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JOURNAL ARTICLE
Francisco J Pastor-Pérez, Iris P Garrido-Bravo, Pablo Peñafiel-Verdú, Noelia Fernández-Villa, Sergio Manzano-Fernández, María José Oliva-Sandoval, María Teresa Pérez-Martínez, César Caro-Martínez, Álvaro Hernández-Vicente, Domingo A Pascual-Figal
Introduction and objectives Cardiac resynchronization therapy (CRT) is an effective treatment for patients with nonischemic dilated cardiomyopathy associated with left bundle branch block (LBBB). In these patients, the device can normalize left ventricular ejection fraction (LVEF). Nevertheless, it remains unclear whether CRT responders still require neurohormonal blockers. The aim of this study is to determine the long-term safety of withdrawing drug therapy in these patients. Methods The REMOVE trial (NCT05151861) is a prospective, multicenter, open-label and randomized 1:1 study designed to assess the effect of withdrawing neurohormonal blockers in patients with nonischemic dilated cardiomyopathy associated with left bundle branch block who recovered LVEF after CRT...
May 1, 2024: Revista Española de Cardiología
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JOURNAL ARTICLE
Ilaria Cani, Giulia Giannini, Pietro Guaraldi, Giorgio Barletta, Luisa Sambati, Luca Baldelli, Pietro Cortelli, Giovanna Calandra-Buonaura
BACKGROUND: Blood pressure control in Parkinson's disease (PD) under subthalamic deep brain stimulation (STN-DBS) is influenced by several intertwined aspects, including autonomic failure and levodopa treatment. OBJECTIVE: To evaluate the effect of chronic STN-DBS, levodopa, and their combination on cardiovascular autonomic functions in PD. METHODS: We performed cardiovascular reflex tests (CRTs) before and 6-months after STN-DBS surgery in 20 PD patients (pre-DBS vs...
May 2, 2024: Movement Disorders Clinical Practice
#3
JOURNAL ARTICLE
Seung-Been Lee, Ji-Won Kim, Hong-Geun Kim, Sung-Hyun Hwang, Kui-Jin Kim, Ju Hyun Lee, Jeongmin Seo, Minsu Kang, Eun Hee Jung, Koung Jin Suh, Se Hyun Kim, Jin Won Kim, Yu Jung Kim, Jee Hyun Kim, Nak-Jung Kwon, Keun-Wook Lee
PURPOSE: This study aimed to compare tumor tissue DNA (ttDNA) and circulating tumor DNA (ctDNA) to explore the clinical applicability of ctDNA and to better understand clonal evolution in patients with metastatic colorectal cancer undergoing palliative first-line systemic therapy. MATERIALS AND METHODS: We performed targeted sequencing analysis of 88 cancer-associated genes using germline DNA, ctDNA at baseline (baseline-ctDNA), and ctDNA at progressive disease (PD-ctDNA)...
April 29, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
#4
JOURNAL ARTICLE
Dong-Hoe Koo, Minkyu Jung, Yeul Hong Kim, Hei-Cheul Jeung, Dae Young Zang, Woo Kyun Bae, Hyunki Kim, Hyo Song Kim, Choong-Kun Lee, Woo Sun Kwon, Hyun Cheol Chung, Sun Young Rha
PURPOSE: Varlitinib is a pan-human epidermal growth (HER) inhibitor targeting epidermal growth factor receptor (EGFR), HER2, and HER4. We present a phase Ib/II study of a combination of varlitinib and weekly paclitaxel as a second-line treatment for patients with EGFR/HER2 co-expressing advanced gastric cancer (AGC). MATERIALS AND METHODS: Patients whose tumors with EGFR and HER2 overexpression by immunohistochemistry (IHC) (≥1+) were enrolled. Varlitinib and paclitaxel were investigated every 4 weeks...
April 29, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
#5
JOURNAL ARTICLE
Junghoon Shin, Sehhoon Park, Kyung Hwan Kim, Eui-Cheol Shin, Hyun Ae Jung, Jong Ho Cho, Jong-Mu Sun, Se-Hoon Lee, Yong Soo Choi, Jin Seok Ahn, Jhingook Kim, Keunchil Park, Young Mog Shim, Hong Kwan Kim, Jae Myoung Noh, Yong Chan Ahn, Hongryull Pyo, Myung-Ju Ahn
PURPOSE: Optimal treatment for stage IIIA/N2 non-small cell lung cancer (NSCLC) is controversial. We aimed to assess the efficacy and safety of adjuvant pembrolizumab for stage IIIA/N2 NSCLC completely resected after neoadjuvant concurrent chemoradiation therapy (CCRT). MATERIALS AND METHODS: In this open-label, single-center, single-arm phase 2 trial, patients with stage IIIA/N2 NSCLC received adjuvant pembrolizumab for up to two years after complete resection following neoadjuvant CCRT...
April 30, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
#6
JOURNAL ARTICLE
Xiangye Ou, Junyi Wu, Jiayi Wu, Yangkai Fu, Zhenxin Zeng, Shuqun Li, Yinan Li, Deyi Liu, Han Li, Bin Li, Jianyin Zhou, Shaowu Zhuang, Shuqun Cheng, Zhibo Zhang, Kai Wang, Shuang Qu, Maolin Yan
PURPOSE: The prognosis of patients with hepatocellular carcinoma (HCC) and portal vein tumor thrombus (PVTT) is extremely poor, and systemic therapy is currently the mainstream treatment. This study aimed to assess the efficacy and safety of lenvatinib combined with anti-PD-1 antibodies and transcatheter arterial chemoembolization (triple therapy) in patients with HCC and PVTT. MATERIALS AND METHODS: This retrospective multicenter study included patients with HCC and PVTT who received triple therapy, were aged between 18 and 75 years, classified as Child Pugh class A or B, and had at least one measurable lesion...
April 30, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
#7
JOURNAL ARTICLE
Dong-Woo Choi, Minyeong Guk, Hyeri Kim, Kwang Sun Ryu, Hyun-Joo Kong, Hyo Soung Cha, Hyun-Jin Kim, Heejung Chae, Young Sang Jeon, Hwanhee Kim, JipMin Jung, Jeong-Soo Im, Kui Son Choi
This paper provides a comprehensive overview of the Cancer Public Library Database (CPLD), established under the Korean Clinical Data Utilization for Research Excellence project (K-CURE). The CPLD links data from four major population-based public sources: the Korea National Cancer Incidence Database in the Korea Central Cancer Registry, cause-of-death data in Statistics Korea, the National Health Information Database in the National Health Insurance Service, and the National Health Insurance Research Database in the Health Insurance Review & Assessment Service...
April 30, 2024: Cancer Research and Treatment: Official Journal of Korean Cancer Association
#8
JOURNAL ARTICLE
Giovanni Morani, Bruna Bolzan, Antonio Pepe, Giampaolo Berton, Mattia Strazzanti, Flavio Luciano Ribichini
BACKGROUND: Axillary vein puncture (AVP) is a valid alternative to Subclavan vein puncture for leads insertion in cardiac implantable electronic device implantation, that may reduce acute and delayed complications. Very few data are available about ICD recipients. A simplified AVP technique is described. METHODS: All the patients who consecutively underwent "de novo" ICD implantation, from March 2006 to December 2020 at the University of Verona, were considered...
April 30, 2024: International Journal of Cardiology
#9
JOURNAL ARTICLE
Hongjin Si, Zhuo He, Saurabh Malhotra, Xinwei Zhang, Fengwei Zou, Siyuan Xue, Zhiyong Qian, Yao Wang, Xiaofeng Hou, Weihua Zhou, Jiangang Zou
BACKGROUND: The segment of the latest mechanical contraction (LMC) does not always overlap with the site of the latest electrical activation (LEA). By integrating both mechanical and electrical dyssynchrony, this proof-of-concept study aimed to propose a new method for recommending left ventricular (LV) lead placements, with the goal of enhancing response to cardiac resynchronization therapy (CRT). METHODS: The LMC segment was determined by single-photon emission computed tomography myocardial perfusion imaging (SPECT MPI) phase analysis...
April 30, 2024: Journal of Nuclear Cardiology
#10
JOURNAL ARTICLE
Javier De Juan Bagudá, Rocío Cózar León, Juan J Gavira Gómez, Marta Pachón, Josebe Goirigolzarri Artaza, Virgilio Martínez Mateo, Vanessa Escolar Pérez, Ángel Manuel Iniesta Manjavacas, Nuria Rivas Gándara, Jesús Álvarez-García, Jesús Gabriel Sánchez Ramos, Cristina Aguilera Agudo, José Manuel Rubín López, Alfonso Macías Gallego, Silvia López Fernández, Luis González Torres, Juan Gabriel Martínez, Natalia Marrero Negrín, Javier Ramos Maqueda, Mercedes Cabrera Ramos, José María Medina Gil, Carlos De Diego Rus, Francisco José Bermúdez Jiménez, Inés Madrazo, Beatriz Díaz Molina, Marta Cobo Marcos, Ana Delia Ruiz Duthil, David Cordero, Ana Belén Méndez Fernández, Laura Peña Conde, María F Arcocha Torres, Nicasio Pérez Castellano, Miguel A Arias, Ignacio García Bolao, Ernesto Díaz Infante, Monica Campari, Fernando Arribas Ynsaurriaga, Juan F Delgado Jiménez, Sergio Valsecchi, Rafael Salguero Bodes
INTRODUCTION AND OBJECTIVES: The multiparametric implantable cardioverter-defibrillator HeartLogic index has proven to be a sensitive and timely predictor of impending heart failure (HF) decompensation. We evaluated the impact of a standardized follow-up protocol implemented by nursing staff and based on remote management of alerts. METHODS: The algorithm was activated in HF patients at 19 Spanish centers. Transmitted data were analyzed remotely, and patients were contacted by telephone if alerts were issued...
April 30, 2024: Revista Española de Cardiología
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JOURNAL ARTICLE
Johannes Kirchner, Muhammed Gerçek, Vanessa Sciacca, Jan-Christian Reil, Denise Guckel, Max Potratz, Hazem Omran, Kai Friedrichs, Thomas Eitz, Sabine Bleiziffer, Rene Schramm, Guram Imnadze, Christian Sohns, Jan Gummert, Volker Rudolph, Tanja K Rudolph, Philipp Sommer, Thomas Fink
BACKGROUND: Permanent pacemaker implantation (PMI) is associated with increased morbidity after transcatheter aortic valve replacement (TAVR). Cardiac resynchronization-therapy (CRT) is recommended for patients if left ventricular ejection fraction (LVEF) is ≤ 40% and ventricular pacing is expected in favor to sole right ventricular (RV) pacing. Meanwhile, LVEF may recover after TAVR in patients with aortic valve disease and the benefit of CRT is unknown. OBJECTIVE: To analyze the impact of CRT implantation as compared to RV pacing after TAVR...
May 2, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
#12
JOURNAL ARTICLE
Gizem Kaval, Merve Gulbiz Dagoglu Kartal, Sena Azamat, Eda Cingoz, Gokhan Ertas, Sule Karaman, Basak Kurtuldu, Metin Keskin, Neslihan Berker, Senem Karabulut, Ethem Nezih Oral, Nergiz Dagoglu Sakin
PURPOSE: Studies examining prediction of complete response (CR) in locally advanced rectum cancer (LARC) from pre/post chemoradiotherapy (CRT) magnetic resonance imaging (MRI) are performed mostly with segmentations of the tumor, whereas only in two studies segmentation included tumor and mesorectum. Additionally, pelvic extramesorectal region, which is included in the clinical target volume (CTV) of radiotherapy, may contain information. Therefore, we aimed to compare predictive rates of radiomics analysis with features extracted from segmentations of tumor, tumor+mesorectum, and CTV...
2024: Pathology Oncology Research: POR
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JOURNAL ARTICLE
Houda Bougrine, Achraf Ammar, Khaled Trabelsi, Ahlem Belgacem, Atef Salem, Hamdi Chtourou, Haitham Jahrami, Nizar Souissi
The present study aimed to investigate the effect of the timing of the last meal, "Suhoor", on diurnal variation in cognitive performance during Ramadan intermittent fasting (RIF). In a randomized order, 26 adolescent female athletes (aged 15.9 ± 0.9 y) were tested in three sessions at 7:00 a.m., 12:00 p.m., and 5:00 p.m. across four different conditions: the 10 days preceding Ramadan (PR); the final 12 days of Ramadan (RO): two different conditions: Early Suhoor (SEarly ), and Late Suhoor (SLate ); and, ultimately, the 10 days immediately after Ramadan (AR) with an in-between recovery period of ≥24 h...
2024: Frontiers in Nutrition
#14
JOURNAL ARTICLE
Takumi Nagasawa, Kazuki Iwata, Raquel Pantojo de Souza Bachour, Keiko Ogawa-Ochiai, Norimichi Tsumura, George C Cardoso
Skin color observation provides a simple and non-invasive method to estimate the health status of patients. Capillary Refill Time (CRT) is widely used as an indicator of pathophysiological conditions, especially in emergency patients. While the measurement of CRT is easy to perform, its evaluation is highly subjective. This study proposes a method to aid quantified CRT measurement using an RGB camera. The procedure consists in applying finger compression to the forearm, and the CRT is calculated based on the skin color change after the pressure release...
May 2024: Medical Engineering & Physics
#15
JOURNAL ARTICLE
Erik Lipsic, Fenna Daniels, Hessel F Groenveld, Michiel Rienstra, Alexander H Maass
Due to increasing use of cardiac implantable electronic devices (CIEDs) with one or more intracardiac electrodes, the rate of lead failure is increasing. Moreover, an upgrade of the CIED is frequently indicated for cardiac resynchronization therapy or other reasons. Both these situations require a new intervention, preferably using the ipsilateral venous access. However, venous obstruction after CIED insertion occurs in 10-20% of patients and poses a major obstacle for implantation of additional leads. Possible solutions include lead extraction, contralateral lead insertion, and venoplasty...
April 29, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
#16
JOURNAL ARTICLE
Eiichi Nakao, Michitaka Honda, Noriyuki Uesugi, Mitsumasa Osakabe, Ayaka Sato, Yukitoshi Todate, Mizunori Yaegashi, Yoshinao Takano, Akira Sasaki, Koji Kono, Tamotsu Sugai
BACKGROUND: The prognostic value of the pathological response to preoperative chemoradiotherapy (CRT) in rectal cancer (RC) remains unknown. OBJECTIVES: We aimed to assess the predictive value of the response to CRT that was derived from an evaluation of the histological findings (whole-section vs. representative-section sampling) and attempted to determine an objective cut-off value for the tumor regression grade (TRG). METHODS: We examined the association of the TRG with the outcomes (recurrence-free survival [RFS] and overall survival [OS]) of 78 patients with RC...
May 1, 2024: Journal of Surgical Oncology
#17
JOURNAL ARTICLE
Jillian Zitars, Deborah Scharf
Police are often the first to encounter individuals when they are experiencing a mental health crisis. Other professionals with different skill sets, however, may be needed to optimize crisis response. Increasingly, police and mental health agencies are creating co-responder teams (CRTs) in which police and mental health professionals co-respond to crisis calls. While past evaluations of CRTs have shown promising results (e.g. hospital diversions; cost-effectiveness), most studies occurred in larger urban contexts...
April 30, 2024: Journal of Behavioral Health Services & Research
#18
JOURNAL ARTICLE
Zhihui Jia, Wen Yu, Jingmo Li, Mingming Zhang, Bin Zhan, Liming Yan, Zhenhua Ming, Yuli Cheng, Xiaolin Tian, Shuai Shao, Jingjing Huang, Xinping Zhu
Helminths produce calreticulin (CRT) to immunomodulate the host immune system as a survival strategy. However, the structure of helminth-derived CRT and the structural basis of the immune evasion process remains unclarified. Previous study found that the tissue-dwelling helminth Trichinella spiralis produces calreticulin (TsCRT), which binds C1q to inhibit activation of the complement classical pathway. Here, we used x-ray crystallography to resolve the structure of truncated TsCRT (TsCRTΔ ), the first structure of helminth-derived CRT...
2024: Frontiers in Immunology
#19
EDITORIAL
Akash Batta, Juniali Hatwal
The deleterious effects of long-term right ventricular pacing necessitated the search for alternative pacing sites which could prevent or alleviate pacing-induced cardiomyopathy. Until recently, biventricular pacing (BiVP) was the only modality which could mitigate or prevent pacing induced dysfunction. Further, BiVP could resynchronize the baseline electromechanical dssynchrony in heart failure and improve outcomes. However, the high non-response rate of around 20%-30% remains a major limitation. This non-response has been largely attributable to the direct non-physiological stimulation of the left ventricular myocardium bypassing the conduction system...
April 26, 2024: World Journal of Cardiology
#20
JOURNAL ARTICLE
Jiahui Zhu, Jinhao Li, Li Zhou, Lingzi Xu, Chengcheng Pu, Bingjie Huang, Qi Zhou, Yunhan Lin, Yajing Tang, Liu Yang, Chuan Shi
AIM: Baseline cognitive functions of patients predicted the efficacy of cognitive remediation therapy (CRT), but results are mixed. Eye movement is a more objective and advanced assessment of cognitive functions than neuropsychological testing. We aimed to investigate the applicability of eye movements in predicting cognitive improvement after patients with schizophrenia were treated with CRT. METHODS: We recruited 79 patients with schizophrenia to complete 8 weeks of CRT and assessed their cognitive improvement outcomes...
2024: Frontiers in Psychiatry
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