Hengkang Liu, Jiawen Gao, Mei Feng, Jinghui Cheng, Yuchen Tang, Qi Cao, Ziji Zhao, Ziqiao Meng, Jiarui Zhang, Guohong Zhang, Chong Zhang, Mingming Zhao, Yicen Yan, Yang Wang, Ruidong Xue, Ning Zhang, Hang Li
In acral melanoma (AM), progression from in situ (AMis) to invasive AM (iAM) leads to significantly reduced survival. However, evolutionary dynamics during this process remain elusive. Here, we report integrative molecular and spatial characterization of 147 AMs using genomics, bulk and single-cell transcriptomics, and spatial transcriptomics and proteomics. Vertical invasion from AMis to iAM displays an early and monoclonal seeding pattern. The subsequent regional expansion of iAM exhibits two distinct patterns, clonal expansion and subclonal diversification...
May 9, 2024: Cancer Cell