Melvin Khee-Shing Leow, Anantharaj Rengaraj, Kothandaraman Narasimhan, Sanjay K Verma, Jadegoud Yaligar, Giang Le Thi Thu, Lijuan Sun, Hui Jen Goh, Priya Govindharajulu, Suresh Anand Sadananthan, Navin Michael, Wei Meng, Xavier Gallart-Palau, Lei Sun, Neerja Karnani, Newman Siu Kwan Sze, S Sendhil Velan
Brown adipose tissue (BAT) is a promising weapon to combat obesity and metabolic disease. BAT is thermogenic and consumes substantial amounts of glucose and fatty acids as fuel for thermogenesis and energy expenditure. To study BAT function in large human longitudinal cohorts, safe and precise detection methodologies are needed. Although regarded a gold standard, the foray of PET-CT into BAT research and clinical applications is limited by its high ionizing radiation doses. Here, we show that brown adipocytes release exosomes in blood plasma that can be utilized to assess BAT activity...
May 27, 2022: Bioscience Reports