Yanliang Chen, Hong Chen, Jianqi Yang, Weiguo Jin, Deyuan Fu, Min Liu, Yan Xu, Zhifang Tao, Ying Li, Lin Lu, Mingzhu Wang, Caiyun Zhu, Yong Chen
OBJECTIVE: Peripherally inserted central venous catheter (PICC)-related thrombosis (PRT) is a serious complication that can lead to interruptions in chemotherapy and other supportive care, as well as increased hospital stay and costs. We conducted a retrospective study to evaluate the patterns of symptomatic PRT in patients with cancer undergoing chemotherapy and their risk factors. METHODS: A retrospective study of 938 PICC patients from our institution between November 2014 and July 2017 was performed...
March 20, 2020: Journal of Vascular Surgery. Venous and Lymphatic Disorders
Thiago H G da Silva, Rafaely X de S Furtado, Marcelo Zaiat, Eduardo B Azevedo
There is a consensus among scientists that domestic sewage treatment plants are the main sources of drugs entry into the aquatic environment. Therefore, this work studies the biodegradation of the drugs ranitidine (RNT), diclofenac (DCF), and simvastatin (SVT) (50 μg L-1 , each), in real domestic sewage, using a continuous anaerobic-aerobic reactor with immobilized biomass and an anaerobic batch reactor. The continuous anaerobic-aerobic reactor was operated for 6 months with hydraulic retention time (HRT) of 8 h...
February 26, 2020: Science of the Total Environment
Nicoletta Riva, Walter Ageno
Cerebral vein thrombosis (CVT) and splanchnic vein thrombosis (SVT) are two manifestations of venous thromboembolism (VTE) at unusual sites. They have an incidence at least 25-50 times lower than usual site VTE, but represent true clinical challenges. Recent evidence on the epidemiology, risk factors, prognosis, and treatment of CVT and SVT has been published in the last two decades, thus contributing to a better understanding of these diseases. The improvement in imaging techniques and a higher degree of clinical suspicion may have led to the observed increased frequency, whereas a better knowledge of provoking mechanisms could have contributed to reducing the proportion of events classified as unprovoked or idiopathic (13%-21% of CVT, 15%-27% of SVT)...
March 10, 2020: Journal of Clinical Medicine
Jaime González-Montero, Lucía Del Valle-Batalla, Raúl Castillo-Astorga, Arnaldo Marín Valdés, Guillermo Conte Lanza
INTRODUCTION: Mesenteric and portal venous thromboses are rare diseases with high mortality rates and are strongly associated with hepatic cirrhosis, and abdominal inflammatory or tumoral processes, but in some cases can be the first sign of myeloproliferative neoplasm (MPN) or hereditary thrombophilia. JAK2V617F mutation detection is an important diagnostic tool for MPN patients. The aim of this study was to describe the JAK2V617F mutation prevalence on Chilean patients suffering from a primary splanchnic venous thrombosis (SVT), in order to assess how it relates to primary MVT and PVT in our specific population...
March 10, 2020: International Journal of Laboratory Hematology
Jieqiong Guan, Ailian Wang, Wenjing Song, Nathan Obore, Pan He, Siyu Fan, Hong Zhi, Lina Wang
BACKGROUND: SnapECG is a new handheld single-lead electrocardiograph (ECG) device used for arrhythmia screening, it is widely used in clinical practice but not in primary care. AIMS: To evaluate the arrhythmia screening value of SnapECG among a community-based population. METHODS: A cross-sectional community-based study of multistage stratified cluster sampling was conducted from March 1st to April 30th 2019. The sensitivities, specificities and the area under the receiver operating characteristic (AUCROC ) curves of the SnapECG and reference 12-lead ECG on arrhythmia were calculated in three age-groups [50-64 years, 65-74 years, and over-75 years]...
March 6, 2020: Aging Clinical and Experimental Research
Anna Sabaté Rotés, Marc Figueras Coll, Ferran Gran Ipiña, Alba Gallardo-Calero, Luis Renter Valdovinos, Pedro Domínguez-Sampedro, Ferran Rosés-Noguer
AIMS: The aim of this study is to establish the incidence of supraventricular tachycardia (SVT) as a main reason for between-hospital transfer in children, as well as to describe the clinical presentation, prognosis and treatment, risk factors presenting with haemodynamic compromise, and to propose a specific management protocol for the transport. METHODS: A retrospective observational study was conducted on all patients with supraventricular tachycardia transferred by the Hospital Vall d'Hebron Sistema de Emergencias Médicas Pediátricas (SEM-P) between January 2005 and June 2017...
March 3, 2020: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
Arwa Younis, Ilan Goldenberg, Scott McNitt, Wojciech Zareba, Valentina Kutyifa, Mehmet K Aktas
INTRODUCTION: We aimed to assess predictors of new supraventricular tachycardia (SVT) and the association of new SVT with subsequent clinical outcomes among mild heart failure (HF) patients. METHODS AND RESULTS: The study population comprised 1820 patients enrolled in MADIT-CRT, after exclusion of patients with atrial arrhythmias prior to enrollment (N=325). Multivariate analysis was used to identify predictors of new onset SVT and the association of time-dependent development of SVT with subsequent ventricular tachyarrhythmic events (VTEs), HF-hospitalizations, and death...
February 27, 2020: Journal of Cardiovascular Electrophysiology
Álvaro López-Samanes, Alberto Pérez-López, Victor Moreno-Pérez, Fabio Yuzo Nakamura, Jorge Acebes-Sánchez, Iñaki Quintana-Milla, Antonio J Sánchez-Oliver, Diego Moreno-Pérez, Valentín Emilio Fernández-Elías, Raúl Domínguez
Beetroot juice (BJ) contains high levels of inorganic nitrate (NO3 - ) and its intake has good evidence in increasing blood nitrate/nitrite concentrations. The ingestion of BJ has been associated with improvements in physical performance of endurance sports, however the literature in intermittent sports is scarce. The aim of this study was to investigate whether BJ could improve physical performance in tennis players. Thirteen well-trained tennis players (25.4 ± 5.1 years) participated in the study during their preparatory period for the tennis season...
February 23, 2020: Nutrients
Edward T O'Leary, Mark E Alexander, Vassilios J Bezzerides, Monika Drogosz, Kathleen E Economy, Kevin G Friedman, Sarah S Pickard, Wayne Tworetzky, Douglas Y Mah
OBJECTIVES: To describe a single institutional experience managing fetuses with SVT and to identify associations between patient characteristics and fetal and postnatal outcomes. BACKGROUND: Sustained fetal supraventricular tachycardia (SVT) is associated with significant morbidity and mortality if untreated, yet the optimal management strategy remains unclear. METHODS: Retrospective cohort study including fetuses diagnosed with sustained SVT (>50% of the diagnostic echocardiogram) between 1985-2018...
February 26, 2020: Journal of Cardiovascular Electrophysiology
Parmeshwar Ramesh Junare, Suhas Udgirkar, Sujit Nair, Prasanta Debnath, Shubham Jain, Ammar Modi, Pravin Rathi, Siddhesh Rane, Qais Contractor
Background: Splanchnic venous system thrombosis is a well recognized local vascular complication of acute pancreatitis (AP). It may involve thrombosis of splenic vein (SplV), portal vein (PV) and superior mesenteric vein (SMV), either separately or in combinations, and often detected incidentally, indeed some cases present with upper gastrointestinal bleed, bowel ischemia and hepatic decompensation. Incidence is variable depending on study subjects and diagnostic modalities. Pathogenesis is multifactorial centered on local and systemic inflammation...
February 2020: Gastroenterology Research
Alberto Alvarez-Larrán, Arturo Pereira, Marta Magaz, Juan Carlos Hernández-Boluda, Marta Garrote, Beatriz Cuevas, Francisca Ferrer-Marín, M Teresa Gómez-Casares, Valentín García-Gutiérrez, M Isabel Mata-Vázquez, Fanny Turon, Virginia Hernandez-Gea, Eduardo Arellano-Rodrigo, Francisco Cervantes, Juan Carlos García-Pagán
Patients with polycythemia vera (PV) or essential thrombocythemia (ET) presenting with splanchnic vein thrombosis (SVT) might have a specific clinico-biological profile. To investigate this hypothesis, 3705 PV/ET patients from three national registers, 118 of them presenting with SVT, were reviewed. After correction for age and sex, PV/ET patients with SVT showed an increased risk of death (HR 2.47, 95% CI 1.5-4.01, p < 0.001), venous thrombosis (IRR 3.4, 95%CI 2.1-5.5, p < 0.001), major bleeding (IRR 3...
February 22, 2020: Annals of Hematology
Charles A Coomer, Irene Carlon-Andres, Maro Iliopoulou, Michael L Dustin, Ewoud B Compeer, Alex A Compton, Sergi Padilla-Parra
There has been resurgence in determining the role of host metabolism in viral infection yet deciphering how the metabolic state of single cells affects viral entry and fusion remains unknown. Here, we have developed a novel assay multiplexing genetically-encoded biosensors with single virus tracking (SVT) to evaluate the influence of global metabolic processes on the success rate of virus entry in single cells. We found that cells with a lower ATP:ADP ratio prior to virus addition were less permissive to virus fusion and infection...
February 21, 2020: PLoS Pathogens
Markus Zarse, Fuad Hasan, Atisha Khan, Zana Karosiene, Bernd Lemke, Harilaos Bogossian
The electrical storm (ES) defined as ≥3 sustained episodes of ventricular tachycardia within a 24 h period comprises a wide spectrum of clinical entities. Mostly patients suffer from severe heart insufficiency and comorbidities making an immediate transfer into a heart center with multidisciplinary expertise in the treatment of ES mandatory. As these patients are often traumatized by ongoing tachycardia despite multiple cardioversions, early deep sedation and β‑blockade to break the vicious circle of sympathico-adrenergic hyperactivation is very effective...
February 14, 2020: Herzschrittmachertherapie & Elektrophysiologie
Gaetan Ploton, Marc-Antoine Pistorius, Alizée Raimbeau, Julien Denis Le Seve, Guillaume Bergère, Chan Ngohou, Yann Goueffic, Mathieu Artifoni, Cécile Durant, Giovanni Gautier, Jérôme Connault, Olivier Espitia
Upper extremity vein thrombosis (UE-VT) are more and more frequent pathologies and yet little studied. The aim is to describe the clinical and ultrasound features, UE-VT-related diseases, and the prevalence of pulmonary embolism (PE) and associated deaths.All UE-VT patients diagnosed by Doppler-ultrasound in Nantes University Hospital, from January 2015 to December 2017, were included retrospectively. UE-VT suspicion patterns, clinical features, UE-VT topography, and prevalence of PE and death were analyzed...
February 2020: Medicine (Baltimore)
Stephanie F Chandler, Esther Chu, Robert D Whitehill, Laura M Bevilacqua, Vassilios J Bezzerides, Elizabeth S DeWitt, Mark E Alexander, Dominic J Abrams, John K Triedman, Edward P Walsh, Douglas Y Mah
BACKGROUND: Sotalol is an important antiarrhythmic in the pediatric population. Given the risk for proarrhythmia, sotalol is initiated in inpatient settings, with adult studies as recent as 2015 supporting this practice. OBJECTIVE: To determine the frequency of adverse events (AE) during sotalol initiation for the management of atrial, supraventricular or ventricular arrhythmias in pediatric patients. METHODS: A retrospective cohort analysis of pediatric patients <21 years of age initiated on oral sotalol for SVT or VT at Boston Children's Hospital from January 1, 2007-July 1, 2016 was performed...
January 31, 2020: Heart Rhythm: the Official Journal of the Heart Rhythm Society
V Sawhney, A Mc Lellan, S Chatha, D Perera, A Aderonke, S Juno, S Whittaker-Axon, H Daw, J Garcia, P D Lambiase, S Cullen, A Bhan, K Von Klemperer, F Walker, B Pandya, M D Lowe, V Ezzat
PURPOSE: Catheter ablation for supraventricular tachycardia (SVT) in adults with congenital heart disease (ACHD) is an important therapeutic option. Cavo-tricuspid isthmus (CTI)-dependent intraatrial re-entrant tachycardia (IART) is common. However, induction of sustained tachycardia at the time of ablation is not always possible. We hypothesised that performing an empiric CTI line in case of non-inducibility leads to good outcomes. Long-term outcomes of empiric versus entrained CTI ablation in ACHD patients were examined...
January 29, 2020: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
Rana Khaznadar, Stephanie F Chandler, A Sami Chaouki, Sabrina Tsao, Gregory Webster
Children with ventricular pre-excitation are at risk for sudden death. This retrospective pediatric study identified patients > 8 years of age who had undergone electrophysiology study (EPS). Our primary objective was to determine the performance characteristics of non-invasive risk stratification. Subjects were separated into two groups. Group 1 was asymptomatic or had non-specific symptoms (palpitations, chest pain, and light headedness) without documented supraventricular tachycardia (SVT). Group 2 had syncope, documented SVT, or a life-threatening event...
January 23, 2020: Pediatric Cardiology
Hitoshi Mori, Naokata Sumitomo, Shota Muraji, Tomohiko Imamura, Noriyuki Iwashita, Toshiki Kobayashi
An 18-year-old male who had a past medical history of an intracardiac total cavopulmonary connection (TCPC) operation was referred to our hospital for radiofrequency catheter ablation (RFCA) of supraventricular tachycardia (SVT). Two types of SVTs were induced, and 3-dimensional (3D) maps were created using an ultra-high-density 3-dimensional mapping system (Rhythmia). The earliest atrial activation site (EAAS) of SVT1 was at the superior part of the conduit, and the EAAS of SVT2 was at the inferior part of the single atrium (SA)...
January 17, 2020: International Heart Journal
Shu-Lin Liu, Zhi-Gang Wang, Hai-Yan Xie, An-An Liu, Don C Lamb, Dai-Wen Pang
Uncovering the mechanisms of virus infection and assembly is crucial for preventing the spread of viruses and treating viral disease. The technique of single-virus tracking (SVT), also known as single-virus tracing, allows one to follow individual viruses at different parts of their life cycle and thereby provides dynamic insights into fundamental processes of viruses occurring in live cells. SVT is typically based on fluorescence imaging and reveals insights into previously unreported infection mechanisms...
January 17, 2020: Chemical Reviews
Irum D Kotadia, Steven E Williams, Mark O'Neill
Supraventricular tachycardia (SVT) is a common cause of hospital admissions and can cause significant patient discomfort and distress. The most common SVTs include atrioventricular nodal re-entrant tachycardia, atrioventricular re-entrant tachycardia and atrial tachycardia. In many cases, the underlying mechanism can be deduced from electrocardiography during tachycardia, comparing it with sinus rhythm, and assessing the onset and offset of tachycardia. Recent European Society of Cardiology guidelines continue to advocate the use of vagal manoeuvres and adenosine as first-line therapies in the acute diagnosis and management of SVT...
January 2020: Clinical Medicine: Journal of the Royal College of Physicians of London
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