Ilias Koutsopetras, Valentine Vaur, Rania Benazza, Hélène Diemer, Charlotte Sornay, Yağmur Ersoy, Léa Rochet, Carmen Longo, Oscar Hernandez-Alba, Stéphane Erb, Alexandre Detappe, Arne Skerra, Alain Wagner, Sarah Cianferani, Guilhem Chaubet
The chemical bioconjugation of proteins has seen tremendous applications in the past decades, with the booming of antibody-drug conjugates and their use in oncology. While genetic engineering has permitted to produce bespoke proteins featuring key (un-)natural amino acid residues poised for site-selective modifications, the conjugation of native proteins is riddled with selectivity issues. Chemoselective strategies are plentiful and enable the precise modification of virtually any residue with a reactive side-chain; site-selective methods are less common and usually most effective on small and medium-sized proteins...
December 5, 2023: Chemistry: a European Journal