Christian Tibor Josef Magyar, Yogesh K Vashist, Deborah Stroka, Corina Kim-Fuchs, Martin D Berger, Vanessa M Banz
PURPOSE: Dysregulated expression of heat shock proteins (HSP) plays a fundamental role in tumor development and progression. Consequently, HSP90 may be an effective tumor target in oncology, including the treatment of gastrointestinal cancers. METHODS: We carried out a systematic review of data extracted from clinicaltrials.gov and pubmed.gov, which included all studies available until January 1st, 2022. The published data was evaluated using primary and secondary endpoints, particularly with focus on overall survival, progression-free survival, and rate of stable disease...
March 26, 2023: Journal of Cancer Research and Clinical Oncology