Luciana Teofili, Patrizia Papacci, Nicoletta Orlando, Maria Bianchi, Tina Pasciuto, Iolanda Mozzetta, Fernando Palluzzi, Luciano Giacò, Carmen Giannantonio, Giulia Remaschi, Michela Santosuosso, Enrico Beccastrini, Marco Fabbri, Caterina Giovanna Valentini, Tiziana Bonfini, Eleonora Cloclite, Patrizia Accorsi, Antonella Dragonetti, Francesco Cresi, Giulia Ansaldi, Genny Raffaeli, Stefania Villa, Giulia Pucci, Isabella Mondello, Michele Santodirocco, Stefano Ghirardello, Giovanni Vento
BACKGROUND: Extremely low gestational age neonates (ELGANs, i.e., neonates born before 28 weeks of gestation) are at high risk of developing retinopathy of prematurity (ROP), with potential long-life visual impairment. Due to concomitant anemia, ELGANs need repeated red blood cell (RBC) transfusions. These produce a progressive replacement of fetal hemoglobin (HbF) by adult hemoglobin (HbA). Furthermore, a close association exists between low levels of HbF and severe ROP, suggesting that a perturbation of the HbF-mediated oxygen release may derange retinal angiogenesis and promote ROP...
December 13, 2022: Trials