Asahi Hishida, Tomotaka Ugai, Ryosuke Fujii, Masahiro Nakatochi, Michael C Wu, Hidemi Ito, Isao Oze, Tajika Masahiro, Niwa Yasumasa, Takeshi Nishiyama, Hiroko Nakagawa-Senda, Sadao Suzuki, Teruhide Koyama, Daisuke Matsui, Yoshiyuki Watanabe, Takahisa Kawaguchi, Fumihiko Matsuda, Yukihide Momozawa, Michiaki Kubo, Mariko Naito, Keitaro Matsuo, Kenji Wakai
Although recent genome-wide association studies (GWASs) have identified genetic variants associated with Helicobacter pylori (HP)-induced gastric cancer, few studies have examined the genetic traits associated with the risk of HP-induced gastric precancerous conditions. This study aimed to elucidate genetic variants associated with these conditions using a genome-wide approach. Data from four sites of the J-MICC Study were used in the discovery phase (Stage I); two datasets from the HERPACC2 Study were used in the replication phases (Stages II and III), and SKAT (SNP-set Kernel Association Test) and single variant-based GWASs were conducted for the risks of gastric atrophy (GA) and severe GA defined by serum pepsinogen (PG) levels, and PG1 and PG1/2 ratios...
February 8, 2019: Carcinogenesis