keyword
https://read.qxmd.com/read/38544658/sensitivity-and-specificity-analysis-of-fine-needle-aspiration-cytology-fnac-for-thyroid-swelling
#21
JOURNAL ARTICLE
Mangesh G Kohale, Anupama V Dhobale, Nandkishor J Bankar, Neha Bhatt, Akshay H Salgar
Introduction Thyroid gland disorders, such as goiters or tumor masses, are the result of localized or systemic aberrations of the thyroid gland. The purpose of this research was to see how effective fine needle aspiration cytology (FNAC) was in detecting thyroid swelling in patients with thyroid swelling. It is critical to be able to differentiate between benign and malignant thyroid nodules to reduce unnecessary thyroid surgeries. It is hypothesized that FNAC is not a reliable diagnostic tool to detect thyroid nodules in patients with thyroid swelling and that there is a significant variation between the number of thyroid nodules detected by FNAC and the number of thyroid nodules that were eventually diagnosed as malignant by surgery...
February 2024: Curēus
https://read.qxmd.com/read/38544612/forgotten-goiter-presenting-as-acute-respiratory-distress-following-a-thyroidectomy-a-case-report
#22
Beatriz Marques, Rita Oliveira, Roberto J Ameiro, Manuela Paiva
Airway complications account for a significant amount of post-thyroidectomy complications. Forgotten goiter is a residual thyroid mass left after total thyroidectomy, an event already depicted in the literature. Clinical presentation is diverse, ranging from asymptomatic tracheal deviation to symptoms caused by hormonally active thyroid tissue or airway obstruction due to mass effect. However, it has never been documented as the cause of acute respiratory distress following thyroid surgery. We report the case of a 65-year-old female undergoing left hemithyroidectomy due to long-standing substernal goiter...
February 2024: Curēus
https://read.qxmd.com/read/38544610/thyroid-lobectomy-under-local-anesthesia-before-lung-transplantation-owing-to-diffuse-panbronchiolitis-a-case-report
#23
Tsuyoshi Kojima, Yo Kishimoto, Keigo Honda, Atsushi Suehiro, Koichi Omori
We herein report a case of thyroid lobectomy performed under local anesthesia for thyroid cancer in a patient who was at a high risk for general anesthesia due to diffuse panbronchiolitis. Although thyroid surgery has been performed in the past under local anesthesia in low-risk patients, thyroid surgery is now rarely performed under local anesthesia. If they are performed, thyroid surgery under local anesthesia is usually performed under monitored anesthesia care; sedation is considered safe and does not cause discomfort to patients...
February 2024: Curēus
https://read.qxmd.com/read/38544601/high-malignancy-risk-and-its-predictors-in-south-indian-patients-with-bethesda-ii-thyroid-nodules
#24
JOURNAL ARTICLE
Sunanda Tirupati, Pradeep Puthenveetil, Shilpa Lakkundi, Anudeep Gaddam, Vijaya Sarathi
BACKGROUND: Global data reports a low malignancy risk, whereas regional data report a variable risk of malignancy in Bethesda II thyroid nodules. The limited availability of surgical histopathology might have underestimated the risk of malignancy. Here, we report the prevalence of malignancy and its predictors in Bethesda II thyroid nodules for which the surgical histopathological diagnosis was available. METHODS:  This retrospective study was done at a tertiary healthcare center in South India between January 2008 and September 2015...
February 2024: Curēus
https://read.qxmd.com/read/38544598/prevalence-and-impact-of-thyroid-dysfunction-in-patients-with-chronic-pulmonary-obstructive-pulmonary-disorder-a-systematic-review-and-meta-analysis
#25
REVIEW
Divine Besong Arrey Agbor, Moulika Kari, Rachel Chandra Harika Chukka, Manisha Guntha, Aung K Zin, Sandipkumar S Chaudhari, Sai Kumar Kurva, Adil Amin
Thyroid gland dysfunction (TGD) has been increasingly recognized as a potential comorbidity in patients with chronic obstructive pulmonary disease (COPD). This study was designed to determine the prevalence of TGD in COPD patients. This systematic review and meta-analysis was conducted according to the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). To comprehensively identify relevant studies, a systematic search was conducted in major electronic databases, including PubMed, Embase, and the Cumulative Index to Nursing and Allied Health Literature (CINAHIL)...
February 2024: Curēus
https://read.qxmd.com/read/38544284/factors-affects-the-implementation-of-active-surveillance-therapy-for-low-risk-papillary-thyroid-microcarcinoma
#26
JOURNAL ARTICLE
Xueqi Zhang, Renaguli Aihaiti, Weiping Teng, Xiaoguang Shi
No abstract text is available yet for this article.
March 28, 2024: Chinese Medical Journal
https://read.qxmd.com/read/38543364/highly-effective-synthetic-polymer-based-blockers-of-non-specific-interactions-in-immunochemical-analyses
#27
JOURNAL ARTICLE
Vladimír Šubr, Libor Kostka, Jan Plicka, Ondřej Sedláček, Tomáš Etrych
In vitro diagnostic methods face non-specific interactions increasing their background level and influencing the efficacy and reproducibility. Currently, the most important and employed blocker of non-specific interactions is bovine serum albumin (BSA), an animal product with some disadvantages like its batch-to-batch variability and contamination with RNases. Herein, we developed amphiphilic water-soluble synthetic copolymers based on the highly biocompatible, non-immunogenic and nontoxic N -2-(hydroxypropyl)methacrylamide (HPMA)-based copolymers or poly(oxazoline)s as highly effective synthetic blockers of non-specific interactions and an effective BSA alternative...
March 10, 2024: Polymers
https://read.qxmd.com/read/38542992/a-pincer-type-of-acridine-triazole-fluorescent-dye-for-iodine-detection-by-both-naked-eye-colorimetric-and-fluorometric-modes
#28
JOURNAL ARTICLE
Mei Yu, Lu Jiang, Lan Mou, Xi Zeng, Ruixiao Wang, Tao Peng, Fuyong Wu, Tianzhu Shi
Iodine, primarily in the form of iodide (I- ), is the bioavailable form for the thyroid in the human body. Both deficiency and excess intake of iodide can lead to serious health issues, such as thyroid disease. Selecting iodide ions among anions has been a significant challenge for decades due to interference from other anions. In this study, we designed and synthesized a new pincer-type acridine-triazole fluorescent probe (probe 1 ) with an acridine ring as a spacer and a triazole as a linking arm attached to two naphthol groups...
March 19, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38542465/metabolic-profiles-and-blood-biomarkers-to-discriminate-between-benign-thyroid-nodules-and-papillary-carcinoma-based-on-uhplc-qtof-esi-ms-analysis
#29
JOURNAL ARTICLE
Gabriela Maria Berinde, Andreea Iulia Socaciu, Mihai Adrian Socaciu, Gabriel Emil Petre, Carmen Socaciu, Doina Piciu
In this study, serum metabolic profiling of patients diagnosed with papillary thyroid carcinoma (PTC) and benign thyroid pathologies (BT) aimed to identify specific biomarkers and altered pathways when compared with healthy controls (C). The blood was collected after a histological confirmation from PTC (n = 24) and BT patients (n = 31) in parallel with healthy controls (n = 81). The untargeted metabolomics protocol was applied by UHPLC-QTOF-ESI+ -MS analysis and the statistical analysis was performed using the MetaboAnalyst 5...
March 20, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542286/is-there-a-link-between-thyroid-peroxidase-gene-promoter-polymorphisms-and-autoimmune-thyroiditis-in-the-polish-population
#30
JOURNAL ARTICLE
Katarzyna Lacka, Adam Maciejewski, Piotr Jarecki, Waldemar Herman, Jan K Lacki, Ryszard Żaba, Michał J Kowalczyk
(1) Autoimmune thyroiditis (AIT) is the most common cause of primary hypothyroidism and one of the most frequent organ-specific autoimmune diseases. Its pathogenesis is polygenic and still requires further research. The aim of the study was to assess, for the first time in the Caucasian population, the role of selected TPO gene promoter polymorphisms (rs2071399 G/A, rs2071400C/T, rs2071402 A/G, and rs2071403 A/G) in the development of AIT. A total of 237 patients diagnosed with AIT and 130 healthy controls were genotyped for four TPO gene polymorphisms, and the results were statistically analyzed to check for the role of these polymorphisms...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542262/the-role-of-fibrogenesis-and-extracellular-matrix-proteins-in-the-pathogenesis-of-graves-ophthalmopathy
#31
REVIEW
Hsun-I Chiu, Shi-Bei Wu, Chieh-Chih Tsai
Graves' ophthalmopathy (GO), or thyroid eye disease (TED), is the most frequent extrathyroidal manifestation of Graves' disease (GD). Inflammation and subsequent aberrant tissue remodeling with fibrosis are important pathogenesis. There are many proposed mechanisms and molecular pathways contributing to tissue remodeling and fibrosis in GO, including adipogenesis, fibroblast proliferation and myofibroblasts differentiation, oxidative stress, endoplasmic reticulum (ER) stress, hyaluronan (HA) and glycosaminoglycans (GAGs) accumulation in the extracellular matrix (ECM) and new concepts of epigenetics modification, such as histone modification, DNA methylation, non-coding RNAs, and gut microbiome...
March 14, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38542128/autoimmune-thyroiditis-and-vitamin-d
#32
REVIEW
Teodoro Durá-Travé, Fidel Gallinas-Victoriano
Hashimoto's thyroiditis (HT) is marked by self-tissue destruction as a consequence of an alteration in the adaptive immune response that entails the evasion of immune regulation. Vitamin D carries out an immunomodulatory role that appears to promote immune tolerance. The aim of this study is to elaborate a narrative review of the relationship between vitamin D status and HT and the role of vitamin D supplementation in reducing HT risk by modulating the immune system. There is extensive literature confirming that vitamin D levels are significantly lower in HT patients compared to healthy people...
March 9, 2024: International Journal of Molecular Sciences
https://read.qxmd.com/read/38541982/current-state-of-molecular-cytology-in-thyroid-nodules-platforms-and-their-diagnostic-and-theranostic-utility
#33
REVIEW
Zeina C Hannoush, Roberto Ruiz-Cordero, Mark Jara, Atil Y Kargi
The high prevalence of thyroid nodules and increased availability of neck ultrasound have led to an increased incidence of diagnostic thyroid fine needle aspirations, with approximately 20% yielding indeterminate results. The recent availability of molecular tests has helped guide the clinical management of these cases. This paper aims to review and compare three main commercially available molecular cytology platforms in the U.S.-Afirma GSC, Thyroseq GC, and ThyGeNEXT + ThyraMIR. Sequential improvements of the Afirma GSC and Thyroseq GC tests have increased positive and negative predictive values, sensitivity, and specificity...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541980/the-influence-of-hyperthyroidism-on-the-coagulation-and-on-the-risk-of-thrombosis
#34
JOURNAL ARTICLE
Nebojsa Antonijevic, Dragan Matic, Biljana Beleslin, Danijela Mikovic, Zaklina Lekovic, Marija Marjanovic, Ana Uscumlic, Ljubica Birovljev, Branko Jakovljevic
Introduction : Apart from the well-known fact that hyperthyroidism induces multiple prothrombotic disorders, there is no consensus in clinical practice as to the impact of hyperthyroidism on the risk of thrombosis. The aim of this study was to examine the various hemostatic and immunologic parameters in patients with hyperthyroidism. Methods : Our study consists of a total of 200 patients comprised of 64 hyperthyroid patients, 68 hypothyroid patients, and 68 euthyroid controls. Patient thyroid status was determined with standard tests...
March 19, 2024: Journal of Clinical Medicine
https://read.qxmd.com/read/38541699/novel-therapeutic-approaches-for-the-management-of-elevated-lipoprotein-a-from-traditional-agents-to-future-treatment-options
#35
REVIEW
György Paragh, Péter Zilahi, László Róbert Kolozsvári, Hajnalka Lőrincz, Péter Fülöp, Mariann Harangi
Cardiovascular disease is the leading cause of mortality worldwide. Despite the availability of effective low-density lipoprotein cholesterol (LDL-C) lowering agents, an increased cardiovascular risk is still observed in individuals with therapeutic LDL-C levels. One of these cardiovascular risk factors is elevated plasma lipoprotein(a) (Lp(a)) concentration, which maintains chronic inflammation through the increased presence of oxidized phospholipids on its surface. In addition, due to its 90 percent homology with the fibrinolytic proenzyme plasminogen, Lp(a) exhibits atherothrombotic effects...
March 12, 2024: Life
https://read.qxmd.com/read/38541628/pulmonary-hypertension-and-hypothyroidism-still-an-important-clinical-coincidence-in-paediatric-population-an-endocrinologist-s-point-of-view
#36
REVIEW
Agnieszka Lecka-Ambroziak, Karolina Kot
There is limited data on hypotheses linking autoimmune thyroid diseases (AITD) and hypothyroidism with pulmonary hypertension (PH). Moreover, the prevalence of this coincidence, as well as the possible common pathogenic mechanisms, are even less explicit in paediatric population. We present a review of recently published articles regarding relatively large cohorts of children with PH, coming from paediatric PH registries, aiming to clarify the coincidence of PH and AITD, especially hypothyroidism, and discuss its possible mutual impact...
February 26, 2024: Life
https://read.qxmd.com/read/38541323/thyroid-cancer-survival-in-the-multiethnic-cohort-study
#37
JOURNAL ARTICLE
Janine V Abe, Song-Yi Park, Christopher A Haiman, Iona Cheng, Loïc Le Marchand, Brenda Y Hernandez, Lynne R Wilkens
OBJECTIVE: The US 5-year survival rate after thyroid cancer (TC) diagnosis is over 95%. Our aim was to investigate survival differences by sex and race and ethnicity in a multiethnic US population. DESIGN: In the Multiethnic Cohort (MEC) study, a total of 605 incident TC cases were identified by linkage to HI and CA statewide cancer registries. Cox models were performed to compare the risk of all-cause mortality among TC cases by sex and race and ethnicity, with adjustment for age, first course of treatment, baseline body mass index, smoking status, alcohol intake, and neighborhood socioeconomic status...
March 10, 2024: International Journal of Environmental Research and Public Health
https://read.qxmd.com/read/38541203/primary-thyroid-lymphoma-a-retrospective-observational-study-in-a-single-institutional-center
#38
JOURNAL ARTICLE
Octavia Vita, Alis Dema, Robert Barna, Remus Cornea, Dan Brebu, Mihaela Vlad, Oana Popa, Ioana Muntean, Diana Szilagyi, Mihaela Iacob, Maria Iordache, Marioara Cornianu, Dorela Codruta Lazureanu
Background and Objectives : primary thyroid lymphoma (PTL) is a rare neoplasm, displaying a variety of histological features. It is often a challenge for pathologists to diagnose this tumor. Materials and Methods : this study is a retrospective analysis of clinical and pathological characteristics of a group of eleven patients (eight women and three men, mean age 68 years, range 50-80 years) diagnosed with PTL. Results : nine patients (81.81%) presented a tumor with progressive growth in the anterior cervical region, usually painless and accompanied by local compressive signs...
March 14, 2024: Medicina
https://read.qxmd.com/read/38541197/the-effect-of-thyroid-surgery-on-the-accuracy-of-palpation-based-cricothyroid-membrane-identification-in-female-patients-a-prospective-observational-cohort-study
#39
JOURNAL ARTICLE
Jaesik Park, A Rim Yang, Hyunji Lee, Kwangsoon Kim, Min Suk Chae
Background and Objectives : This study examined how a history of thyroid surgery impacts the precision of cricothyroid membrane (CTM) identification through palpation (validated by ultrasound) in female patients visiting the operating room for surgeries unrelated to neck procedures. Materials and Methods : This prospective observational cohort study enrolled adult female patients undergoing elective non-neck surgery, dividing them into control (no thyroid surgery history; n = 40) and experimental (with thyroid surgery history; n = 40) groups...
March 13, 2024: Medicina
https://read.qxmd.com/read/38541194/frequency-of-thyroid-microcarcinoma-in-patients-who-underwent-total-thyroidectomy-with-benign-indication-a-5-year-retrospective-review
#40
JOURNAL ARTICLE
Vasiliki Magra, Kassiani Boulogeorgou, Eleni Paschou, Christina Sevva, Vasiliki Manaki, Ioanna Mpotani, Stylianos Mantalovas, Styliani Laskou, Isaak Kesisoglou, Triantafyllia Koletsa, Konstantinos Sapalidis
Background and Objectives : Incidental thyroid cancers (ITCs) are often microcarcinomas. The most frequent histologic type is a papillary microcarcinoma. Papillary thyroid microcarcinomas are defined as papillary thyroid tumours measuring less than 10 mm at their greatest diameter. They are clinically occult and frequently diagnosed incidentally in histopathology reports after a thyroidectomy. The aim of this study is to evaluate the rate of papillary thyroid microcarcinomas (PTMC) in patients who were thyroidectomised with indications of benign disease...
March 12, 2024: Medicina
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