keyword
https://read.qxmd.com/read/38537203/68ga-dotanoc-pet-ct-in-2-siblings-with-von-hippel-lindau-disease
#1
JOURNAL ARTICLE
Priyanka G B, Nishikant Avinash Damle, Ravindranath Reddy K, Nikhil Tandon, Priyanka Naranje, Devasenathipathy Kandasamy, Kishan Subudhi
Von Hippel-Lindau disease is a rare multisystem disorder that shows autosomal dominant inheritance. It is a cancer syndrome that is characterized by the development of a variety of benign and malignant tumors-CNS hemangioblastomas, retinal angiomas, endolymphatic sac tumors, renal cysts and tumors, pancreatic cysts and tumors, adrenal pheochromocytomas, and epididymal cystadenomas. Here we present the 68Ga-labeled DOTANOC scans of 2 siblings who show an interesting spectrum of findings consistent with Von Hippel-Lindau disease...
March 25, 2024: Clinical Nuclear Medicine
https://read.qxmd.com/read/38536816/iqgap1-and-nwasp-promote-human-cancer-cell-dissemination-and-metastasis-by-regulating-%C3%AE-1-integrin-via-fak-and-mrtf-srf
#2
JOURNAL ARTICLE
Camilla Cerutti, Serena Lucotti, Sofia T Menendez, Nicolas Reymond, Ritu Garg, Ignacio A Romero, Ruth Muschel, Anne J Ridley
Attachment of circulating tumor cells to the endothelial cells (ECs) lining blood vessels is a critical step in cancer metastatic colonization, which leads to metastatic outgrowth. Breast and prostate cancers are common malignancies in women and men, respectively. Here, we observe that β1-integrin is required for human prostate and breast cancer cell adhesion to ECs under shear-stress conditions in vitro and to lung blood vessel ECs in vivo. We identify IQGAP1 and neural Wiskott-Aldrich syndrome protein (NWASP) as regulators of β1-integrin transcription and protein expression in prostate and breast cancer cells...
March 26, 2024: Cell Reports
https://read.qxmd.com/read/38536666/non-cancerous-complications-in-htlv-1-carriers
#3
REVIEW
Akihiro Ohmoto, Shigeo Fuji
INTRODUCTION: Human T-cell leukemia virus type 1 (HTLV-1) carriers may develop adult T-cell leukemia (ATL), or HTLV-1-associated myelopathy (HAM)/tropical spastic paraparesis (TSP). The evidence is limited regarding other diseases potentially associated with HTLV-1, such as HTLV-1-associated autoimmune diseases. AREA COVERED: We summarized the available information on complications associated with HTLV-1 infection. EXPERT OPINION: Previous studies showed that HTLV-1 carriers have an increased incidence of collagen diseases including Sjögren's syndrome, as well as dysthyroidism, diabetes mellitus, and atherosclerosis...
March 27, 2024: Expert Review of Anti-infective Therapy
https://read.qxmd.com/read/38534956/paraneoplastic-syndromes-in-neuroendocrine-prostate-cancer-a-systematic-review
#4
REVIEW
Mohammad Abufaraj, Raghad Ramadan, Amro Alkhatib
Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS...
March 21, 2024: Current Oncology
https://read.qxmd.com/read/38534264/sebaceomas-in-a-muir-torre-like-phenotype-in-a-patient-with-mutyh-associated-polyposis
#5
Julia Guarrera, James C Prezzano, Kathleen A Mannava
This case report describes a case of a patient with MUTYH-associated polyposis (MAP), who presented with multiple sebaceomas in a Muir-Torre-like phenotype. MAP is caused by mutations in MUTYH, a base excision repair gene responsible for detecting and repairing the 8-oxo-G:A transversion caused by reactive oxygen species. MAP is associated with an increased risk of developing adenomatous polyps and colorectal cancer. Muir-Torre syndrome is a clinical phenotype of Lynch syndrome, which presents with multiple cutaneous sebaceous neoplasms...
March 4, 2024: Dermatopathology (Basel, Switzerland)
https://read.qxmd.com/read/38533737/combined-effects-of-smoking-and-alcohol-consumption-on-the-risk-of-liver-cancer-according-to-metabolic-syndrome-a-nested-case-control-study-in-south-korea
#6
JOURNAL ARTICLE
Thi Tra Bui, Eunjung Park, Hee-Yeon Kang, Jin-Kyoung Oh
Tobacco and alcohol may interact to increase the risk of liver cancer, which might be modified by other risk factors. Their combined effects in the context of metabolic syndrome (MetS) remain unclear. Given the increasing prevalence of MetS, this nested case-control study was conducted to evaluate the combined effects of smoking and alcohol consumption on liver cancer risk with stratification by MetS. We included 15,352 liver cancer patients and 92,112 matched controls who attended the nationwide general health examination during 2009-2019, using a customized database (N = 5,545,835) from the Korean National Health Insurance Service...
March 27, 2024: International Journal of Cancer. Journal International du Cancer
https://read.qxmd.com/read/38533131/progerin-inhibits-the-proliferation-and-migration-of-melanoma-cells-by-regulating-the-expression-of-paxillin
#7
JOURNAL ARTICLE
Weixian Liu, Xinxian Huang, Weizhao Luo, Xinguang Liu, Weichun Chen
OBJECTIVE: Progerin, the underlying cause of Hutchinson-Gilford Progeria Syndrome (HGPS), has been extensively studied for its impact on normal cells and premature aging patients. However, there is a lack of research on its specific effects on tumor cells. Melanoma is one of the most common malignant tumors with high morbidity and mortality. This study aimed to elucidate the potential therapeutic role of progerin in melanoma. MATERIALS AND METHODS: We constructed the melanoma A375 cell line and M14 cell line with stable expression of progerin...
2024: OncoTargets and Therapy
https://read.qxmd.com/read/38532515/inflammation-and-acute-cardiotoxicity-in-adult-hematological-patients-treated-with-car-t-cells-results-from-a-pilot-proof-of-concept-study
#8
JOURNAL ARTICLE
Massimiliano Camilli, Marcello Viscovo, Tamara Felici, Luca Maggio, Federico Ballacci, Giacomo Carella, Alice Bonanni, Priscilla Lamendola, Lorenzo Tinti, Antonio Di Renzo, Giulia Coarelli, Eugenio Galli, Giovanna Liuzzo, Francesco Burzotta, Rocco Antonio Montone, Federica Sorà, Simona Sica, Stefan Hohaus, Gaetano Antonio Lanza, Filippo Crea, Antonella Lombardo, Giorgio Minotti
AIMS: Chimeric Antigen Receptor-T (CAR-T) cell infusion is a rapidly evolving antitumor therapy; however, cardiovascular (CV) complications, likely associated with cytokine release syndrome (CRS) and systemic inflammation, have been reported to occur. The CARdio-Tox study aimed at elucidating incidence and determinants of cardiotoxicity related to CAR-T cell therapy. METHODS: Patients with blood malignancies candidate to CAR-T cells were prospectively evaluated by echocardiography at baseline and 7 and 30 days after infusion...
March 27, 2024: Cardio-Oncology
https://read.qxmd.com/read/38532510/care-management-and-use-of-ferrets-in-biomedical-research
#9
REVIEW
Ravindran Kumar Pramod, Pravin Kumar Atul, Mamta Pandey, S Anbazhagan, Suhas T Mhaske, R Barathidasan
The ferret (Mustela putorius furo) is a small domesticated species of the family Mustelidae within the order Carnivora. The present article reviews and discusses the current state of knowledge about housing, care, breeding, and biomedical uses of ferrets. The management and breeding procedures of ferrets resemble those used for other carnivores. Understanding its behavior helps in the use of environmental enrichment and social housing, which promote behaviors typical of the species. Ferrets have been used in research since the beginning of the twentieth century...
March 26, 2024: Laboratory Animal Research
https://read.qxmd.com/read/38532453/current-prospects-of-hereditary-adrenal-tumors-towards-better-clinical-management
#10
REVIEW
Akihiro Ohmoto, Naomi Hayashi, Shunji Takahashi, Arisa Ueki
Adrenocortical carcinoma (ACC) and pheochromocytoma/paraganglioma (PPGL) are two rare types of adrenal gland malignancies. Regarding hereditary tumors, some patients with ACC are associated with with Li-Fraumeni syndrome (LFS), and those with PPGL with multiple endocrine neoplasia type 2. Recent studies have expanded this spectrum to include other types of hereditary tumors, such as Lynch syndrome or familial adenomatous polyposis. Individuals harboring germline TP53 pathogenic variants that cause LFS have heterogeneous phenotypes depending on the respective variant type...
March 26, 2024: Hereditary Cancer in Clinical Practice
https://read.qxmd.com/read/38531653/2-o-methylation-nm-in-rna-progress-challenges-and-future-directions
#11
JOURNAL ARTICLE
Katherine I Zhou, Chad V Pecot, Christopher L Holley
RNA 2'-O-methylation (Nm) is highly abundant in noncoding RNAs including ribosomal RNA (rRNA), transfer RNA (tRNA), and small nuclear RNA (snRNA), and occurs in the 5' cap of virtually all messenger RNAs (mRNAs) in higher eukaryotes. More recently, Nm has also been reported to occur at internal sites in mRNA. High-throughput methods have been developed for the transcriptome-wide detection of Nm. However, these methods have mostly been applied to abundant RNAs such as rRNA, and the validity of the internal mRNA Nm sites detected with these approaches remains controversial...
March 26, 2024: RNA
https://read.qxmd.com/read/38531626/extent-of-investigation-and-management-of-cases-of-unexplained-mismatch-repair-deficiency-u-dmmr-a-uk-cancer-genetics-group-consensus
#12
JOURNAL ARTICLE
Terri Patricia McVeigh, Kevin J Monahan, Joseph Christopher, Nick West, Malcolm Scott, Jennie Murray, Helen Hanson
BACKGROUND: Mismatch repair deficiency (dMMR) is a characteristic feature of cancers linked to Lynch syndrome. However, in most cases, it results from sporadic somatic events rather than hereditary factors. The term 'Lynch-like syndrome' (LLS) has been used to guide colorectal cancer surveillance for relatives of individuals with a dMMR tumour when somatic and germline genomic testing is uninformative. As the assessment of mismatch repair through immunohistochemistry and/or microsatellite instability is increasingly applied across various tumour types for treatment planning, dMMR is increasingly detected in tumours where suspicion of hereditary aetiology is low...
March 26, 2024: Journal of Medical Genetics
https://read.qxmd.com/read/38531023/a-validated-highly-sensitive-microsatellite-instability-assay-accurately-identifies-individuals-harboring-biallelic-germline-pms2-pathogenic-variants-in-constitutional-mismatch-repair-deficiency
#13
JOURNAL ARTICLE
Fátima Marín, Júlia Canet-Hermida, Vanessa Bianchi, Jiil Chung, Katharina Wimmer, William Foulkes, Vanesa Pérez-Alonso, Nerea Domínguez-Pinilla, Constantino Sábado, Felisa Vázquez-Gómez, Antonio Molinés, Victoria Fioravantti, Estela Carrasco, Lucie Stengs, Melissa Edwards, Logine Negm, Anirban Das, Melyssa Aronson, Ángela Pastor, Daniel Rueda, Luis Ignacio González-Granado, Uri Tabori, Gabriel Capellá, Marta Pineda
BACKGROUND: Constitutional mismatch repair deficiency (CMMRD) is a rare and extraordinarily penetrant childhood-onset cancer predisposition syndrome. Genetic diagnosis is often hampered by the identification of mismatch repair (MMR) variants of unknown significance and difficulties in PMS2 analysis, the most frequently mutated gene in CMMRD. We present the validation of a robust functional tool for CMMRD diagnosis and the characterization of microsatellite instability (MSI) patterns in blood and tumors...
March 26, 2024: Clinical Chemistry
https://read.qxmd.com/read/38530745/hiv-infection-and-esophageal-cancer-in-sub-saharan-africa-a-comprehensive-meta-analysis
#14
JOURNAL ARTICLE
Gabriel Kamsu-Tchuente, Eugene J Ndebia
Africa hosts the highest burden of esophageal cancer (49%) and HIV (60%) worldwide. It is imperative to investigate the synergistic impact of these two diseases on African populations. This study conducted an exhaustive computerized search of databases, including Medline/PubMed, Embase, Web of Science, Scopus, Cochrane library, and African Journals Online, to identify eligible studies up to October 2023. HIV infection was the exposure, esophageal cancer risk was the outcome, and healthy subjects with no cancer history served as comparators...
2024: AIDS Reviews
https://read.qxmd.com/read/38530571/cascade-genetic-testing-for-hereditary-cancer-syndromes-a-review-of-barriers-and-breakthroughs
#15
REVIEW
Rachel Levine, Ryan M Kahn, Luiza Perez, Jesse Brewer, Samantha Ratner, Xuan Li, Effi Yeoshoua, Melissa K Frey
Germline genetic sequencing is now at the forefront of cancer treatment and preventative medicine. Cascade genetic testing, or the testing of at-risk relatives, is extremely promising as it offers genetic testing and potentially life-saving risk-reduction strategies to a population exponentially enriched for the risk of carrying a cancer-associated pathogenic variant. However, many relatives do not complete cascade testing due to barriers that span individual, relationship, healthcare community, and societal/policy domains...
March 26, 2024: Familial Cancer
https://read.qxmd.com/read/38530242/hypertension-and-risk-of-endometrial-cancer-a-pooled-analysis-in-the-epidemiology-of-endometrial-cancer-consortium-e2c2
#16
JOURNAL ARTICLE
Talar S Habeshian, Noah C Peeri, Immaculata De Vivo, Leo J Schouten, Xiao-Ou Shu, Michele L Cote, Kimberly A Bertrand, Yu Chen, Megan A Clarke, Tess V Clendenen, Linda S Cook, Laura Costas, Luigino Dal Maso, Jo L Freudenheim, Christine M Friedenreich, Grace Gallagher, Gretchen L Gierach, Marc T Goodman, Susan J Jordan, Carlo La Vecchia, James V Lacey, Fabio Levi, Linda M Liao, Loren Lipworth, Lingeng Lu, Xavier Matías-Guiu, Kirsten B Moysich, George L Mutter, Renhua Na, Jeffin Naduparambil, Eva Negri, Kelli O'Connell, Tracy A O'Mara, Irene Onieva Hernández, Julie R Palmer, Fabio Parazzini, Alpa V Patel, Kathryn L Penney, Anna E Prizment, Fulvio Ricceri, Harvey A Risch, Carlotta Sacerdote, Sven Sandin, Rachael Z Stolzenberg-Solomon, Piet A van den Brandt, Penelope M Webb, Nicolas Wentzensen, Akemi T Wijayabahu, Lynne R Wilkens, Wanghong Xu, Herbert Yu, Anne Zeleniuch-Jacquotte, Wei Zheng, Mengmeng Du, Veronica Wendy Setiawan
BACKGROUND: The incidence rates of endometrial cancer (EC) are increasing, which may partly be explained by the rising prevalence of obesity, an established risk factor for EC. Hypertension, another component of metabolic syndrome, is also increasing in prevalence, and emerging evidence suggests that it may be associated with the development of certain cancers. The role of hypertension independent of other components of metabolic syndrome in the etiology of EC remains unclear. In this study we evaluated hypertension as an independent risk factor for EC and whether this association is modified by other established risk factors...
March 26, 2024: Cancer Epidemiology, Biomarkers & Prevention
https://read.qxmd.com/read/38530195/stay-on-track-a-pilot-randomized-control-trial-on-the-feasibility-of-a-diet-and-exercise-intervention-in-patients-with-breast-cancer-receiving-radiation-therapy
#17
JOURNAL ARTICLE
Gopika SenthilKumar, Aronne M Schottstaedt, Lindsay L Peterson, Lauren N Pedersen, Christopher R Chitambar, Alexis Vistocky, Anjishnu Banerjee, John M Longo, Tracy Kelly, Adam Currey, Melinda R Stolley, Carmen Bergom
BACKGROUND: Among patients with breast cancer undergoing radiation therapy (RT), post-treatment cardiovascular disease and worsened quality of life (QOL) are leading causes of morbidity and mortality. To overcome these negative RT effects, this prospective, randomized clinical trial pilots a 12-week Stay on Track exercise and diet intervention for overweight patients with non-metastatic breast cancer undergoing whole-breast RT. METHODS: The intervention group (n=22) participated in three personal exercise and dietary counseling sessions, and received three text reminders/week to adhere to recommendations...
March 26, 2024: Cancer Res Commun
https://read.qxmd.com/read/38529878/exposure-to-holocaust-is-associated-with-chronic-morbidity-in-older-adults-results-from-national-health-and-nutrition-surveys
#18
JOURNAL ARTICLE
Shay Y Lubel, Rita Dichtiar, Tali Sinai, Lital Keinan-Boker
BACKGROUND: Although studies have suggested that Holocaust survivors are more likely than their non-Holocaust-exposed counterparts to suffer from mental and chronic morbidity, methodology differences and potential confounders often compromise result replicability and external validity. We examined associations between Holocaust exposure and chronic morbidity, as well as overall risk of mortality. METHODS: Sociodemographic, health-related behavior and nutritional-intake data from two representative National Health and Nutrition Survey Ages 65 and Over-the 2005-2006 MABAT ZAHAV 1 (MZ1) and the 2014-2015 MZ2, including face-to-face interviews and anthropometric measurements-were analyzed...
March 26, 2024: Journal of the American Geriatrics Society
https://read.qxmd.com/read/38529392/the-thrombotic-risk-in-cushing-s-syndrome-questions-answers-and-the-algorithm-to-consider-in-its-assessment-part-i-thrombotic-risk-not-related-to-surgery
#19
REVIEW
Agata Hanna Bryk-Wiązania, Mari Minasyan, Renata Świątkowska-Stodulska, Anetta Undas, Alicja Hubalewska-Dydejczyk, Susan M Webb, Elena Valassi, Aleksandra Gilis-Januszewska
INTRODUCTION: Recently, it has been reported that there is a great diversity in strategies used for thromboprophylaxis in patients with Cushing's syndrome (CS). An aim of this review was to discuss these practices in light of the existing data on the thrombotic risk in patients with CS and guidelines for medically ill patients. METHODS: The four relevant topics and questions on thrombotic risk in CS were identified. The current guidelines on prevention and diagnosis of venous thromboembolism (VTE) were reviewed for the answers...
2024: Frontiers in Endocrinology
https://read.qxmd.com/read/38529381/numb-cheek-syndrome-in-breast-cancer-a-case-report
#20
Zhibin Tan, Si Ying Tan
BACKGROUND: Numb cheek syndrome, a rare corollary of numb chin syndrome, is due to infra-orbital neuropathy. It can occur in association with an underlying malignancy, which can cause neuropathy by direct malignant nerve infiltration or via a paraneoplastic mechanism. Although numb cheek syndrome has been reported in association with a variety of cancers, it has previously not been reported in association with breast cancer. We report a case of left breast cancer presenting with left numb cheek syndrome...
2024: Frontiers in Oncology
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