Ling-Ling Ge, Zhi-Chao Wang, Cheng-Jiang Wei, Jing-Xuan Huang, Jun Liu, Yi-Hui Gu, Wei Wang, Qing-Feng Li
Dermatofibrosarcoma protuberans (DFSP) stands as a rare and locally aggressive soft tissue tumor, characterized by intricated molecular alterations. The imperative to unravel the complexities of intratumor heterogeneity underscores effective clinical management. Herein, we harnessed single-cell RNA sequencing (scRNA-seq) to conduct a comprehensive analysis encompassing samples from primary sites, satellite foci, and lymph node metastases. Rigorous preprocessing of raw scRNA-seq data ensued, and employing t-distributed stochastic neighbor embedding (tSNE) analysis, we unveiled seven major cell populations and fifteen distinct subpopulations...
November 8, 2023: Cancer Immunology, Immunotherapy: CII