Yan Li, Yongying Zhou, Mingliu Huang, Zhen Wang, Daoquan Liu, Jianmin Liu, Xun Fu, Shu Yang, Shidong Shan, Liang Yang, Yuhang Guo, Pengfei Ren, Ping Chen, Guang Zeng, Yuming Guo, Xinghuan Wang, Michael E DiSanto, Xinhua Zhang
Bladder cancer (BCa) is a common malignancy with uncertain molecular mechanism. 7-dehydrocholesterol reductase (DHCR7), the enzyme of mammalian sterol biosynthesis, plays important roles in several types of cancers but its specific function in BCa is still unknown. The current study aimed to determine the bioinformatic characteristics and biological functions of DHCR7 in BCa. Sequencing results and clinical data from online public databases, human BCa tissues and matched noncancerous tissues, xenograft nude mice, DHCR7 deficiency and overexpression BCa cell (T24 and EJ) models were used...
December 3, 2022: Cellular Signalling