Katarzyna Kościelska-Kasprzak, Dorota Bartoszek, Marta Myszka, Marcelina Zabińska, Marian Klinger
Serum complement cascade, a part of innate immunity required for host protection against invading pathogens, is also a mediator of various forms of disease and injury. It is activated by classical, lectin, and alternative pathways that lead to activation of C3 component by C3 convertases, release of C3b opsonin, C5 conversion and eventually membrane attack complex formation. The tightly regulated activation process yields also C3a and C5a anaphylatoxins, which target a broad spectrum of immune and non-immune cells...
February 2014: Archivum Immunologiae et Therapiae Experimentalis