Simon G Ammanuel, Nyle C Almeida, Garret Kurteff, Sofia Kakaizada, Annette M Molinaro, Mitchel S Berger, Edward F Chang, Shawn L Hervey-Jumper
OBJECTIVE: Impairments of speech are common in patients with glioma and negatively impact health-related quality of life (HRQoL). The benchmark for clinical assessments is task-based measures, which are not always feasible to administer and may miss essential components of HRQoL. In this study, the authors tested the hypothesis that variations in natural language (NL) correlate with HRQoL in a pattern distinct from task-based measures of language performance. METHODS: NL use was assessed using audio samples collected unobtrusively from 18 patients with newly diagnosed low- and high-grade glioma...
July 30, 2021: Journal of Neurosurgery
Meeki Lad, Radhika Gupta, Alex Raman, Neil Parikh, Raghav Gupta, Ankush Chandra, Ashok Para, Manish K Aghi, Justin Moore
OBJECTIVE: Given its minimally invasive nature and effectiveness, stereotactic radiosurgery (SRS) has become a mainstay for the multimodal treatment of intracranial neoplasm. However, no studies have evaluated recent trends in the use of SRS versus those of open resection for the management of brain tumor or trends in the involvement of neurosurgeons in SRS (which is primarily delivered by radiation oncologists). Here, the authors used publicly available Medicare data from 2009 to 2018 to elucidate trends in the treatment of intracranial neoplasm and to compare reimbursements between these approaches...
July 30, 2021: Journal of Neurosurgery
Alexandre Roux, Kévin Beccaria, Thomas Blauwblomme, Nizar Mahlaoui, Fabrice Chretien, Pascale Varlet, Stéphanie Puget, Johan Pallud
OBJECTIVE: Transitional care in surgical neurooncology is poorly studied. However, this period is pivotal, since it allows the patient to be empowered in his or her disease management. Here, the authors describe the experience of the Necker-Enfants Malades and the Sainte-Anne Hospital collaboration. METHODS: The mixed transitional consultations started in September 2019 in a dedicated space for transitional care, named the "La Suite" department, located in the Necker-Enfants Malades Hospital, Paris, France...
July 30, 2021: Journal of Neurosurgery. Pediatrics
Jitendra Thakur, Christian T Ulrich, Ralph T Schär, Kathleen Seidel, Andreas Raabe, C Marvin Jesse
The authors present an illustrative technical note on microsurgical resection of ventrolateral completely ossified spinal meningiomas (OSMs) and a literature review of the surgical management of calcified spinal meningiomas or OSMs. These tumors are surgically demanding due to their solid consistency, especially when in a ventrolateral location with dislocation of the spinal cord. A challenging case with significant thoracic cord compression and displacement is described. Due to the firm consistency and the ventrolateral localization of the meningioma, a piecemeal resection was necessary...
July 30, 2021: Journal of Neurosurgery. Spine
Gabriele Manzella, Devmini C Moonamale, Michaela Römmele, Peter Bode, Marco Wachtel, Beat W Schäfer
First-line therapy for most pediatric sarcoma is based on chemotherapy in combination with radiotherapy and surgery. A significant number of patients experience drug resistance and development of relapsed tumors. Drugs that have the potential to re-sensitize relapsed tumor cells toward chemotherapy treatment are therefore of great clinical interest. Here, we used a drug profiling platform with PDX-derived primary rhabdomyosarcoma cells to screen a large drug library for compounds re-sensitizing relapse tumor cells toward standard chemotherapeutics used in rhabdomyosarcoma therapy...
July 27, 2021: Neoplasia: An International Journal for Oncology Research
Nicolò Bizzarri, Luca Boldrini, Gabriella Ferrandina, Francesco Fanfani, Luigi Pedone Anchora, Giovanni Scambia, Salvatore Gueli Alletti
Liu and colleagues performed a retrospective study to validate a computed tomography (CT) scan-based radiomic model to detect lymph node metastasis in cervical cancer. The proposed model incorporating the arterial and venous phase CT-scan features represented a non-invasive method exhibiting high sensitivity in the prediction of lymph node metastasis. It is well established that lymph node metastasis is one of the most significant prognostic factors in cervical cancer. For this reason, management of cervical cancer is strictly related to lymph node status, with international guidelines recommending definitive chemo-radiation in case of metastatic lymph node...
July 27, 2021: Translational Oncology
Małgorzata Białek, Agnieszka Białek, Anna Ruszczyńska, Ewa Bulska, Kamil Zaworski, Marian Czauderna
BACKGROUND: The 'developmental origin of health and disease' (DOHaD) hypothesis assumes that due to the action of some stimuli during fetal life the long-term physiological changes occurs and may affects the risk of various diseases. The main aim of this study was to assess impact of supplementation of maternal' and early postnatal diet with conjugated linoleic acids (CLA) isomers on selected elements content in hearts of their female offspring with chemically induced breast cancer. METHODS: Elemental composition was determined by quadrupole mass spectrometer with inductively coupled plasma ionization (ICP-MS)...
July 7, 2021: Journal of Trace Elements in Medicine and Biology
Ambika Chamoli, Abhishek S Gosavi, Urjita P Shirwadkar, Khushal V Wangdale, Santosh Kumar Behera, Nawneet Kumar Kurrey, Kiran Kalia, Amit Mandoli
Oral cavity squamous cell carcinoma (OCSCC) is the most common malignancy of the oral cavity. The substantial risk factors for OCSCC are the consumption of tobacco products, alcohol, betel quid, areca nut, and genetic alteration. However, technological advancements have occurred in treatment, but the survival decreases with late diagnosis; therefore, new methods are continuously being investigated for treatment. In addition, the rate of secondary tumor formation is 3-7% yearly, which is incomparable to other malignancies and can lead to the disease reoccurrence...
July 27, 2021: Oral Oncology
Eliane R Nieuwenhuis, Barry Kolenaar, Alexander J M van Bemmel, Jurrit J Hof, Joop van Baarlen, Anke Christenhusz, Joost J Pouw, Bernard Ten Haken, Lejla Alic, Remco de Bree
OBJECTIVES: To assess the feasibility and merits of a complete magnetic approach for a sentinel lymph node biopsy (SLNB) procedure in oral cancer patients. MATERIALS AND METHODS: This study included ten oral cancer patients (stage cT1-T2N0M0) scheduled for elective neck dissection (END). Superparamagnetic iron oxide nanoparticles (SPIO) were administered peritumorally prior to surgery. A preoperative MRI was acquired to identify lymph nodes (LNs) with iron uptake...
July 27, 2021: Oral Oncology
Andrey Finegersh, Rohith S Voora, Bharat Panuganti, Farhoud Faraji, F Christopher Holsinger, Kevin T Brumund, Charles Coffey, Joseph Califano, Ryan K Orosco
BACKGROUND: Hypopharyngeal cancer is associated with poor survival. Robotic surgery is emerging as a treatment for hypopharyngeal tumors, but no rigorous data are available to assess its effect on survival. METHODS: The National Cancer Database (NCDB) was used to identify patients with T1 and T2 hypopharyngeal tumors undergoing robotic surgery, laser surgery, and primary radiation with or without chemotherapy from 2010 to 2016. All adult patients with available staging and no distant metastasis were included...
July 27, 2021: Oral Oncology
Emiliano Calvo, Alexander Spira, María de Miguel, Shunsuke Kondo, Anas Gazzah, Michael Millward, Hans Prenen, Sylvie Rottey, Lydia Warburton, Tuomo Alanko, Philippe A Cassier, Kiyotaka Yoh, Antoine Italiano, Victor Moreno, Katriina Peltola, Takashi Seto, Ryo Toyozawa, Daniel E Afar, Stefan Englert, Philip Komarnitsky, Stacie Lambert, Apurvasena Parikh, Gregory Vosganian, Bo Gao
BACKGROUND: Agents targeting programmed cell death protein 1 (PD-1) have been approved as monotherapy for patients with small cell lung cancer (SCLC). In preclinical models, the combined targeting of PD-1 and delta-like protein 3 resulted in enhanced antitumor activity. Herein, we report results from the expansion arm of study NCT03000257 evaluating the combination of the anti-PD-1 antibody budigalimab and the targeted antibody-drug conjugate rovalpituzumab tesirine (Rova-T) in patients with previously treated SCLC...
May 25, 2021: Cancer Treatment and Research Communications
Pim J J Damen, Tiuri E Kroese, Richard van Hillegersberg, Ewoud Schuit, Max Peters, Joost J C Verhoeff, Steven H Lin, Peter S N van Rossum
BACKGROUND: Emerging evidence suggests a detrimental prognostic association between radiation-induced lymphopenia (RIL) and pathologic response, progression-free and overall survival (OS) in patients who undergo radiotherapy for cancer. The aim of this study was to systematically review and meta-analyze the prognostic impact of RIL on OS in patients with solid tumors. METHODS: PubMed/MEDLINE and Embase were systematically searched. The analysis included intervention and prognostic studies that reported on the prognostic relationship between RIL and survival in patients with solid tumors...
July 27, 2021: International Journal of Radiation Oncology, Biology, Physics
Nienke Hoekstra, Steven Habraken, Annemarie Swaak-Kragten, Jean-Philippe Pignol, Mischa Hoogeman
INTRODUCTION: With the introduction of accelerated partial breast irradiation (APBI) and the trend of reducing the number of fractions, the geometric accuracy of treatment delivery becomes critical. APBI patient setup is often based on fiducials, as the seroma is frequently not visible on pretreatment imaging. We assessed the motion of fiducials relative to the tumor bed between planning CT and treatment, and calculated margins to compensate for this motion. METHODS: A cohort of seventy patients treated with APBI on a Cyberknife was included...
July 27, 2021: Radiotherapy and Oncology
A Dhadda, A Sun Myint, B Thamphya, I Hunter, M Hershman, J Gerard
INTRODUCTION: Early rectal cancers are increasingly diagnosed through screening programmes and are often treated using local excision (LE). In the case of adverse pathological features completion total mesorectal excision surgery (TME) is the standard recommendation. The morbidity and mortality risks of TME have stimulated the use of adjunctive treatments following LE to achieve organ preservation. MATERIAL AND METHODS: Patients treated with adjuvant CXB following local excision between 2004-2017 in three centres were identified (Clatterbridge, Hull, Nice)...
July 27, 2021: Radiotherapy and Oncology
N Peters, P Wohlfahrt, C V Dahlgren, L de Marzi, M Ellerbrock, F Fracchiolla, J Freeh, C Gomà, J Góra, M F Jensen, T Kajdrowicz, R Mackay, S Molinelli, I Rinaldi, V Rompokos, D Siewert, P van der Tol, X Vermeren, H Nyström, A Lomax, C Richter
PURPOSE: Experimental assessment of inter-centre variation and absolute accuracy of stopping-power-ratio (SPR) prediction within 17 particle therapy centres of the European Particle Therapy Network. MATERIAL AND METHODS: A head and body phantom with seventeen tissue-equivalent materials were scanned consecutively at the participating centres using their individual clinical CT scan protocol and translated into SPR with their in-house CT-number-to-SPR conversion. Inter-centre variation and absolute accuracy in SPR prediction were quantified for three tissue groups: lung, soft tissues and bones...
July 27, 2021: Radiotherapy and Oncology
Wenyu Yang, Jiaoyang Cai, Shuhong Shen, Ju Gao, Jie Yu, Shaoyan Hu, Hua Jiang, Yongjun Fang, Changda Liang, Xiuli Ju, Xuedong Wu, Xiaowen Zhai, Xin Tian, Ningling Wang, Aiguo Liu, Hui Jiang, Runming Jin, Lirong Sun, Minghua Yang, Alex W K Leung, Kaili Pan, Yingchi Zhang, Jing Chen, Yiping Zhu, Hui Zhang, Chunfu Li, Jun J Yang, Cheng Cheng, Chi-Kong Li, Jingyan Tang, Xiaofan Zhu, Ching-Hon Pui
BACKGROUND: Vincristine plus dexamethasone pulses are generally used throughout maintenance treatment for childhood acute lymphoblastic leukaemia. However, previous studies remain inconclusive about the benefit of this maintenance therapy and the absence of randomised, controlled trials in patients with low-risk or high-risk acute lymphoblastic leukaemia provides uncertainty. We therefore aimed to determine if this therapy could be safely omitted beyond 1 year of treatment without leading to an inferior outcome in any risk subgroup of childhood acute lymphoblastic leukaemia...
July 27, 2021: Lancet Oncology
Ryan C Lynch, Ryan D Cassaday, Stephen D Smith, Jonathan R Fromm, Andrew J Cowan, Edus H Warren, Mazyar S Shadman, Andrei Shustov, Brian G Till, Chaitra S Ujjani, Edward N Libby, Mary Philip, Hilary Coye, Christen N Martino, Sandra L Bhark, Karolyn Morris, Heather Rasmussen, Sanaz Behnia, Jenna Voutsinas, Ajay K Gopal
BACKGROUND: Relapsed or refractory classical Hodgkin lymphoma could be treated with multiagent salvage chemotherapy followed by autologous haematopoietic stem-cell transplantation. The aim of this study is to establish the safety and activity of dose-dense brentuximab vedotin combined with ifosfamide, carboplatin, and etoposide (BV-ICE) chemotherapy in second-line treatment of classical Hodgkin lymphoma. METHODS: We conducted a single-arm, open-label, phase 1/2 study of dose-dense BV-ICE at the Seattle Cancer Care Alliance, University of Washington (Seattle, WA, USA)...
August 2021: Lancet Haematology
Miao Xian Zhou, Emma F Johnson, Kevin Arce, Scott F Gruwell
Oral cavity lymphomas constitute only 3% of all lymphomas in the general population but are the third most common oral malignancy. A 67-year-old female with a history of osteoporosis, Graves' disease and non-Hodgkin's lymphoma was referred to the Department of Dental Specialties with a chief complaint of persistent soft tissue swelling facial to the maxillary incisors of possible non-odontogenic origin. To expedite care, the patient was first seen via teledentistry and subsequently appointed for an in-person evaluation and treatment...
July 30, 2021: Special Care in Dentistry
Kheira Hireche, Mathieu Moqaddam, Nicolas Lonjon, Charles Marty-Ané, Laurence Solovei, Baris Ata Ozdemir, Ludovic Canaud, Pierre Alric
OBJECTIVES: This article aims to evaluate the feasibility and safety of a hybrid video-assisted thoracic surgery (VATS) approach to achieve en bloc lobectomy and spinal resection for non-small-cell lung cancer (NSCLC). METHODS: Between October 2015 and November 2020, 10 patients underwent VATS anatomical lobectomy and en bloc chest wall and spinal resection through a limited posterior midline incision as a single operation for T4 (vertebral involvement) lung cancer...
July 30, 2021: Interactive Cardiovascular and Thoracic Surgery
Yefei Shu
No abstract text is available yet for this article.
August 1, 2021: American Journal of Clinical Oncology
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