Matthew M Pier, Luke J Pasick, Daniel A Benito, Juan Nogues, Punam Thakkar, Arjun S Joshi, Joseph F Goodman
OBJECTIVE: Thyroid and parathyroid surgeries are frequently performed with the aid of electromyogram endotracheal tubes. However, the most common adverse events have not been reported comprehensively. This study aimed to summarize the device adverse events, patient complications, and subsequent interventions related to electromyogram endotracheal tubes. METHODS: In this retrospective cross-sectional analysis, the US Food and Drug Administration's Manufacturer and User Facility Device Experience database was queried for electromyogram endotracheal tube adverse events between 2010 and 2020...
July 29, 2021: Journal of Patient Safety
Dongfang Bai, Chong Guo, Aimin Wang, Guolong Pang, Jing Gao, Chuan Wang, Dapeng Zhao, Jie Yang, Jianmin Ren
Long noncoding RNAs (lncRNAs) play crucial roles in the regulation of human thyroid cancer (TC), including papillary thyroid carcinoma (PTC); PTC is the most common pathological subtype of TC. To date, the expression, function, and mechanism of the lncRNA CASC15 in PTC remain unclear. The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo. Mechanistic studies demonstrated that CASC15 could serve as an endogenous miRNA sponge to absorb and downregulate miR-7151-5p, thereby preventing the inhibition of WNT7A during PTC progression...
July 21, 2021: Pathology, Research and Practice
Xue-Lei Fu, Hua Wu, Yan Qian, Xiao-Hong Jin, Hai-Rong Yu, Lin Du, Hong-Lin Chen, Ya-Qin Shi
The aim of our study was to investigate the suicide rates among childhood cancer survivors and assess factors associated with higher suicide risk. A review of data from Surveillance, Epidemiology, and End Results (SEER) program from 1975 to 2016 was performed for this study. This program is based on the US population and is supported by the US National Cancer Institute (NCI). Survivors diagnosed with childhood cancer were recorded. There were 40 suicides among 567,233 person-years, giving a suicide rate of 7...
July 18, 2021: Psychiatry Research
Maria Oneide Silva de Moraes, João de Deus Pereira de Moraes Segundo, Marcos Marques da Silva Paula, Maria Goreti Ferreira Sales, Walter Ricardo Brito
The highly sensitive detection of serum thyroglobulin (Tg) is essential in the post-treatment follow-up of patients with differentiated thyroid cancer undergoing total or partial thyroidectomy and radioactive iodine ablation and requires sensitive, accurate and stable methods. This work proposes an electrochemical immunosensor for the detection of serum Tg antigen, making use of innovative nanocomposites including polyvinylidene fluoride (PVDF) microparticles coated with streptavidin (MP) and gold nanoparticles (AuNPs)...
July 16, 2021: Bioelectrochemistry
Volkan Yeter, Nurullah Koçak, Mustafa Subaşi, Utku Parlak
OBJECTIVE: To investigate the choroidal vascularity index (CVI) in patients with thyroid-associated ophthalmopathy (TAO) and its relationship with clinical features and clinical activity score METHODS: Right eyes of 53 patients with TAO and 53 healthy subjects were scanned for subfoveal choroidal thickness (SFCT), CVI, choroid-stromal area (C-SA), choroid-luminal area (C-LA), choroidal stromal index (CSI), choroid-stromal-to-luminal-area ratio, and CVI and CSI within the central 1500 µm of the macula (CVI1500 and CSI1500 ) by enhanced-depth imaging optical coherence tomography...
July 26, 2021: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
M Sarić Matutinović, T Diana, B Nedeljković Beleslin, J Ćirić, M Žarković, G J Kahaly, S Ignjatović
PURPOSE: Thyrotropin receptor autoantibodies (TSH-R-Ab) are heterogeneous in their biological function and play a significant role in the pathophysiology of both Graves' disease and Graves' orbitopathy (GO). The clinical significance and utility of determining functional TSH-R-Ab in a Serbian collective were evaluated. METHODS: 91 consecutive patients with GO were included in this study. Total TSH-R-Ab concentration, referred to as TSH-R binding inhibitory immunoglobulins (TBII) was detected using a competitive-binding immunoassay...
July 29, 2021: Journal of Endocrinological Investigation
Fátima Ramos da Silva, Pedro Weslley Rosario, Gabriela Franco Mourão
OBJECTIVE: To evaluate a criterion for the selective indication of radioactive iodine (RAI) based on the short-term behavior of antithyroglobulin antibodies (TgAb) in patients with papillary thyroid carcinoma (PTC) who have negative thyroglobulin (Tg) and neck ultrasonography (US) without abnormalities after total thyroidectomy but elevated TgAb. DESIGN: This was a prospective study that evaluated 216 patients with low- or intermediate risk PTC who had nonstimulated Tg ≤ 0...
July 29, 2021: Clinical Endocrinology
Sara Abou Sherif, Rebecca Newman, Sara Haboosh, Ahmed Al-Sharefi, Nikoleta Papanikolaou, Anastasia Dimakopoulou, Lisa J Webber, Ali Abbara, Stephen Franks, Waljit S Dhillo, Channa N Jayasena
OBJECTIVES: Functional hypothalamic amenorrhoea (FHA) is a common cause of amenorrhoea, but diagnosis can be challenging. The aim of this study was to investigate the clinical and biochemical features of FHA, compared to that of polycystic ovarian syndrome (PCOS) and assess the diagnostic performance of the different parameters for differentiating the two conditions. DESIGN AND PATIENTS: This was a retrospective observational study. We analysed clinical and biochemical parameters of women diagnosed with FHA and PCOS following specialist assessment at the reproductive endocrine gynaecology clinic, St Mary's Hospital, London, UK...
July 29, 2021: Clinical Endocrinology
Li Zhang, Shichen Xu, Xian Cheng, Jing Wu, Xiaowen Wang, Liying Wu, Huixin Yu, Jiandong Bao
Radioactive iodine (RAI) is commonly used to treat differentiated thyroid cancer (DTC). A major challenge is the dedifferentiation of DTC with the loss of radioiodine uptake. Patients with distant metastases have persistent or recurrent disease and develop resistance to RAI therapy due to tumor dedifferentiation. Hence, tumor redifferentiation to restore sensitivity to RAI therapy is considered a promising strategy to overcome RAI resistance. In the present study, curcumin, a natural polyphenolic compound, was found to re-induce cell differentiation and increase the expression of thyroid-specific transcription factors, TTF-1, TTF-2 and transcriptional factor paired box 8 (PAX8), and iodide-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase (TPO) and sodium iodide symporter (NIS) in dedifferentiated thyroid cancer cell lines, BCPAP and KTC-1...
July 29, 2021: Food & Function
Hui Xiong, Huimei Yu, Guangwei Jia, Jinsong Yu, Yang Su, Jianliang Zhang, Jin Zhou
Previous studies have identified the dysregulation of various circRNAs in many types of human cancers including thyroid cancer (TC). Circular RNA ZFR (circZFR) serves as an oncogenic circRNA in TC. However, the detailed molecular mechanism of circZFR in TC progression remains to be further explored. CircZFR and miR-16 expressions in TC cells were analyzed through qRT-PCR. Cell viability, invasion, and apoptosis were detected using CCK-8, transwell invasion assay, and flow cytometry analysis, respectively. The relationship between circZFR and miR-16 was explored using luciferase reporter assay, RNA pull-down assay, and qRT-PCR...
July 28, 2021: Environmental Toxicology
Basak Yalici-Armagan, Ecem Bostan, Neslihan Akdogan, Sibel Ersoy-Evans
BACKGROUND: Lichen sclerosus et atrophicus (LSA) is a chronic inflammatory cutaneous disease. AIM: To evaluate the characteristics of pediatric LSA patients in Turkey. MATERIAL AND METHODS: Data for patients aged <18 years that were diagnosed with LSA by a pediatric dermatologist were retrospectively reviewed. Patient demographic characteristics, clinical features, disease duration, the vitamin D level, accompanying diseases, presence of atopy, therapeutic approach, and treatment response were recorded...
July 29, 2021: International Journal of Clinical Practice
Tomoe Nakao, Michiko Matsuse, Vladimir Saenko, Tatiana Rogounovitch, Aya Tanaka, Keiji Suzuki, Miyoko Higuchi, Hisanori Sasai, Tsutomu Sano, Mitsuyoshi Hirokawa, Akira Miyauchi, Atsushi Kawakami, Norisato Mitsutake
OBJECTIVE: Telomerase reverse transcriptase promoter (TERT-p) mutations are strongly associated with tumour aggressiveness and worse prognosis in papillary thyroid carcinomas (PTCs). Since the TERT-p mutations have been reported to be subclonal, it is unclear how accurately they can be detected by preoperative fine-needle aspiration (FNA). The objective of this study was to analyse the concordance rate of the TERT-p mutations between preoperative FNA and corresponding postoperative surgical specimens...
July 28, 2021: Clinical Endocrinology
T Boers, S J Braak, M Versluis, S Manohar
BACKGROUND: Two-dimensional (2D) ultrasound is well established for thyroid nodule assessment and treatment guidance. However, it is hampered by a limited field of view and observer variability that may lead to inaccurate nodule classification and treatment. To cope with these limitations, we investigated the use of real-time three-dimensional (3D) ultrasound to improve the accuracy of volume estimation and needle placement during radiofrequency ablation. We assess a new 3D matrix transducer for nodule volume estimation and image-guided radiofrequency ablation...
July 29, 2021: European radiology experimental
Skand Shekhar, Janet E Hall, Joanna Klubo-Gwiezdzinska
Sleep has a bidirectional relationship with the hypothalamic-pituitary-thyroid (HPT) axis, and both these homeostatic processes are inter-dependent for robust physiological functioning. The quality and quantity of sleep influence the circadian pattern of TSH and thyroid hormone secretion. Short term sleep restriction significantly reduces the amplitude of nocturnal TSH secretion and may modulate active thyroid hormone secretion, likely through an increased sympathetic tone. Conversely, TSH and active thyroid hormone affect the quantity and architecture of sleep...
April 2021: Current opinion in endocrine and metabolic research
Li-Cheng Tan, Wan-Lin Liu, Xiao-Li Zhu, Peng-Cheng Yu, Xiao Shi, Pei-Zhen Han, Ling Zhang, Liang-Yu Lin, Arseny Semenov, Yu Wang, Qing-Hai Ji, Dong-Mei Ji, Yu-Long Wang, Ning Qu
Background: Though fine-needle aspiration (FNA) improved the diagnostic methods of thyroid nodules, there are still parts of nodules that cannot be determined according to cytology. In the Bethesda system for reporting thyroid cytopathology, there are two uncertain cytology results. Thanks to the development of next-generation sequencing technology, it is possible to gain the genetic background of pathological tissue efficiently. Therefore, a combination of the cytology and genetic background may enhance the accuracy of diagnosis in thyroid nodules...
2021: Frontiers in Oncology
Yuan Tian, Ran Li, Yan Liu, Meng Li, Yuxiao Song, Yan Zheng, Aiqin Gao, Qing Wen, Guohai Su, Yuping Sun
Background: Thyroid dysfunction is common for cancer patients receiving PD-1/PD-L1 inhibitor therapies. To clarify the incidence risk of thyroid dysfunction would be important for guiding anti-PD-1 and anti-PD-L1 immunotherapy. Therefore, the updated meta-analysis was conducted to evaluate the incidence risk of thyroid dysfunction caused by PD-1/PD-L1 inhibitors. Methods: PD-1/PD-L1 inhibitor related clinical trials were collected by a systematic search of the PubMed...
2021: Frontiers in Oncology
Divyani Garg, Ankit Gupta, Rajinder K Dhamija
Thyroid orbitopathy holds a dominant place in the list of causes for external ophthalmoplegia and is commonly accompanied by eye surface signs such as congestion, lacrimation, and proptosis. An elderly male presented to us with painless diplopia in the absence of proptosis, conjunctival congestion, tearing or irritative symptoms. He had bilateral complete external ophthalmoplegia. He was evaluated to have hypothyroidism with elevated anti-thyroid peroxidase antibodies. MRI revealed bulky extraocular muscles in a pattern of sparing of tendinous insertions, highly suggestive of thyroid orbitopathy...
June 2021: Curēus
Andrew G Gianoukakis, Shelly Gupta, Theresa N Tran, Patrick Richards, Marelle Yehuda, Sarah E Tomassetti
BACKGROUND: Graves' disease (GD) has been associated with iron deficiency anemia (IDA). Atrophic gastritis leads to IDA and has been associated with autoimmune thyroid disease. This study prospectively determined the prevalence of atrophic gastritis markers and the relationship between these markers and markers of IDA in GD subjects. METHODS: Newly diagnosed GD patients (90) and controls (41) were studied. Of the newly diagnosed GD patients, 65 were consecutively enrolled and identified with GD irrespective of anemia, 25 had GD and IDA...
2021: American Journal of Blood Research
Mehrdad Nabahati, Naser Ghaemian, Zoleika Moazezi, Rahele Mehraeen
Purpose: To investigate the association of peripheral calcification, as well as its sonographic features, with thyroid nodule malignancy. Material and methods: This study was prospectively conducted during 2015-2020 on patients diagnosed with thyroid nodule undergoing ultrasound-guided fine-needle aspiration in Shahid Beheshti teaching hospital or private offices in Babol, northern Iran. The ultrasonographic characteristics of the nodules, as well as the cytological findings, were recorded...
2021: Polish Journal of Radiology
Luca Quartuccio, Ginevra De Marchi, Simone Longhino, Valeria Manfrè, Maria Teresa Rizzo, Saviana Gandolfo, Alberto Tommasini, Salvatore De Vita, Robert Fox
Common variable immunodeficiency disorders (CVID) are a group of rare diseases of the immune system and the most common symptomatic primary antibody deficiency in adults. The "variable" aspect of CVID refers to the approximately half of the patients who develop non-infective complications, mainly autoimmune features, in particular organ specific autoimmune diseases including thyroiditis, and cytopenias. Among these associated conditions, the incidence of lymphoma, including mucosal associated lymphoid tissue (MALT) type, is increased...
2021: Frontiers in Immunology
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