Erwin Danil Yulian, Ahmad Kurnia, Diani Kartini, Putri Arum Melati
BACKGROUND: Most patients in Indonesia present with large-sized thyroid nodules, which need surgical removal to exclude malignancy. Many surgeons prefer endoscopic thyroidectomy to avoid a large and visible surgical scar on the neck and to reduce postoperative complications. This study aims to evaluate and analyze surgical feasibility, safety, oncologic outcome, and patient satisfaction of endoscopic thyroidectomy via the axillary-breast-shoulder approach. METHODS: Between August 2010 and September 2015, 42 endoscopic thyroidectomies via the axillary-breast-shoulder approach with carbon dioxide insufflation up to 8-10 mmHg were performed and retrospectively reviewed...
July 4, 2020: Surgical Oncology
Remus Gaga, Maria Lucia Sur, Călin Lazăr, Cecilia Lazea
Finding multiple familial patients with Hashimoto thyroiditis in our clinic a search in the literature confirms that genetic factors, in addition to environmental factors, seem involved in the etiology of this disease.
August 2020: Pediatric Endocrinology Reviews: PER
Alessandro Brancatella, Debora Ricci, Daniele Cappellani, Nicola Viola, Daniele Sgrò, Ferruccio Santini, Francesco Latrofa
CONTEXT: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has infected more than 18 million people worldwide and the pandemic is still spreading. After the first case we reported, we observed 4 additional cases of SAT related to SARS-CoV-2 infection. OBJECTIVES: To describe additional cases of SAT associated with SARS-CoV-2 infection in order to alert physicians that SAT may be a manifestation of SARS-CoV-2 infection. METHODS: We describe clinical, biochemical and imaging features of the 4 patients with SAT related to SARS-CoV-2 infection...
August 11, 2020: Journal of Clinical Endocrinology and Metabolism
M Knobel
Goiters tend to grow slowly and steadily over many years, occasionally reaching the mediastinum and extending through the thoracic inlet into the visceral compartment. In most cases, retrosternal goiters originate from the cervical portion of the thyroid. The incidence of retrosternal goiters varies considerably, ranging from 0.2 to 45% of all thyroidectomies, depending on the criteria used to define this type of goiter. Symptoms are generally related to the compressive nature of the mass on the adjacent structures, and most patients report some form of respiratory manifestation associated with the goiter...
August 11, 2020: Journal of Endocrinological Investigation
Laura Sabatino, Claudia Kusmic, Giorgio Iervasi
The deiodinases regulate the activation and inactivation of Thyroid hormones (TH), in both physiological and pathological conditions. The three deiodinases, DIO1, DIO2 and DIO3, have different catalytic role and cellular and tissue distribution. Aim of this study is to evaluate a rat model of regional ischemia/reperfusion (I/R), the modification of cardiac main function after the administration of 6 µg/kg/day of triiodothyronine (T3), and the associated to DIO1, DIO2 and DIO3 gene expression. We also aim to study DIO1 and DIO2 protein levels in different left ventricular regions after an ischemic event...
August 11, 2020: Molecular and Cellular Biochemistry
Yume Minagawa, Kazutaka Koganei, Kenji Tatsumi, Ryo Futatsuki, Hirosuke Kuroki, Hiroyuki Hayashi, Tomoaki Suga, Akira Sugita
The patient is 36-year-old woman who complained of proptosis and was diagnosed as thyroid cancer. The pathologic diagnosis of her resected specimen was papillary thyroid cancer, cribriform morular variant (CMV). Subsequently, she was suspected of having familial adenomatous polyposis (FAP), although she had no family history of it. The diagnosis of FAP was confirmed following colonoscopy, which showed multiple polyps, and the biopsies that revealed multiple adenomas and cancers with APC gene mutation. She underwent restorative proctocolectomy, rectal mucosectomy with ileal pouch anal anastomosis, and ileostomy in our department...
2020: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Yu Wu, Kai Huang, Xiangqian Zheng, Ming Gao, Hui Liu
BACKGROUND: We studied the clinical characteristics, diagnosis, treatment, and prognosis of secondary tumors of the thyroid (STTs) and analyzed this rare phenomenon based on our clinical experience. METHODS: We reviewed 16 000 malignant thyroid tumors diagnosed at 2 medical centers in China from 1978 to 2018, including 55 patients with STTs. RESULTS: The most frequent primary tumor sites included lung (21.8%), gastrointestinal (18.2%), breast (14...
July 2020: Cancer Control: Journal of the Moffitt Cancer Center
Adile Merve Baki, Abdurrahman Fatih Aydın, Pervin Vural, Vakur Olgaç, Semra Doğru Abbasoğlu, Müjdat Uysal
Objective: There are controversial data about the prooxidant-antioxidant balance in hypothyroidism. We aimed to investigate the effect of α-lipoic acid (ALA) on oxidative stress parameters in the liver and brain of propylthiouracil (PTU)-induced hypothyroid rats. Materials and Methods: In this experimental study, PTU (500 mg/L) was given to rats in drinking water for 10 weeks. ALA (0.2% in diet) alone and together with thyroxine (T4, 20 μg/kg body weight, s.c) were given to hypothyroid rats in the last 5 weeks of the experimental period...
July 2020: Cell Journal
Sara Shakeri, Parinaz Jahanpanah, Ghasemali Divband, Toktam Massoudi, Kamran Aryana
Brain metastases of PTC are rare and occur in 0.1-5% of the patients, especially in the poorly differentiated types that usually fail to concentrate iodine. We present a rare case of PTC with probable brain metastasis in a 58-year-old woman with a history of poorly differentiated PTC that showed elevated Tg levels and no metastasis was detected in the whole-body iodine scan, despite the positive 99m Tc-octreotide scintigraphy. This imaging modality could be helpful as a diagnostic guide for radionuclide therapy with labeled somatostatin analogs in cases of thyroid carcinoma with elevated Tg levels and negative whole-body iodine scan...
2020: Nuclear Medicine Review. Central & Eastern Europe
Egesta Lopci, Angelo Castello, Emanuela Mazziotti
Herein, we report imaging findings related to an ectopic focus of thyroid tissue in a young female with Graves' disease. The occurrence of ectopic thyroid tissue affects approximately 7% of adult population and represents commonly an occasional finding. Only rarely ectopic tissue can present with metastasis or develop a primary thyroid carcinoma. Multimodality imaging may be of help in this case to detect thyroid ectopia, although recent studies question its capability to differentiate benign from malignant tissue...
2020: Nuclear Medicine Review. Central & Eastern Europe
Neel Rajan, Tilak Khanal, Matthew D Ringel
Distant metastasis classically has been defined as a late-stage event in cancer progression. However, it has become clear that metastases also may occur early in the "lifetime" of a cancer and that they may remain stable at distant sites. This stability of metastatic cancer deposits has been termed "metastatic dormancy" or, as we term it, "metastatic progression dormancy" as the progression either may reflect growth of already existing metastases or new cancer spread. Biologically, dormancy is the presence of nongrowing, static metastatic cells that survive over time...
August 11, 2020: Endocrine
Xing Yu, Chang Liu, Maoxiao Yan, Weihua Gong, Yong Wang
PURPOSE: The hyperthermal liquid, spray and smog caused by energy-based surgical devices (EBDs) may be the potential risk factors for recurrent laryngeal nerve (RLN) thermal injury, but not been reported previously. We aim to demonstrated it both in thyroid surgeries and animal experiments. METHODS: 321 thyroid patients and 32 rats were divided into two groups respectively. A type of endoscopic gauze was implemented in the protected group to prevent nerve from thermal risks...
August 10, 2020: Endocrine
Ikhwan Rinaldi, Abdul Muthalib, Pujo Astowo, Bambang Irawan, Nelly Susanto, Lingga Magdalena, Ilham H R Tulus Maha, Satrio Wicaksono
Global widespread of current coronavirus disease 2019 (COVID-19) pandemic has emerged huge predicament to healthcare systems globally. This disease caused by a new beta-type coronavirus, known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), may lead to systemic multiorgan dysfunction syndrome and subsequently cause death due to abundant angiotensin converting enzyme 2 as its functional receptors throughout body. Oncology patients even have a worse prognosis with greater infection susceptibility because they are in a state of suppression of the systemic immune system due to malignancy and anticancer therapy...
April 2020: Acta Medica Indonesiana
Libo Yang, Hongmei Wang, Jinying Guo, Guanlin Zheng, Dailin Wei, Tie Zhang
BACKGROUND AND OBJECTIVE: Studies on the relationship of thyroid stimulating hormone (TSH) within the reference range and thyroid autoimmunity with osteoporosis have produced conflicting results. The objective of this study was to investigate the association of thyroid function and thyroid autoimmune bodies (TPOAb and TgAb) with osteoporosis in euthyroid postmenopausal women. METHODS: A total of 174 subjects were retrospectively included. Serum TSH, total T3, total T4, TPOAb, TgAb, vitamin D, calcium and bone mineral density were measured...
August 10, 2020: Endocrine, Metabolic & Immune Disorders Drug Targets
Isabelle Vandernoot, Benoit Haerlingen, Pierre Gillotay, Achim Trubiroha, Véronique Janssens, Robert Opitz, Sabine Costagliola
BACKGROUND: Congenital hypothyroidism (CH) due to thyroid dysgenesis is a frequent congenital endocrine disorder for which the molecular mechanisms remain unresolved in the majority of cases. This situation reflects, in part, our still limited knowledge about the mechanisms involved in the early steps of thyroid specification from the endoderm, in particular the extrinsic signaling cues that regulate foregut endoderm patterning. In this study, we used small molecules and genetic zebrafish models to characterize the role of various signaling pathways in thyroid specification...
August 10, 2020: Thyroid: Official Journal of the American Thyroid Association
Laszlo Hegedus, Akira Miyauchi, Robert Michael Tuttle
Editorial do not have an abstract.
August 10, 2020: Thyroid: Official Journal of the American Thyroid Association
M Al-Hassani, B Carey, J Sanderson, E Hullah, M Escudier
Ascher's syndrome is a rare, benign entity with just over 100 reported cases. The condition is characterised by a 'double' upper lip, blepharochalasis and non-toxic thyroid enlargement. It presents before the age of 20 years in the majority of cases and shows no racial or gender differences. While the exact cause is unknown, hormonal dysfunction and autosomal dominant inheritance have been suggested as possible aetiological factors. We present two cases of Ascher's syndrome referred for investigation of lip swelling...
August 11, 2020: Annals of the Royal College of Surgeons of England
Ling Hou, Yan Liang, Wei Wu, Han-Hua Lin, Xiao-Ping Luo, Yan-Qin Ying
PURPOSE: The present study aimed to compare the efficacy and safety of recombinant human growth hormone (rhGH) therapy between children with idiopathic short stature (ISS) and growth hormone deficiency (GHD). METHODS: A total of 150 pediatric patients with ISS and 153 pediatric patients with GHD who received rhGH treatment for more than one year from 2005 to 2016 were enrolled. Growth velocity (GV); height standard deviation (HtSD); insulin-like growth factor-1 standard deviation (IGF-1SD); body mass index (BMI); and the incidence of fasting hyperglycemia, fasting hyperinsulinemia, and hypothyroidism were recorded and compared...
July 17, 2020: Growth Hormone & IGF Research
Edward Margolin
This article presents an overview of the most important points a neurologist must remember when dealing with a patient complaining of diplopia. Patients with monocular diplopia and those with full ocular motility and comitant misalignment should be referred to an ophthalmologist and do not require further testing. Patients with recent onset of binocular diplopia who have associated "brainstem" symptoms should have an urgent brain MRI. All patients with 3rd cranial nerve palsy require urgent brain CTA to rule out compressive aneurysmal lesion...
August 5, 2020: Journal of the Neurological Sciences
Oleg Golovchenko, Maria Abramova, Irina Ponomarenko, Evgeny Reshetnikov, Inna Aristova, Alexey Polonikov, Volodymyr Dvornyk, Mikhail Churnosov
OBJECTIVE: This study aimed to investigate the role ofESR1 and PGR gene polymorphisms in development of intrauterine growth restriction (IUGR) among Russian women in Central Russia. STUDY DESIGN: This case-control study recruited a total of 520 women in the third trimester of pregnancy, including 196 IUGR patients and 324 controls. The participants were unrelated women of self-reported Russian ethnicity. Participants were genotyped at 4 functionally significant polymorphisms of theESR1 (rs2234693, rs9340799) and the PGR (rs484389, rs1042838) genes...
July 28, 2020: European Journal of Obstetrics, Gynecology, and Reproductive Biology
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