Gayathri R Ediriweera, Neville J Butcher, Ashok Kothapalli, Jiacheng Zhao, Joanne T Blanchfield, Christopher N Subasic, James L Grace, Changkui Fu, Xiao Tan, John F Quinn, David B Ascher, Michael R Whittaker, Andrew K Whittaker, Lisa M Kaminskas
Inhalable nanomedicines are increasingly being developed to optimise the pharmaceutical treatment of respiratory diseases. Large lipid-based nanosystems at the forefront of the inhalable nanomedicines development pipeline, though, have a number of limitations. The objective of this study was, therefore, to investigate the utility of novel small lipidated sulfoxide polymers based on poly(2-(methylsulfinyl)ethyl acrylate) (PMSEA) as inhalable drug delivery platforms with tuneable membrane permeability imparted by differential albumin binding kinetics...
April 29, 2024: Biomaterials Science