Laura W Dillon, Gege Gui, Niveditha Ravindra, Georgia Andrew, Devdeep Mukherjee, Zoë C Wong, Ying Huang, Jason Gerhold, Matt Holman, Julian D'Angelo, Jeffrey Miller, Jake Higgins, Jesse J Salk, Jeffery J Auletta, Firas El Chaer, Steven M Devine, Antonio Martin Jimenez-Jimenez, Marcos J G De Lima, Mark R Litzow, Partow Kebriaei, Wael Saber, Stephen R Spellman, Scott L Zeger, Kristin M Page, Christopher S Hourigan
IMPORTANCE: Persistence of FLT3 internal tandem duplication (ITD) in adults with acute myeloid leukemia (AML) in first complete remission (CR) prior to allogeneic hematopoietic cell transplant (HCT) is associated with increased relapse and death after transplant, but the association between the level of measurable residual disease (MRD) detected and clinical outcome is unknown. OBJECTIVE: To examine the association between pre-allogeneic HCT MRD level with relapse and death posttransplant in adults with AML in first CR...
May 2, 2024: JAMA Oncology