Michelle Khrom, Millie Long, Shishir Dube, Lori Robbins, Gregory J Botwin, Shaohong Yang, Emebet Mengesha, Dalin Li, Takeo Naito, Nirupama N Bonthala, Christina Ha, Gil Melmed, Shervin Rabizadeh, Gaurav Syal, Eric Vasiliauskas, David Ziring, Steven R Brant, Judy Cho, Richard H Duerr, John Rioux, Phil Schumm, Mark Silverberg, Ashwin N Ananthakrishnan, William A Faubion, Bana Jabri, Sergio A Lira, Rodney D Newberry, Robert S Sandler, Ramnik J Xavier, Subra Kugathasan, David Hercules, Stephan R Targan, R Balfour Sartor, Talin Haritunians, Dermot P B McGovern
BACKGROUND & AIMS: Patients with inflammatory bowel disease (IBD) frequently develop extraintestinal manifestations (EIMs) that contribute substantially to morbidity. We assembled the largest multicohort data set to date to investigate the clinical, serologic, and genetic factors associated with EIM complications in IBD. METHODS: Data were available in 12,083 unrelated European ancestry IBD cases with presence or absence of EIMs (eg, ankylosing spondylitis [ankylosing spondylitis and sacroiliitis], primary sclerosing cholangitis [PSC], peripheral arthritis, and skin and ocular manifestations) across 4 cohorts (Cedars-Sinai Medical Center, National Institute for Diabetes and Digestive and Kidney Diseases IBD Genetics Consortium, Sinai Helmsley Alliance for Research Excellence Consortium, and Risk Stratification and Identification of Immunogenetic and Microbial Markers of Rapid Disease Progression in Children with Crohn's Disease cohort)...
March 13, 2024: Gastroenterology