Swathi Kesh, Rajaretinam Rajesh Kannan, Anandan Balakrishnan
6-Hydroxydopamine (6-OHDA) is a neurotoxin that inhibits the mitochondrial complex I causing mitochondrial impairment, aetiology of Parkinson's. Naringenin is a flavanone predominantly present in citrus fruits. Due to its high antioxidant and anti-inflammatory potential, it has been widely studied against various disorders. In this study, the neuroprotective effect of naringenin was determined against 6-OHDA induced toxicity with Levodopa (l-DOPA) as the standard. Naringenin reduced 6-OHDA induced oxidative stress biomarker levels such as CAT, GSH, SOD, and ROS...
September 16, 2020: Comparative Biochemistry and Physiology. Toxicology & Pharmacology: CBP
Jesús Alfredo Araujo-León, Rolffy Ortiz-Andrade, Rivelino Armando Vera-Sánchez, Julio Enrique Oney-Montalvo, Tania Isolina Coral-Martínez, Zulema Cantillo-Ciau
The purpose of this study was to develop, optimize, and fully validate a high-sensitivity methodology using UHPLC-MS/MS to simultaneously quantify hesperidin and naringenin in microsamples (100 µL) of murine plasma after intragastric administration of single pure flavonoids and a mixture. The optimization process allowed for high sensitivity with detection limits of approximately picogram order using an electrospray ionization (ESI) source in negative mode and an experiment based on multiple reaction monitoring (MRM)...
September 16, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Gema Pereira-Caro, Michael N Clifford, Thelma Polyviou, Iziar A Ludwig, Hani Alfheeaid, José Manuel Moreno-Rojas, Ada L Garcia, Dalia Malkova, Alan Crozier
The health benefits of orange juice (OJ) consumption are attributed in part to the circulating flavanone phase II metabolites and their microbial-derived ring fission phenolic catabolites. The present study investigated these compounds in the bloodstream after acute intake of 500 mL of OJ. Plasma samples obtained at 0, 1, 2, 3, 4, 5, 6, 7, 8 and 24 h after OJ intake were analysed by HPLC-HR-MS. Eleven flavanone metabolites and 36 phenolic catabolites were identified and quantified in plasma. The main metabolites were hesperetin-3´-sulfate with a peak plasma concentration (Cmax ) of 80 nmol/L, followed by hesperetin-7-glucuronide (Cmax 24 nmol/L), hesperetin-3´-glucuronide (Cmax 18 nmol/L) and naringenin-7-glucuronide (Cmax 21 nmol/L)...
September 11, 2020: Free Radical Biology & Medicine
Jiaming Gao, Yating Wu, Dajun He, Xiaoqi Zhu, Hongbin Li, Haifeng Liu, Hailiang Liu
Aging is associated with neurological impairment and cognitive decline. Flavonoids are very promising in anti-aging research in mouse models. Ribes meyeri anthocyanins are rich in abundant flavonoids, but their anti-aging biological activities remain unknown. In this study, we prepared an R. meyeri anthocyanin extract and analyzed its effects on neural stem cell (NSC) senescence in vivo and in vitro . We isolated mouse NSCs and used cell counting kit-8 (CCK-8), cell cycle, reactive oxygen species (ROS), and immunofluorescence methods to analyze the anti-aging effects of R...
September 12, 2020: Aging
Larissa Albuquerque de Oliveira Mendes, Carolina Sousa Ponciano, Allan Henrique Depieri Cataneo, Pryscilla Fanini Wowk, Juliano Bordignon, Heveline Silva, Mauro Vieira de Almeida, Eloah Pereira Ávila
Flavonoids are natural products widely recognized for their plurality of applications such as antiviral, antiproliferative, antitumor activities and, antioxidant properties. The flavanone naringenin is presented in citrus fruits and has been studied to combat recurrent diseases that still lack effective treatment. Research groups have been investing efforts to the development of new, safe and active candidates to combat these agents or conditions and despite good results recently reported against the Zika virus (ZIKV) and tumor cells, the use of citrus naringenin is limited due to its low bioavailability...
September 8, 2020: Chemico-biological Interactions
Inas Youssef Younis, Mohamed Saeed Hifnawy, Seham Salaheldin El-Hawary, Mahitab Helmi El Bishbishy, Sawsan Youssef Elateek
The aim of this study is to estimate the nutritive values, metabolites of Hass and Reed Avocado cultivars and evaluate their antimicrobial and anticancer activities. Hass was rich in water soluble vitamins, iron and calcium while, Reed contains more fat soluble vitamins. Benzaldehyde and butyl phenol derivatives were the major volatile components identified by solid phase extraction in Hass and Reed, respectively. Naringenin and rutin were the major compounds identified in Hass and Reed by HPLC analysis respectively...
September 11, 2020: Natural Product Research
Reza Heidary Moghaddam, Zeinab Samimi, Seyed Zachariah Moradi, Peter J Little, Suowen Xu, Mohammad Hosein Farzaei
Cardiovascular disease is an important cause for morbidity and mortality worldwide. Flavonoids, such as naringin, and naringenin are important natural phytochemicals in the treatment or prevention of various disorders such as obesity, cardiac diseases, diabetes, and metabolic syndrome. Naringin and naringenin have significant therapeutic potential in several diseases through anti-oxidative, anti-inflammatory, and anti-apoptotic actions; these flavonoids play a protective role in human pathophysiology. In this review, based on the latest evidence, we present a summary of the impact of naringin, and naringenin on cardiovascular disease, and analyze and discuss the basic roles of naringin and naringenin and their mechanisms of actions in cardiovascular disease and other vascular dysfunction...
September 7, 2020: European Journal of Pharmacology
Ting-Ting Zhu, Hui Liu, Piao-Yi Wang, Rong Ni, Chun-Jing Sun, Jing-Cong Yuan, Meng Niu, Hong-Xiang Lou, Ai-Xia Cheng
Flavonoid glucosides, typically generated from aglycones via the action of uridine diphosphate-dependent glycosyltransferases (UGTs), both contribute to plant viability and are pharmacologically active. The properties of UGTs produced by liverworts, one of the basal groups of non-vascular land plants, have not been systematically explored. Here, two UGTs potentially involved in flavonoids synthesis were identified from the transcriptome of Plagiochasma appendiculatum. Enzymatic analysis showed that PaUGT1 and PaUGT2 accepted various flavones, flavonols, flavanones and dihydrochalcones as substrates...
October 2020: Plant Science: An International Journal of Experimental Plant Biology
Fangchan Jiao, Lu Zhao, Xingfu Wu, Zhongbang Song, Yongping Li
BACKGROUND: Anthocyanins determinate the flower color of many plants. Tobacco is a model plant for studying the molecular regulation of flower coloration. We investigated the mechanism underlying flower coloration in tobacco by profiling flavonoid metabolites,expression of anthocyanin biosynthetic structural genes and their regulator genes in the pink-flowered tobacco cultivar Yunyan 87 and white-flowered Yunyan 87 mutant. RESULT: Significant down-accumulation of anthocyanins, including cyanidin 3-O-glucoside, cyanin, cyanidin 3-O-rutinoside, pelargonidin 3-O-beta-D-glucoside, cyanidin O-syringic acid, pelargonin, and pelargonidin 3-O-malonylhexoside (log2 fold change < - 10), endowed the flower color mutation in Yunyan 87 mutant...
September 7, 2020: BMC Genomics
Xiao Guo, Ailing Guo, Erhu Li
Microbial processes are being developed to transform flavonoid glycosides to varieties of metabolites with higher bioavailability. The aim of this study was to determine the metabolic activity and survival of five lactic acid bacteria (LAB) stains (L. rhamnosus LRa05, L. casei LC89, L. plantarum N13, L. acidophilus LA85, and L. brevis LB01) in two different citrus flavanone standards (hesperetin-7-O-rutinoside and naringenin-7-O-rutinoside). The enzymatic activity, metabolites, antioxidant activities, and α-glucosidase inhibition property in the two standards were also investigated before and after incubated with LAB...
September 4, 2020: Bioprocess and Biosystems Engineering
Varittha Sritalahareuthai, Piya Temviriyanukul, Nattira On-Nom, Somsri Charoenkiatkul, Uthaiwan Suttisansanee
Kadsura spp. in the Schisandraceae family are woody vine plants, which produce edible red fruits that are rich in nutrients and antioxidant activities. Despite their valuable food applications, Kadsura spp. are only able to grow naturally in the forest, and reproduction handled by botanists is still in progress with a very low growth rate. Subsequently, Kadsura spp. were listed as endangered species by the International Union for Conservation of Nature and Natural Resources (IUCN) in 2011. Two different Kadsura spp...
September 2, 2020: Foods (Basel, Switzerland)
Fatemeh Naeini, Zahra Namkhah, Alireza Ostadrahimi, Helda Tutunchi, Mohammad Javad Hosseinzadeh-Attar
Nonalcoholic fatty liver disease (NAFLD) has become the most common cause of liver dysfunction worldwide. Recently, some natural compounds have attracted growing interest in the treatment of NAFLD. In this context, most attention has been paid to natural products derived from fruits, vegetables, and medicinal herbs. Naringenin, a natural flavanone, has been revealed to have pharmacological effects in the treatment of obesity and associated metabolic disorders such as NAFLD. The aim of this study was to examine the therapeutic effects of naringenin and its possible mechanisms of action in the management of NAFLD and related risk factors...
September 2, 2020: Advances in Nutrition
Mihaela Pruteanu, José I Hernández Lobato, Thomas Stach, Regine Hengge
Like all macroorganisms, plants have to control bacterial biofilm formation on their surfaces. On the other hand, biofilms are highly tolerant against antimicrobial agents and other stresses. Consequently, biofilms are also involved in human chronic infectious diseases, which generates a strong demand for anti-biofilm agents. Therefore, we systematically explored major plant flavonoids as putative anti-biofilm agents using different types of biofilms produced by Gram-negative and Gram-positive bacteria. In Escherichia coli macrocolony biofilms, the flavone luteolin and the flavonols myricetin, morin and quercetin were found to strongly reduce the extracellular matrix...
August 31, 2020: Environmental Microbiology
Daniel S Peiffer, Emily Ma, Debra Wyatt, Kathy S Albain, Clodia Osipo
Recurrence of estrogen receptor (ER)-positive breast tumors despite curative-intent adjuvant therapy is thought to be due to enrichment of tumor initiating cells (TIC) during endocrine therapy (ET). Recently, it was identified that by antagonizing the ER, ET promotes rapid degradation of the death-associated factor 6 (DAXX) protein, which is necessary and sufficient to potently inhibit TICs. Thus, the goal of the current study was to identify a DAXX-inducing agent to inhibit TICs and prevent proliferation of the tumor...
2020: NPJ Breast Cancer
Jianzhi Wu, Guangrui Huang, Yajing Li, Xiaojiaoyang Li
Background: Liver diseases and related complications are major sources of morbidity and mortality, which places a huge financial burden on patients and lead to nonnegligible social problems. Therefore, the discovery of novel therapeutic drugs for the treatment of liver diseases is urgently required. Aurantii Fructus Immaturus (AFI) and Aurantii Fructus (AF) are frequently used herbal medicines in traditional Chinese medicine (TCM) formulas for the treatment of diverse ailments. A variety of bioactive ingredients have been isolated and identified from AFI and AF, including alkaloids, flavonoids, coumarins and volatile oils...
2020: Chinese Medicine
Abhishek Gour, Ashish Dogra, Priya Wazir, Gurdarshan Singh, Utpal Nandi
Hydroxyurea (HU) is the first-ever approved drug by the United States Food and Drug Administration (USFDA) for the management of sickle cell anemia (SCA). However, its treatment is associated with severe liabilities like myelosuppression. Therefore, the aim of the present investigation was to identify phytotherapeutics through assessment of the pharmacokinetic interaction of HU with dietary bioflavonoids followed by elucidation of the same phytoconstituents for their ability to protect HU-induced toxicity in hematological profile...
July 27, 2020: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Miguel Ayuso-Calles, Ignacio García-Estévez, Alejandro Jiménez-Gómez, José D Flores-Félix, M Teresa Escribano-Bailón, Raúl Rivas
Lettuce ( Lactuca sativa L.) is a widely consumed horticultural species. Its significance lies in a high polyphenolic compound content, including phenolic acids and flavonols. In this work, we have probed the ability of Rhizobium laguerreae HUTR05 to promote lettuce growth, under in vitro and greenhouse conditions (both non-saline and saline conditions). This strain has shown several in vitro plant growth promotion mechanisms, as well as capacity to colonize lettuce seedlings roots. We have analyzed the effect of the rhizobacterium inoculation on mineral and bioactive compounds in lettuce, under greenhouse conditions, and found a rise in the content of certain phenolic acids and flavonoids, such as derivatives of caffeoyl acid and quercetin...
August 24, 2020: Foods (Basel, Switzerland)
Xiaofeng Li, Yaoming Zhao, Xueneng Lai, Jiangwen Nong, Guanglei Zhao, Xinglong Xiao
Citrus peel wastes are an important renewable resource and rich in naringin, a flavonoid compound with multiple bioactivities. To cope with the low bioavailability of naringin, a new bienzyme whole-cell system was developed for bioconversion of naringin into two lipophilic derivatives. A series of naringin esters with different fatty acid chain length were successfully synthesized via cell-bound lipase catalyzed acylation, and another lipophilic product naringenin was simultaneously yielded via intracellular naringinase-catalyzed hydrolysis...
October 2020: Food Research International
Hieu Tran Trung, Hoa Truong Thi Huynh, Linh Nguyen Thi Thuy, Hoang Nguyen Van Minh, My-Nuong Thi Nguyen, My Ngan Luong Thi
The aim of the present study was to assess antimicrobial effects of naringenin (NRG), luteolin (LUT), myricetin (MCT), and protocatechuic acid (PCA) identified in a Hibiscus rosa sinensis flower against two reference strains and five clinical isolates of Helicobacter pylori . NRG displayed the most growth inhibitory and bactericidal activities to seven bacterial strains including six strains resistant to one or several antibiotics, azithromycin (MIC, 16-32 mg/L), erythromycin (MIC, 32 mg/L), levofloxacin (MIC, 32 mg/L), and/or metronidazole (24-64 mg/L), followed by LUT and MCT, while PCA showed weak activities toward the strains...
August 18, 2020: ACS Omega
Anuj Kumar, Mansi Sharma, Swaroopa Nand Chaubey, Avneesh Kumar
Chalcone synthase (CHS) and chalcone isomerase (CHI) plays a major role in the biosynthesis of flavonoid in plants. In this study, we made extensive bioinformatics analysis to gain functional and structural insight into PeCHS and PeCHI proteins . The phylogenetic distribution of PeCHS and PeCHI genes encoding proteins demonstrated the close evolutionary relationship with different CHS and CHI proteins of other dicot plants. MicroRNA target analysis showed miR169n and 3p miR5053 targeting PeCHS gene while miR169c-3p and miR4248 are targeting PeCHI gene, respectively...
August 2020: 3 Biotech
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