Çiğdem Vural, Umay Kiraz, Gupse Turan, Sevgiye Kaçar Özkara, Mehmet Sözen, Berrin Çetinarslan
INTRODUCTION: Solid variant papillary thyroid cancer (SVPTC) is a rare variant of papillary thyroid carcinoma (PTC) and its prognostic value is still unclear. Therefore, we re-evaluate the histopathological and clinicopathological features of 28 patients with SVPTC in the light of current literature. MATERIAL-METHODS: Of the 1308 cases were previously diagnosed with PTC and 28 (2,1%) of them which had been diagnosed with SVPTC were re-evaluated retrospectively. RESULTS: Of the 28 patients with SVPTC, 85...
March 31, 2021: Annals of Diagnostic Pathology
Jonathan Dismukes, Jessica Fazendin, Ruth Obiarinze, Gianina C Hernández Márquez, Kimberly M Ramonell, Erin Buczek, Brenessa Lindeman, Herbert Chen
BACKGROUND: Central neck dissection (CND) remains a controversial intervention for papillary thyroid carcinoma (PTC) patients with clinically negative nodes (cN0) in the central compartment. Proponents state that CND in cN0 patients prevents locoregional recurrence, while opponents deem that the risks of complications outweigh any potential benefit. Thus, there remains conflicting results amongst studies assessing oncologic and surgical outcomes in cN0 PTC patients who undergo CND. To provide clarity to this controversy, we sought to evaluate the efficacy, safety, and oncologic impact of CND in cN0 PTC patients at our institution...
April 7, 2021: Journal of Surgical Research
Ahmet Dirikoc, Abbas Ali Tam, Nurcan Ince, Didem Ozdemir, Oya Topaloglu, Afra Alkan, Aylin Kilic Yazgan, Reyhan Ersoy, Bekir Cakir
PURPOSE: We aimed to determine clinicopathological features that can predict lymph node metastasis (LNM) in papillary thyroid microcarcinomas (PTMC). METHODS: Medical records of 872 patients with papillary thyroid cancer >1 cm (PTC > 1 cm) and 1184 patients with papillary thyroid microcancer (PTMC) (≤1 cm) were reviewed retrospectively. Demographical, clinical and histopathological features of (PTC > 1 cm) and PTMC were compared. Association between clinicopathological features and LNM in PTMC was investigated...
March 31, 2021: American Journal of Otolaryngology
Oded Cohen, Ralph P Tufano, AngKoon Anuwong, Ashok R Shaha, Kerry D Olsen, Mark Zafereo, Alessandra Rinaldo, Antti A Mäkitie, Iain J Nixon, Jonathon O Russell, Alfio Ferlito, Avi Khafif
OBJECTIVES: To describe the evolution and recent series on transoral endoscopic vestibular approach thyroidectomy and parathyroidectomy (TOET/PVA). DATA SOURCES: PubMed, Google Scholar. REVIEW METHODS: Review of the available English literature. RESULTS: TOET/PVA may offer several advantages over other remote access thyroidectomy approaches and has been adopted by many centers worldwide with excellent success rates. Indications include benign disease and early thyroid cancer patients...
March 31, 2021: American Journal of Otolaryngology
Yongze Li, Zhongyan Shan, Weiping Teng
OBJECTIVE: Mandatory universal salt iodization in China was implemented 20 years ago; however, the current iodine status and prevalence of thyroid disorders among childbearing-age women are unknown. METHODS: A nationally representative cross-sectional study with 26166 enrolled participants aged 18 to 49 years from all 31 provincial regions of mainland China was performed. The participants were given a questionnaire and underwent B-mode ultrasonography of the thyroid...
April 7, 2021: Endocrine Practice
Rossano Kepler Alvim Fiorelli, Alfredo Jorge Vasconcelos Duarte, Aline de Quadros Teixeira, Thiago Scharth Montenegro, Pedro Eder Portari Filho, Maria Ribeiro Santos Morard, Manuel Silva Ascenção, Carlos Alberto Basílio Oliveira, Pietro Novellino
Thyroid surgery is the primary treatment for substernal goiters, and iatrogenic injury to the recurrent laryngeal nerve (RNL) is always a risk. The literature suggests that iatrogenic lesions of the RNL post resection of substernal goiter are not equally distributed, being more frequent on the right recurrent laryngeal nerve (R-RLN) in comparison to the left recurrent laryngeal nerve (L-RLN). The relative paucity of basic anatomical and clinical reportages on R-RLN iatrogenic injuries and on the developmental factors that may help explain its higher incidence justifies this study's undertaking...
April 9, 2021: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
Fábia Cheyenne Gomes de Morais Fernandes, Dyego Leandro Bezerra de Souza, Maria Paula Curado, Talita Araujo de Souza, Arthur de Almeida Medeiros, Isabelle Ribeiro Barbosa
OBJECTIVE: To describe trends in thyroid cancer incidence and mortality in Latin America. METHODS: Ecological study of time series, with incidence data from the International Agency for Research on Cancer for the 1990-2012 period and mortality data of 16 countries obtained from WHO for the 1995-2013 period. The trends of incidence rates were analyzed by the Joinpoint regression. Average annual percentage change and 95% confidence intervals were calculated for incidence and mortality...
April 10, 2021: Tropical Medicine & International Health
Thaer Idrees, Antonio C Bianco
No abstract text is available yet for this article.
April 10, 2021: Journal of Clinical Endocrinology and Metabolism
Anupam Kotwal, M Hassan Murad, Fares Alahdab
No abstract text is available yet for this article.
April 10, 2021: Journal of Clinical Endocrinology and Metabolism
Grace Wong, Andrew Ghabbour, Farzad Borumandi
Giant parathyroid adenomas are rare and underreported benign tumours of parathyroid gland. Preoperative differentiation between giant parathyroid adenoma (GPA) and parathyroid carcinoma can be challenging, as they both may present as a large parathyroid tumour with hyperparathyroidism. Very few GPAs had been described in the literature, with only 60 cases including our present case. We report a case of GPA and the preoperative diagnostic challenges we faced in differential diagnosis of a potential parathyroid malignancy...
April 9, 2021: BMJ Case Reports
Michael Self, Jason Signorelli, Daniel Lasoff, Andrew Lafree, Christopher Coyne, Stephen R Hayden, Gabriel Wardi
BACKGROUND: Thiamine deficiency is an uncommon cause of severe illness in the United States that can lead to significant morbidity because of high-output cardiac failure, peripheral neuropathy, and permanent neurologic impairment. We report the case of a middle-aged woman with extreme malnutrition caused by complications of Roux-en-Y gastric bypass (RYGB) surgery who presented with signs and symptoms of severe thiamine deficiency and septic shock. CASE REPORT: A 43-year-old woman who had undergone RYGB surgery and who had multiple complications presented to the emergency department with agitation, confusion, and lethargy...
April 6, 2021: Journal of Emergency Medicine
Jingzhu Zhao, Xiangqian Zheng, Ming Gao, Sheng Zhang, Xinwei Yun, Jiadong Chi, Guangwei Xu
BACKGROUND: Medullary thyroid cancer (MTC) has more aggressive behavior and poor prognosis. Ultrasound (US) has facilitated the qualitative diagnosis of thyroid nodules, however, some MTC may be diagnosed as a benign nodule on ultrasound because ultrasound features of malignancy are lacking. The aim of the study was to investigate the association between ultrasound features and biological behavior of MTC. METHODS: Ultrasound findings and medical records of patients with MTC between Jan 2015 to Jun 2017 were retrospectively reviewed at Tianjin Medical University Cancer Institute and Hospital...
April 9, 2021: Cancer Imaging: the Official Publication of the International Cancer Imaging Society
Giorgos Pikis, Eleni Kandaraki, Demetris Lamnisos, Sereen Abbara, Katerina Kyriakou, Aliki Economides, Panayiotis A Economides
BACKGROUND: Fine needle aspiration (FNA) cytology, the gold standard in assessing thyroid nodules, is limited by its inability to determine the true risk of malignancy in Thy 3 nodules. Most patients with Thy3 cytology undergo surgery to establish a histologic diagnosis. The aims of this study were to evaluate the prevalence of malignancy in Thy3 nodules, to examine the ultrasound (US) characteristics that are associated with a high cancer risk and to assess the role of real-time strain elastography...
April 9, 2021: Thyroid Research
Pedro Righetti Arnaut, Gabriel da Silva Viana, Lucimauro da Fonseca, Warley Junior Alves, Jorge Cunha Lima Muniz, James Eugene Pettigrew, Fabyano Fonseca E Silva, Horácio Santiago Rostagno, Melissa Izabel Hannas
BACKGROUND: Selenium (Se) has been recognized as an essential micronutrient for nearly all forms of life. In recent decades, broiler responses to dietary Se supplemental levels and sources have received considerable attention. On environmental grounds, organic trace mineral utilization in practical broiler feeds has been defended due to its higher bioavailability. In such feeds, trace minerals are provided simultaneously in the same supplement as inorganic salts or organic chelates, a fact commonly ignored in assays conducted to validate organic trace mineral sources...
April 9, 2021: BMC Veterinary Research
Sijian Li, Tengyu Yang, Yang Xiang, Xiaoyan Li, Limeng Zhang, Shan Deng
BACKGROUND: Malignant struma ovarii (MSO) is a unique type of ovarian malignancy that data on the survival outcome is limited and management strategy remains controversial due to its extreme rarity. METHODS: To investigate the clinical characteristics and treatment options in patients with MSO confined to the ovary, while also evaluating the recurrent-free survival (RFS) and overall survival (OS) rate in this population, a retrospective study was conducted. One hundred twenty-five cases of MSO confined to the ovary were enrolled and their clinical characteristics, treatment strategies, and results of follow-up were analyzed...
April 9, 2021: BMC Cancer
Onur Cil, Xiaolan Chen, Henry R Askew Page, Samuel N Baldwin, Maria C Jordan, Pyone Myat Thwe, Marc O Anderson, Peter M Haggie, Iain A Greenwood, Kenneth P Roos, Alan S Verkman
Hypertension is a major cause of cardiovascular morbidity and mortality, despite the availability of antihypertensive drugs with different targets and mechanisms of action. Here, we provide evidence that pharmacological inhibition of TMEM16A (ANO1), a calcium-activated chloride channel expressed in vascular smooth muscle cells, blocks calcium-activated chloride currents and contraction in vascular smooth muscle in vitro and decreases blood pressure in spontaneously hypertensive rats. The acylaminocycloalkylthiophene TMinh-23 fully inhibited calcium-activated TMEM16A chloride current with nanomolar potency in Fischer rat thyroid cells expressing TMEM16A, and in primary cultures of rat vascular smooth muscle cells...
April 6, 2021: Kidney International
Ali A Al-Mubarak, Peter van der Meer, Nils Bomer
PURPOSE OF REVIEW: (Mal-)nutrition of micronutrients, like selenium, has great impact on the human heart and improper micronutrient intake was observed in 30-50% of patients with heart failure. Low selenium levels have been reported in Europe and Asia and thought to be causal for Keshan disease. Selenium is an essential micronutrient that is needed for enzymatic activity of the 25 so-called selenoproteins, which have a broad range of activities. In this review, we aim to summarize the current evidence about selenium in heart failure and to provide insights about the potential mechanisms that can be modulated by selenoproteins...
April 9, 2021: Current Heart Failure Reports
Alexandre Bellier, Yann Wazne, Thibaut Chollier, Nathalie Sturm, Philippe Chaffanjon
BACKGROUND: The aim of this original study was to determine the number of parathyroid glands that can be saved and reimplanted thanks to autofluorescence during thyroid surgery. Preservation of parathyroid function remains challenging during thyroid surgery. The parathyroid glands must be identified and immediately autotransplanted in the case of devascularization. Near-infrared autofluorescence of parathyroid glands has recently been proposed to help surgeons during the dissection. METHODS: A total of 116 thyroid lobectomies were performed on 70 consecutive adult patients...
April 9, 2021: World Journal of Surgery
Ryoko Saito, Hironori Ninomiya, Sakae Okumura, Mingyon Mun, Hironobu Sasano, Yuichi Ishikawa
Small tumor cell nests such as micropapillary nests are histologic poor prognostic markers for adenocarcinomas of various organs, including the lung. However, for the lung, the association of micropapillary patterns with smoking is controversial, which may be because of a vague definition of micropapillary patterns. This study clarifies the implications of small tumor cell nests by introducing a new dichotomic classification based on the glandular polarity of tumor cells: pure micropapillary nests (pMPs), preserving glandular polarity, and small solid nests (SSNs), lacking polarity...
May 1, 2021: American Journal of Surgical Pathology
Philip R Brauer, Brian B Burkey, Chandana A Reddy, Eric D Lamarre
OBJECTIVES: To assess risk factors and non-thyroid specific postoperative complications for thyroid lobectomy compared to total thyroidectomy. METHODS: A retrospective, cross-sectional study of adults undergoing a lobectomy or total thyroidectomy using the National Surgical Quality Improvement Program database between 2005 and 2017. Patients not treated by otolaryngologists or general surgeons and with unknown demographic variables were excluded. RESULTS: A total of 106 915 patients were analyzed, 64 763 total thyroidectomies and 42 152 lobectomies...
April 9, 2021: Annals of Otology, Rhinology, and Laryngology
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