulware, Christopher J Lindsell, Thomas G Stewart, Adrian F Hernandez, Sean Collins, Matthew William McCarthy, Dushyantha Jayaweera, Nina Gentile, Mario Castro, Mark Sulkowski, Kathleen McTigue, G Michael Felker, Adit A Ginde, Sarah E Dunsmore, Stacey J Adam, Allison DeLong, George Hanna, April Remaly, Florence Thicklin, Rhonda Wilder, Sybil Wilson, Elizabeth Shenkman, Susanna Naggie
BACKGROUND: The effectiveness of inhaled glucocorticoids in shortening the time to symptom resolution or preventing hospitalization or death among outpatients with mild-to-moderate coronavirus disease 2019 (Covid-19) is unclear. METHODS: We conducted a decentralized, double-blind, randomized, placebo-controlled platform trial in the United States to assess the use of repurposed medications in outpatients with confirmed coronavirus disease 2019 (Covid-19). Nonhospitalized adults 30 years of age or older who had at least two symptoms of acute infection that had been present for no more than 7 days before enrollment were randomly assigned to receive inhaled fluticasone furoate at a dose of 200 μg once daily for 14 days or placebo...
September 21, 2023: New England Journal of Medicine
Cheryl Rowe-Rendleman, David Eveleth, Jeffrey L Goldberg, Ula Jurkunas, Naoki Okumura, Daniel Dawson, Onkar B Sawant
On February 24-27, 2021, the Association for Ocular Pharmacology and Therapeutics (AOPT) held its 15th biennial scientific meeting online. The meeting was organized by Dr. Sanjoy Bhattacharya of the University of Miami in conjunction with the board of trustees of the AOPT. The 3-day conference was attended by academic scientists, clinicians, and industry and regulatory professionals. The theme of the meeting was Restoring Vision through Regeneration and it was sponsored, in part, by the National Institutes of Health, Bright Focus, Regeneron, and Santen (USA)...
September 21, 2023: Journal of Ocular Pharmacology and Therapeutics
Viktor Lugnet, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, Peter Paal
Lugnet, Viktor, Miles McDonough, Les Gordon, Mercedes Galindez, Nicolas Mena Reyes, Alison Sheets, Ken Zafren, and Peter Paal. Termination of cardiopulmonary resuscitation in mountain rescue: a scoping review and ICAR MedCom 2023 recommendations. High Alt Med Biol 00:000-000, 2023. Background: In 2012, the International Commission for Mountain Emergency Medicine (ICAR MedCom) published recommendations for termination of cardiopulmonary resuscitation (CPR) in mountain rescue. New developments have necessitated an update...
September 22, 2023: High Altitude Medicine & Biology
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