Senait Tadesse, Ariaya Hymete, Marya Lieberman, Seifu Hagos Gebreyesus, Ayenew Ashenef
BACKGROUND: Iodine is one of the crucial micronutrients needed by the human body, and is vitally important during pregnancy. This study aimed to determine the relationship between the iodine status of pregnant women and their knowledge, and practices regarding iodized salt. All participants were enrolled in the Butajira nutrition, mental health and pregnancy (BUNMAP) cohort, Butajira, Ethiopia in February-May, 2019. METHODS: In this cross-sectional study, 152 pregnant women without hypertension or known thyroid disease before or during pregnancy were randomly selected from the BUNMAP mother to child cohort (n = 832)...
2022: PloS One
Eoin P Flanagan, Michael D Geschwind, A Sebastian Lopez-Chiriboga, Kyle M Blackburn, Sanchit Turaga, Sophie Binks, Jennifer Zitser, Jeffrey M Gelfand, Gregory S Day, S Richard Dunham, Stefanie J Rodenbeck, Stacey L Clardy, Andrew J Solomon, Sean J Pittock, Andrew McKeon, Divyanshu Dubey, Anastasia Zekeridou, Michel Toledano, Lindsey E Turner, Steven Vernino, Sarosh R Irani
IMPORTANCE: Autoimmune encephalitis misdiagnosis can lead to harm. OBJECTIVE: To determine the diseases misdiagnosed as autoimmune encephalitis and potential reasons for misdiagnosis. DESIGN, SETTING, AND PARTICIPANTS: This retrospective multicenter study took place from January 1, 2014, to December 31, 2020, at autoimmune encephalitis subspecialty outpatient clinics including Mayo Clinic (n = 44), University of Oxford (n = 18), University of Texas Southwestern (n = 18), University of California, San Francisco (n = 17), University of Washington in St Louis (n = 6), and University of Utah (n = 4)...
November 28, 2022: JAMA Neurology
Clarissa V de Souza, Patricia C C Motta, Albanett B Nestor, Renee Coifman, Marcelo M P Demarzo
OBJECTIVE: To describe a case of subacute thyroiditis (SAT) secondary to COVID-19 in the primary health care (PHC). CASE DESCRIPTION: A 51-year-old woman was treated in a PHC facility for flu-like symptoms for 5 days and pain in the lower neck. Symptomatic drugs were prescribed, and the patient was tested for COVID-19. On reassessment, the patient presented a painful oedema on the thyroid gland, dysphagia, and improvement in flu-like symptoms. Nonsteroidal anti-inflammatories were prescribed, and thyroid function analysis and inflammatory markers were collected...
November 28, 2022: Family Practice
Jin Wang, Lirong Wu, Wei Lu, Hui Zhang, Yefeng Wu
Introduction: Thyroid carcinoma (THCA) is the most common endocrine tumor worldwide. Insulin-like growth factor 1 (IGF1) is a polypeptide hormone with a high degree of structural similarity to human proinsulin. Materials and Methods: We used online data to investigate the expression pattern of IGF1 in THCA. We also identified gene signatures and pathways downstream of IGF1 to elucidate potential mechanisms. Further analysis identified critical hub genes and pathways using the STRING database and the DAVID online tool...
November 2022: Genetic Testing and Molecular Biomarkers
Letian Yuan, Peng Zhao, Xiangtao Lin, Tianyi Yu, Ruiyuan Diao, Guqing Ning
BACKGROUND: Reduced field-of-view DWI could be proved to quantitatively identify thyroid papillary carcinoma and there is no literature regarding the use of T1-mapping to distinguish nodular goiter from thyroid papillary carcinoma. PURPOSE: To compare T1-mapping with reduced field-of-view DWI in differentiating nodular goiter and thyroid papillary carcinoma. STUDY TYPE: Prospective study. POPULATIONS: Ninety-five hospitalized patients with thyroid nodules were were included into the research...
November 28, 2022: Clinical Physiology and Functional Imaging
Gustavo Savino, Roberta Mattei, Annabella Salerni, Claudia Fossataro, Pia Clara Pafundi
OBJECTIVE: Thyroid-associated orbitopathy (TAO) is the most frequent cause of extraocular muscle enlargement, with consecutive restrictive strabismus. The main muscles involved are inferior and medial rectus, resulting in horizontal esotropia and/or vertical strabismus. Surgery may either establish or improve binocular single vision. The aim of the present study is to describe long-term follow-up of patients who underwent horizontal or vertical TAO strabismus surgery. METHODS: This observational retrospective study included 29 patients suffering from either vertical or horizontal TAO strabismus and diplopia, of whom 11 underwent bilateral medial recti muscle recession (Group A) and 18 underwent unilateral inferior rectus muscle recession (Group B)...
2022: Frontiers in Endocrinology
Inés Amich, Eduardo Anguita, Silvia Escribano-Serrat, Cristina Alvarez, Diego Rodríguez-Muñoz, Verónica García, Rocío Bello, José Alberto Peña-Pedrosa, Neus Martínez-Micaelo, Nuria Amigó, Pablo Ortiz, María José Torrejón, Lisardo Boscá, Javier Martín-Sánchez, Ana Aranda, Susana Alemany
Metabolic reprogramming is required to fight infections and thyroid hormones are key regulators of metabolism. We have analyzed in hospitalized COVID-19 patients: 40 euthyroid and 39 levothyroxine (LT4)-treated patients in the ward and 29 euthyroid and 9 LT4-treated patients in the intensive care unit (ICU), the baseline characteristics, laboratory data, thyroid-stimulating hormone (TSH), free thyroxine (FT4), free triiodothyronine (FT3), the FT3/FT4 ratio, 11 antiviral cytokines and 74 metabolomic parameters...
2022: Frontiers in Endocrinology
Letizia Chiara Pezzaioli, Elisa Gatta, Francesca Bambini, Paolo Facondo, Maria Gava, Maria Cavadini, Caterina Buoso, Elena Di Lodovico, Mario Rotondi, Alberto Ferlin, Carlo Cappelli
PURPOSE: The purpose of this study was to describe the current knowledge on the potential endocrine adverse effects post-COVID-19 vaccines. METHODS: A PubMed/MEDLINE, Web of Science, and Scopus research was performed. Case reports, case series, original studies, and reviews written in English and published online up to 31 July 2022 were selected and reviewed. The final reference list was defined based on the relevance of each paper to the scope of this review. RESULTS: The available data showed that endocrine side effects are generally rare and with favorable outcome, being thyroid disorders the most common...
2022: Frontiers in Endocrinology
Malak A Jaber, Hicham Benabdelkamel, Lina A Dahabiyeh, Afshan Masood, Reem H AlMalki, Mohthash Musambil, Assim A Alfadda, Anas M Abdel Rahman
BACKGROUND: Hyperthyroidism is characterized by increased thyroid hormone production, which impacts various processes, including metabolism and energy expenditure. Yet, the underlying mechanism and subsequent influence of these changes are unknown. Metabolomics is a broad analytical method that enables qualitative and quantitative examination of metabolite level changes in biological systems in response to various stimuli, pathologies, or treatments. OBJECTIVES: This study uses untargeted metabolomics to explore the potential pathways and metabolic patterns associated with hyperthyroidism treatment...
2022: Frontiers in Endocrinology
Jinyun Wang, Dingwei Liu, Yong Xie
OBJECTIVE: Current evidence on the associations between plasma thyroid stimulating hormone and Helicobacter pylori infection is conflicting. Therefore, our study aimed to examine TSH in relation to H. pylori infection. METHODS: Based on the US National Health and Nutrition Examination Survey (NHANES) 1999-2000, a cross-sectional study was conducted with 948 participants aged 30 to 85 years. The associations between H. pylori seropositivity and TSH were evaluated using binary logistic regression models...
2022: Frontiers in Endocrinology
Hua-Chu Zuo, Jin-Yue Huang, Xiao-Li Hu, Lin-Sheng Zhao
To the best of our knowledge, thus far there are no reported cases of melanotic neuroectodermal tumor of infancy (MNTI) with multiple complications. In this case report, we describe the clinical phenotype of MNTI in a 9-month-old female infant associated with tetralogy of Fallot (TOF), a congenital heart defect, and congenital hypothyroidism (CH). Our study showed that the growth of MNTI was delayed by a lower dosage of levothyroxine (L-T4) that was prescribed to treat CH because of the presence of TOF, a severe congenital heart disease...
2022: Frontiers in Cardiovascular Medicine
Ruxin Wang, Haowen Ye, Ying Wang, Li Ma, Jinjing Wei, Xiaofang Zhang, Lihong Wang
Radiation therapy (RT) is one of the common and widely used treatment method for thyroid tumors. Considering that the thyroid is located close to the heart, the radiation generated during the treatment of thyroid tumors may have an adverse greater impact on the heart. This study is to explore the influencing factors, especially additional effects of RT, on cardiac-specific death among patients with malignant thyroid tumors. Collecting information from the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) database using SEER*Stat...
2022: Frontiers in Cardiovascular Medicine
Joey Seuferling, Alex Diaz, Neal Futran, Anshu Bandhlish, Pattana Wangaryattawanich
The aim of this case report is to demonstrate a case of primary thyroid hemangioma in a 62-year-old female who presented with a painless neck mass, treated with right hemithyroidectomy and diagnosed by surgical biopsy. Thyroid hemangiomas are rare, benign lesions which present a diagnostic challenge given the lack of specific imaging findings and clinical manifestations associated with them. However, accurate recognition of these lesions is important and can facilitate conservative, rather than surgical, management strategies...
February 2023: Radiology Case Reports
Zhipeng Ye, Keren Wu, Zhao Hu, Fa Jin
BACKGROUND: Damage to the parathyroid glands remains a frequent complication after thyroidectomy, often resulting in hypoparathyroidism. Accordingly, identifying the parathyroid glands during thyroid surgical procedures is indispensable to prevent accidental surgical removal. METHODS: The participants were randomly divided into three groups (indocyanine green [ICG], nanocarbon [NC], and control group). To identify and protect parathyroid glands during neck lymph node dissection in patients with thyroid cancer, IG was intravenously administered to the ICG group, whereas the NC group received an intra-thyroid injection of the NC suspension before dissection...
2022: Frontiers in Surgery
Si-Rui Wang, Qiao-Li Li, Feng Tian, Jun Li, Wen-Xiao Li, Ming Chen, Tian Sang, Chun-Li Cao, Li-Nan Shi
OBJECTIVE: This study compared the diagnostic value of various diagnostic methods for lymph node metastasis (LNM) of papillary thyroid carcinoma (PTC) through network meta-analysis. METHODS: In this experiment, databases such as CNKI, Wanfang, PubMed, and Web of Science were retrieved according to the Cochrane database, Prisma, and NMAP command manual. A meta-analysis was performed using STATA 15.0, and the value of the surface under the cumulative ranking curve (SUCRA) was used to determine the most effective diagnostic method...
2022: Frontiers in Oncology
Chunyang Mu, Xin Ming, Ye Tian, Yang Liu, Menglin Yao, Yinyun Ni, Yong Liu, Zhihui Li
INTRODUCTION: An emerging public health issue is brought on by the worldwide increase of thyroid nodules (TNs). The goal of the current study is to determine the global prevalence of TNs among the general population. METHODS: We screened articles published from January 2000 to May 2022. TN prevalence was calculated with the DerSimonian-Laird random effects model with arcsine transformation. RESULTS: A total of 20,358 entries were found in our research, and 102 of them met our inclusion criteria...
2022: Frontiers in Oncology
Lucheng Zhu, Shenglin Ma, Bing Xia
Little is known about the efficacy of alectinib for papillary thyroid cancer with STRN-ALK fusion. A 64-year-old female presented with metastatic papillary thyroid cancer, widespread to lungs, mediastinal lymph nodes and brain 20 years after surgery. Disease progression still occurred after radioactive iodine therapy, chemotherapy, and radiotherapy. Tissue obtained from left cervical lymph node confirmed metastatic papillary thyroid cancer. Molecular profiling from re-biopsy tissue identified an STRN-ALK fusion rearrangement...
2022: Frontiers in Oncology
Jing Wang, Zhendong Li
PURPOSES: To identify the differentially expressed genes (DEGs) related to the immune microenvironment and elucidate the biological functions of key genes in papillary thyroid cancer (PTC) by analyzing the immune microenvironment. METHODS: The relative quantities of immune and matrix components in 507 patients with PTC were calculated from the TCGA database. Analysis of differentially expressed genes in tumor samples throughout the genome, intersection of DEGs obtained from PTC patients, and genome-wide tumor samples and survival analysis were performed...
2022: Disease Markers
Giuseppe Barbesino, Alicia Algeciras-Schimnich, Joshua Bornhorst
CONTEXT: Thyroglobulin autoantibodies (TgAbs) affect thyroglobulin immunometric assays (TgIMAs), causing falsely low results. Conversely, heterophilic antibodies (HAs) may cause falsely elevated results. Thyroglobulin (Tg) measurements by mass spectrometry (MS) resist antibody interference. The most effective use of TgIMA/TgMS in the evaluation of Tg remains unclear. OBJECTIVE: The objective of this work was to study the usefulness of TgMS vs TgIMA in the presence of Tg measurement interference by HA and TgAb...
November 17, 2022: Journal of the Endocrine Society
Wen-Fang Chiang, Jenq-Shyong Chan, Po-Jen Hsiao, Shih-Hua Lin
Statin treatment for hypercholesterolemia may cause reversible rhabdomyolysis and acute kidney injury in susceptible patients. However, persistent rhabdomyolysis and acute kidney injury following discontinuation of statins require careful evaluation of the underlying causes to avoid missing a curable disease. We describe a 50-year-old woman with hypercholesterolemia [total cholesterol 345 mg/dl, low-density lipoprotein cholesterol (LDL-C) 266 mg/dL] on atorvastatin therapy (40 mg daily) for 1 month that presented with myalgia and muscle weakness...
2022: Frontiers in Medicine
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