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JOURNAL ARTICLE
J Adam Law, Laura V Duggan, Mathieu Asselin, Paul Baker, Edward Crosby, Andrew Downey, Orlando R Hung, George Kovacs, François Lemay, Rudiger Noppens, Matteo Parotto, Roanne Preston, Nick Sowers, Kathryn Sparrow, Timothy P Turkstra, David T Wong, Philip M Jones
PURPOSE: Since the last Canadian Airway Focus Group (CAFG) guidelines were published in 2013, the published airway management literature has expanded substantially. The CAFG therefore re-convened to examine this literature and update practice recommendations. This second of two articles addresses airway evaluation, decision-making, and safe implementation of an airway management strategy when difficulty is anticipated. SOURCE: Canadian Airway Focus Group members, including anesthesia, emergency medicine, and critical care physicians were assigned topics to search...
September 2021: Canadian Journal of Anaesthesia
#42
JOURNAL ARTICLE
Nazario Martin, Marta Ruiz-Santaquiteria, Beatriz M Illescas, Rana Abdelnabi, Arnaud Boonen, Alberto Mills, Olaia Martí-Marí, Sam Noppen, Johan Neyts, Dominique Schols, Federico Gago, Ana San-Félix, María-José Camarasa, Nazario Martín
Unprecedented 3D hexa-adducts of [60]fullerene peripherally decorated with twelve tryptophan (Trp) or tyrosine (Tyr) residues have been synthesized. Studies on the antiviral activity of these novel compounds against HIV and EV71 reveal that they are much more potent against HIV and equally active against EV71 than the previously described dendrimer prototypes AL-385 and AL-463 , which possess the same number of Trp/Tyr residues on the periphery but attached to a smaller and more flexible pentaerythritol core...
April 14, 2021: Chemistry: a European Journal
#43
JOURNAL ARTICLE
Ana Rita Goncalves Cabecinhas, Tim Roloff, Madlen Stange, Claire Bertelli, Michael Huber, Alban Ramette, Chaoran Chen, Sarah Nadeau, Yannick Gerth, Sabine Yerly, Onya Opota, Trestan Pillonel, Tobias Schuster, Cesar M J A Metzger, Jonas Sieber, Michael Bel, Nadia Wohlwend, Christian Baumann, Michel C Koch, Pascal Bittel, Karoline Leuzinger, Myrta Brunner, Franziska Suter-Riniker, Livia Berlinger, Kirstine K Søgaard, Christiane Beckmann, Christoph Noppen, Maurice Redondo, Ingrid Steffen, Helena M B Seth-Smith, Alfredo Mari, Reto Lienhard, Martin Risch, Oliver Nolte, Isabella Eckerle, Gladys Martinetti Lucchini, Emma B Hodcroft, Richard A Neher, Tanja Stadler, Hans H Hirsch, Stephen L Leib, Lorenz Risch, Laurent Kaiser, Alexandra Trkola, Gilbert Greub, Adrian Egli
The rapid spread of the SARS-CoV-2 lineages B.1.1.7 (N501Y.V1) throughout the UK, B.1.351 (N501Y.V2) in South Africa, and P.1 (B.1.1.28.1; N501Y.V3) in Brazil has led to the definition of variants of concern (VoCs) and recommendations for lineage specific surveillance. In Switzerland, during the last weeks of December 2020, we established a nationwide screening protocol across multiple laboratories, focusing first on epidemiological and microbiological definitions. In January 2021, we validated and implemented an N501Y-specific PCR to rapidly screen for VoCs, which are then confirmed using amplicon sequencing or whole genome sequencing (WGS)...
March 25, 2021: Microorganisms
#44
JOURNAL ARTICLE
Yagmur Yildizhan, Venkata Suresh Vajrala, Edward Geeurickx, Charles Declerck, Nevena Duskunovic, Delphine De Sutter, Sam Noppen, Filip Delport, Dominique Schols, Johannes V Swinnen, Sven Eyckerman, An Hendrix, Jeroen Lammertyn, Dragana Spasic
Extracellular vesicles (EVs) have drawn huge attention for diagnosing myriad of diseases, including cancer. However, the EV detection and analyses procedures often lack much desired sample standardization. To address this, we used well-characterized recombinant EVs (rEVs) for the first time as a biological reference material in developing a fiber optic surface plasmon resonance (FO-SPR) bioassay. In this context, EV binding on the FO-SPR probes was achieved only with EV-specific antibodies (e.g. anti-CD9 and anti-CD63) but not with non-specific anti-IgG...
February 2021: Journal of Extracellular Vesicles
#45
JOURNAL ARTICLE
Pia Van Noppen, Kim van Dun, Siel Depestele, Stefanie Verstraelen, Raf Meesen, Mario Manto
Background: Burnout is characterized by deficiencies in attention and several components of the working memory, of which the lingering effects of impaired attention and executive functions are the most frustrating. We hypothesized that anodal transcranial direct current stimulation (atDCS) over the left dorsolateral prefrontal cortex (DLPFC) can improve the executive control of attention and possibly several other components of working memory in patients with burnout. Methods: This was a randomized double-blind sham-controlled pilot study with two groups...
2020: F1000Research
#46
JOURNAL ARTICLE
James Pius, Ruediger R Noppens
Difficult airways can be managed with a range of devices, with video laryngoscopes (VLs) being the most common. The C-MAC® Video-Stylet (VS; Karl-Storz Germany), a hybrid between a flexible and a rigid intubation endoscope, has been recently introduced. The aim of this study is to investigate the performance of the VS compared to a VL (C-MAC Macintosh blade, Karl-Storz Germany) with regards to the learning curve for each device and its ability to manage a simulated difficult airway manikin. This is a single-center, prospective, randomized, crossover study involving twenty-one anesthesia residents performing intubations on a Bill 1™ (VBM, Germany) airway manikin model...
2020: PloS One
#47
JOURNAL ARTICLE
Arnaud Boonen, Abhimanyu K Singh, Anneleen Van Hout, Kalyan Das, Tom Van Loy, Sam Noppen, Dominique Schols
G protein-coupled receptors (GPCRs) are involved in a plethora of different diseases. Consequently, these proteins are considered as an important class of drug targets. Measuring detailed kinetic information on these types of proteins has been challenging. Surface plasmon resonance (SPR) can provide this information, however, the use of SPR on GPCRs remains a complex issue. Here, we report an SPR assay to investigate the interactions between the full-length chemokine receptor CXCR4 and nanobody-Fc (Nb-Fc) ligands...
October 21, 2020: Biosensors
#48
JOURNAL ARTICLE
Antonios Fikatas, Peter Vervaeke, Belén Martínez-Gualda, Olaia Martí-Marí, Sam Noppen, Eef Meyen, María-José Camarasa, Ana San-Félix, Christophe Pannecouque, Dominique Schols
Here, we report a class of tryptophan trimers and tetramers that inhibit (at low micromolar range) dengue and Zika virus infection in vitro These compounds (AL family) have three or four peripheral tryptophan moieties directly linked to a central scaffold through their amino groups; thus, their carboxylic acid groups are free and exposed to the periphery. Structure-activity relationship (SAR) studies demonstrated that the presence of extra phenyl rings with substituents other than COOH at the N1 or C2 position of the indole side chain is a requisite for the antiviral activity against both viruses...
February 21, 2020: Antimicrobial Agents and Chemotherapy
#49
REVIEW
Jillian C Belrose, Ruediger R Noppens
BACKGROUND: The impact of general anesthesia on cognitive impairment is controversial and complex. A large body of evidence supports the association between exposure to surgery under general anesthesia and development of delayed neurocognitive recovery in a subset of patients. Existing literature continues to debate whether these short-term effects on cognition can be attributed to anesthetic agents themselves, or whether other variables are causative of the observed changes in cognition...
December 27, 2019: BMC Anesthesiology
#50
JOURNAL ARTICLE
Marc Kriege, Florian Heid, Christian Alflen, Irene Schmidtmann, Frank Dette, Ruediger Noppens, Tim Piepho
BACKGROUND: Gastric tube insertion, either orally or nasally, is daily practice in anesthesia and intensive care. "Blind" insertion represents the common conventional method and is associated with low first-pass success and frequent complications. This trial aimed to evaluate the novel gastric tube guide as a rigid conduit in regard to insertion success rate, time required and associated complications vs. the conventional "blind" insertion method. We hypothesized that the insertion success rate is higher using the Orogastric tube guide...
December 6, 2019: Minerva Anestesiologica
#51
JOURNAL ARTICLE
Belén Martínez-Gualda, Liang Sun, Olaia Martí-Marí, Sam Noppen, Rana Abdelnabi, Carol M Bator, Ernesto Quesada, Leen Delang, Carmen Mirabelli, Hyunwook Lee, Dominique Schols, Johan Neyts, Susan Hafenstein, María-José Camarasa, Federico Gago, Ana San-Felix
Currently there are only three FDA-approved drugs that inhibit HIV entry-fusion into host cells. The situation is even worse for enterovirus EV71 infection for which no antiviral therapies are available. We describe here the discovery of potent entry dual inhibitors of HIV and EV71. These compounds contain in their structure three or four tryptophan (Trp) residues linked to a central scaffold. Critical for anti-HIV/EV71 activity is the presence of extra phenyl rings, bearing one or two carboxylates, at the C2 position of the indole ring of each Trp residue...
December 6, 2019: Journal of Medicinal Chemistry
#52
JOURNAL ARTICLE
Ana Marzo-Mas, Laura Conesa-Milián, Sam Noppen, Sandra Liekens, Eva Falomir, Juan Murga, Miguel Carda, Juan A Marco
BACKGROUND: In the last years, many efforts have been made to find colchicine derivatives with reduced toxicity. Additionally, the deregulation of amino acid uptake by cancer cells provides an opportunity to improve anticancer drug effectiveness. OBJECTIVE: To design new colchicine derivatives with reduced cytotoxicity and enhanced selectivity by means of introducing aminoacyl groups. METHODS: 34 colchicine analogues bearing L- and D-amino acid pendants were synthetized and characterized by NMR, IR and MS techniques...
2021: Medicinal Chemistry
#53
JOURNAL ARTICLE
S Banik, A G Parrent, R R Noppens
Super obesity with a body mass index (BMI) >50 kg/m2 presents a challenge for the neuroanesthesiologist during awake craniotomy procedures and poses increased perioperative risk of complications, even vis-à-vis morbid obesity. This article presents a super obese patient (BMI 57 kg/m2 ) with drug-refractory epilepsy and obstructive sleep apnea who underwent left anterior temporal lobectomy through awake craniotomy to preserve language and memory, using warmed humidified high flow nasal cannula (HFNC) oxygen therapy...
November 2019: Der Anaesthesist
#54
JOURNAL ARTICLE
Merel Oeyen, Sam Noppen, Emiel Vanhulle, Sandra Claes, Bernt O Myrvold, Kurt Vermeire, Dominique Schols
In Gordts et al. (2015), we have shown that lignosulfonic acid, a commercially available lignin derivative, possesses broad antiviral activity against human immunodeficiency virus (HIV) and Herpes simplex virus (HSV) by preventing viral entry into susceptible target cells. Because of the interesting safety profile as potential microbicide, we now determined the antiviral activity of a series of lignosulfonates in order to understand better which molecular features can contribute to their antiviral activity...
October 13, 2019: Virus Research
#55
RANDOMIZED CONTROLLED TRIAL
Lisa A Uebelacker, Donnell Van Noppen, Geoffrey Tremont, Genie Bailey, Ana Abrantes, Michael Stein
The purpose of this project was to assess the feasibility and acceptability of a hatha yoga program designed to target chronic pain in people receiving opioid agonist therapy for opioid use disorder. We conducted a pilot randomized trial in which people with chronic pain who were receiving either methadone maintenance therapy (n = 20) or buprenorphine (n = 20) were randomly assigned to weekly hatha yoga or health education (HE) classes for 3 months. We demonstrated feasibility in many domains, including recruitment of participants (58% female, mean age 43), retention for follow-up assessments, and ability of teachers to provide interventions with high fidelity to the manuals...
October 2019: Journal of Substance Abuse Treatment
#56
JOURNAL ARTICLE
Vasily Rybakin, Melissa Stas, Estefania Ugarte-Berzal, Sam Noppen, Jennifer Vandooren, Ilse Van Aelst, Sandra Liekens, Paul Proost, Ghislain Opdenakker
Interleukin 2 (IL-2) is critical for T cell development and homeostasis, being a key regulator of adaptive immune responses in autoimmunity, hypersensitivity reactions and cancer. Therefore, its abundance in serum and peripheral tissues needs tight control. Here, we described a new mechanism contributing to the immunobiology of IL-2. We demonstrated, both in biochemical and cell-based assays, that IL-2 is subject to proteolytic processing by neutrophil matrix metalloproteinase-9 (MMP-9). IL-2 fragments produced after cleavage by MMP-9 remained linked by a disulfide bond and displayed reduced affinity for all IL-2 receptor subunits and a distinct pattern and timing of signal transduction...
July 1, 2019: Biochemical Journal
#57
JOURNAL ARTICLE
Ana C S Gondim, Suzete Roberta da Silva, Leen Mathys, Sam Noppen, Sandra Liekens, Alexandre Holanda Sampaio, Celso S Nagano, Cintia Renata Costa Rocha, Kyria S Nascimento, Benildo S Cavada, Peter J Sadler, Jan Balzarini
Brazil has one of the largest biodiversities in the world. The search for new natural products extracted from the Brazilian flora may lead to the discovery of novel drugs with potential to treat infectious and other diseases. Here, we have investigated 9 lectins extracted and purified from the Northeastern Brazilian flora, from both leguminous species: Canavalia brasiliensis (ConBr), C. maritima (ConM), Dioclea lasiocarpa (DLasiL) and D. sclerocarpa (DSclerL), and algae Amansia multifida (AML), Bryothamniom seaforthii (BSL), Hypnea musciformis (HML), Meristiella echinocarpa (MEL) and Solieria filiformis (SfL)...
March 1, 2019: MedChemComm
#58
JOURNAL ARTICLE
Michael D Stein, Micah T Conti, Debra S Herman, Bradley J Anderson, Genie L Bailey, Donnell Van Noppen, Ana M Abrantes
BACKGROUND AND OBJECTIVES: Despite the benefits of maintenance buprenorphine treatment for opioid use disorder (OUD), many individuals report an interest in discontinuing the medication, while also expressing worries about tapering. The purpose of this study was to develop a measure of worries about buprenorphine discontinuation ("Off Bupe") and determine the demographic and clinical characteristics associated with these worries. METHODS: Between May 2017 and May 2018, we surveyed adults in an outpatient primary care buprenorphine program (n = 138)...
July 2019: American Journal on Addictions
#59
JOURNAL ARTICLE
James Pius, Khrystyna Ioanidis, Ruediger R Noppens
Video laryngoscopes are commonly used to manage difficult airways, among other devices. However, they present a challenge when inserting the blade in patients with a limited mouth opening, and an adequate visualization of the glottis does not always translate into successful intubation. The C-MAC Video-Stylet-with its small diameter and flexible tip-offers an effective alternative. We describe the successful use of the novel C-MAC Video-Stylet to secure the airway in a patient with minimal mouth opening due to the side effects of previous neck surgery and radiation therapy...
March 25, 2019: A&A Practice
#60
EDITORIAL
Ruediger R Noppens, James Pius
No abstract text is available yet for this article.
June 2019: Canadian Journal of Anaesthesia
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