Richard Sherva, Rui Zhang, Nathan Sahelijo, Gyungah Jun, Tori Anglin, Catherine Chanfreau, Kelly Cho, Jennifer R Fonda, J Michael Gaziano, Kelly M Harrington, Yuk-Lam Ho, William S Kremen, Elizabeth Litkowski, Julie Lynch, Zoe Neale, Panos Roussos, David Marra, Jesse Mez, Mark W Miller, David H Salat, Debby Tsuang, Erika Wolf, Qing Zeng, Matthew S Panizzon, Victoria C Merritt, Lindsay A Farrer, Richard L Hauger, Mark W Logue
While genome wide association studies (GWASs) of Alzheimer's Disease (AD) in European (EUR) ancestry cohorts have identified approximately 83 potentially independent AD risk loci, progress in non-European populations has lagged. In this study, data from the Million Veteran Program (MVP), a biobank which includes genetic data from more than 650,000 US Veteran participants, was used to examine dementia genetics in an African descent (AFR) cohort. A GWAS of Alzheimer's disease and related dementias (ADRD), an expanded AD phenotype including dementias such as vascular and non-specific dementia that included 4012 cases and 18,435 controls age 60+ in AFR MVP participants was performed...
December 22, 2022: Molecular Psychiatry