Muhammad Tayyab, H Zaidi, P Vieira, T Qureshi, N Figueiredo, A Parvaiz
PURPOSE: Abdominoperineal resection of the rectum has evolved over the last century, with few modifications until 2007, when extralevator abdominoperineal resection was introduced, which improved local disease control but resulted in a significant rise in perineal complications. We adopted a modified approach in which dissection was tailored according to magnetic resonance-defined tumour involvement. The aim of this study was to assess short-term and long-term oncological outcomes following a tailored abdominoperineal resection (APR) approach...
February 27, 2021: Langenbeck's Archives of Surgery
Hao Zhang, Ling Liu, Lulu Chen, Haihui Liu, Saisai Ren, Yanling Tao
Autophagy is an important mechanism involved in the regulation of acute myeloid leukemia (AML) chemoresistance. The long noncoding RNA (lncRNA) differentiation antagonizing non-protein coding RNA (DANCR) exhibits oncogenic activity in several types of human cancers, including AML, but it remains unclear whether it regulates autophagy and chemoresistance in AML. We report here that cytarabine (Ara-C) treatment elevates DANCR expression in human AML cells. In addition, DANCR overexpression confers and its knockdown diminishes Ara-C resistance in human AML cells, suggesting that DANCR positively regulates AML chemoresistance to Ara-C...
February 27, 2021: Molecular Oncology
Christian Günther, Frank Steffen, Daniela S Alder, Laura Beatrice, Caroline Geigy, Katrin Beckmann
BACKGROUND: Relapses in steroid-responsive meningitis-arteritis (SRMA) are frequently observed but specific treatment protocols to address this problem are sparsely reported. Standard treatment includes prolonged administration of glucocorticoids as monotherapy or in combination with immunosuppressive drugs. The aim of this study was to assess the safety and efficacy of cytosine arabinoside (CA) in combination with glucocorticoids for treatment of SRMA relapses in 12 dogs on a retrospective basis...
July 2020: Veterinary Record
Amaury Thiabaud, Anne Iten, Carlo Balmelli, Laurence Senn, Nicolas Troillet, Andreas Widmer, Domenica Flury, Peter W Schreiber, Miriam Vázquez, Lauro Damonti, Michael Buettcher, Danielle Vuichard-Gysin, Christoph Kuhm, Alexia Cusini, Thomas Riedel, Yvonne Nussbaumer-Ochsner, Roman Gaudenz, Ulrich Heininger, Christoph Berger, Franziska Zucol, Sara Bernhard-Stirnemann, Natascia Corti, Petra Zimmermann, Anita Uka, Anita Niederer-Loher, Céline Gardiol, Maroussia Roelens, Olivia Keiser
BACKGROUND: SARS-CoV-2/COVID-19, which emerged in China in late 2019, rapidly spread across the world with several million victims in 213 countries. Switzerland was severely hit by the virus, with 43,000 confirmed cases as of 1 September 2020. AIM: In cooperation with the Federal Office of Public Health, we set up a surveillance database in February 2020 to monitor hospitalised patients with COVID-19, in addition to their mandatory reporting system. METHODS: Patients hospitalised for more than 24 hours with a positive polymerase chain-reaction test, from 20 Swiss hospitals, are included...
February 15, 2021: Swiss Medical Weekly
Laurie E McLouth, Kaitlyn Weyman, Shannon L Golden, Jennifer S Cheavens, Amy Peterman, Vilma Bursac, Jennifer Gabbard, Kathryn E Weaver
OBJECTIVE: Between 40% and 65% of lung cancer patients report concern about maintaining valued activities and roles, yet few interventions address this concern. Hope, a patient's perceived ability to generate goals and identify ways to pursue them, may be a promising intervention target to support function among lung cancer patients. The goal of this study was to assess metastatic non-small cell lung cancer (mNSCLC) patient interest and preferences for a hope-enhancing intervention. METHODS: We conducted a sequential mixed-methods (survey followed by semi-structured interviews) study with patients with mNSCLC...
February 26, 2021: Psycho-oncology
Maria Vittoria Cicinelli, Maura Di Nicola, Carmen Rosaria Gigliotti, Marco Battista, Elisabetta Miserocchi, Antonella Del Vecchio, Pietro Mortini, Francesco Bandello, Giulio Maria Modorati
BACKGROUND AND PURPOSE: To report the factors predictive of radio-induced complications (i.e. radiation retinopathy [RR], radiation papillopathy [RP] and neovascular glaucoma [NVG]) in uveal melanoma (UM) patients undergoing gamma knife radiosurgery (GKR). MATERIALS AND METHODS: Longitudinal cohort study on patients with UM treated at the Ocular Oncology Service, San Raffaele Scientific Institute, Milan, between June 1994 and November 2018. Data were retrospectively reviewed...
February 26, 2021: Acta Ophthalmologica
Lifeng Zhang, Wei Chen, Chang Ding, Yanjia Hu, Yuan Tian, Huiyang Luo, Jing Chen
PURPOSE: The aim of this study was to investigate the efficacy and safety of initial Gamma Knife radiosurgery (GKRS) for elderly patients with nonfunctioning pituitary adenomas (NFPAs). METHODS: We retrospectively reviewed 45 elderly patients underwent GKRS as the initial treatment for NFPAs at our institution between December 2007 and December 2017. Patients' radiographic and clinical data were collected. RESULTS: The median age of patients at the time of GKRS was 71 years (range 65-82 years)...
February 27, 2021: Journal of Neuro-oncology
Michael L Horsey, Salvatore A Parascandola, Andrew D Sparks, Salini Hota, Matthew Ng, Vincent Obias
BACKGROUND: Elderly patients are underrepresented in studies demonstrating the advantages of laparoscopy for the management of colorectal diseases. Moreover, few studies have examined the robotic approach in this population. In this retrospective analysis, we compare outcomes for open, laparoscopic, and robotic approaches in elderly patients with nonmetastatic rectal cancer. METHODS: The U.S. National Cancer Database was queried for patients aged ≥ 65 with nonmetastatic adenocarcinoma of the rectum who underwent surgical resection from 2010 to 2016...
February 26, 2021: Surgical Endoscopy
Yozo Suzuki, Mitsuyoshi Tei, Masaki Wakasugi, Yujiro Nakahara, Atsushi Naito, Manabu Mikamori, Kenta Furukawa, Masahisa Ohtsuka, Jeong Ho Moon, Mitsunobu Imasato, Tadafumi Asaoka, Kentaro Kishi, Hiroki Akamatsu
BACKGROUND: Long-term outcomes of single-incision laparoscopic colectomy (SILC) for colon cancer (CC), as practiced in real-world settings, especially in relation to disease stage, have not been established. We examined, retrospectively, both short- and long-term outcomes of SILC versus those of multiport laparoscopic colectomy (MPLC) performed for CC in a propensity-score-matched cohort. METHODS: The study involved 263 patient pairs matched 1:1 from among 691 patients who, between January 2008 and May 2014, underwent either SILC or MPLC for a primary solitary CC at our hospital...
February 26, 2021: Surgical Endoscopy
Federico Felizzi, Noman Paracha, Johannes Pöhlmann, Joshua Ray
Novel cancer therapies are associated with survival patterns that differ from established therapies, which may include survival curves that plateau after a certain follow-up time point. A fraction of the patient population is then considered statistically cured and subject to the same mortality experience as the cancer-free general population. Mixture cure models have been developed to account for this characteristic. As compared to standard survival analysis, mixture cure models can often lead to profoundly different estimates of long-term survival, required for health economic evaluations...
February 26, 2021: PharmacoEconomics Open
Jia-Chun Ma, Xiao-Rong Zhong, Ting Luo, Zhong-Zheng Xiang, Jia-Yuan Li, Chuanxu Luo, Xi Yan, Ping He, Ting-Lun Tian, Fang Liu, Lei Liu, Hong Zheng
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Alexandra M Adams, Timothy J Vreeland, Guy T Clifton, George E Peoples
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Kazuaki Matsui, Hirofumi Kawakubo, Yuki Hirata, Satoru Matsuda, Shuhei Mayanagi, Tomoyuki Irino, Kazumasa Fukuda, Rieko Nakamura, Norihito Wada, Yuko Kitagawa
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Sanjay P Bagaria, Alessandro Gronchi
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Michael M Jonczyk, Abhishek Chatterjee
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Taro Oshikiri, Yoshihiro Kakeji
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Richard J Straker, Giorgos C Karakousis
No abstract text is available yet for this article.
February 26, 2021: Annals of Surgical Oncology
Elena Tsangaris, Andrea L Pusic, Manraj N Kaur, Sophocles Voineskos, Louise Bordeleau, Toni Zhong, Raghavan Vidya, Justin Broyles, Anne F Klassen
BACKGROUND: To assess the impact of animation deformity on health-related quality of life, a content-specific, valid, and reliable patient-reported outcome measure is needed. This report describes the development and validation of the BREAST-Q Animation Deformity scale. METHODS: Women with breast cancer who had an implant-based reconstruction provided data. In phase 1 (January 2017 and December 2018), qualitive and cognitive patient interviews and expert input were used to develop and refine scale content...
February 26, 2021: Annals of Surgical Oncology
Sergej Telentschak, Daniel Ruess, Stefan Grau, Roland Goldbrunner, Niklas von Spreckelsen, Karolina Jablonska, Harald Treuer, Martin Kocher, Maximilian Ruge
PURPOSE: The introduction of hypofractionated stereotactic radiosurgery (hSRS) extended the treatment modalities beyond the well-established single-fraction stereotactic radiosurgery and fractionated radiotherapy. Here, we report the efficacy and side effects of hSRS using Cyberknife® (CK-hSRS) for the treatment of patients with critical brain metastases (BM) and a very poor prognosis. We discuss our experience in light of current literature. METHODS: All patients who underwent CK-hSRS over 3 years were retrospectively included...
February 26, 2021: Journal of Cancer Research and Clinical Oncology
Justin R Gregg, Timothy C Thompson
Therapeutic gene manipulation has been at the forefront of popular scientific discussion and basic and clinical research for decades. Basic and clinical research applications of CRISPR-Cas9-based technologies and ongoing clinical trials in this area have demonstrated the potential of genome editing to cure human disease. Evaluation of research and clinical trials in gene therapy reveals a concentration of activity in prostate cancer research and practice. Multiple aspects of prostate cancer care - including anatomical considerations that enable direct tumour injections and sampling, the availability of preclinical immune-competent models and the delineation of tumour-related antigens that might provide targets for an induced immune system - make gene therapy an appealing treatment option for this common malignancy...
February 26, 2021: Nature Reviews. Urology
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