Addie Hill, Eutiquio Gutierrez, Jennifer Liu, Sarah Sammons, Gretchen Kimmick, Mina S Sedrak
Breast cancer is a disease of aging, and the incidence of breast cancer is projected to increase dramatically as the global population ages. The majority of breast cancers that occur in older adults are hormone-receptor positive, human epidermal growth factor receptor-2 (HER2)-negative phenotypes, with favorable tumor biology; yet, because of underrepresentation in clinical trials, less evidence is available to guide the complex care for this population. Providing care for older patients with metastatic breast cancer, with coexisting medical conditions, increased risk of treatment toxicity, and frailty, remains a clinical challenge in oncology...
March 30, 2020: Drugs & Aging
Priya U Kumthekar, Erin M Dunbar
No abstract text is available yet for this article.
March 30, 2020: Neuro-oncology
Julie Bennett, Eric Bouffet
No abstract text is available yet for this article.
March 30, 2020: Neuro-oncology
Leland S Hu, Kristin R Swanson
No abstract text is available yet for this article.
March 30, 2020: Neuro-oncology
Alessandra Murabito, Emilio Hirsch, Alessandra Ghigo
Cardiac side effects are a major drawback of anticancer therapies, often requiring the use of low and less effective doses or even discontinuation of the drug. Among all the drugs known to cause severe cardiotoxicity are anthracyclines that, though being the oldest chemotherapeutic drugs, are still a mainstay in the treatment of solid and hematological tumors. The recent expansion of the field of Cardio-Oncology, a branch of cardiology dealing with prevention or treatment of heart complications due to cancer treatment, has greatly improved our knowledge of the molecular mechanisms behind anthracycline-induced cardiotoxicity (AIC)...
2020: Frontiers in Cardiovascular Medicine
Michael Jonathan Kucharczyk, James Man Git Tsui, Farzin Khosrow-Khavar, Boris Bahoric, Luis Souhami, Maurice Anidjar, Stephan Probst, Ahmad Chaddad, Paul Sargos, Tamim Niazi
Purpose: Following radical prostatectomy, prostate bed radiotherapy (PBRT) has been combined with either long-term androgen deprivation therapy (LT-ADT) or short-term ADT with pelvic lymph node radiotherapy (PLNRT) to provide an oncological benefit in randomized trials. McGill 0913 was designed to characterize the efficacy of combining PBRT, PLNRT, and LT-ADT. It is the first study to do so prospectively. Methods: In a single arm phase II trial conduced from 2010 to 2016, 46 post-prostatectomy prostate cancer patients at a high-risk for relapse (pathological Gleason 8+ or T3) were assessed for treatment with combined LT-ADT (24 months), PBRT, and PLNRT...
2020: Frontiers in Oncology
Guoxin Cai, Chuanbao Li, Jinming Yu, Xue Meng
Objectives: The aim of this study was to assess the association between heart dosimetric parameters and cardiac events or overall survival (OS) for patients with stage III esophageal cancer receiving definitive radiotherapy. Materials and Methods: Patients with stage III esophageal cancer receiving definitive radiotherapy at our hospital from 2011 to 2013 were enrolled retrospectively. The primary endpoint was grade ≥ 2 cardiac events, and the second endpoint was 5-year OS. Competing risk analysis and Cox regressions analysis were performed to evaluate the association between heart dose and cardiac events or OS...
2020: Frontiers in Oncology
Phuong H-L Tran, Dongxi Xiang, Tuong N-G Nguyen, Thao T-D Tran, Qian Chen, Wang Yin, Yumei Zhang, Lingxue Kong, Andrew Duan, Kuisheng Chen, Miomio Sun, Yong Li, Yingchun Hou, Yimin Zhu, Yongchao Ma, Guoqin Jiang, Wei Duan
In the past decade, the study of exosomes, nanosized vesicles (50-150 nm) released into the extracellular space via the fusion of multivesicular bodies with the plasma membrane, has burgeoned with impressive achievements in theranostics applications. These nanosized vesicles have emerged as key players in homeostasis and in the pathogenesis of diseases owing to the variety of the cargos they can carry, the nature of the molecules packaged inside the vesicles, and the robust interactions between exosomes and target cells or tissues...
2020: Theranostics
Jie Xu, Yong Lin, Mu Yang, Lanjing Zhang
Trend analysis is the analysis using statistical models to estimate and predict potential trends over time, space or any independent continuous-variable. It has been widely used in epidemiology and public health, but much less so in clinical oncology and basic cancer research. Methodological imitations of the chosen statistical package also appear to result in biased or less rigorous interrogation of cancer-related data. We thus review the basic statistics of trend analysis, commonly used commands of statistical packages and the common pitfalls of conducting trend analysis...
2020: Journal of Cancer
Alchiede Simonato, Gianluca Giannarini, Alberto Abrate, Riccardo Bartoletti, Alessandro Crestani, Cosimo De Nunzio, Andrea Gregori, Giovanni Liguori, Giacomo Novara, Nicola Pavan, Carlo Trombetta, Andrea Tubaro, Francesco Porpiglia, Vincenzo Ficarra
The public health emergency caused by the Coronavirus Disease 2019 (COVID-19) pandemic has resulted in a significant reallocation of health resources with a consequent reorganization of the clinical activities also in several urological centers. A panel of Italian urologists has agreed on a set of recommendations on pathways of pre-, intra- and post-operative care for urological patients undergoing urgent procedures or non-deferrable oncological interventions during the COVID-19 pandemic. Simplification of the diagnostic and staging pathway has to be prioritized in order to reduce hospital visits and consequently the risk of contagion...
March 30, 2020: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
Yu-Li Su, Hao-Lun Luo, Chun-Chieh Huang, Ting-Ting Liu, Eng-Yen Huang, Ming-Tse Sung, Jen-Jie Lin, Po-Hui Chiang, Yen-Ta Chen, Chih-Hsiung Kang, Yuan-Tso Cheng
Galectin-1 (GAL1) is a β-galactoside-binding protein involved in multiple aspects of tumorigenesis. However, the biological role of GAL1 in upper tract urothelial carcinoma (UTUC) has not been entirely understood. Herein, we investigated the oncological effects of GAL1 expression in tumor specimens and identified related gene alterations through molecular analysis of GAL1. Clinical parameter data and tumor specimens were collected from 86 patients with pT3N0M0 UTUC who had undergone radical nephroureterectomy...
March 26, 2020: Cells
In Ja Park, Yun Suk Yu, Bilal Mustafa, Jin Young Park, Yong Bae Seo, Gun-Do Kim, Jinpyo Kim, Chang Min Kim, Hyun Deok Noh, Seung-Mo Hong, Yeon Wook Kim, Mi-Ju Kim, Adnan Ahmad Ansari, Luigi Buonaguro, Sung-Min Ahn, Chang-Sik Yu
Preoperative chemoradiotherapy (PCRT) and subsequent surgery is the standard multimodal treatment for locally advanced rectal cancer (LARC), albeit PCRT response varies among the individuals. This creates a dire necessity to identify a predictive model to forecast treatment response outcomes and identify patients who would benefit from PCRT. In this study, we performed a gene expression study using formalin-fixed paraffin-embedded (FFPE) tumor biopsy samples from 156 LARC patients (training cohort n = 60; validation cohort n = 96); we identified the nine-gene signature ( FGFR3 , GNA11 , H3F3A , IL12A , IL1R1 , IL2RB , NKD1 , SGK2 , and SPRY2 ) that distinctively differentiated responders from non-responders in the training cohort (accuracy = 86...
March 26, 2020: Cancers
Joanna K Bujak, Iwona M Szopa, Rafał Pingwara, Olga Kruczyk, Natalia Krzemińska, Joanna Mucha, Kinga Majchrzak-Kuligowska
Crosstalk between neoplastic and immune cells in the tumor microenvironment (TME) influences the progression of disease in human and canine cancer patients. Given that canine mammary tumors are a useful model to study breast cancer biology, we aimed to evaluate the expression of genes associated with T lymphocyte activity in benign, malignant, and metastatic canine mammary tumors. Interestingly, metastatic tumors exhibit increased expression of CXCR3 , CCR2 , IL-4 , IL-12p40, and IL-17 . In particular, we focused on IL-17, a key interleukin associated with the Th17 lymphocyte phenotype...
March 26, 2020: International Journal of Molecular Sciences
Evrosina I Isaac, Andrea R Meisman, Kirstin Drucker, Stephanie Violante, Kathryn L Behrhorst, Alfonso Floyd, Jennifer M Rohan
Not only do racial and ethnic minority children and adolescents with chronic illness experience disparities in health status and health outcomes, they also experience significant healthcare disparities, including differences in healthcare coverage, access to care, and quality of care. It is well known that the interaction between psychosocial functioning, health behaviors and ethnic and racial disparities, ultimately leads to worse health and psychosocial outcomes in pediatric and AYA chronic illness patient populations, including increased rates of morbidity and mortality...
March 26, 2020: International Journal of Environmental Research and Public Health
Fabio Nicoli, Daniel B Saleh, Bence Baljer, Corey D Chan, Tom Beckingsale, Kanishka M Ghosh, Maniram Ragbir, Kenneth S Rankin
BACKGROUND: Complete excision of sarcomas to maximize function without compromising the oncological outcome can be challenging. The aim of this study was to investigate the feasibility and potential drawbacks of near-infrared (NIR) fluorescence imaging with indocyanine green during resection of bone and soft tissue sarcomas. METHODS: Eleven patients with high-grade sarcomas were enrolled in the study. All patients received intravenous indocyanine green (75 mg) between 16 and 24 hours before the resection...
March 27, 2020: Annals of Surgery
Thomas W A Koedam, Boukje T Bootsma, Charlotte L Deijen, Tim van de Brug, Geert Kazemier, Miguel A Cuesta, Alois Fürst, Antonio M Lacy, Eva Haglind, Jurriaan B Tuynman, Freek Daams, Hendrik J Bonjer
OBJECTIVE: The aim of this study was to evaluate oncological outcome for patients with and without anastomotic leakage after colon or rectal cancer surgery. SUMMARY OF BACKGROUND DATA: The role of anastomotic leakage in oncological outcome after colorectal cancer surgery is still topic of debate and impact on follow-up and consideration for further treatment remains unclear. METHODS: Patients included in the international, multicenter, non-inferior, open label, randomized, controlled trials COLOR and COLOR II, comparing laparoscopic surgery for curable colon (COLOR) and rectal (COLOR II) cancer with open surgery, were analyzed...
March 27, 2020: Annals of Surgery
Tomoaki Yoh, François Cauchy, Olivier Soubrane
: Laparoscopic surgery has become an increasingly popular alternative approach to open surgery, resulting in a paradigm shift in liver surgery. Although laparoscopic liver resection (LLR) was initially indicated for small benign and peripheral tumors, at present more than half of LLRs are performed in malignant tumors. Several studies have reported the feasibility of LLR in malignant disease and suggested various short-term benefits compared to open liver resection, including decreased blood loss and postoperative complications and a shorter hospital stay...
March 27, 2020: Annals of Surgery
Alexander Harris, James Butterworth, Piers R Boshier, Hugh MacKenzie, Masanori Tokunaga, Hideki Sunagawa, Stella Mavroveli, Melody Ni, Sameh Mikhail, Chi-Chuan Yeh, Natalie S Blencowe, Kerry N L Avery, Richard Hardwick, Arnulf Hoelscher, Manuel Pera, Giovanni Zaninotto, Simon Law, Donald E Low, Jan J B van Lanschot, Richard Berrisford, Christopher Paul Barham, Jane M Blazeby, George B Hanna
OBJECTIVE: The aim was to develop a reliable surgical quality assurance system for 2-stage esophagectomy. This development was conducted during the pilot phase of the multicenter ROMIO trial, collaborating with international experts. SUMMARY OF BACKGROUND DATA: There is evidence that the quality of surgical performance in randomized controlled trials influences clinical outcomes, quality of lymphadenectomy and loco-regional recurrence. METHODS: Standardization of 2-stage esophagectomy was based on structured observations, semi-structured interviews, hierarchical task analysis, and a Delphi consensus process...
March 27, 2020: Annals of Surgery
Hanae Tokita, Rebecca Twersky, Vincent Laudone, Marcia Levine, Daniel Stein, Peter Scardino, Brett A Simon
Minimally invasive operative techniques and enhanced recovery after surgery (ERAS) protocols have transformed clinical practice and made it possible to perform increasingly complex oncologic procedures in the ambulatory setting, with recovery at home after a single overnight stay. Capitalizing on these changes, Memorial Sloan Kettering Cancer Center's Josie Robertson Surgery Center (JRSC), a freestanding ambulatory surgery facility, was established to provide both outpatient procedures and several surgeries that had previously been performed in the inpatient setting, newly transitioned to this ambulatory extended recovery (AXR) model...
March 27, 2020: Anesthesia and Analgesia
Louise Benoit, Lea Pauly, Juliette Phelippeau, Martin Koskas
INTRODUCTION: Quality of care is an emerging concern, notably in oncology. The aim of the present study was to identify the sociodemographic factors influencing the quality of care in the USA concerning the surgical management of endometrial cancer (EC) through the Surveillance Epidemiology and End Results (SEER) database using already published Belgian quality indicators (QI). METHODS: Using the SEER database 1988-2013, we identified 151,752 patients treated for EC...
March 30, 2020: Gynecologic and Obstetric Investigation
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