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https://read.qxmd.com/read/31951121/single-virus-tracking-from-imaging-methodologies-to-virological-applications
#1
Shu-Lin Liu, Zhi-Gang Wang, Hai-Yan Xie, An-An Liu, Don C Lamb, Dai-Wen Pang
Uncovering the mechanisms of virus infection and assembly is crucial for preventing the spread of viruses and treating viral disease. The technique of single-virus tracking (SVT), also known as single-virus tracing, allows one to follow individual viruses at different parts of their life cycle and thereby provides dynamic insights into fundamental processes of viruses occurring in live cells. SVT is typically based on fluorescence imaging and reveals insights into previously unreported infection mechanisms...
January 17, 2020: Chemical Reviews
https://read.qxmd.com/read/31941731/supraventricular-tachycardia-an-overview-of-diagnosis-and-management
#2
Irum D Kotadia, Steven E Williams, Mark O'Neill
Supraventricular tachycardia (SVT) is a common cause of hospital admissions and can cause significant patient discomfort and distress. The most common SVTs include atrioventricular nodal re-entrant tachycardia, atrioventricular re-entrant tachycardia and atrial tachycardia. In many cases, the underlying mechanism can be deduced from electrocardiography during tachycardia, comparing it with sinus rhythm, and assessing the onset and offset of tachycardia. Recent European Society of Cardiology guidelines continue to advocate the use of vagal manoeuvres and adenosine as first-line therapies in the acute diagnosis and management of SVT...
January 2020: Clinical Medicine: Journal of the Royal College of Physicians of London
https://read.qxmd.com/read/31940217/interaction-between-regional-lung-volumes-and-ventilator-induced-lung-injury-in-the-normal-and-endotoxaemic-lung
#3
Seiha Yen, Melissa Preissner, Ellen Bennett, Stephen Dubsky, Richard Carnibella, Rhiannon P Murrie, Andreas Fouras, Peter A Dargaville, Graeme R Zosky
Both overdistension and atelectasis contribute to lung injury and mortality during mechanical ventilation. It has been proposed that combinations of tidal volume and end expiratory lung volume exist that minimise lung injury linked to mechanical ventilation. The aim of this study was to examine this at the regional level in the healthy and endotoxaemic lung. Adult female BALB/c mice were injected intraperitoneally with 10 mg.kg-1 of lipopolysaccharide (LPS) in saline or saline alone. Four hours later, mice were mechanically ventilated for 2 hours...
January 15, 2020: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://read.qxmd.com/read/31930919/single-virus-tracking-with-quantum-dots-packaged-into-enveloped-viruses-using-crispr
#4
Yong-Bo Yang, Yan-Dong Tang, Yue Hu, Fang Yu, Jun-Yao Xiong, Ming-Xia Sun, Chuang Lyu, Jin-Mei Peng, Zhi-Jun Tian, Xue-Hui Cai, Tong-Qing An
Labeling viruses with high photoluminescence quantum dots (QDs) for single virus tracking (SVT) provides a visual tool to aid our understanding of viral infection mechanisms. However, efficiently labeling internal viral components without modifying the viral envelope and capsid remains a challenge, and existing strategies are not applicable to most viruses. Here, we have devised a strategy using the clustered regularly interspaced short palindromic repeats (CRISPR) imaging system to label the nucleic acids of Pseudorabies virus (PRV) with QDs...
January 13, 2020: Nano Letters
https://read.qxmd.com/read/31916010/anticoagulant-therapy-in-the-treatment-of-splanchnic-vein-thrombosis-associated-to-acute-pancreatitis-a-3-year-single-centre-experience
#5
Danilo Pagliari, Rossella Cianci, Maria Gabriella Brizi, Francesco Antonio Mancarella, Massimiliano Musso, Marco Cintoni, Laura Franza, Roberto Antonio Flore, Antonio Gasbarrini, Paolo Tondi
Splanchnic vein thrombosis (SVT) is a possible complication of acute pancreatitis (AP). There are no precise guidelines on the use of anticoagulant therapy (AT) in these patients. The aim of the study was to determine the safety and the efficacy of AT in AP-associated SVT. Two hundred twenty-one patients were retrospectively and consecutively enrolled from the Pancreatic Outpatient Clinic of the "A. Gemelli" hospital. Patients had a diagnosis of AP and a diagnostic imaging to evaluate whether they had or not SVT...
January 8, 2020: Internal and Emergency Medicine
https://read.qxmd.com/read/31910195/isolated-superficial-vein-thrombosis-in-multiple-thrombotic-defects
#6
Carmine Siniscalchi, Anna Rocci
Superficial Vein Thrombosis (SVT) is generally a benign, self-limited disorder; however, when larger veins are involved, propagation into deep vein system can occur. Thrombophilic disorders denote several risk factors that predispose individuals to develop venous thromboembolism. It includes inherited thrombophilia, acquired thrombophilia and hyperhomocysteinemia. For thrombophilic patients who develop SVT, the current guidelines don't clarify for how long time anticoagulation therapy must be performed. We describe a case of SVT in a patient with multiple thrombotic defects, for which we starting Fondaparinux 2...
December 23, 2019: Acta Bio-medica: Atenei Parmensis
https://read.qxmd.com/read/31902263/incidence-of-supraventricular-tachycardia-after-inhaled-short-acting-beta-agonist-treatment-in-children
#7
Stephanie Woodward, Michael Mundorff, Cindy Weng, David G Gamboa, Michael D Johnson
Introduction: Albuterol can trigger supraventricular tachycardia (SVT). The clinical characteristics, incidence, and risk factors of SVT after inhaled SABA treatment in children are currently unknown. Through review of regional care delivery, we will describe cases of SVT during asthma treatment in hospital-based settings, define the incidence of SVT in our population, and evaluate risk factors of SABA-induced SVT. Methods: We identified hospital-based care episodes of children 0-18 years old between 2006 and 2015 recorded in the Intermountain Healthcare EDW with either 1) diagnosis codes for both asthma and SVT or 2) both SABA and adenosine listed as billed medications...
January 6, 2020: Journal of Asthma
https://read.qxmd.com/read/31901968/posttraumatic-cerebrovascular-injuries-in-children-a-systematic-review
#8
REVIEW
Nader Hejrati, Florian Ebel, Raphael Guzman, Jehuda Soleman
INTRODUCTION: Posttraumatic craniocervical vascular injuries in pediatric traumatic brain injury (TBI) are rare, and children-specific, evidence-based standards on screening and therapy of posttraumatic carotid-cavernous fistula (CCF), craniocervical artery dissections (CCAD), traumatic aneurysms (TA), and posttraumatic sinus venous thrombosis (SVT) is lacking. The aim of this review is to summarize the data on epidemiology, clinical presentation, and treatment of these traumatic lesions in a systematic manner...
January 4, 2020: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://read.qxmd.com/read/31894681/-effects-of-sustained-military-physical-related-activity-on-balance-ability
#9
Sheng-Jia Xu, Lin Xu, Wei Jia, Dong Tian, Hai-Song Huang, Jin-Zhi Wang, Jing Yang, Ji-Zheng Ma
OBJECTIVE: To evaluate the effects of sustained military physical related activity on balance abilities and the role of visual system in it, so as to provide the basis for precise training. METHODS: Fifty-four healthy males (age: 20.28±3.72 y, height: 173.21±5.67 cm; weight: 64.29±5.12 kg) were recruited in this experiment. Multiple military subjects were completed within 36 hours, and the workload was recorded (randomly select 11 people). After military activity, the balance abilities with opened eyes (54 people) and closed eyes (randomly selected 27 people) were evaluated...
September 2019: Chinese Journal of Applied Physiology
https://read.qxmd.com/read/31885188/congenital-antithrombin-deficiency-in-patients-with-splanchnic-vein-thrombosis
#10
Anna Baiges, María Eugenia de la Morena-Barrio, Fanny Turon, Antonia Miñano, José Alberto Ferrusquía, Marta Magaz, Juan Carlos Reverter, Vicente Vicente, Virginia Hernández-Gea, Javier Corral, Juan Carlos García-Pagán
BACKGROUND AND AIMS: Splanchnic vein thromboses (SVT) are a rare condition that can be life-threatening. The most severe thrombophilia associated to SVT is antithrombin (AT) deficiency, usually caused by SERPINC1 mutations. Although transitory AT deficiencies and congenital disorders of the N-glycosylation pathways (CDG) have been recently reported as causes of AT deficiency, the current AT clinical screening still only includes anti-FXa activity. This study aims to 1) improve the detection of antithrombin deficiency in SVT and 2) characterize the features of antithrombin deficiency associated with SVT...
December 29, 2019: Liver International: Official Journal of the International Association for the Study of the Liver
https://read.qxmd.com/read/31871796/hypertrophic-cardiomyopathy-and-wolff-parkinson-white-syndrome-in-a-young-african-soldier-with-recurrent-syncope
#11
Mohammed Abdullahi Talle, Faruk Buba, Aimé Bonny, Musa Mohammed Baba
Syncope is a common manifestation of both hypertrophic cardiomyopathy (HCM) and Wolff-Parkinson-White (WPW) syndrome. The most common arrhythmia in HCM is ventricular tachycardia (VT) and atrial fibrillation (AF). While preexcitation provides the substrate for reentry and supraventricular tachycardia (SVT), AF is more common in patients with preexcitation than the general population. Concurrence of HCM and WPW has been reported in many cases, but whether the prognosis or severity of arrhythmia is different compared to the individual disorders remains unsettled...
2019: Case Reports in Cardiology
https://read.qxmd.com/read/31866554/comparison-of-arrhythmia-detection-by-conventional-holter-and-a-novel-ambulatory-ecg-system-using-patch-and-android-app-over-24-hour-period
#12
Karunadas Chakkalakkal Prabhakaran, Cibu Mathew
BACKGROUND: Ambulatory electrocardiogram (AECG) is done for evaluation of arrhythmia. Commonly used AECG system is 24 hour Holter. Patch based second generation AECG monitoring devices, which can record for longer periods, are now available. OBJECTIVE: Android App Based WebCardio using WiPatch is a new AECG system which records ECG in two leads for 72 hours. Our study compared the arrhythmia detection by WebCardio and conventional Holter by simultaneously connecting both for 24 hours in patients having indication for AECG...
December 19, 2019: Indian Pacing and Electrophysiology Journal
https://read.qxmd.com/read/31844477/ultra-high-density-mapping-of-intra-atrial-reentrant-tachycardia-in-a-patient-after-a-lateral-tunnel-total-cavopulmonary-connection
#13
Hitoshi Mori, Naokata Sumitomo, Shota Muraji, Noriyuki Iwashita, Toshiki Kobayashi, Ritsushi Kato
We report a case of an 18-year-old male with a postsurgical lateral tunnel (LT) total cavopulmonary connection (TCPC) and supraventricular tachycardia (SVT). Patients after an LT TCPC have complicated suture lines and a considerable area of damaged myocardium in the LT, which could become a complex arrhythmogenic substrate of tachycardias. Detailed three-dimensional (3D) mapping of the LT and atrium is important for a successful ablation. In this patient, successful catheter ablation of two types of complex tachycardias was accomplished using an ultra-high density 3D mapping system inside the LT...
December 2019: Journal of Arrhythmia
https://read.qxmd.com/read/31843557/repeated-misclassifications-of-tachycardia-by-an-implantable-cardiac-defibrillator
#14
Atsuyuki Watanabe, Osamu Fujimura
This case describes repeated misclassifications of SVT due to AV node reentry as VT by an ICD. This case illustrates the limitations of SVT-VT discrimination algorithm. Careful analysis of the stored tracings is of critical importance to reach the correct diagnosis.
December 13, 2019: Indian Pacing and Electrophysiology Journal
https://read.qxmd.com/read/31834569/-if-at-first-you-don-t-succeed-repeat-ablations-in-young-patients-with-supraventricular-tachycardia
#15
Ellis Rochelson, Bradley C Clark, Christopher M Janson, Scott R Ceresnak, Lynn Nappo, Robert H Pass
PURPOSE: Success rates for catheter ablation of supraventricular tachycardia (SVT) in the young exceed 90%. While studies have described reasons for initial ablation failure, less is known about outcomes of repeat ablation attempts. The purpose of this study was to report acute and mid-term success rates for second ablation attempts in young patients, as well as to analyze factors that may affect these outcomes. METHODS: Retrospective single-center study of all patients undergoing a second ablation attempt for WPW (Wolff-Parkinson-White) or SVT from 2008 to 2017...
December 13, 2019: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/31825681/etripamil-nasal-spray-an-investigational-agent-for-the-rapid-termination-of-paroxysmal-supraventricular-tachycardia-svt
#16
Anthony H Kashou, Peter A Noseworthy
Introduction : Paroxysmal supraventricular tachycardia (SVT) can be very bothersome and may potentially lead to considerable health-care utilization. Non-parenteral medication is currently unavailable for the rapid termination of paroxysmal SVT. However, an intranasal spray formulation of etripamil, a short-acting calcium-channel blocker, is under investigation as a convenient, safe, and rapidly efficacious means to terminate paroxysmal SVT. Areas covered : This review summarizes the clinical rationale, potential benefit, and clinical trials safety and efficacy data for the use of etripamil nasal spray to terminate paroxysmal SVT...
December 12, 2019: Expert Opinion on Investigational Drugs
https://read.qxmd.com/read/31820272/ventriculoatrial-conduction-in-patients-without-high-grade-av-block-when-is-it-present
#17
Claude S Elayi, Gustavo Morales, Muhammad Butt, Jignesh Shah, Gbolahan Ogunbayo, Naoki Misumida, John Catanzaro, Luigi Di Biase, Andrea Natale, Brian Delisle, Yousef Darrat
INTRODUCTION: Ventriculoatrial (VA) conduction is a critical component in many arrhythmias, has a diagnostic value in electrophysiology study (EPS), and is implicated in pacemaker-mediated arrhythmias. This study sought to characterize retrograde conduction during EPS and to utilize it as a diagnostic tool in patients without AV block. METHODS AND RESULTS: Patients with intact AV conduction undergoing EPS were included in this study to systematically evaluate baseline VA conduction...
December 9, 2019: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
https://read.qxmd.com/read/31807127/guidelines-for-superficial-venous-thrombosis
#18
Marcelo José de Almeida, Ana Terezinha Guillaumon, Daniel Miquelin, Edwaldo Edner Joviliano, Ludvig Hafner, Marcone Lima Sobreira, Martin Andreas Geiger, Regina Moura, Selma Raymundo, Winston Bonnetti Yoshida
Superficial venous thrombosis (SVT) or superficial thrombophlebitis is characterized by thrombi within superficial veins, with partial involvement or occlusion of the lumen and inflammatory reaction along the course of the vein. Clinical diagnosis tends to be straightforward, but supplementary tests and examinations are needed to confirm thrombosis extension and possible thromboembolic complications. SVT can be associated with deep venous thrombosis in 6 to 40% of cases, with asymptomatic pulmonary embolism (PE) in 20 to 33%, and with symptomatic PE in 2 to 13%...
November 20, 2019: Jornal Vascular Brasileiro
https://read.qxmd.com/read/31802764/supraventricular-tachycardia-of-the-sick-a-unique-entity
#19
Fuad J Habash, Peyton Card, Mohammed Eid Madmani, Bradley Boye, Hakan Paydak
OBJECTIVE: This study explored a unique form of atrioventricular nodal reentrant tachycardia (AVNRT) in which certain acutely ill patients have a first episode of supraventricular tachycardia (SVT) with a short RP interval. METHODS: A retrospective chart review was conducted of patients at a single institution who developed SVT with short RP and yielded 19 patients. RESULTS: None of the 19 patients had a prior history of AVNRT or any other arrhythmia...
December 2019: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
https://read.qxmd.com/read/31790855/a-new-mapping-method-with-the-rhythmia%C3%A2-navigation-system-reduces-radiation-exposure-preliminary-experience-in-svt-procedures
#20
Filippo Maria Cauti, Pietro Rossi, Luigi Iaia, Stefano Bianchi
PURPOSE: Electrophysiological studies and ablation procedures expose both physicians and patients to a significant amount of radiation. Most 3-D mapping systems provide improved tracking of catheters and enable radiation exposure to be reduced or even eliminated. However, there are no data on the ability of the Rhythmia ™ mapping system (Boston Scientific) to minimize fluoroscopy time and dose. METHODS: Here, we report on the feasibility and safety of a novel non-fluoroscopic approach (NFA) that uses the Rhythmia ™ mapping system and a novel navigation-enabled ablation catheter in SVT and atrial flutter procedures, and describe in detail our modified procedural work-flow...
November 23, 2019: Journal of Electrocardiology
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