Almut Dutz, Armin Lühr, Linda Agolli, Rebecca Bütof, Chiara Valentini, Esther G C Troost, Michael Baumann, Xavier Vermeren, Dirk Geismar, Nayan Lamba, Emily F Lebow, Meghan Bussière, Jillian E Daly, Marc R Bussière, Mechthild Krause, Beate Timmermann, Helen A Shih, Steffen Löck
BACKGROUND: The limited availability of proton beam therapy (PBT) requires individual treatment selection strategies that can be based on normal tissue complication probability (NTCP) models. We developed and externally validated NTCP models for common late side-effects following PBT in brain tumour patients to optimise patients' quality of life. METHODS: Cohorts from three PBT centres (216 patients) were investigated for several physician-rated endpoints at 12 and 24 months after PBT: alopecia, dry eye syndrome, fatigue, headache, hearing and memory impairment, and optic neuropathy...
January 19, 2021: Radiotherapy and Oncology