Eliza Bollinger, Matthew Peloquin, Jenna Libera, Bina Albuquerque, Evanthia Pashos, Arun Shipstone, Angela Hadjipanayis, Zhongyuan Sun, Gang Xing, Michelle Clasquin, John C Stansfield, Brendan Tierney, Steven Gernhardt, C Parker Siddall, Timothy Greizer, Frank J Geoly, Sarah R Vargas, Lily C Gao, George Williams, Mackenzie Marshall, Amy Rosado, Claire Steppan, Kevin J Filipski, Bei B Zhang, Russell A Miller, Rachel J Roth Flach
OBJECTIVE: Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms underlying these improvements. METHODS: The rate limiting step of BCAA catabolism is the irreversible decarboxylation by the branched chain ketoacid dehydrogenase (BCKDH) enzyme complex, which is post-translationally controlled through phosphorylation by BCKDH kinase (BDK)...
October 8, 2022: Molecular Metabolism