Ashley S P Boggs, Lisa E Kilpatrick, Carolyn Q Burdette, Denise S Tevis, Zachary A Fultz, Michael A Nelson, Jeffery M Jarrett, Jennifer V Kemp, Ravinder J Singh, Stefan K G Grebe, Stephen A Wise, Brittany L Kassim, Stephen E Long
Objectives Matrix differences among serum samples from non-pregnant and pregnant patients could bias measurements. Standard Reference Material 1949, Frozen Human Prenatal Serum, was developed to provide a quality assurance material for the measurement of hormones and nutritional elements throughout pregnancy. Methods Serum from non-pregnant women and women in each trimester were bottled into four levels based on pregnancy status and trimester. Liquid chromatography tandem mass spectrometry (LC-MS/MS) methods were developed and applied to the measurement of thyroid hormones, vitamin D metabolites, and vitamin D-binding protein (VDBP)...
October 26, 2020: Clinical Chemistry and Laboratory Medicine: CCLM
Saira Fatima, Rabia Qureshi, Sumbul Imran, Romana Idrees, Zubair Ahmad, Naila Kayani, Arsalan Ahmed
BACKGROUND: Fine needle aspiration cytology (FNAC) along with the thyroid ultrasound is an important tool in evaluation of the thyroid nodules & help in further management of these patients i-e decision of surgical intervention vs follow-up. The Bethesda system for reporting thyroid cytopathology (TBSRTC) category III of Atypia of undetermined significance/follicular lesion of undetermined significance (AUS/FLUS) has risk of malignancy ranging from 5-15%. The aim of the present study was to describe the frequency of AUS/FLUS in thyroid gland FNACs and the surgical outcomes of these cases...
October 24, 2020: Cytopathology: Official Journal of the British Society for Clinical Cytology
Hongwei Xu, Yang Liu, Zheng Liu, Xiaoming Wang, Xiubo Lu
Forkhead box (FOX) proteins have been identified as key transcription factors in diverse biological processes involved in tumor progression. A large number of FOX proteins are implicated in tumorigenesis of papillary thyroid carcinoma (PTC). Here we investigated the role of Forkhead box K1 (FOXK1) in PTC progression. First, we found that FOXK1 was elevated in both PTC tissues (N = 68) and cell lines. Moreover, up-regulated FOXK1 was associated with shorter overall survival of PTC patients. Second, in vitro functional assays showed that FOXK1 promoted progression of PTC...
October 24, 2020: Human Cell
Rachel Houten, Nigel Fleeman, Eleanor Kotas, Angela Boland, Tosin Lambe, Rui Duarte
PURPOSE: Health state utility values are commonly used to inform economic evaluations and determine the cost-effectiveness of an intervention. The aim of this systematic review is to summarise the utility values available to represent the health-related quality of life (HRQoL) of patients with thyroid cancer. METHODS: Eight electronic databases were searched from January 1999 to April 2019 for studies which included assessment of HRQoL for patients with thyroid cancer...
October 24, 2020: Quality of Life Research
Michael H Berger, Harrison W Lin, Neil Bhattacharyya
OBJECTIVES/HYPOTHESIS: To determine the food security status of patients with a history of head and neck cancer and compare to other types of cancer. STUDY DEIGN: A retrospective analysis using the National Health Interview Series. METHODS: The National Health Interview Series (NHIS) for the calendar years 2014 to 18 was used to elicit food security status (secure, marginally secure/not secure) among adult patients with a history of throat/pharynx head and neck cancer (pHNC), thyroid cancer, and colon cancer...
October 24, 2020: Laryngoscope
Katherine C Wai, Mary Jue Xu, Rex H Lee, Ivan H El-Sayed, Jonathan R George, Chase M Heaton, P Daniel Knott, Andrea M Park, William R Ryan, Rahul Seth, Patrick K Ha
BACKGROUND: Guidelines regarding head and neck surgical care have evolved during the coronavirus-19 (COVID-19) pandemic. Data on operative management have been limited. METHODS: We compared two cohorts of patients undergoing head and neck or reconstructive surgery between March 16, 2019 and April 16, 2019 (pre-COVID-19) and March 16, 2020 and April 16, 2020 (COVID-19) at an academic center. Perioperative, intraoperative, and postoperative outcomes were recorded...
October 23, 2020: Head & Neck
Paweł Radwan, Bartosz Wielgomas, Michał Radwan, Rafał Krasiński, Anna Klimowska, Radosław Zajdel, Dorota Kaleta, Joanna Jurewicz
Triclosan (TCS) is a widespread environmental endocrine-disrupting chemical. Animal and in vitro studies suggested that triclosan may affect homesostasis of sex and thyroid hormones and impact on reproduction. Due to limited data derived from human epidemiological studies, this study was performed to examine the association between urinary concentration of triclosan and in vitro reproductive outcomes (methaphase II (MII) oocyte yield, top quality embryo, fertilization rate, implantation rate, and clinical pregnancy) among women from infertility clinic...
October 23, 2020: Environmental Science and Pollution Research International
Aparna Hegde, Alexander Y Andreev-Drakhlin, Jason Roszik, Le Huang, Shuang Liu, Kenneth Hess, Maria Cabanillas, Mimi I Hu, Naifa L Busaidy, Steven I Sherman, Ramona Dadu, Elizabeth G Grubbs, Siraj M Ali, Jessica Lee, Yasir Y Elamin, George R Simon, George R Blumenschein, Vassiliki A Papadimitrakopoulou, David Hong, Funda Meric-Bernstam, John Heymach, Vivek Subbiah
PURPOSE: The receptor tyrosine kinase rearranged during transfection (RET) can be oncogenically activated by gene fusions or point mutations. Multikinase inhibitors such as cabozantinib, lenvatinib and vandetanib have demonstrated activity in RET-dependent malignancies, and selective RET inhibitors (Selpercatinib and Pralsetinib) are in clinical trials. However, the responsiveness of RET-dependent malignancies to immune checkpoint inhibitors (ICIs) is unknown. We compared the time to treatment discontinuation (TTD) for ICI versus non-ICI therapy in patients with malignancies harbouring activating RET mutations or fusions (RET+)...
October 2020: ESMO Open
Ann D Thor, Reema S Wahdan-Alaswad, Susan M Edgerton, Hiba Salem, Hyunmin Kim, Aik-Choon Tan, Jessica Finlay-Schultz, Elizabeth Wellberg, Carol A Sartorius, Britta M Jacobsen, Bryan R Haugen, Bolin Liu
PURPOSE: Thyroid disease is a frequent comorbidity in women with breast cancer (BC), and many require thyroid hormone(TH) replacement therapy(THRT). We postulated that THRT has a deleterious clinical effect mechanistically through hormonal interactions, nuclear receptor cross-talk and upregulation of high-risk BC genes. EXPERIMENTAL DESIGN: Observational studies of lymph node-negative (LN-) BC patients (n= 820 and n=160) were performed to test interactions between THRT and clinical, histologic, outcome and treatment variables...
October 23, 2020: Clinical Cancer Research
R D Frisina, P Bazard, M Bauer, J Pineros, X Zhu, B Ding
Provocative research has revealed both positive and negative effects of hormones on hearing as we age; with in some cases, mis-regulation of hormonal levels in instances of medical comorbidities linked to aging, lying at the heart of the problem. Animal model studies have discovered that hormonal fluctuations can sharpen hearing for improved communication and processing of mating calls during reproductive seasons. Sex hormones sometimes have positive effects on auditory processing, as is often the case with estrogen, whereas combinations of estrogen and progesterone, and testosterone, can have negative effects on hearing abilities, particularly in aging subjects...
October 15, 2020: Hearing Research
Wei Qiang, Rongxin Sun, Xiaopu Zheng, Yuan Du
BACKGROUND: Patients with Turner syndrome (TS) are prone to autoimmune disorders. Although most patients with TS are diagnosed at younger ages, delayed diagnosis is not rare. CASE PRESENTATION: A 31-year-old woman was presented with facial edema, chest tightness and dyspnea. She had primary amenorrhea. Physical examination revealed short stature, dry skin and coarse hair. Periorbital edema with puffy eyelids were also noticed with mild goiter. Bilateral cardiac enlargement, distant heart sounds and pulsus paradoxus, in combination with hepatomegaly and jugular venous distention were observed...
October 23, 2020: BMC Cardiovascular Disorders
Hieu Huu Le, Majid Shakeri, Hafiz Ansar Rasul Suleria, Weicheng Zhao, Rachel Mai McQuade, Deborah Jayne Phillips, Eva Vidacs, John Barton Furness, Frank Rowland Dunshea, Valeria Artuso-Ponte, Jeremy James Cottrell
Heat stress (HS) compromises productivity of pork production, in part as a result of increased oxidative stress and inflammatory responses, particularly within the gastrointestinal tract. This study aimed to investigate whether plant-derived betaine and isoquinoline alkaloids could ameliorate HS in pigs. Fifty female Large White × Landrace grower pigs, which were acclimated to control (CON), control plus betaine (BET), or control plus isoquinoline alkaloids (IQA) diets for 14 days were then exposed to heat stress or thermoneutral condition...
October 21, 2020: Antioxidants (Basel, Switzerland)
Zhenyu Xie, Xin Li, Yu Lun, Yuzhen He, Song Wu, Shiyue Wang, Jianjian Sun, Yuchen He, Shijie Xin, Jian Zhang
BACKGROUND: Tumor mutation burden (TMB) as a prognostic marker for immunotherapy has shown prognostic value in many cancers. However, there is no systematic investigation on TMB in papillary thyroid carcinoma (PTC). METHODS: Based on the somatic mutation data of 487 PTC patients from The Cancer Genome Atlas (TCGA), TMB was calculated, and we classified the samples into high-TMB (H-TMB) and low-TMB (L-TMB) groups. Bioinformatics methods were used to explore the characteristics and potential mechanism of TMB in PTC...
October 19, 2020: International Immunopharmacology
Elisabetta Macerola, Anello Marcello Poma, Fulvio Basolo
In the setting of cancer pathology, molecular characterization of tumors providing diagnostic and predictive information is acquiring more and more relevance. Moreover, the advent of innovative technologies continuously improves the knowledge of the molecular landscape of tumors and strengthens the links between clinics, tumor pathology and molecular features. In the clinical management of patients with thyroid nodules and thyroid tumors, the aid of molecular testing is encouraged but still not strongly recommended by current guidelines...
October 19, 2020: Seminars in Cancer Biology
Martina Chiacchiarini, Sofia Trocchianesi, Zein Mersini Besharat, Agnese Po, Elisabetta Ferretti
Medullary thyroid carcinoma (MTC) is a rare neuroendocrine tumor comprising hereditary or sporadic form with frequent mutations in the rearranged during transfection (RET) or RAS genes. Diagnosis is based on presence of thyroid tumor mass with altered levels of calcitonin (Ctn) and carcinoembryonal antigen (CEA) in the serum and/or in the cytological smears from fine needle aspiration biopsies. Treatment consists of total thyroidectomy, followed by tyrosine kinase inhibitors (TKi) in case of disease persistence...
October 19, 2020: Pharmacology & Therapeutics
Shijie Yang, Chao Jin, Xiequn Xu
No abstract text is available yet for this article.
October 22, 2020: Journal of Clinical Endocrinology and Metabolism
Barbara M L C Bocco, Gustavo W Fernandes, Tatiana L Fonseca, Antonio C Bianco
More than a billion people worldwide are at risk of iodine deficiency (ID), with well-known consequences for development of the central nervous system. Furthermore, ID has also been associated with dyslipidemia and obesity in humans. To further understand the metabolic consequences of ID, here we kept 8-week-old C57/Bl6 mice at thermoneutrality (~28 oC) while feeding on a low iodine diet (LID). When compared to mice kept on control diet (CD; LID + 0.71 ug/g iodine), the LID mice exhibited marked reduction in T4 and elevated plasma TSH, without changes in plasma T3 levels...
October 22, 2020: Endocrinology
Khalil Issa, Madelyn N Stevens, Yuhui Sun, Samantha Thomas, Alissa Collins, Jonathan Cohen, Ramon M Esclamado, Daniel J Rocke
OBJECTIVE: Lateral neck dissection (LND) is important in managing papillary thyroid carcinomas (PTCs). This study aimed to evaluate the relationship between lymph node yield (LNY) for LND and patient outcomes, specifically postoperative serum thyroglobulin levels (sTG) and radioiodine uptake on thyroid scan, and to estimate a threshold LNY to signify adequate LND. METHODS: Patients diagnosed with PTC who underwent LND from 2006 to 2015 at a single institution were included...
October 22, 2020: Ear, Nose, & Throat Journal
Priyanka Thatipamala, Julia E Noel, Lisa Orloff
OBJECTIVES: To determine whether thyroidectomy improves quality of life in patients with Hashimoto thyroiditis with persistent symptoms despite biochemical euthyroidism. METHODS: A retrospective cohort study was conducted of patients undergoing thyroidectomy for Hashimoto thyroiditis at our institution between 2014 and 2018. The following variables were collected: age, race, body mass index, preoperative symptoms, preoperative thyroid peroxidase antibody titer, thyroglobulin antibody titer, thyroid-stimulating hormone, free thyroxine, specimen weight, and histologic presence of thyroiditis...
October 22, 2020: Ear, Nose, & Throat Journal
Elizabeth Sharp, Melissa Roberts, Agnieszka Żurada-ZieliŃska, Anna Zurada, Jerzy Gielecki, R Shane Tubbs, Marios Loukas
INTRODUCTION: Iatrogenic nerve injury during surgery is a major source of concern for both patients and surgeons. This study aimed to identify the nerves most commonly injured during surgery, along with the commonly associated operative procedures. MATERIALS AND METHODS: A literature search was conducted using the PubMed database to identify nerves commonly injured during surgery, along with the surgical procedure associated with the injury. RESULTS: The following eleven nerves, ranked in order with their associated surgical procedures, were found to be the most commonly injured: (1) intercostobrachial nerve in axillary lymph node dissections and transaxillary breast augmentations, (2) vestibulocochlear nerve in cerebellopontine tumor resections and vestibular schwannoma removals, (3) facial nerve in surgeries of the inner ear and cheek region, (4) long thoracic nerve in axillary lymph node dissections, (5) spinal accessory nerve in surgeries of the posterior triangle of the neck and cervical lymph node biopsies, (6) recurrent laryngeal nerve in thyroid surgeries, (7) genitofemoral nerve in inguinal hernia and varicocele surgeries, (8) sciatic nerve in acetabular fracture repairs and osteotomies, (9) median nerve in carpal tunnel release surgeries, (10) common fibular nerve in varicose vein and short saphenous vein surgeries, and (11) ulnar nerve in supracondylar fracture surgeries...
October 14, 2020: Clinical Anatomy
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