Beatriz Mayol, Sandra Pradana-López, Alba García, Cristina de la Torre, Paula Díez, Anabel Villalonga, Carlos Anillo, Diana Vilela, Alfredo Sánchez, Paloma Martínez-Ruiz, Ramón Martínez-Máñez, Reynaldo Villalonga
Here, we report the preparation of a novel Janus nanoparticle with opposite Ir and mesoporous silica nanoparticles through a partial surface masking with toposelective modification method. This nanomaterial was employed to construct an enzyme-powered nanomachine with self-propulsion properties for on-command delivery. The cargo-loaded nanoparticle was provided with a pH-sensitive gate and unit control at the mesoporous face by first attaching boronic acid residues and further immobilization of glucose oxidase through reversible boronic acid esters with the carbohydrate residues of the glycoenzyme...
May 19, 2024: Journal of Colloid and Interface Science