Georg Homuth, Julika Lietzow, Nancy Schanze, Janine Golchert, Josef Köhrle
Thyroid hormone metabolites (THM) with few or no iodine substituents such as 3,5-T2, the thyronamines 3-T1AM and T0AM, and their oxidation products, the thyroacetic acids (TA) formed by monoamine oxidases, have recently attracted major interest due to their metabolic actions which are in part distinct from those of the classical thyromimetic hormone T3, the major ligand of T3 receptors. This review compiles and discusses in vitro effects of 3,5-T2, TAM and TA reported for thyrocytes, pancreatic islets and hepatocytes as well as findings from in vivo studies in mouse models after single or repeated administration of pharmacological doses of these agents...
May 25, 2020: Experimental and Clinical Endocrinology & Diabetes
Kyoung-Nam Kim, Hwa Young Kim, Youn-Hee Lim, Choong Ho Shin, Johanna Inhyang Kim, Bung-Nyun Kim, Young Ah Lee, Yun-Chul Hong
BACKGROUND: Limited studies have investigated the association between prenatal and early childhood phthalate exposures and thyroid function among children. OBJECTIVES: To investigate the association between early life phthalate exposure and thyroid function among school-age children, considering both prenatal and early childhood exposures, using longitudinal data from an established prospective cohort. METHODS: We measured urinary phthalate metabolite levels during pregnancy and at 2, 4, and 6 years of age and conducted thyroid function tests at 6 years of age...
May 22, 2020: Environment International
Trudeau Vl, Thomson P, Zhang Ws, Reyaud S, L Navarro-Martin, V S Langlois
Concern over global amphibian declines and possible links to agrochemical use has led to research on the endocrine disrupting actions of agrochemicals, such as fertilizers, fungicides, insecticides, acaricides, herbicides, metals, and mixtures. Amphibians, like other species, have to partition resources for body maintenance, growth, and reproduction. Recent studies suggest that metabolic impairments induced by endocrine disrupting chemicals, and more particularly agrichemicals, may disrupt physiological constraints associated with these limited resources and could cause deleterious effects on growth and reproduction...
May 22, 2020: Molecular and Cellular Endocrinology
Huan Wang, Jian Tang, Zhiwei Su
Medullary thyroid cancer (MTC) is the third most common thyroid cancer. RET (Rearranged in Transformation) gene mutations are considered as one of the major drivers of MTC. Vandetanib suppresses RET activity, and has shown promise in clinical trials. Unfortunately, acquired resistance to vandetanib has been observed in MTC, although the mechanism was largely unknown. We investigated the critical role of YAP (Yes-Associated Protein) on vandetanib resistance in MTC. For this, TT cells (medullary thyroid cancer cells) were treated with vandetanib for 3 months to generate a vandetanib-resistant cell line (TT-R)...
May 25, 2020: Biochemistry and Cell Biology
Emmely M de Vries, Hermina C van Beeren, Albert C W A van Wijk, Andries Kalsbeek, Johannes A Romijn, Eric Fliers, Anita Boelen
Fasting induces profound changes in the hypothalamus-pituitary-thyroid axis and peripheral thyroid hormone (TH) metabolism, ultimately leading to lower serum thyroid hormone (TH) concentrations. In the present study, we aimed to investigate the regulation of type 3 deiodinase (D3) during fasting in two metabolic tissues: liver and white adipose tissue (WAT). To this end, we studied the effect of modulation of the mammalian target of rapamycin (mTOR) and hypoxia inducible factor 1α (HIF1α) on D3 expression in a primary rat hepatocytes and in 3T3-L1 adipocytes...
May 1, 2020: Endocrine Connections
Sonia Moretti, Elisa Menicali, Nicole Nucci, Martina Guzzetti, Silvia Morelli, Efisio Puxeddu
Immunotherapy has arisen in use in the field of oncology with seven immune checkpoint inhibitors approved for the treatment of a variety of cancer histologies. Depending on the cancer type, the success rate might be different, but in average it is about 20%, with some cases showing a durable response, lasting also after the interruption of the treatment, with a clear benefit on OS. The development of an efficacious cure for advanced thyroid carcinomas is still an unmet need and immunotherapy represents an interesting alternative option also for this cancer...
May 1, 2020: European Journal of Endocrinology
Sarah C Clement, Chantal A Lebbink, Mariëlle S Klein Hesselink, Jop C Teepen, Thera P Links, Cécile M Ronckers, Hanneke M van Santen
Objective Childhood cancer survivors (CCS) are at increased risk to develop differentiated thyroid cancer predominantly after radiotherapy (subsequent DTC). It is insufficiently known whether subsequent DTC in CCS has a different presentation or outcome than sporadic DTC. Methods Patients with subsequent DTC (n= 31) were matched to patients with sporadic DTC (n= 93) on gender, age and year of diagnosis to compare presentation and DTC outcomes. Clinical data were collected retrospectively. Results Among the CCS with subsequent DTC, all but one had received chemotherapy for their childhood cancer; 19 (61...
May 1, 2020: European Journal of Endocrinology
Angelo Carfì, Allegra Romano, Giulia Zaccaria, Emanuele Rocco Villani, Ester Manes Gravina, Davide Liborio Vetrano, Roberto Bernabei, Graziano Onder
Data on clinical characteristics of adults with Down syndrome (DS) are limited and the clinical phenotype of these persons is poorly described. This study aimed to describe the occurrence of chronic diseases and pattern of medication use in a population of adults with DS. Participants were 421 community dwelling adults with DS, aged 18 years or older. Individuals were assessed through a standardized clinical protocol. Multimorbidity was defined as the occurrence of two or more chronic conditions and polypharmacy as the concomitant use of five or more medications...
May 25, 2020: American Journal of Medical Genetics. Part A
Virginia Cappagli, Adele Caldarella, Gianfranco Manneschi, Paolo Piaggi, Valeria Bottici, Laura Agate, Eleonora Molinaro, Francesca Bianchi, Rossella Elisei
The long-term survival of differentiated thyroid cancer (DTC) patients and the need to perform several treatments with radioiodine (131-I) lead to the question if the lifetime risk of developing a non-thyroidal second primary cancer (NTSPC) is increased in these patients. In this study we assessed the prevalence of NTSPCs in thyroid cancer population and evaluated the possible causative role of 131-I treatment. We analyzed 1096 consecutive patients followed at our institution from 1964 to 1998. A total of 101 NTSPCs were observed in 92/1096 patients (8...
May 24, 2020: International Journal of Cancer. Journal International du Cancer
Jiyoung Yoon, Jung Hyun Yoon, Kyunghwa Han, Jandee Lee, Eun-Kyung Kim, Hee Jung Moon, Vivian Youngjean Park, Jin Young Kwak
PURPOSE: To investigate the role of neck US surveillance in patients with papillary thyroid carcinoma (PTC) after total thyroidectomy according to dynamic risk stratification (DRS) based on response to initial therapy. METHODS: This retrospective study included 812 patients with PTC who underwent total thyroidectomy with prophylactic central neck dissection from January 2003 through February 2007. The relative risk of recurrence/persistence according to DRS was evaluated with the multivariable Cox regression proportional hazard model...
May 24, 2020: Endocrine
M S Siddiqui, Z M Lai, L Spain, V Greener, S Turajlic, J Larkin, D L Morganstein
PURPOSE: Ipilimumab, a monoclonal antibody inhibiting CLTA-4, is an established treatment in metastatic melanoma, either alone or in combination with nivolumab, and results in immune mediated adverse events, including endocrinopathy. Hypophysitis is one of the most common endocrine abnormalities. An early recognition of hypophysitis may prevent life threatening consequences of hypopituitarism; therefore, biomarkers to predict which patients will develop hypophysitis would have clinical utility...
May 24, 2020: Journal of Endocrinological Investigation
Mohammad Abuqbeitah, Mustafa Demir, Nami Yeyin, Sait Sager, David Gray
COTI (collar therapy indicator) has been recently introduced for the detection of gamma rays with emphasis on thyroid investigations. The aim of this study was to test the feasibility of a prototype version of COTI including activity detectors with low sensitivity in performing thyroid uptake measurements for a large group of patients. Consequently, thyroid uptake tests were carried out for a total of 89 patients (22 males and 67 females; age: 44 ± 13 years) with thyroid cancer (n = 74), hyperthyroidism (n = 16) at 2 and 24 h after administration of 0...
May 24, 2020: Radiation and Environmental Biophysics
G Baud, L Brunaud, J-C Lifante, C Tresallet, F Sebag, J-P Bizard, M Mathonnet, F Menegaux, R Caiazzo, E Mirallié, F Pattou
The COVID-19 pandemic commands a major reorganisation of the entire French healthcare system. In France, general rules have been issued nationally and implemented by each healthcare centre, both public and private, throughout France. Guidelines drafted by an expert group led by the French-speaking Association of Endocrine Surgery (AFCE) propose specific surgical management principles for thyroid, parathyroid, endocrine pancreas and adrenal surgery during and after the COVID-19 epidemic.
April 30, 2020: Journal of Visceral Surgery
Daniel L Miller, Lester D R Thompson, Justin A Bishop, Lisa M Rooper, Syed Z Ali
INTRODUCTION: Primary thyroid gland malignant teratomas are extremely rare and can pose diagnostic challenges on fine needle aspiration (FNA) due to their cytomorphologic heterogeneity. Recent next generation sequencing studies have identified recurrent DICER1 hotspot mutations in these tumors, suggesting that malignant teratomas of the thyroid should be considered a distinct pathological entity. Herein, we review the clinico-radiologic and FNA findings in a series of DICER1 mutated malignant teratomas...
April 28, 2020: Journal of the American Society of Cytopathology
Shaoyong Xu, Yuxin Jiang, Aihua Jia, Juan Zhang, Bin Gao, Jing Xu, Xiaorui Jing, Yang Jiao, Jia Wei, Wenlei Xu, Ruikun Chen, Ling Gao, Lei Shang
BACKGROUND: Subacute thyroiditis (SAT) is the most common cause of thyroid pain. Several clinical guidelines recommend that patients who fail to respond to full doses of non-steroidal anti-inflammatory drugs (NSAIDs) should be treated instead with oral corticosteroid therapy. However, albeit strong recommendations, the treatment protocol is based on low-quality evidence and high-quality clinical trials are lacking with respect to the optimal initiation dosage and usage of corticosteroid...
May 24, 2020: Trials
Mario Tamburrini, Parikshit Thakare, Umberto Zuccon
There is paucity in literature on the use of endobronchial ultrasound through esophagus (EUS-B) for the diagnosing thyroid gland lesions. We report the first case of colloid goiter diagnosed using EUS-B- FNA technique. A 77-year-old man presented with ophthalmic symptoms and an incidental finding of lung nodule on chest x-ray. The computed tomography of thorax revealed a left upper lobe nodule and an oval shaped left paratracheal lesion near left pole of thyroid gland. EUS-B- FNAC was performed which lead to the diagnosis of colloid goiter...
May 21, 2020: Monaldi Archives for Chest Disease
J Cao, T R Zhu, J Li
Perfluoroalkyl and polyfluoroalkyl substances (PFASs) are a new subgroup of the persistent organic pollutants that have been widely used in industrial production and daily life for over 60 years. The presence of PFASs can be detected in rivers, soil, humans and wildlifes. Studies have shown that PFASs can induce multi-system toxicity in laboratory animals, including liver toxicity, neurotoxicity, reproductive and developmental toxicity, endocrine toxicity and immunotoxicity. PFASs are closely related to the birth outcomes, growth and development of the offspring...
April 20, 2020: Chinese Journal of Industrial Hygiene and Occupational Diseases
Kirsten Lindner, Jochen Kußmann, Volker Fendrich
BACKGROUND: Potassium iodide (KI) treatment affects the vascularity of the thyroid gland and therefore may improve intraoperative visualization of essential structures. However, clear evidence for its usage is lacking, and its implementation in patients suffering from Graves' disease is becoming rare. The objective of this retrospective study was to assess the impact of KI treatment on the intraoperative course and the outcome of patients undergoing thyroidectomy for Graves' diseases...
May 23, 2020: World Journal of Surgery
Jwu Jin Khong, Alan McNab
Thyroid eye disease (TED) affects 25% of patients with Graves' hyperthyroidism, where 1 in 20 patients has active, moderate-to-severe disease that will require medical treatment for reducing TED activity and severity. Intravenous corticosteroid has been the mainstay of treatment for active moderate-to-severe TED. With improved understanding of the pathophysiology of TED, immunotherapy targeting different molecular pathways including T cells, B cells, cytokines and cell surface receptors have been investigated in randomised clinical trials...
May 23, 2020: British Journal of Ophthalmology
Huan Liu, Ai-Lin Ma, Ying-Shi Zhou, Ding-Hong Yang, Jing-Liang Ruan, Xiao-Di Liu, Bao-Ming Luo
PURPOSE: To investigate the interobserver agreement of different thyroid imaging report and data system (TI-RADS) and ultrasound (US) features. METHODS: Two researchers independently searched PubMed, Embase and the Web of Science for relevant studies published between October 1972 and December 2018. Studies investigating interobserver agreement between different radiologists were included. The Guidelines for Reporting Reliability and Agreement Studies (GRRAS) and the Quality Assessment of Diagnostic Accuracy Studies-2 (QUADAS-2) score tools were applied to assess the quality of the studies...
May 13, 2020: European Journal of Radiology
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