keyword
https://read.qxmd.com/read/38474563/optimized-conditions-for-the-extraction-of-phenolic-compounds-from-aeginetia-indica-l-and-its-potential-biological-applications
#21
JOURNAL ARTICLE
Nattira On-Nom, Sirinapa Thangsiri, Woorawee Inthachat, Piya Temviriyanukul, Yuraporn Sahasakul, Amornrat Aursalung, Chaowanee Chupeerach, Uthaiwan Suttisansanee
Aeginetia indica L., a parasitic root in the Orobanchaceae family, is used as a food colorant in traditional Thai desserts. However, scant information is available on its food applications as well as medicinal properties, while overharvesting by the local people has severely depleted wild plant populations. This research, thus, aimed to extract optimized total phenolic content (TPC) in varying extraction conditions using response surface methodology (RSM) and the Box-Behnken design (BBD). Results indicated that an extraction temperature of 90 °C, 80% ( v / v ) aqueous ethanol, and 0...
February 28, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/38472781/variation-in-flavonoid-compounds-volatiles-and-yield-related-traits-in-different-iranian-rosa-damascena-mill-cultivars-based-on-spme-arrow-and-lc-ms-ms
#22
JOURNAL ARTICLE
Safoora Behnamnia, Mehdi Rahimmalek, Maryam Haghighi, Ali Nikbakht, Shima Gharibi, Natalia Pachura, Antoni Szumny, Jacek Łyczko
Damask rose ( Rosa damascena Mill.) is an aromatic industrial plant with different applications. Selection of cultivars with high-value metabolites such as flavonoids-with acceptable yields-can lead to elite cultivars for mass propagation in various industries. A field experiment was carried out in a randomized complete block design (RCBD) to evaluate metabolites and some yield-related morphological data. In the present investigation, for the first time 13 flavonoid components of nine Iranian damask rose cultivars were compared using LC-MS/MS...
February 22, 2024: Foods (Basel, Switzerland)
https://read.qxmd.com/read/38468401/constructing-protein-scaffolded-multienzyme-assembly-enhances-the-coupling-efficiency-of-the-p450-system-for-efficient-daidzein-biosynthesis-from-2-s-naringenin
#23
JOURNAL ARTICLE
Zhe Wang, Yiqiang Dai, Fidelis Azi, Zhongjiang Wang, Weimin Xu, Daoying Wang, Mingsheng Dong, Xiudong Xia
Daidzein is a major isoflavone compound with an immense pharmaceutical value. This study applied a novel P450 CYP82D26 which can biosynthesize daidzein from (2 S )-naringenin. However, the recombinant P450 systems often suffer from low coupling efficiency, leading to an electron transfer efficiency decrease and harmful reactive oxygen species release, thereby compromising their stability and catalytic efficiency. To address these challenges, the SH3-GBD-PDZ (SGP) protein scaffold was applied to assemble a multienzyme system comprising CYP82D26, P450 reductase, and NADP+ -dependent aldehyde reductase in desired stoichiometric ratios...
March 11, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38460905/naringenin-nanoparticles-targeting-cyclin-b1-suppress-the-progression-of-rheumatoid-arthritis-associated-lung-cancer-by-inhibiting-fibroblast-to-myofibroblast-transition
#24
JOURNAL ARTICLE
Xilong Wang, Xiaoyu Zhang, Zhipu Liu, Na Zhao, Xiaohan Li, Peng Su, Guixi Zheng, Xin Zhang, Hongxing Wang, Yi Zhang
There is growing evidence of an elevated risk of lung cancer in patients with rheumatoid arthritis. The poor prognosis of rheumatoid arthritis-associated lung cancer and the lack of therapeutic options pose an even greater challenge to the clinical management of patients. This study aimed to identify potential molecular targets associated with the progression of rheumatoid arthritis-associated lung cancer and examine the efficacy of naringenin nanoparticles targeting cyclin B1. Mendelian randomizatio analysis revealed that rheumatoid arthritis has a positive correlation with the risk of lung cancer...
March 7, 2024: International Journal of Biochemistry & Cell Biology
https://read.qxmd.com/read/38457573/network-pharmacological-analysis-on-the-mechanism-of-linggui-zhugan-decoction-for-nonalcoholic-fatty-liver-disease
#25
JOURNAL ARTICLE
Songlin Gao, Liuting Wei, Yan Qin, Peng Zhang, Tingwei Quan, Fei Liang, Guihua Huang
Nonalcoholic fatty liver disease (NAFLD), represents a chronic progressive disease that imposes a significant burden on patients and the healthcare system. Linggui Zhugan decoction (LGZGD) plays a substantial role in treating NAFLD, but its exact molecular mechanism is unknown. Using network pharmacology, this study aimed to investigate the mechanism of action of LGZGD in treating NAFLD. Active ingredients and targets were identified through the integration of data from the TCMSP, GEO, GeneCards, and OMIM databases...
March 8, 2024: Medicine (Baltimore)
https://read.qxmd.com/read/38447910/leveraging-a-y-lipolytica-naringenin-chassis-for-biosynthesis-of-apigenin-and-associated-glucoside
#26
JOURNAL ARTICLE
Celeste B Marsan, Sung Gyung Lee, Ankim Nguyen, Angela R Gordillo Sierra, Sarah M Coleman, Sierra M Brooks, Hal S Alper
Flavonoids are a diverse set of natural products with promising bioactivities including anti-inflammatory, anti-cancer, and neuroprotective properties. Previously, the oleaginous host Yarrowia lipolytica has been engineered to produce high titers of the base flavonoid naringenin. Here, we leverage this host along with a set of E. coli bioconversion strains to produce the flavone apigenin and its glycosylated derivative isovitexin, two potential nutraceutical and pharmaceutical candidates. Through downstream strain selection, co-culture optimization, media composition, and mutant isolation, we were able to produce168 mg/L of apigenin, representing a 46% conversion rate of 2-(R/S)-naringenin to apigenin...
March 4, 2024: Metabolic Engineering
https://read.qxmd.com/read/38446401/mycorrhiza-induced-resistance-in-citrus-against-tetranychus-urticae-is-plant-species-dependent-and-inversely-correlated-to-basal-immunity
#27
JOURNAL ARTICLE
María Manresa-Grao, Victoria Pastor, Paloma Sánchez-Bel, Ana Cruz, Miguel Cerezo, Josep A Jaques, Víctor Flors
BACKGROUND: Mycorrhizal plants show enhanced resistance to biotic stresses, but few studies address mycorrhiza-induced resistance (MIR) against biotic challenges in woody plants and particularly in citrus. Here we present a comparative study of two citrus species, Citrus aurantium, which is resistant, and Citrus reshni, which is highly susceptible to Tetranychus urticae. Although both mycorrhizal species are protected in locally infested leaves, they show very distinct responses to MIR...
March 6, 2024: Pest Management Science
https://read.qxmd.com/read/38445305/enantiomeric-separation-of-thiourea-derivatives-of-naringenin-on-amylose-and-cellulose-polymeric-chromatographic-chiral-columns
#28
JOURNAL ARTICLE
Imran Ali, Rekia Nabti, Nasser Belboukhari, Khaled Sekkoum, Mohammed El Amin Zaid, Khairedine Kraim, Zeid A ALOthman, Marcello Locatelli, Ersin Demir
Due to a great demand for amylose and cellulose polymeric chromatographic chiral columns, the enantiomeric separation of thiourea derivatives of naringenin was achieved on the different amylose (Chiralpak-IB) and cellulose chiral (Chiralcel-OJ and Chiralcel-OD-3R) columns with varied chromatographic conditions. The isocratic mobile phases used were ethanol and methanol, where ethanol/hexane and methanol/hexane were used as gradient mode and were prepared in volume/volume relation. The separation and resolution factors for all the enantiomers were in the range of 1...
March 2024: Chirality
https://read.qxmd.com/read/38441872/systematic-engineering-of-genistein-biosynthetic-pathway-through-genetic-regulators-and-combinatorial-enzyme-screening
#29
JOURNAL ARTICLE
Yunhee Hwang, Hyun Gyu Hwang, Ji Yeon Lee, Gyoo Yeol Jung
Microbial production of genistein, an isoflavonoid primarily found in soybeans, is gaining prominence in the food industry due to its significant nutritional and health benefits. However, challenges arise in redesigning strains due to intricate regulatory nodes between cell growth and genistein production and in systematically exploring core enzymes involving genistein biosynthesis. To address this, this study devised a strategy that simultaneously and precisely rewires flux at both acetyl-CoA and malonyl-CoA nodes toward genistein synthesis...
March 5, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38438083/optimization-of-naringenin-loaded-nanoparticles-for-targeting-of-vanin-1-inos-and-mcp-1-signaling-pathway-in-hfd-induced-obesity
#30
JOURNAL ARTICLE
Ahmed Salah, Nada Mohammed El-Laban, Seikh Mafiz Alam, Mohammad Shahidul Islam, Mohammed Abdalla Hussein, Tamer Roshdy
Naringenin, a natural dihydrochalcone flavonoid, exhibits diverse pharmacological properties. This study investigates the hypolipidemic effects of Nar-NPs on obese mice. The characteristics of Nar-NPs, including morphology, particle size, zeta potential, UV-vis, and FT-IR spectra, were examined. The anti-obesity properties of Nar-NPs were evaluated in obese rats, considering LD50 , 1/20 LD50 , and 1/50 LD50 for treatment preparation. Results indicated that synthesized Nar-NPs were uniform, spherical, and well-dispersed, with a size of 130...
March 2, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38437940/potato-starch-naringenin-complexes-for-high-stability-pickering-emulsions-structure-properties-and-emulsion-stabilization-mechanism
#31
JOURNAL ARTICLE
Hong Feng, Ting Li, Lian Zhou, Lei Chen, Qingyun Lyu, Gang Liu, Xuedong Wang, Xi Chen
In this study, potato starch (PS)/naringenin (NAR) complex was prepared, and its properties and emulsification behavior were evaluated. The experimental results demonstrated that NAR successfully formed a complex with PS molecules through hydrogen bonds and other non-covalent interactions. The emulsifying capacity (ROV) of PS/NAR complex with 16 % composite ratio was 0.9999, which was higher than PS (ROV = 0.3329) (p < 0.05). Based on particle property analysis and molecular dynamics simulation, the mechanism of improving the emulsification performance might be the action of the benzene ring of NAR and intermolecular hydrogen bonding...
March 2, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38431829/network-pharmacology-analysis-and-clinical-efficacy-of-the-traditional-chinese-medicine-bu-shen-jian-pi-part%C3%A2-2-modulation-of-hypoxia-redox-status-and-mitochondrial-protection-in%C3%A2-a-neuroblastoma-cell-line-sh-sy5y
#32
JOURNAL ARTICLE
Wenli Yuan, Jiacheng Lin, Jun Wang, Chenghui Wang, Yuetong Shan, Wei Jing, Zhimin Fei, Weidong Pan
OBJECTIVE: To examine the mitochondrial protective effects of icariin, naringenin, kaempferol, and formononetin, potentially active agents in Bu-Shen-Jian-Pi formula (BSJP) identified using network pharmacology analysis. MATERIALS AND METHODS: Mitochondrial protection activity was determined using a hypoxia-reoxygenation in vitro model based on the neuroblastoma cell line SH-SY5Y and measurements of anti-ferroptotic activity. RESULTS: Icariin, naringenin, kaempferol, and formononetin showed mitochondrial protective activity involving diverse signaling pathways...
March 3, 2024: International Journal of Clinical Pharmacology and Therapeutics
https://read.qxmd.com/read/38430431/biofortified-rice-provides-rich-sakuranetin-in-endosperm
#33
JOURNAL ARTICLE
Yao Zhao, Jitao Hu, Zhongjing Zhou, Linying Li, Xueying Zhang, Yuqing He, Chi Zhang, Junmin Wang, Gaojie Hong
Sakuranetin plays a key role as a phytoalexin in plant resistance to biotic and abiotic stresses, and possesses diverse health-promoting benefits. However, mature rice seeds do not contain detectable levels of sakuranetin. In the present study, a transgenic rice plant was developed in which the promoter of an endosperm-specific glutelin gene OsGluD-1 drives the expression of a specific enzyme naringenin 7-O-methyltransferase (NOMT) for sakuranetin biosynthesis. The presence of naringenin, which serves as the biosynthetic precursor of sakuranetin made this modification feasible in theory...
March 2, 2024: Rice
https://read.qxmd.com/read/38428770/the-protective-effects-of-naringenin-a-citrus-flavonoid-non-complexed-or-complexed-with-hydroxypropyl-%C3%AE-cyclodextrin-against-multiorgan-damage-caused-by-neonatal-endotoxemia
#34
JOURNAL ARTICLE
Luana Heimfarth, Katielen Silvana Dos Santos, Brenda Souza Monteiro, Anne Karoline de Souza Oliveira, Henrique Douglas M Coutinho, Irwin R A Menezes, Marcio Roberto Viana Dos Santos, Adriano Antunes de Souza Araújo, Laurent Picot, Raimundo Gonçalves de Oliveira Júnior, Raphaël Grougnet, Jullyana de Souza Siqueira Quintans, Lucindo José Quintans-Júnior
BACKGROUND: Endotoxemia is a severe and dangerous clinical syndrome that results in elevated morbidity, especially in intensive care units. Neonates are particularly susceptible to endotoxemia due to their immature immune systems. There are few effective treatments for neonatal endotoxemia. One group of compounds with potential in the treatment of neonatal inflammatory diseases such as endotoxemia is the flavonoids, mainly due to their antioxidant and anti-inflammatory properties. Among these, naringenin (NGN) is a citrus flavonoid which has already been reported to have anti-inflammatory, antioxidant, anti-nociceptive and anti-cancer effects...
February 28, 2024: International Journal of Biological Macromolecules
https://read.qxmd.com/read/38428659/exploring-the-mechanism-of-erteng-sanjie-capsule-in-treating-gastric-and-colorectal-cancers-via-network-pharmacology-and-in-vivo-validation
#35
JOURNAL ARTICLE
Wencui Zhang, Ying Wang, Han Yu, Zengcai Jin, Yuyao Yuan, Likun Liu, Jing Zhou
ETHNOPHARMACOLOGICAL RELEVANCE: The Erteng-Sanjie capsule (ETSJC) has therapeutic effects against gastric cancer (GC) and colorectal cancer (CRC). However, its underlying pharmacological mechanism remains unclear. AIM OF THE STUDY: To explore the pharmacological mechanism of ETSJC against GC and CRC via network pharmacology and in-vivo validation. MATERIALS AND METHODS: Data on the ingredients of ETSJC were obtained from the TCMSP and HERB databases...
February 28, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38423648/naringenin-induces-cellular-apoptosis-in-melanoma-cells-via-intracellular-ros-generation
#36
JOURNAL ARTICLE
Pincha Devage Sameera Madushan Fernando, Ao Xuan Zhen, Mei Jing Piao, Herath Mudiyanselage Udari Lakmini Herath, Kyoung Ah Kang, Sang-Pil Yoon, Hye-Jin Boo, Chang Lim Hyun, Jin Won Hyun
BACKGROUND/AIM: Melanoma is a prevalent malignant tumor that arises from melanocytes. The treatment of malignant melanoma has become challenging due to the development of drug resistance. It is, therefore, imperative to identify novel therapeutic drug candidates for controlling malignant melanoma. Naringenin is a flavonoid abundant in oranges and other citrus fruits and recognized for its numerous medicinal benefits. The objective of the study was to assess the anti-carcinogenic potential of naringenin by evaluating its ability to regulate the cellular production of reactive oxygen species (ROS) and its effect on mitochondrial function and apoptosis in melanoma cells...
March 2024: Anticancer Research
https://read.qxmd.com/read/38423240/naringenin-reduces-oxidative-stress-and-necroptosis-apoptosis-and-pyroptosis-in-random-pattern-skin-flaps-by-enhancing-autophagy
#37
JOURNAL ARTICLE
Shuai Jiang, Feixia Ma, Junsheng Lou, Jiafeng Li, Xiushuai Shang, Yifan Li, Junsong Wu, Sanzhong Xu
BACKGROUND: Random skin flap grafting is one of the most commonly used techniques in plastic and orthopedic surgery. However, necrosis resulting from ischemia and ischemia-reperfusion injury in the distal part of the flap can severely limit the clinical application of the flap. Studies have revealed that naringenin reduces pyroptosis, apoptosis, and necroptosis, inhibits oxidative stress, and promotes autophagy. In this study, the effects of Naringenin on flap viability and its underlying mechanism were evaluated...
February 27, 2024: European Journal of Pharmacology
https://read.qxmd.com/read/38421706/study-of-therapeutic-mechanisms-of-bupi-yichang-formula-against-colon-cancer-based-on-network-pharmacology-machine-learning-and-experimental-verification
#38
JOURNAL ARTICLE
Juan Du
Bupi Yichang formula (BPYCF) has shown the anti-cancer potential; however, its effects on colon cancer and the mechanisms remain unknown. This study intended to explore the effects of BPYC on colon cancer and its underlying mechanisms. BPYCF-related and colon cancer-related targets were acquired from public databases, followed by differentially expressed genes (DEG) identification. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed using clusterProfiler. A protein-protein interaction (PPI) network was constructed using STRING database...
2024: Critical Reviews in Immunology
https://read.qxmd.com/read/38413989/targeting-of-mitochondrial-fission-through-natural-flavanones-elicits-anti-myeloma-activity
#39
JOURNAL ARTICLE
Roberta Torcasio, Maria Eugenia Gallo Cantafio, Claudia Veneziano, Carmela De Marco, Ludovica Ganino, Ilenia Valentino, Maria Antonietta Occhiuzzi, Ida Daniela Perrotta, Teresa Mancuso, Filomena Conforti, Bruno Rizzuti, Enrica Antonia Martino, Massimo Gentile, Antonino Neri, Giuseppe Viglietto, Fedora Grande, Nicola Amodio
BACKGROUND: Mitochondrial alterations, often dependent on unbalanced mitochondrial dynamics, feature in the pathobiology of human cancers, including multiple myeloma (MM). Flavanones are natural flavonoids endowed with mitochondrial targeting activities. Herein, we investigated the capability of Hesperetin (Hes) and Naringenin (Nar), two aglycones of Hesperidin and Naringin flavanone glycosides, to selectively target Drp1, a pivotal regulator of mitochondrial dynamics, prompting anti-MM activity...
February 27, 2024: Journal of Translational Medicine
https://read.qxmd.com/read/38412792/screening-and-evaluation-of-quality-markers-of-radix-cudramiae-for-liver-disease-based-on-an-integrated-strategy-of-in-vivo-pharmacokinetics-and-in-vitro-hplc-fingerprint
#40
JOURNAL ARTICLE
Qing Liu, Luyao Liu, Lintong Xie, Linyu Zheng, Qianwei Xu, Weidong Li, Xiao Liu
Radix Cudramiae, the dried root of Cudrania cochinchinensis (Lour.) Kudo et Masam., is a valuable ethnomedicine with outstanding antihepatitis activity. However, the lack of reports on quality markers (Q-markers) hindered its quality evaluation and standardization, as a result restricted its clinical application. This paper aimed to discover the Q-markers of Radix Cudramiae with a comprehensive strategy based on in vivo pharmacokinetics and in vitro HPLC fingerprint. A rapid and sensitive ultra-high performance liquid chromatography-mass spectrometry (UHPLC-MS/MS) analytical method was firstly developed and validated for simultaneous determination of six potential active ingredients (eriodictyol, dihydrokaempferol, dihydromorin, kaempferol, naringenin and morin) of Radix Cudramiae in rat plasma and tissues, which was successfully applied to the holistic comparison of pharmacokinetics and tissue distribution between normal and acute liver injury rats...
February 17, 2024: Journal of Pharmaceutical and Biomedical Analysis
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