Mei Kadoya, Nobuyasu Suganuma, Yuka Matsubara, Hiroki Takase, Eita Kumagai, Soji Toda, Haruhiko Yamazaki, Katsuhiko Masudo, Satoshi Fujii, Aya Saito
BACKGROUND: Mixed medullary and follicular cell-derived thyroid carcinoma (MMFCC) is characterized by the coexistence of follicular and C cell-derived tumour cell populations within the same lesion. Due to its rarity, its etiology and clinical course remain unclear, and treatment for advanced or recurrent cases has not been established. CASE PRESENTATION: We report a case of MMFCC treated with selpercatinib. The patient was a 69-year-old male presenting with tumors in the right thyroid lobe and in the upper mediastinum...
April 22, 2024: Surgical Case Reports
Nori Nakamura
PURPOSE: It has long been thought that the carcinogenic effect of radiation resulted from the induction of oncogenic mutations which then led to an increase in the proportion of cancer-bearing individuals. However, even as early as the 1960s, there were indications that the carcinogenic effect of radiation might result from the induction of an earlier onset of cancer. Recently, the former notion was challenged by its inability to explain time-dependent decline of the relative risk following an exposure to radiation, and a parallel shift of mouse survival curves toward younger ages following an exposure to radiation...
April 22, 2024: International Journal of Radiation Biology
H Summia Parveen, S Karthik, Kavitha M S
In the contemporary world, thyroid disease poses a prevalent health issue, particularly affecting women's well-being. Recognizing the significance of maternal thyroid (MT) hormones in fetal neurodevelopment during the first half of pregnancy, this study introduces the HNN-GSO model. This groundbreaking hybrid approach, utilizing the MT dataset, integrates ResNet-50 and Artificial Neural Network (ANN) within a Glow-worm Swarm Optimization (GSO) framework for optimal parameter tuning. With a comprehensive methodology involving dataset preprocessing and Genetic Algorithm (GA) for feature selection, our model leverages ResNet-50 for feature extraction and ANN for classification tasks...
April 22, 2024: Computer Methods in Biomechanics and Biomedical Engineering
Jae Jun Yang, Jin-Bog Lee, Jun-Young Choi
BACKGROUND AND OBJECTIVES: Prevertebral soft-tissue swelling (PSTS) after anterior cervical diskectomy and fusion (ACDF) is known to be influenced by several factors. We considered the effect of lateral deviation on the traction force and attempted to find a relationship with the PSTS. This study was designed to evaluate the preoperative lateral deviation of the hyoid bone and thyroid cartilage and its effect on PSTS, airway collapse, and clinical outcomes after ACDF. METHODS: Preoperative lateral deviations of the hyoid bone and thyroid cartilage at the superior cornu and inferior cornu were measured...
April 22, 2024: Neurosurgery
Fabienne Blunschi, Imogen Schofield, Sofie Muthmann, Natali B Bauer, Katarina Hazuchova
BACKGROUND: Health-related quality-of-life (HRQoL) assessment tools are becoming increasingly important for the assessment of diseases in veterinary medicine. OBJECTIVES: To develop a tool to assess the HRQoL of hyperthyroid cats and their owners. ANIMALS: Cats with hyperthyroidism (n = 229) and without hyperthyroidism (n = 322). METHODS: Cross-sectional study design. A preliminary list of 28 questions relating to the HRQoL of hyperthyroid cats and the influence their cat's disease might have on owners was created...
April 22, 2024: Journal of Veterinary Internal Medicine
Krzysztof Korzeniewski
BACKGROUND: After COVID-19 restrictions were lifted, people started to travel again. Each year, thousands of Poles travel internationally, and many travel to tropical or subtropical destinations in Asia, Africa or South America. The aim of this article was to describe the characteristics of Polish travellers based on the information from a retrospective 12-month review of the medical records of Polish patients seeking pre-travel advice at the largest diagnostic and treatment travel medicine centre in Poland in 2023...
2024: International Maritime Health
Lotem Gotnayer Lilian, Yarden Nahmias, Gabriel Yazbek Grobman, Lonia Friedlander, Dina Aranovich, Uri Yoel, Netta Vidavsky
One of the key challenges in diagnosing thyroid cancer lies in the substantial percentage of indeterminate diagnoses of thyroid nodules that have undergone ultrasound-guided fine-needle aspiration (FNA) biopsy for cytological evaluation. This delays the definitive diagnosis and treatment plans. We recently demonstrated that hydroxyapatite microcalcifications (MCs) aspirated from thyroid nodules may aid nodule diagnosis based on their composition. In particular, Zn-enriched MCs have emerged as potential cancer biomarkers...
April 22, 2024: Journal of Materials Chemistry. B, Materials for Biology and Medicine
Yingying Lu, Runyu Zhao, Yi Zhang, Shuixian Huang, Xiaoping Chen
INTRODUCTION: The objective was to investigate the correlation between Epstein-Barr virus (EBV) and human papillomavirus (HPV) infection in the development of benign thyroid lesions. MATERIAL AND METHODS: 29 cases of Hashimoto's thyroiditis (HT), 133 cases of thyroid adenoma, and 34 cases of HT with thyroid adenoma paraffin embedded tissue samples were used for EBV and HPV quantitative detection. RESULTS: None of the tissue samples carried HPV DNA...
April 22, 2024: Endokrynologia Polska
Agnieszka Żyłka, Katarzyna Dobruch-Sobczak, Hanna Piotrzkowska-Wróblewska, Maciej Jędrzejczyk, Piotr Góralski, Jacek Gałczyński, Elwira Bakuła-Zalewska, Marek Dedecjus
INTRODUCTION: The latest World Health Organization (WHO) classification from 2022 distinguishes the division of low-risk thyroid neoplasms such as non-invasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP), follicular tumour of uncertain malignant potential (FT-UMP), and well-differentiated tumour of uncertain malignant potential (WDT-UMP). The final diagnosis is made postoperatively according to histopathologic results. The aim of the study was the assessment of ultrasonographic and cytopathological features of borderline lesions to predict low-risk tumours preoperatively and plan the optimal treatment for that group of patients...
April 22, 2024: Endokrynologia Polska
Agata Czarnywojtek, Paweł Gut, Kamil Dyrka, Jerzy Sowiński, Nadia Sawicka-Gutaj, Katarzyna Katulska, Piotr Stajgis, Mateusz Wykrętowicz, Jakub Moskal, Jeremi Kościński, Krzysztof Pietrończyk, Patryk Graczyk, Maciej Robert Krawczyński, Ewa Florek, Ewelina Szczepanek-Parulska, Marek Ruchała, Alfio Ferlito
Glioblastoma multiforme (GBM) is the most aggressive malignant brain tumour. The average survival time for a patient diagnosed with GBM, using standard treatment methods, is several months. Authors of the article pose a direct question: Is it possible to treat GBM solely with radioactive iodine (¹³¹I) therapy without employing the sodium iodide symporter (NIS) gene? After all, NIS has been detected not only in the thyroid but also in various tumours. The main author of this article (A.C.), with the assistance of her colleagues (physicians and pharmacologists), underwent ¹³¹I therapy after prior iodine inhibition, resulting in approximately 30% reduction in tumour size as revealed by magnetic resonance imaging (MRI)...
April 22, 2024: Endokrynologia Polska
S Adeleh Razavi, Babak Khorsand, Pouya Salehipour, Mehdi Hedayati
BACKGROUND: Thyroid cancer (TC) is the predominant malignancy within the endocrine system. However, the standard method for TC diagnosis lacks the capability to identify the pathological condition of all thyroid lesions. The metabolomics approach has the potential to manage this problem by identifying differential metabolites. AIMS: This study conducted a systematic review and meta-analysis of the NMR-based metabolomics studies in order to identify significant altered metabolites associated with TC...
April 2024: Cancer Medicine
Hallie Lundquist, Julie Hess, Madeline Comeau, Joanne Slavin
Iodine insufficiencies are common among many populations, particularly pregnant women. One of the main functions of iodine is making thyroid hormone. The 2 main hormones that iodine influences are triiodothyronine and thyroxine. Thyroid hormone affects metabolism of most tissues. For the average adult, the recommended dietary allowance (RDA) for iodine is 150 µg. During certain stages of life, such as pregnancy, lactation, and infancy, the importance of iodine is even greater as it supports brain, bone, and organ development...
May 2024: JDS Commun
Fadi Khreish, Andrea Schaefer-Schuler, Leonie Roth, Caroline Burgard, Florian Rosar, Samer Ezziddin
No abstract text is available yet for this article.
2024: Frontiers in Medicine
Guirong Luo, Liting Zhang, Lihong Zhang, Wenyi Wu, Jianqing Lin, Haihong Shi, Yihuang Yu, Weigang Qiu, Jinyan Chen, Hansen Ding, Xinyao Chen
Smad-ubiquitination regulator 2 (SMURF2) functions as a homolog of E6AP carboxyl terminus-type E3 ubiquitin ligase to regulate cell cycle progression and tumor growth factor expression. SMURF2 has been revealed to function as a tumor suppressor in a number of cancers; however, its function in papillary thyroid carcinoma (PTC) remains largely unknown. Therefore, the aim of the present study was to investigate the function of SMURF2 in PTC. Reverse transcription-quantitative PCR and western blotting were used to detect cellular expression of SMURF2 in vitro ...
June 2024: Oncology Letters
Marie-Gabrielle Courtès, Melpomeni Kountouri, Wenwen Wang, Jean-Christophe Tille, Patrick Petignat, Manuela Undurraga, S Intidhar Labidi-Galy
Clear cell carcinoma is a rare and very aggressive subset of cervical cancer, with poor outcome if diagnosed at advanced stage. There are few data available on the optimal management of this histotype, and treatment recommendations that include surgery and chemoradiotherapy, are essentially based on those for squamous cell carcinoma. Here we report the case of a young patient newly diagnosed with advanced stage (FIGO IIB) clear cell carcinoma of the uterine cervix who received a window of opportunity one injection of nivolumab followed by standard chemoradiotherapy...
June 2024: Gynecologic Oncology Reports
Yongkun Wang, Zhen Wu, Jinqiang Yan, Yumin Yao, Lin Han
OBJECTIVE: There is still controversy about whether cervical lymph node dissection should be performed in surgical treatment of PTC. Based on the data of thyroid cancer patients from Liaocheng People's Hospital from 2015 to 2018, this study focused on appropriate indications for cervical lymph node dissection surgery. METHODS: The clinical and pathological data of patients with initial treatment of PTC in thyroid surgery department from 2015 to 2018 were collected...
2024: Frontiers in Oncology
Joseph Bonanno, Timothy Grannell, Gregory Maves, Joseph D Tobias
In pediatric-aged patients, hyperthyroidism generally results from the autoimmune disorder, Graves' disease (GD). Excessive levels of thyroid hormones (triiodothyronine and thyroxine) result in irritability, emotional lability, nervousness, tremors, palpitations, tachycardia, and arrhythmias. The risk of morbidity and mortality is increased when surgical intervention is required in patients with hyperthyroidism due to the potential for the development of thyroid storm (TS). A 3-year, 1-month-old child with a past medical history of GD presented for total thyroidectomy when pharmacologic control with methimazole was not feasible due to intolerance following development of a serum sickness-like illness...
April 2024: Journal of Medical Cases
Yasser A Obadiel, Mohammed Al-Shehari, Yaseen Algmaly, Bilquis Al-Jammra, Iman Kahtan, Nashwan Tashan, Faisal Ahmed
BACKGROUND: The preferred standard treatment for retrosternal goiter (RSG), a slow-growing, often benign tumor, remains thyroidectomy. An alternative strategy may be required when the goiter is intrathoracic. Data on the results of RSG procedures are rarely reported. Careful patient selection and assessment are critical to avoiding an unexpected sternotomy during surgery and postoperative complications. This study aims to examine the clinical findings and treatment outcomes of RSG and to identify the variables affecting postoperative complications in a resource-limited setting...
March 2024: Curēus
Hadi Afandi Al-Hakami, Renad M Alsolamy, Baraa I Awad, Roaa M Mandora, Dalia Hamdan, Rakan Alzahrani, Yousef Alaqsam, Mohammed Al-Garni
INTRODUCTION: Thyroidectomy technique and extent are related to parathyroid injury and hypoparathyroidism. Total thyroidectomy is one of the most commonly performed endocrine surgeries, and the majority of patients recover completely without any complications. However, persistent hypoparathyroidism is the most prevalent long-term consequence following total thyroidectomy. While it is seldom deadly, it can cause severe morbidity for the patient and raise healthcare expenses. METHODS: This retrospective cohort study was conducted at King Abdulaziz Medical City, Jeddah, Saudi Arabia...
March 2024: Curēus
Mitsuki Tanaka, Yoshiomi Hatayama, Hideo Kawaguchi, Ichitaro Fujioka, Masahiro Aoki
Anaplastic thyroid carcinoma, a rare type of primary thyroid cancer, is one of the most aggressive neoplasms with a poor prognosis. Many cases are in the advanced stage at the time of the initial visit, and curative treatment is impossible. Because of the highly radioresistant nature of anaplastic thyroid carcinoma, this condition cannot be properly controlled with conventional radiotherapy. Herein, we report the case of a patient with anaplastic thyroid carcinoma who underwent hypofractionated radiotherapy, attained a complete response, and is still alive more than 10 years after treatment with no evidence of disease...
March 2024: Curēus
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