Carlos Matellan, Ciarán Kennedy, Miren Itxaso Santiago-Vela, Johanna Hochegger, Méabh B Ní Chathail, Amanda Wu, Christopher Shannon, Helen M Roche, Seema S Aceves, Catherine Godson, Mario C Manresa
Fibroblasts acquire a proinflammatory phenotype in inflammatory bowel disease, but the factors driving this process and how fibroblasts contribute to mucosal immune responses are incompletely understood. TNF superfamily member 12 (TNFSF12, or TNF-like weak inducer of apoptosis [TWEAK]) has gained interest as a mediator of chronic inflammation. In this study, we explore its role as a driver of inflammatory responses in fibroblasts and its contribution to fibroblast-monocyte interaction using human primary colonic fibroblasts, THP-1 and primary monocytes...
May 3, 2024: Journal of Immunology