Boris Babenko, Ilana Traynis, Christina Chen, Preeti Singh, Akib Uddin, Jorge Cuadros, Lauren P Daskivich, April Y Maa, Ramasamy Kim, Eugene Yu-Chuan Kang, Yossi Matias, Greg S Corrado, Lily Peng, Dale R Webster, Christopher Semturs, Jonathan Krause, Avinash V Varadarajan, Naama Hammel, Yun Liu
BACKGROUND: Photographs of the external eye were recently shown to reveal signs of diabetic retinal disease and elevated glycated haemoglobin. This study aimed to test the hypothesis that external eye photographs contain information about additional systemic medical conditions. METHODS: We developed a deep learning system (DLS) that takes external eye photographs as input and predicts systemic parameters, such as those related to the liver (albumin, aspartate aminotransferase [AST]); kidney (estimated glomerular filtration rate [eGFR], urine albumin-to-creatinine ratio [ACR]); bone or mineral (calcium); thyroid (thyroid stimulating hormone); and blood (haemoglobin, white blood cells [WBC], platelets)...
March 23, 2023: The Lancet. Digital health
Azizeh Farshbaf-Khalili, Hanieh Salehi-Pourmehr, Farzad Najafipour, Naimeh Mesri Alamdari, Samira Pourzeinali, Nava Ainehchi
Emerging evidence suggests an association of hyperemesis gravidarum (HG) with transient hyperthyroidism and high HCG levels. For synthesizing the current evidence to determine the association between HG with hormones related to thyroid function, a comprehensive systematic search was performed in the electronic databases comprised Medline, Web of Science, Scopus, Embase, ProQuest, and Cochrane Library up to December 2021. All published observational studies that evaluated the association of hyperemesis gravidarum with transient hyperthyroidism were investigated considering the PICO method...
March 2023: Taiwanese Journal of Obstetrics & Gynecology
Xuhui Chen, Li Mou, Jiayuan Qu, Liling Wu, Changjiang Liu
With the COVID-19 pandemic, the use of disinfectants has grown significantly around the world. Triclosan (TCS), namely 5-chloro-2-(2,4-dichlorophenoxy) phenol or 2,4,4'-trichloro-2'-hydroxydiphenyl ether, is a broad-spectrum, lipophilic, antibacterial agent that is extensively used in multifarious consumer products. Due to the widespread use and bioaccumulation, TCS is frequently detected in the environment and human biological samples. Accumulating evidence suggests that TCS is considered as a novel endocrine disruptor and may have potential unfavorable effects on human health, but studies on the toxic effect mediated by TCS exposure as well as its underlying mechanisms of action are relatively sparse...
March 23, 2023: Science of the Total Environment
Lu Zang, Xiaorui Liu, Xianjing Xie, Xuming Zhou, Yitao Pan, Jiayin Dai
Although previous studies have reported an association between maternal serum perfluoroalkyl substance (PFAS) exposure and gestational diabetes mellitus (GDM) risk, results have been inconsistent. Few studies have focused on the combined effects of emerging and legacy PFASs on glucose homeostasis while humans are always exposed to multiple PFASs simultaneously. Moreover, the potential pathways by which PFAS exposure induces GDM are unclear. A total of 295 GDM cases and 295 controls were enrolled from a prospective cohort of 2700 pregnant women in Shanghai, China...
March 24, 2023: Environmental Pollution
Jose Vinoth Raja Antony Samy, Rajeswari Ranga Anantha Sayanam, Chitra Balasubramanian, Natesan Vijayakumar, Sung-JinKim, Sekar Vijayakumar, Mansour K Gatasheh, Mohammad Shamsul Ola, Omar Ahmed Basudan, Mohamed Saad Daoud, Moneera Saud Al-Bagmi, Badr Tayeb Hazazi
An excess of thyroid hormones in the blood characterizes hyperthyroidism. Long-term use of prescription medications to treat hyperthyroidism has substantial adverse effects, and when discontinued, the symptoms frequently recur. Several plant species have been utilized to cure hyperthyroidism. In the present work, we investigated the impact of polyherbal extract (POH) of four medicinal plants to treat hyperthyroidism. Biochemical analysis revealed the presence of a high concentration of phytochemicals in the POHs...
March 23, 2023: International Journal of Biological Macromolecules
Sharanya Balachandran, Xuebin Qin, Chen Jiang, Ehsan Seyed Blouri, Amir Forouzandeh, Masood Dehghan, Dornoosh Zonoobi, Jeevesh Kapur, Jacob Jaremko, Kumaradevan Punithakumar
Segmentation of anatomical structures in ultrasound images is a challenging task due to existence of artifacts inherit to the modality such as speckle noise, attenuation, shadowing, uneven textures and blurred boundaries. This paper presents a novel attention-based predict-refine network, called ACU2 E-Net, for segmentation of soft-tissue structures in ultrasound images. The network consists of two modules: a predict module, which is built upon our newly proposed attentive coordinate convolution; and a novel multi-head residual refinement module, which consists of three parallel residual refinement modules...
March 21, 2023: Computers in Biology and Medicine
Junhyeok Ock, Dayeong Hong, Sojin Moon, Yong-Seok Park, Dong-Woo Seo, Joo Heung Yoon, Sung-Hoon Kim, Namkug Kim
BACKGROUND AND OBJECTIVES: Proper airway management during emergencies can prevent serious complications. However, cricothyroidotomy is challenging in patients with obesity. Since this technique is not performed frequently but at a critical time, the opportunity for trainees is rare. Simulators for these procedures are also lacking. Therefore, we proposed a realistic and interactive cricothyroidotomy simulator. METHODS: All anatomical structures were modeled based on computed tomography images of a patient with obesity...
March 12, 2023: Computer Methods and Programs in Biomedicine
Yaxin Wang, Jingyi Lu, Jiaying Ni, Ming Wang, Yun Shen, Wei Lu, Wei Zhu, Yuqian Bao, Jian Zhou
AIMS: Diabetic retinopathy (DR) can occur even in well-controlled type 2 diabetes, suggesting residual risks of DR in this population. In particular, we investigated the combined effect of thyroid function and glycemic control assessed by an emerging metric, time in range (TIR), with DR. MATERIALS AND METHODS: In this cross-sectional study, a total of 2,740 euthyroid patients with type 2 diabetes were included. Thyroid indicators, including thyroid stimulating hormone (TSH), free triiodothyronine, free thyroxine, thyroid peroxidase antibody and thyroglobulin antibody, were measured...
March 25, 2023: Diabetes/metabolism Research and Reviews
Evert F S van Velsen, Frederik A Verburg
No abstract text is available yet for this article.
March 25, 2023: Journal of Clinical Endocrinology and Metabolism
Nicholas Kesby, Robert Mechera, Talia Fuchs, Alexander Papachristos, Matti Gild, Venessa Tsang, Roderick Clifton-Bligh, Bruce Robinson, Mark Sywak, Stan Sidhu, Angela Chou, Anthony J Gill, Anthony Glover
PURPOSE: Management of sporadic medullary thyroid microcarcinoma smaller than 1 cm (micro-MTC) is controversial due to conflicting reports of prognosis. As these cancers are often diagnosed incidentally, they pose a management challenge when deciding on further treatment and follow-up. METHODS: Micro-MTCs were identified from a prospectively maintained surgery database and slides were reviewed to determine pathological grade. The primary endpoints were recurrence, time to recurrence and disease-specific survival...
March 25, 2023: Journal of Clinical Endocrinology and Metabolism
Fulvio Basolo, Elisabetta Macerola, Anello Marcello Poma, Liborio Torregrossa
The 5th edition of the World Health Organization (WHO) classification of endocrine tumors was released in 2022. Several novelties have been introduced concerning the nomenclature and histopathological diagnosis of follicular-derived thyroid neoplasms. Tumor types have been sharply classified according to prognostic risk categories into benign tumors, low-risk neoplasms and malignant neoplasms. A grading system for differentiated thyroid carcinomas has been implemented with the aim of improving the stratification of tumors...
March 25, 2023: Endocrine
Marta G Podda, Cristina Meazza, Giovanna Gattuso, Giovanna Sironi, Olga Nigro, Luca Bergamaschi, Veronica Biassoni, Michela Casanova, Stefano Chiaravalli, Andrea Ferrari, Roberto Luksch, Nadia Puma, Elisabetta Schiavello, Filippo Spreafico, Paolo Grampa, Siranoush Manoukian, Sabina Vennarini, Paola Collini, Primo A Daolio, Massimiliano Gennaro, Marco Guzzo, Carlo Morosi, Davide Biasoni, Maura Massimino, Monica Terenziani
Each year approximately 35,000 children and adolescents are diagnosed with cancer in Europe. Five-year survival rates have improved and now reach 80% in most European countries, thanks to a combination of chemotherapy, radiotherapy, and surgery. To date, there are more than 44,000 Italians still living several years after being diagnosed with cancer in developmental age. The risk of premature morbidity and mortality for cancer survivors is well known and documented. Approximately 60% of survivors of cancer in childhood and adolescence have at least one chronic health condition in later life, and more than one in four develop severe or life-threatening disorders...
March 24, 2023: Tumori
Shirzad Nasiri, Seyed Mostafa Meshkati Yazd, Mahsa Gholami, Sepehr Shahriarirad, Sina Sharghi, Reza Shahriarirad
BACKGROUND: Papillary thyroid carcinoma PTC is the most prevalent of all thyroid carcinomas. On the other hand, Hashimoto's thyroiditis (HT), as part of the spectrum of autoimmune thyroid diseases, is a major cause of thyroid hypofunction worldwide. Several studies have aimed to indicate a possible correlation between PTC and HT over the years. This study aims to investigate the correlation between HT disease and PTC tumor invasion rate. METHOD: In the present cross-sectional study, PTC patients with HT were selected among patients referred to the surgical ward of Shariati hospital from 2016 to 2019 and compared in terms of tumor invasion and central LN dissection...
March 24, 2023: BMC Endocrine Disorders
P Perumal, A K De, D Bhattacharya, E B Chakurkar
The present study was designed to assess the interrelationship between hematological, serum biochemical, and endocrinological profiles and oxidative stress markers and lactational stages in crossbred (CB) dairy cows of Andaman and Nicobar Islands (ANI). Healthy (n = 6) CB cows (50-62.50% exotic inheritance; Holstein Friesian × Andaman local) of 4th parity with age of 7-9 years and body weight of 350-400 kg were selected from Cattle Breeding Farm, ICAR-Central Island Agricultural Research Institute (ICAR-CIARI), Port Blair, ANI...
March 24, 2023: Tropical Animal Health and Production
Jianhong Liu, Ming Zhang, Dan Deng, Xiao Zhu
Metformin has been used clinically for more than 60 years. As time goes by, more and more miraculous effects of metformin beyond the clinic have been discovered and discussed. In addition to the clinically approved hypoglycemic effect, it also has a positive metabolic regulation effect on the human body that cannot be ignored. Such as anti-cancer, anti-aging, brain repair, cardiovascular protection, gastrointestinal regulation, hair growth and inhibition of thyroid nodules, and other nonclinical effects...
March 24, 2023: Archives of Pharmacal Research
Sandra Herranz-Antolín, Cristina Sánchez-Cendra, Javier Enrique Romo-Gonzales, José Manuel García Gil, Juan Pablo De la Fuente-Escobar, Antonio Rosell-Cernevilla
No abstract text is available yet for this article.
March 22, 2023: Endocrinología, diabetes y nutrición
Javiera Araya, Sabhyta Sabharwal, César A Briceño
No abstract text is available yet for this article.
April 1, 2023: International Ophthalmology Clinics
Alisha Kamboj, Michael S Lee, Collin M McClelland
No abstract text is available yet for this article.
April 1, 2023: International Ophthalmology Clinics
Jane Z Spadaro, Anita A Kohli
No abstract text is available yet for this article.
April 1, 2023: International Ophthalmology Clinics
Jorge L Jo Kamimoto, Jeremy J Flood
No abstract text is available yet for this article.
April 1, 2023: International Ophthalmology Clinics
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