Connie R Bezzina, Raha Pazoki, Abdennasser Bardai, Roos F Marsman, Jonas S S G de Jong, Marieke T Blom, Brendon P Scicluna, J Wouter Jukema, Navin R Bindraban, Peter Lichtner, Arne Pfeufer, Nanette H Bishopric, Dan M Roden, Thomas Meitinger, Sumeet S Chugh, Robert J Myerburg, Xavier Jouven, Stefan Kääb, Lukas R C Dekker, Hanno L Tan, Michael W T Tanck, Arthur A M Wilde
Sudden cardiac death from ventricular fibrillation during acute myocardial infarction is a leading cause of total and cardiovascular mortality. To our knowledge, we here report the first genome-wide association study for this trait, conducted in a set of 972 individuals with a first acute myocardial infarction, 515 of whom had ventricular fibrillation and 457 of whom did not, from the Arrhythmia Genetics in The Netherlands (AGNES) study. The most significant association to ventricular fibrillation was found at 21q21 (rs2824292, odds ratio = 1...
August 2010: Nature Genetics