Hitomi Takada, Koji Yamashita, Leona Osawa, Yasuyuki Komiyama, Masaru Muraoka, Yuichiro Suzuki, Mitsuaki Sato, Shoji Kobayashi, Takashi Yoshida, Shinichi Takano, Shinya Maekawa, Nobuyuki Enomoto
AIM: Atezolizumab plus bevacizumab (AB) combination therapy is the first-line treatment for unresectable hepatocellular carcinoma (u-HCC). The management of immune-related adverse events (irAEs) is an important issue associated with achieving a good therapeutic response in patients receiving AB therapy. However, few studies have reported irAE development in patients receiving AB therapy. This study focused on the the association between irAE development and autoantibodies at baseline in patients receiving AB therapy...
September 23, 2023: Hepatology Research: the Official Journal of the Japan Society of Hepatology
Ayumi Ryu, Keiichiro Honma, Yoshimi Umeno, Fusayo Uefuji, Takako Muramatsu, Sanako Nishimura, Satoshi Tanada, Takashi Yamamoto, Shigenori Nagata, Tomoyuki Yamasaki, Masayuki Ohue
INTRODUCTION: Cellprep® (CP) is a novel liquid-based cytology (LBC) system. This study aimed to assess the immunoreactivity of control samples stored long-term under two storage conditions using CP. METHODS: The immunoreactivity in control samples was evaluated under two sample storage conditions: CP vial storage at room temperature (RT: 20-25°C) and CP slide storage in a refrigerator (2-6°C). Clinical samples as controls (total: positive/negative) were immunostained using thyroid transcription factor-1 (TTF-1) (20: 14/6), GATA binding protein 3 (GATA-3) (13: 10/3), carcinoembryonic antigen (CEA) (23: 15/8), and the p16/Ki67 cocktail (20: 12/8) markers...
September 23, 2023: Diagnostic Cytopathology
Joris A J Osinga, Arash Derakhshan, Ulla Feldt-Rasmussen, Kun Huang, Tanja G M Vrijkotte, Tuija Männistö, Judit Bassols, Abel López-Bermejo, Ashraf Aminorroaya, Marina Vafeiadi, Maarten A C Broeren, Glenn E Palomaki, Ghalia Ashoor, Liangmiao Chen, Xuemian Lu, Peter N Taylor, Fang-Biao Tao, Suzanne J Brown, Georgiana Sitoris, Lida Chatzi, Bijay Vaidya, Polina V Popova, Elena A Vasukova, Maryam Kianpour, Eila Suvanto, Elena N Grineva, Andrew Hattersley, Victor J M Pop, Scott M Nelson, John P Walsh, Kypros H Nicolaides, Mary E D'Alton, Kris G Poppe, Layal Chaker, Sofie Bliddal, Tim I M Korevaar
CONTEXT: Guidelines recommend use of population- and trimester-specific TSH and FT4 reference intervals (RIs) in pregnancy. Since these are often unavailable, clinicians frequently rely on alternative diagnostic strategies. We sought to quantify the diagnostic consequences of current recommendations. METHODS: We included cohorts participating in the Consortium on Thyroid and Pregnancy. Different approaches were used to define RIs: a TSH fixed upper limit of 4.0 mU/L (fixed limit approach), a fixed subtraction from the upper limit for TSH of 0...
September 22, 2023: Journal of Clinical Endocrinology and Metabolism
Cristina Nieto-Jiménez, Adrián Sanvicente, Cristina Díaz-Tejeiro, Víctor Moreno, Alfonso Lopez de Sá, Emiliano Calvo, Joaquín Martínez-López, Pedro Pérez-Segura, Alberto Ocaña
INTRODUCTION: Antibody-drug conjugates (ADCs) are a family of therapeutic agents that have demonstrated clinical activity in several indications. MATERIAL AND METHODS: In this article, we performed a deep analysis of their clinical landscape matched with public genomic human datasets from tumour antigen targets (TATs), to identify empty areas for clinical development. RESULTS: We observed that TATs used in haematological malignancies were more specific than the ones developed in solid cancers...
September 2023: Clinical and Translational Medicine
Elise A Lucotte, Yazdan Asgari, Pierre-Emmanuel Sugier, Mojgan Karimi, Cloé Domenighetti, Fabienne Lesueur, Anne Boland-Augé, Evgenia Ostroumova, Florent de Vathaire, Monia Zidane, Pascal Guénel, Jean-François Deleuze, Marie-Christine Boutron-Ruault, Gianluca Severi, Benoît Liquet, Thérèse Truong
Breast cancer (bc) risk is suspected to be linked to thyroid disorders, however observational studies exploring the association between bc and thyroid disorders gave conflicting results. We proposed an alternative approach by investigating the shared genetic risk factors between bc and several thyroid traits. We report a positive genetic correlation between bc and thyroxine (FT4) levels (corr = 0.13, p-value = 2.0x10-4) and a negative genetic correlation between bc and thyroid-stimulating hormone (TSH) levels (corr = -0...
September 22, 2023: Human Molecular Genetics
Kai Lou, Shudong Liu, Fengxia Zhang, Wenxiu Sun, Xinhuan Su, Wenkai Bi, Qingqing Yin, Yaxin Qiu, Zhenyuan Zhang, Mengzhe Jing, Shizhan Ma
BACKGROUND: Increasing evidence has linked the thyroid dysfunction to the pathogenesis of dementia. Evidence from clinical studies has demonstrated that hypothyroidism is related to an increased risk of dementia. But the association of hyperthyroidism with dementia is largely unknown. METHODS: We used the adenovirus containing thyrotropin receptor (TSHR) amino acid residues 1-289 (Ad-TSHR289)-induced Graves' disease (GD) phenotype in Alzheimer's disease (AD) model mice (APP/PS1 mice) to evaluate the effect of hyperthyroidism on the cognitive function and β-amyloid (Aβ) accumulation...
September 22, 2023: Journal of Translational Medicine
Zhi Liu, Congjie Bi, Xingguo Li, Ruonan Song
PURPOSE: In the context of the current comfort medicine and enhanced recovery after surgery, there is a demand for a new anesthesia method to reduce adverse reactions and accelerate recovery after surgery. This randomized controlled trial aimed to compare the efficacy and safety between opioid-free anesthesia (OFA) combined with ultrasound-guided intermediate cervical plexus block (ICPB) and opioid-based anesthesia in patients after thyroid surgery. METHODS: In this study, 75 patients scheduled for thyroid surgery under general anesthesia were randomly allocated into two groups...
September 23, 2023: Journal of Anesthesia
Jiapeng Xue, Hongfen Wu, Yun Shi, Zhi Li
PURPOSE: The overexpression of TRIP13 has been observed in many types of cancer and has been identified as an oncogene. However, its role in hepatocellular carcinoma (HCC) has not been extensively studied. This study aimed to investigate the expression of TRIP13 in HCC and its impact on immune cell infiltration and prognosis. METHODS: We analyzed TCGA and GSE62232 datasets to assess TRIP13 expression in HCC. Kaplan-Meier and subgroup analysis were performed to examine the correlation between TRIP13 expression and HCC...
September 22, 2023: Discover. Oncology
Tyler C Owens, Nicolas Anton, Mohamed F Attia
Computed tomography (CT) is a powerful and widely used imaging technique in modern medicine. However, it often requires the use of contrast agents to visualize structures with similar radiographic density. Unfortunately, current clinical contrast agents (CAs) for CT have remained largely unchanged for decades and come with several significant drawbacks, including serious nephrotoxicity and short circulation half-lives. The next generation of CT radiocontrast agents should strive to be long-circulating, non-toxic, and non-immunogenic...
September 20, 2023: Acta Biomaterialia
Hadar Rotem Betito, Hen Chaushu, Yonatan Lahav, Sapir Pinhas, Meir Warman, Taiba Zornitzki, Liron Malka, Jonathan Cohen, Gil Lahav, Oded Cohen
OBJECTIVE: The association between follicular carcinoma and iodine deficiency (ID) is based on epidemiological studies and their inherent biases. The aim of the study was to assess the impact of long-term ID exposure on thyroid nodule cytology and final pathology in a distinct group of patients within a single institution. METHODS: Ethiopian origin patients were compared to an aged-matched group of non-Ethiopian patients. Demographics, risk factors, clinical presentation, cytology and pathology were collected and compared...
September 6, 2023: American Journal of Otolaryngology
Antonio C Bianco
Levothyroxine (LT4) is effective for most patients with hypothyroidism. However, a minority of the patients remain symptomatic despite the normalization of serum thyrotropin levels. Randomized clinical trials including all types of patients with hypothyroidism revealed that combination levothyroxine and liothyronine (LT4+LT3) therapy is safe and is the preferred choice of patients versus LT4 alone. Many patients who do not fully benefit from LT4 experience improved quality of life and cognition after switching to LT4+LT3...
September 22, 2023: Annual Review of Medicine
Wu-Cai Xiao, Xin Li, Rui Shan, Fang Mei, Shi-Bing Song, Jing Chen, Bang-Kai Sun, Chun-Hui Yuan, Zheng Liu
BACKGROUND: Differentiated thyroid cancer (DTC) is very common in women of reproductive age. However, it remains unclear whether pregnancy is associated with DTC progression before surgical treatment. METHODS: This retrospective cohort study, conducted at the Peking University Third Hospital in Beijing, China between January 2012 and December 2022, included 311 eligible women aged 20 to 45 years. To control for potential confounders, we first used propensity score matching (PSM) to match the pregnant group (n = 48) with the non-pregnant group (n = 154) on age, tumor size, tumor type, and Hashimoto's thyroiditis status at baseline, and then used Cox proportional risk models stratified by the matched pairs to estimate the association of pregnancy with DTC progression...
September 20, 2023: Journal of Clinical Endocrinology and Metabolism
Xiaowen Zhang, Yong Wang, Hongwei Wang, Xinlin Zhang
CONTEXT: Various dynamic factors could influence the prevalence and distribution of thyroid dysfunction. OBJECTIVE: To provide national estimates and temporal trends in prevalence of thyroid dysfunction over the past 3 decades in US, and determine the impact of thyroid dysfunction on mortality in US adults. METHODS: A cross-sectional analysis of data from 33,117 participants aged 12 years or older in the NHANES III (1988-1994), 1999-2002, and 2007-2012...
September 20, 2023: Journal of Clinical Endocrinology and Metabolism
Georgi Popivanov, Ivon Daskalova, Borislav Zlatev, Elena Piperkova, Marina Konaktchieva, Stefka Ivanova, Mihail Tabakov, Kirien Kjosev, Ivanka Dimova, Ventsislav Mutafchiyski
INTRODUCTION: Parathyroid cancer (PTC) is an extremely rare malignancy with an incidence of 5.7 per 10 million people. The exact preoperative or intraoperative diagnosis is difficult, but of paramount importance, because resection with negative margins is the only effective treatment. CASE REPORT: A 46-years-old female was referred from another hospital with a diagnosis of "hyper-functioning thyroid nodule", based on the ultrasound showing a lesion of the right thyroid lobe and elevated FT4...
July 18, 2023: Annali Italiani di Chirurgia
Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
OBJECTIVE: This study aimed to investigate prevalences of head and neck cancers in patients with and those without Sjögren's syndrome using a population-based dataset. METHODS: We retrieved sampled patients from Taiwan's Longitudinal Health Insurance Database. This study included 38 930 patients with Sjögren's syndrome and 155 720 propensity-score matched comparison patients without Sjögren's syndrome. RESULTS: Chi-squared tests revealed that there was a statistically significant difference in the prevalences of head and neck cancers between patients with Sjögren's syndrome and comparison patients (1...
September 22, 2023: Head & Neck
Luigi Mansi
No abstract text is available yet for this article.
September 22, 2023: European Journal of Nuclear Medicine and Molecular Imaging
Rashida Khan, Aayesha Riaz, Samina Asghar Abbasi, Tanzeela Sadaf, Ruqia Mehmood Baig, Qaisar Mansoor
Thyroid cancer (TC) is caused by genetic factors and or their cross talk with lifestyle and environment. An important role of miRNA involvement has been identified in different human diseases alongside the cancer. The growing cloud of miRNA discoveries narrates miRNA-221 and miRNA-222 as key elements of ready arsenal in the cancer micro-niches. The aim of present study was to identify the variations of miRNA-221 and miRNA-222 expression in TC tissues and their likely association with TC. miRNA-221 and miRNA-222 were investigated for their expressional alterations in TC tissue samples and healthy thyroid tissue...
September 22, 2023: Scientific Reports
Mohammad Sadegh Fakhari, Fatemeh Dorreh, Mohammad Ahangar Davood, Yazdan Ghandi
OBJECTIVE: Congenital heart disease (CHD) is one of the common diseases of childhood, which is classified into non-cyanotic and cyanotic types. It can affect thyroid function and lead to disruptions in thyroid hormone secretion and hypofunction. This study aimed to evaluate thyroid function in patients younger than 2 years old with cyanotic and non-cyanotic CHD. MATERIALS AND METHODS: In our study, 101 patients (female/male: 50/51) were included. The thyroid-stimulating hormone and thyroid hormones such as thyroxine (T4) and triiodothyronine (T3) were measured using the electrochemiluminescence method, and thyroid peroxidase antibodies were measured by an enzyme-linked immunosorbent assay...
September 22, 2023: Turkish archives of pediatrics
Chaisak Dumrikarnlert, Smathorn Thakolwiboon, Vorapun Senanarong
BACKGROUND: Hashimoto encephalopathy has multiple clinical presentations, and other than the presence of thyroid antibody, laboratory and imaging investigations are all non-specific. Data specific to the clinical presentations and treatment outcomes of patients with Hashimoto encephalopathy in Thailand remain scarce. OBJECTIVES: To retrospectively investigate the clinical presentations and treatment outcomes of patients with Hashimoto encephalopathy at Siriraj Hospital...
September 22, 2023: BMC Neurology
C Sparano, M Puccioni, V Adornato, E Zago, B Fibbi, B Badii, L Bencini, G Mannelli, V Vezzosi, M Maggi, L Petrone
PURPOSE: Indeterminate cytology still puzzles clinicians, due to its wide range of oncological risks. According to the Italian SIAPEC-IAP classification, TIR3B cytology holds up to 30% of thyroid cancer, which justifies the surgical indication, even if more than half of cases do not result in a positive histology. The study aim is to identify potential clinical, ultrasound or cytological features able to improve the surgical indication. METHODS: Retrospective analysis...
September 22, 2023: Journal of Endocrinological Investigation
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