keyword
https://read.qxmd.com/read/38533335/integrating-transcriptomics-and-metabolomics-to-analyze-the-defense-response-of-morus-notabilis-to-mulberry-ring-rot-disease
#1
JOURNAL ARTICLE
Qianqian Qian, Xinqi Deng, Sumbul Mureed, Yujie Gan, Danping Xu, Xie Wang, Habib Ali
INTRODUCTION: The mulberry industry has thrived in China for millennia, offering significant ecological and economic benefits. However, the prevalence of mulberry ring rot disease poses a serious threat to the quality and yield of mulberry leaves. METHODS: In this study, we employed a combination of transcriptomic and metabolomic analyses to elucidate the changes occurring at the transcriptional and metabolic levels in Morus notabilis in response to this disease infestation...
2024: Frontiers in Microbiology
https://read.qxmd.com/read/38530768/a-targeted-and-an-untargeted-metabolomics-approach-to-study-the-phytochemicals-of-tomato-cultivars-grown-under-different-salinity-conditions
#2
JOURNAL ARTICLE
Fakir Shahidullah Tareq, Jashbir Singh, Jorge F S Ferreira, Devinder Sandhu, Donald L Suarez, Devanand L Luthria
In this study, we evaluated the effect of increasing the salinity of irrigation water on the metabolic content and profiles of two tomato cultivars ('Jaune Flamme' (JF) and 'Red Pear' (RP)) using targeted and untargeted metabolomics approaches. Irrigation of tomato plants was performed with four different salt concentrations provided by chloride (treatment 1) and sulfate (treatment 2) salts. Targeted analysis of the methanolic extract resulted in the identification of nine major polyphenols. Among them, chlorogenic acid, rutin, and naringenin were the prominent compounds in both cultivars...
March 26, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38516841/naringenin-inhibits-acid-sphingomyelinase-mediated-membrane-raft-clustering-to-reduce-nadph-oxidase-activation-and-vascular-inflammation
#3
JOURNAL ARTICLE
Meng Ding, Yuan Zhu, Xiaoting Xu, Hui He, Tianyu Jiang, Xiaochuan Mo, Zhuting Wang, Wenfeng Yu, Hailong Ou
Macrophage inflammation and oxidative stress promote atherosclerosis progression. Naringenin is a naturally occurring flavonoid with antiatherosclerotic properties. Here, we elucidated the effects of naringenin on monocyte/macrophage endothelial infiltration and vascular inflammation. We found naringenin inhibited oxidized low-density lipoprotein (oxLDL)-induced pro-inflammatory cytokines such as IL-1β, IL-6, and TNF-α toward an M2 macrophage phenotype and inhibited oxLDL-induced TLR4 (Toll-like receptor 4) membrane translocation and downstream NF-κB transcriptional activity...
March 22, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38516657/-dictyophora-indusiata-and-bacillus-aryabhattai-improve-sugarcane-yield-by-endogenously-associating-with-the-root-and-regulating-flavonoid-metabolism
#4
JOURNAL ARTICLE
Mingzheng Duan, Xiang Li, Xiaojian Wu, Shengfeng Long, Hairong Huang, Yijie Li, Qi-Huai Liu, Guanghu Zhu, Bin Feng, Sunqian Qin, Changning Li, Hai Yang, Jie Qin, Zhendong Chen, Zeping Wang
INTRODUCTION: Endophytes play a significant role in regulating plant root development and facilitating nutrient solubilization and transportation. This association could improve plant growth. The present study has uncovered a distinct phenotype, which we refer to as "white root", arising from the intricate interactions between endophytic fungi and bacteria with the roots in a sugarcane and bamboo fungus ( Dictyophora indusiata ) intercropping system. METHODS: We investigated the mechanisms underlying the formation of this "white root" phenotype and its impact on sugarcane yield and metabolism by metabarcoding and metabolome analysis...
2024: Frontiers in Plant Science
https://read.qxmd.com/read/38511857/cloning-expression-and-functional-characterization-of-two-highly-efficient-flavonoid-di-o-glycosyltransferases-zmugt84a1-and-zmugt84a2-from-maize-zea-mays-l
#5
JOURNAL ARTICLE
Xiaorong Sun, Zhao Ke, Dengyu Zheng, Meng She, Zhongyi Wu, Qing X Li, Zhongbao Zhang
The maize ( Zea mays L.) glycosyltransferase family 1 comprises many uridine diphosphate glycosyltransferase (UGT) members. However, UGT activities and biochemical functions have seldom been revealed. In this study, the genes of two flavonoid di- O -glycosyltransferases ZmUGT84A1 and ZmUGT84A2 were cloned from maize plant and expressed in Escherichia coli . Phylogenetic analysis showed that the two enzymes were homologous to AtUGT84A1 and AtUGT84A3. The two recombinant enzymes showed a high conversion rate of luteolin to its glucosides, mainly 4',7-di- O -glucoside and minorly 3',7-di- O -glucoside in two-step glycosylation reactions in vitro ...
March 21, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38509491/integrated-transcriptomic-and-metabolomic-analyses-reveals-anthocyanin-biosynthesis-in-leaf-coloration-of-quinoa-chenopodium-quinoa-willd
#6
JOURNAL ARTICLE
Min Zhang, Yueyou Li, Junling Wang, Shaopu Shang, Hongxia Wang, Xinlei Yang, Chuan Lu, Mei Wang, Xinbo Sun, Xiaoqing Liu, Xiaoxia Wang, Boxiang Wei, Wei Lv, Guojun Mu
BACKGROUND: Quinoa leaves demonstrate a diverse array of colors, offering a potential enhancement to landscape aesthetics and the development of leisure-oriented sightseeing agriculture in semi-arid regions. This study utilized integrated transcriptomic and metabolomic analyses to investigate the mechanisms underlying anthocyanin synthesis in both emerald green and pink quinoa leaves. RESULTS: Integrated transcriptomic and metabolomic analyses indicated that both flavonoid biosynthesis pathway (ko00941) and anthocyanin biosynthesis pathway (ko00942) were significantly associated with anthocyanin biosynthesis...
March 20, 2024: BMC Plant Biology
https://read.qxmd.com/read/38504297/crataegus-pentagyna-willd-fruits-leaves-and-roots-phytochemicals-antioxidant-and-antimicrobial-potentials
#7
JOURNAL ARTICLE
Akram Taleghani, Samira Eghbali, Roya Moghimi, Majid Mokaber-Esfahani
BACKGROUND: The hawthorn has recently been used as a popular herbal medicine in food applications and phytotherapy, especially for the cardiovascular system. METHODS: In this study, phytochemicals were evaluated by LC-ESI-MS, GC-MS, and biological activity, including antioxidant (DPPH test) and antibacterial (broth dilution assay), in different extracts of Crataegus pentagyna fruit, leaf, and root. RESULTS: Globally, 49 phenolics were tentatively identified using HPLC-ESI-MS/MS in the hydro-methanolic extract of the fruit (major apigenin, caffeoylquinic acid derivative, and 4-O-(3'-O-glucopyranosyl)-caffeoyl quinic acid), 42 in the leaf (major salicylic acid, naringenin-6-C-glucoside, and naringin), and 33 in the root (major naringenin-7-O-neohesperidoside, isovitexin-2″-O-rhamnoside, and 4-O-(3'-O-glucopyranosyl)-caffeoyl quinic acid)...
March 19, 2024: BMC complementary medicine and therapies
https://read.qxmd.com/read/38504208/developing-liver-targeted-naringenin-nanoparticles-for-breast-cancer-endocrine-therapy-by-promoting-estrogen-metabolism
#8
JOURNAL ARTICLE
Yuying Zhao, Hanxu Tan, Juping Zhang, Dandan Zhan, Bowen Yang, Shicui Hong, Bo Pan, Neng Wang, Tongkai Chen, Yafei Shi, Zhiyu Wang
Endocrine therapy is standard for hormone receptor-positive (HR+ ) breast cancer treatment. However, current strategies targeting estrogen signaling pay little attention to estradiol metabolism in the liver and is usually challenged by treatment failure. In a previous study, we demonstrated that the natural compound naringenin (NAR) inhibited HR+ breast cancer growth by activating estrogen sulfotransferase (EST) expression in the liver. Nevertheless, the poor water solubility, low bio-barrier permeability, and non-specific distribution limited its clinical application, particularly for oral administration...
March 19, 2024: Journal of Nanobiotechnology
https://read.qxmd.com/read/38504151/chromosome-level-genome-assembly-provides-insights-into-the-genome-evolution-and-functional-importance-of-the-phenylpropanoid-flavonoid-pathway-in-thymus-mongolicus
#9
JOURNAL ARTICLE
Zhenhua Dang, Ying Xu, Xin Zhang, Wentao Mi, Yuan Chi, Yunyun Tian, Yaling Liu, Weibo Ren
BACKGROUND: Thymus mongolicus (family Lamiaceae) is a Thyme subshrub with strong aroma and remarkable environmental adaptability. Limited genomic information limits the use of this plant. RESULTS: Chromosome-level 605.2 Mb genome of T. mongolicus was generated, with 96.28% anchored to 12 pseudochromosomes. The repetitive sequences were dominant, accounting for 70.98%, and 32,593 protein-coding genes were predicted. Synteny analysis revealed that Lamiaceae species generally underwent two rounds of whole genome duplication; moreover, species-specific genome duplication was identified...
March 19, 2024: BMC Genomics
https://read.qxmd.com/read/38498946/naringenin-roled-octacalcium-phosphate-reinforced-with-polyvinyl-alcohol-composite-for-sarcoma-affected-bone-repair
#10
JOURNAL ARTICLE
Qiang Lin, Xuzheng Wang, Bin Jia, Minghua Bai, Kunzheng Wang
Osteosarcoma is a rare cancer affecting disease for children and young adults; complete healing from this condition is quite difficult. Recently, new regeneration materials have been preferred, including natural compound companied implants for affected bone repair, and it is effectively used to treat osteosarcoma disease. Hence, Octa calcium phosphate (OCP) reinforced with poly (vinyl alcohol) (PVA) and oleic acid (OA) with Naringenin (NRG) composite was prepared and studied to cure the sarcoma affected bone...
March 18, 2024: Biomedical Materials
https://read.qxmd.com/read/38496846/flavonoids-a-treasure-house-of-prospective-pharmacological-potentials
#11
REVIEW
Hasin Hasnat, Suriya Akter Shompa, Md Mirazul Islam, Safaet Alam, Fahmida Tasnim Richi, Nazim Uddin Emon, Sania Ashrafi, Nazim Uddin Ahmed, Md Nafees Rahman Chowdhury, Nour Fatema, Md Sakhawat Hossain, Avoy Ghosh, Firoj Ahmed
Flavonoids are organic compounds characterized by a range of phenolic structures, which are abundantly present in various natural sources such as fruits, vegetables, cereals, bark, roots, stems, flowers, tea, and wine. The health advantages of these natural substances are renowned, and initiatives are being taken to extract the flavonoids. Apigenin, galangin, hesperetin, kaempferol, myricetin, naringenin, and quercetin are the seven most common compounds belonging to this class. A thorough analysis of bibliographic records from reliable sources including Google Scholar, Web of Science, PubMed, ScienceDirect, MEDLINE, and others was done to learn more about the biological activities of these flavonoids...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38494263/characterization-of-phenylalanine-ammonia-lyase-and-revealing-flavonoid-biosynthesis-in-gymnema-sylvestre-r-br-through-transcriptomic-approach
#12
JOURNAL ARTICLE
Kuldeepsingh A Kalariya, Ravina R Mevada, Manish Das
BACKGROUND: Gymnema sylvestre R.Br. is famous medicinal plant among diabetics for its gymnemic acid content. It also contains flavonoids, which are an essential component in various other products. Though some molecular information on the biosynthesis of gymnemic acid, polyoxypregnane, micro RNAs and photosynthetic efficiency is available, there is no gene level information available on the biosynthesis of flavonoids in this plant. RNA was extracted from winter-collected Gymnema sylvestre leaves and cDNA libraries were prepared and used for next generation sequencing...
March 2024: Journal, Genetic Engineering & Biotechnology
https://read.qxmd.com/read/38488414/multi-omics-analysis-reveals-the-biosynthesis-of-flavonoids-during-the-browning-process-of-malus-sieversii-explants
#13
JOURNAL ARTICLE
Chen Yang, Nan Sun, Xin Qin, Yangbo Liu, Mengyi Sui, Yawen Zhang, Yanli Hu, Zhiquan Mao, Xuesen Chen, Yunfei Mao, Xiang Shen
Malus sieversii is a precious apple germplasm resource. Browning of explants is one of the most important factors limiting the survival rate of plant tissue culture. In order to explore the molecular mechanism of the browning degree of different strains of Malus sieversii, we compared the dynamic changes of Malus sieversii and Malus robusta Rehd. during the whole browning process using a multi-group method. A total of 44 048 differentially expressed genes (DEGs) were identified by transcriptome analysis on the DNBSEQ-T7 sequencing platform...
2024: Physiologia Plantarum
https://read.qxmd.com/read/38486466/integrated-network-pharmacology-molecular-docking-and-lipidomics-to-reveal-the-regulatory-effect-of-qingxuan-zhike-granules-on-lipid-metabolism-in-lipopolysaccharide-induced-acute-lung-injury
#14
JOURNAL ARTICLE
Hui Chen, Jiabin Chen, Lu Feng, Hua Shao, Yang Zhou, Jinjun Shan, Lili Lin, Jin Ye, Shouchuan Wang
Qingxuan Zhike granules (QXZKG), a traditional Chinese patent medication, has shown therapeutic potential against acute lung injury (ALI). However, the precise mechanism underlying its lung-protective effects requires further investigation. In this study, integrated network pharmacology, molecular docking, and lipidomics were used to elucidate QXZKG's regulatory effect on lipid metabolism in lipopolysaccharide-induced ALI. Animal experiments were conducted to substantiate the efficacy of QXZKG in reducing pro-inflammatory cytokines and mitigating pulmonary pathology...
March 14, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38486344/a-novel-strategy-for-the-quality-control-of-carbonized-typhae-pollen-using-colorimeter-liquid-chromatography-mass-spectrometry-and-efficacy-evaluation-coupled-with-multivariate-statistical-analysis
#15
JOURNAL ARTICLE
Li Jiaqi, Tang Min, Zhong Yongqi, Li Xiaolong, Ge Yuewei, Wang Shumei, Liang Shengwang, Meng Jiang, Sun Fei
In this study, a novel quality control strategy was proposed, aiming to establish a multivariate specification for the processing step by exploring the correlation between colors, chemical components, and hemostatic effects of the carbonized Typhae pollen (CTP) using multivariate statistical analysis. The CTP samples were stir-fried at different durations. Afterward, the colorimeter and LC-MS techniques were applied to characterize the CTP samples, followed by the determination of bleeding time and clotting time using mice to evaluate their hemostatic effect...
March 14, 2024: Biomedical Chromatography: BMC
https://read.qxmd.com/read/38485674/genome-assembly-and-multi-omic-analyses-reveal-the-mechanisms-underlying-flower-color-formation-in-torenia-fournieri
#16
JOURNAL ARTICLE
Jiaxing Song, Haiming Kong, Jing Yang, Jiaxian Jing, Siyu Li, Nan Ma, Rongchen Yang, Yuman Cao, Yafang Wang, Tianming Hu, Peizhi Yang
Torenia fournieri Lind. is an ornamental plant that is popular for its numerous flowers and variety of colors. However, its genomic evolutionary history and the genetic and metabolic bases of flower color formation remain poorly understood. Here, we report the first T. fournieri reference genome, which was resolved to the chromosome scale and was 164.4 Mb in size. Phylogenetic analyses clarified relationships with other plant species, and a comparative genomic analysis indicated that the shared ancestor of T...
March 14, 2024: Plant Genome
https://read.qxmd.com/read/38484542/a-sustainable-and-efficient-strategy-for-bioconverting-naringin-to-l-rhamnose-2r-naringenin-and-kaempferol
#17
JOURNAL ARTICLE
Mengfan Lu, Simin Liu, Jiamei Liu, Linguo Zhao, Jianjun Pei
The development of a sustainable and efficient bioconversion strategy is crucial for the full-component utilization of naringin. In this study, an engineering Pichia pastoris co-culture system was developed to produce L-rhamnose and 2S/2R-naringenin. By optimizing transformation conditions, the co-culture system could completely convert naringin while fully consuming glucose. The production of 2S/2R-naringenin reached 59.5 mM with a molar conversion of 99.2%, and L-rhamnose reached 59.1 mM with a molar conversion of 98...
March 9, 2024: Food Chemistry
https://read.qxmd.com/read/38481937/hypermethylation-in-the-promoter-regions-of-flavonoid-pathway-genes-is-associated-with-skin-color-fading-during-daihong-apple-fruit-development
#18
JOURNAL ARTICLE
Jihua Xu, Lan Xiong, Jia-Long Yao, Peilei Zhao, Shenghui Jiang, Xiaohong Sun, Chaohua Dong, Hongyuan Jiang, Xinyue Xu, Yugang Zhang
Apple fruit skin color fading is not well understood although the molecular mechanism of skin color formation is well known. The red-fleshed apple cultivar 'Daihong' (DH) exhibited fading skin color during fruit development despite having a heterozygous R6 allele but lacking Red-TE for red fruit skin. In this study, transcriptomic analysis revealed the expression level of MdMYB10 increased with fruit development whereas reduced expression levels of MdMYBPA1 , MdCHS , MdANS , MdUFGT , MdLAR , and MdANR were observed, consistent with decreased levels of chalcone, anthocyanin, catechin, epicatechin, and procyanidin B2...
March 2024: Horticulture Research
https://read.qxmd.com/read/38479200/metabolism-of-phenolic-compounds-catalyzed-by-tomato-cyp736a61
#19
JOURNAL ARTICLE
Thanh Dat Mai, Hyun Min Kim, Seo Young Park, Sang Hoon Ma, Ju Hui Do, Won Choi, Hye Min Jang, Hyeon Bae Hwang, Eun Gyeong Song, Jae Sung Shim, Young Hee Joung
Cytochrome P450s (CYPs) regulate plant growth and stress responses by producing diverse primary and secondary metabolites. However, the function of many plant CYPs remains unknown because, despite their structural similarity, predicting the enzymatic activity of CYPs is difficult. In this study, one member of the CYP736A subfamily (CYP736A61) from tomatoes was isolated and characterized its enzymatic functions. CYP736A61 was successfully expressed in Escherichia coli through co-expression with molecular chaperones...
March 7, 2024: Enzyme and Microbial Technology
https://read.qxmd.com/read/38474645/pulp-or-peel-comparative-analysis-of-the-phytochemical-content-and-selected-cosmetic-related-properties-of-annona-cherimola-l-diospyros-kaki-thumb-cydonia-oblonga-mill-and-fortunella-margarita-swingle-pulp-and-peel-extracts
#20
JOURNAL ARTICLE
Magdalena Lasota, Paulina Lechwar, Wirginia Kukula-Koch, Marcin Czop, Karolina Czech, Katarzyna Gaweł-Bęben
Fruit peels might be a valuable source of active ingredients for cosmetics, leading to more sustainable usage of plant by-products. The aim of the study was to evaluate the phytochemical content and selected biological properties of hydroglycolic extracts from peels and pulps of Annona cherimola , Diospyros kaki , Cydonia oblonga , and Fortunella margarita as potential cosmetic ingredients. Peel and pulp extracts were compared for their antiradical activity (using DPPH and ABTS radical scavenging assays), skin-lightening potential (tyrosinase inhibitory assay), sun protection factor (SPF), and cytotoxicity toward human fibroblast, keratinocyte, and melanoma cell lines...
March 3, 2024: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
keyword
keyword
52180
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.